Protein ingestion before sleep improves postexercise overnight recovery

Journal article


Res, Peter T., Groen, Bart, Pennings, Bart, Beelen, Milou, Wallis, Gareth A., Gijsen, Annemie P., Senden, Joan M. and Van Loon, Luc J.C.. (2012) Protein ingestion before sleep improves postexercise overnight recovery. Medicine and Science in Sports and Exercise. 44(8), pp. 1560 - 1569. https://doi.org/10.1249/MSS.0b013e31824cc363
AuthorsRes, Peter T., Groen, Bart, Pennings, Bart, Beelen, Milou, Wallis, Gareth A., Gijsen, Annemie P., Senden, Joan M. and Van Loon, Luc J.C.
Abstract

RES, P. T., B. GROEN, B. PENNINGS, M. BEELEN, G. A. WALLIS, A. P. GIJSEN, J. M. G. SENDEN, and L. J. C. VAN LOON. Protein Ingestion before Sleep Improves Postexercise Overnight Recovery. Med. Sci. Sports Exerc., Vol. 44, No. 8, pp. 1560–1569, 2012. Introduction: The role of nutrition in modulating postexercise overnight recovery remains to be elucidated. We assessed the effect of protein ingestion immediately before sleep on digestion and absorption kinetics and protein metabolism during overnight recovery from a single bout of resistance-type exercise. Methods: Sixteen healthy young males performed a single bout of resistance-type exercise in the evening (2000 h) after a full day of dietary standardization. All subjects were provided with appropriate recovery nutrition (20 g of protein, 60 g of CHO) immediately after exercise (2100 h). Thereafter, 30 min before sleep (2330 h), subjects ingested a beverage with (PRO) or without (PLA) 40 g of specifically produced intrinsically [1-13C]phenylalanine-labeled casein protein. Continuous intravenous infusions with [ring-2 H5]phenylalanine and [ring-2 H2]tyrosine were applied with blood and muscle samples collected to assess protein digestion and absorption kinetics, whole-body protein balance and mixed muscle protein synthesis rates throughout the night (7.5 h). Results: During sleep, casein protein was effectively digested and absorbed resulting in a rapid rise in circulating amino acid levels, which were sustained throughout the remainder of the night. Protein ingestion before sleep increased whole-body protein synthesis rates (311 T 8 vs 246 T 9 KmolIkgj1 per 7.5 h) and improved net protein balance (61 T 5 vs j11 T 6 KmolIkgj1 per 7.5 h) in the PRO vs the PLA experiment (P G 0.01). Mixed muscle protein synthesis rates were È22% higher in the PRO vs the PLA experiment, which reached borderline significance (0.059%Ihj1 T 0.005%Ihj1 vs 0.048%Ihj1 T 0.004%Ihj1 , P = 0.05). Conclusions: This is the first study to show that protein ingested immediately before sleep is effectively digested and absorbed, thereby stimulating muscle protein synthesis and improving whole-body protein balance during postexercise overnight recovery.

KeywordsSleep; Recovery; Exercise; Muscle; Stable Isotopes; Casein
Year2012
JournalMedicine and Science in Sports and Exercise
Journal citation44 (8), pp. 1560 - 1569
PublisherLippincott Williams and Wilkins
ISSN0195-9131
Digital Object Identifier (DOI)https://doi.org/10.1249/MSS.0b013e31824cc363
Scopus EID2-s2.0-84863981572
Page range1560 - 1569
Research GroupMary MacKillop Institute for Health Research
Place of publicationUnited States
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