An examination of the effects of the antioxidant Pycnogenol® on cognitive performance, serum lipid profile, endocrinological and oxidative stress biomarkers in an elderly population

Journal article


Ryan, John, Croft, Kevin, Mori, Trevor, Wesnes, Keith, Spong, Joanne, Downey, Luke, Kure, Christina, Lloyd, Jenny and Stough, Con. (2008) An examination of the effects of the antioxidant Pycnogenol® on cognitive performance, serum lipid profile, endocrinological and oxidative stress biomarkers in an elderly population. Journal of Psychopharmacology. 22(5), pp. 553 - 562. https://doi.org/10.1177/0269881108091584
AuthorsRyan, John, Croft, Kevin, Mori, Trevor, Wesnes, Keith, Spong, Joanne, Downey, Luke, Kure, Christina, Lloyd, Jenny and Stough, Con
Abstract

The study examines the effects of the antioxidant flavonoid Pycnogenol on a range of cognitive and biochemical measures in healthy elderly individuals. The study used a double-blind, placebo-controlled, matched-pair design, with 101 elderly participants (60—85 years) consuming a daily dose of 150 mg of Pycnogenol for a three-month treatment period. Participants were assessed at baseline, then at 1, 2, and 3 months of the treatment. The control (placebo) and Pycnogenol groups were matched by age, sex, body mass index, micronutrient intake, and intelligence. The cognitive tasks comprised measures of attention, working memory, episodic memory, and psychomotor performance. The biological measures comprised levels of clinical hepatic enzymes, serum lipid profile, human growth hormone, and lipid peroxidation products. Statistically significant interactions were found for memory-based cognitive variables and lipid peroxidation products, with the Pycnogenol group displaying improved working memory and decreased concentrations of F2-isoprostanes relative to the control group.

Keywordsantioxidant; aged; cognition; oxidative stress; Pycnogenol
Year2008
JournalJournal of Psychopharmacology
Journal citation22 (5), pp. 553 - 562
PublisherSage Publications Ltd.
ISSN0269-8811
Digital Object Identifier (DOI)https://doi.org/10.1177/0269881108091584
Page range553 - 562
Research GroupSchool of Nursing, Midwifery and Paramedicine
Place of publicationUnited Kingdom
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