Falls in people with MS - An individual data meta-analysis from studies from Australia, Sweden, United Kingdom and the United States

Journal article


Nilsagård, Ylva E., Gunn, Hilary, Freeman, Jennifer, Hoang, Phu, Lord, Stephen R., Mazumder, Rajarshi and Cameron, Michelle. (2015). Falls in people with MS - An individual data meta-analysis from studies from Australia, Sweden, United Kingdom and the United States. Multiple Sclerosis Journal. 21(1), pp. 92 - 100. https://doi.org/10.1177/1352458514538884
AuthorsNilsagård, Ylva E., Gunn, Hilary, Freeman, Jennifer, Hoang, Phu, Lord, Stephen R., Mazumder, Rajarshi and Cameron, Michelle
Abstract

Background: Falls are common in people with multiple sclerosis (PwMS). Previous studies have generally included small samples and had varied methods. Objectives: The objectives of this paper are to compile fall rates across a broad range of ages and disease severity and to definitively assess the extent to which MS-associated and demographic factors influence fall rates. Methods: Individual data from studies in four countries that prospectively measured falls for three months were analyzed. We determined fall rates, prevalence of fallers (≥1 falls) and frequent fallers (≥2 falls), location and timing of falls, and fall-related demographic factors. Results: A total of 537 participants reported 1721 falls: 56% were fallers and 37% frequent fallers. Most falls occurred indoors (65%) between 6 a.m. and 6 p.m. (75%). Primary progressive MS was associated with significantly increased odds of being a faller (odds ratio (OR) 2.02; CI 1.08–3.78). Fall risk peaked at EDSS levels of 4.0 and 6.0 with significant ORs between 5.30 (2.23–12.64) and 5.10 (2.08–12.47). The fall rate was lower in women than men (relative risk (RR) 0.80; CI 0.67–0.94) and decreased with increasing age (RR 0.97 for each year, CI 0.95–0.98). Conclusion: PwMS are at high risk of falls and there are important associations between falls and MS-associated disability, gender and age.

Keywordsaccidental falls; multiple sclerosis; risk factors; cohort studies; meta-analysis
Year2015
JournalMultiple Sclerosis Journal
Journal citation21 (1), pp. 92 - 100
PublisherSage Publications Ltd.
ISSN1352-4585
Digital Object Identifier (DOI)https://doi.org/10.1177/1352458514538884
Scopus EID2-s2.0-84922933779
Page range92 - 100
Research GroupSports Performance, Recovery, Injury and New Technologies (SPRINT) Research Centre
Publisher's version
File Access Level
Controlled
Place of publicationUnited Kingdom
Permalink -

https://acuresearchbank.acu.edu.au/item/85305/falls-in-people-with-ms-an-individual-data-meta-analysis-from-studies-from-australia-sweden-united-kingdom-and-the-united-states

Restricted files

Publisher's version

  • 74
    total views
  • 0
    total downloads
  • 0
    views this month
  • 0
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Exercise and Sports Science Australia (ESSA) position statement on exercise for people with mild to moderate multiple sclerosis
Hoang, Phu D., Lord, Stephen, Gandevia, Simon and Menant, Jasmine. (2022). Exercise and Sports Science Australia (ESSA) position statement on exercise for people with mild to moderate multiple sclerosis. Journal of Science and Medicine in Sport. 25(2), pp. 146-154. https://doi.org/10.1016/j.jsams.2021.08.015
Brief report : Passive mechanical properties of gastrocnemius in multiple sclerosis and ankle contracture
Hoang, Phu D., Psarakis, Michael, Kwah, Li Khim, Clarke, Jillian L., Gandevia, Simon C. and Diong, Joanna. (2021). Brief report : Passive mechanical properties of gastrocnemius in multiple sclerosis and ankle contracture. Clinical Biomechanics. 84, p. Article 105338. https://doi.org/10.1016/j.clinbiomech.2021.105338
Safety, feasibility, and efficacy of an eccentric exercise intervention in people with multiple sclerosis with ankle contractures
Psarakis, Michael, Lord, Stephen R. and Hoang, Phu D.. (2021). Safety, feasibility, and efficacy of an eccentric exercise intervention in people with multiple sclerosis with ankle contractures. International Journal of MS Care. 23(1), pp. 31-36. https://doi.org/10.7224/1537-2073.2019-022
The frequency of bowel and bladder problems in multiple sclerosis and its relation to fatigue : A single centre experience
Lin, Sophia D., Butler, Jane E., Boswell-Ruys, Claire L., Phu, Hoang, Jarvis, Tom, Gandevia, Simon C. and McCaughey, Euan J.. (2019). The frequency of bowel and bladder problems in multiple sclerosis and its relation to fatigue : A single centre experience. PLoS ONE. 14(9), p. Article e0222731. https://doi.org/10.1371/journal.pone.0222731
Cold Water Ingestion Improves Exercise Tolerance of Heat-Sensitive People with MS
Georgia K. Chaseling, Davide Filingeri, Michael Barnett, Phu Hoang, Scott L. Davis and Ollie Jay. (2018). Cold Water Ingestion Improves Exercise Tolerance of Heat-Sensitive People with MS. Medicine and Science in Sports and Exercise. 50(4), pp. 643-649. https://doi.org/10.1249/MSS.0000000000001496
Relationship between physiological and perceived fall risk in people with multiple sclerosis: Implications for assessment and management
Gunn, Hilary, Cameron, Michelle, Hoang, Phu, Lord, Stephen R., Shaw, Steve and Freeman, Jennifer. (2018). Relationship between physiological and perceived fall risk in people with multiple sclerosis: Implications for assessment and management. Archives of Physical Medicine and Rehabilitation. 99(10), pp. 2022 - 2029. https://doi.org/10.1016/j.apmr.2018.03.019
Wearable technology reveals gait compensations, unstable walking patterns and fatigue in people with multiple sclerosis
Psarakis, Michael, Greene, David A., Cole, Michael H., Lord, Stephen R., Hoang, Phu and Brodie, Matthew A. D.. (2018). Wearable technology reveals gait compensations, unstable walking patterns and fatigue in people with multiple sclerosis. Physiological Measurement. 39(7), pp. 1 - 13. https://doi.org/10.1088/1361-6579/aac0a3
Afferent thermosensory function in relapsing–remitting multiple sclerosis following exercise-induced increases in body temperature
Filingeri, Davide, Chaseling, Georgia K., Hoang, Phu, Barnett, Michael, Davis, Scott L. and Jay, Ollie. (2017). Afferent thermosensory function in relapsing–remitting multiple sclerosis following exercise-induced increases in body temperature. Experimental Physiology. 102(8), pp. 887 - 893. https://doi.org/10.1113/EP086320
Impaired heel to toe progression during gait is related to reduced ankle range of motion in people with Multiple Sclerosis
Psarakis, Michael, Greene, David, Moresi, Mark, Baker, Michael, Stubbs, Peter, Brodie, Matthew, Lord, Stephen and Hoang, Phu. (2017). Impaired heel to toe progression during gait is related to reduced ankle range of motion in people with Multiple Sclerosis. Clinical Biomechanics. 49, pp. 96-100. https://doi.org/10.1016/j.clinbiomech.2017.08.012
A simple test of choice stepping reaction time for assessing fall risk in people with multiple sclerosis
Tijsma, Mylou, Vister, Eva, Hoang, Phu and Lord, Stephen R.. (2017). A simple test of choice stepping reaction time for assessing fall risk in people with multiple sclerosis. Disability and Rehabilitation. 39(6), pp. 601 - 607. https://doi.org/10.3109/09638288.2016.1148784
Effects of a home-based step training programme on balance, stepping, cognition and functional performance in people with multiple sclerosis - A randomized controlled trial
Hoang, Phu, Schoene, Daniel, Gandevia, Simon C., Smith, Stuart T. and Lord, Stephen R.. (2016). Effects of a home-based step training programme on balance, stepping, cognition and functional performance in people with multiple sclerosis - A randomized controlled trial. Multiple Sclerosis Journal. 22(1), pp. 94 - 103. https://doi.org/10.1177/1352458515579442
Gyroscopic corrections improve wearable sensor data prior to measuring dynamic sway in the gait of people with Multiple Sclerosis
Brodie, Matthew A. D., Psarakis, Michael and Hoang, Phu. (2016). Gyroscopic corrections improve wearable sensor data prior to measuring dynamic sway in the gait of people with Multiple Sclerosis. Computer Methods in Biomechanics and Biomedical Engineering. 19(12), pp. 1339 - 1346. https://doi.org/10.1080/10255842.2016.1140747
Medications are associated with falls in people with multiple sclerosis - A Prospective Cohort study
Cameron, Michelle H., Karstens, Lisa, Hoang, Phu, Bourdette, Dennis and Lord, Stephen R.. (2015). Medications are associated with falls in people with multiple sclerosis - A Prospective Cohort study. International Journal of MS Care. 17(5), pp. 207 - 214. https://doi.org/10.7224/1537-2073.2014-076
Neuromuscular electrical stimulation cycling exercise for persons with advanced multiple sclerosis
Fornusek, Ché and Hoang, Phu. (2014). Neuromuscular electrical stimulation cycling exercise for persons with advanced multiple sclerosis. Journal of Rehabilitation Medicine. 46(7), pp. 698 - 702. https://doi.org/10.2340/16501977-1792
Passive mechanical properties of the gastrocnemius after spinal cord injury
Diong, Joanna, Herbert, Robert, Harvey, Lisa, Kwah, Li, Clark, Jillian, Hoang, Phu, Martin, Josh, Clarke, E, Bilston, L and Gandevia, S. (2012). Passive mechanical properties of the gastrocnemius after spinal cord injury. Muscle & Nerve. 46(2), pp. 237 - 245. https://doi.org/10.1002/mus.23356