The role of outdoor fungi on asthma hospital admissions in children and adolescents: a 5-year time stratified case-crossover analysis

Journal article


Tham, Rachel, Katelaris, Constance H., Vicendese, Don, Dharmage, Shyamali C., Lowe, Adrian J., Bowatte, Gayan, Taylor, Philip, Burton, Pamela, Abramson, Michael J. and Erbas, B.. (2017) The role of outdoor fungi on asthma hospital admissions in children and adolescents: a 5-year time stratified case-crossover analysis. Environmental Research. 154, pp. 42 - 49. https://doi.org/10.1016/j.envres.2016.12.016
AuthorsTham, Rachel, Katelaris, Constance H., Vicendese, Don, Dharmage, Shyamali C., Lowe, Adrian J., Bowatte, Gayan, Taylor, Philip, Burton, Pamela, Abramson, Michael J. and Erbas, B.
Abstract

Background
Some fungal spores can trigger asthma exacerbation but knowledge of which outdoor fungal spores contribute to asthma hospitalisation is limited.
Objectives
To examine the role of outdoor fungal spores in child and adolescent asthma hospitalisations.
Methods
We conducted a bi-directional time-stratified case-crossover study of child and adolescent asthma hospitalisations over 5 years. Conditional logistic regression assessed the role of 20 fungi taxa (Same day [L0] and lagged [L1-3]) adjusted for maximum temperature, humidity and grass pollen. Strata specific effects were explored if there was evidence of effect modification by age, sex, air pollutants or grass pollen. Non-linear effects examined with Generalized Additive Models.
Results
Of 2098 children hospitalised for asthma, 60% were boys; mean age was 5.5±3.7 years. Fungal spore counts peaked during warm months. Regression models found weak associations with Coprinus [L0,L1: OR=1.03, 1.01–1.06], Periconia [L0: OR=1.03, 1.001–1.07] and Chaetomium [L2: OR=1.08, 1.0–1.2]. Sex appeared to act as an effect modifier with girls having stronger associations with Cladosporium, Coprinus and total fungi. Older adolescent (14–18 years) hospitalisation was significantly associated with Coprinus and Ustilago/smuts. Air pollutants and grass pollen did not appear to act as effect modifiers. Non-linearity was not detected.
Conclusion
There may be associations between some outdoor fungal spores and asthma hospitalisations. Further research needed to explore whether these findings can be replicated; and examine whether fungal sensitisation and/or human rhinovirus infections are associated with stronger effects. If findings are replicated, then the need to develop predictive models for fungal spore distribution and levels may become more important.

KeywordsChild; Adolescent; Asthma; hospitalisations; Outdoor fungi; Case cross-over
Year2017
JournalEnvironmental Research
Journal citation154, pp. 42 - 49
PublisherAcademic Press
ISSN0013-9351
Digital Object Identifier (DOI)https://doi.org/10.1016/j.envres.2016.12.016
Scopus EID2-s2.0-85007251520
Page range42 - 49
Research GroupMary MacKillop Institute for Health Research
Place of publicationUnited States of America
EditorsJ. L. Domingo
Permalink -

https://acuresearchbank.acu.edu.au/item/853vx/the-role-of-outdoor-fungi-on-asthma-hospital-admissions-in-children-and-adolescents-a-5-year-time-stratified-case-crossover-analysis

Restricted files

Publisher's version

  • 0
    total views
  • 0
    total downloads
  • 0
    views this month
  • 0
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Outdoor fungal spores and acute respiratory effects in vulnerable individuals
Tham, Rachel, Erbas, Bircan, Dharmage, Shyamali Chandrika, Tang, Mimi L. K., Aldakheel, Fahad, Lodge, Caroline J., Thomas, Paul S., Taylor, Philip E., Abramson, Michael J. and Lowe, Adrian J.. (2019) Outdoor fungal spores and acute respiratory effects in vulnerable individuals. Environmental Research. 178, pp. 1 - 9. https://doi.org/10.1016/j.envres.2019.108675
Association between fire smoke fine particulate matter and asthma-related outcomes: Systematic review and meat-analysis
Arriagada, Nicolas Borchers, Horsley, Joshua A., Palmer, Andrew J., Morgan, Geoffrey G., Tham, Rachel and Johnston, Fay H.. (2019) Association between fire smoke fine particulate matter and asthma-related outcomes: Systematic review and meat-analysis. Environmental Research. 179, pp. 1 - 11. https://doi.org/10.1016/j.envres.2019.108777
High ambient levels of grass, weed and other pollen are associated with asthma admissions in children and adolescents: A large 5-year case-crossover study
Shrestha, Som K., Katelaris, C. H., Dharmage, S. C., Burton, Pamela, Vicendese, Don, Tham, Rachel, Abramson, Michael J. and Erbas, B.. (2018) High ambient levels of grass, weed and other pollen are associated with asthma admissions in children and adolescents: A large 5-year case-crossover study. Clinical and Experimental Allergy. 48(11), pp. 1421 - 1428. https://doi.org/10.1111/cea.13225
Outdoor pollen is a trigger of child and adolescent asthma emergency department presentations: A systematic review and meta-analysis
Erbas, Bircan, Jazayeri, Mitra, Lambert, Katrina A., Katelaris, Constance H., Prendergast, Luke A., Tham, Rachel, Parrodi, M.J., Davies, Janet M., Newbigin, Ed J., Abramson, Michael J. and Charmage, Shyamali C.. (2018) Outdoor pollen is a trigger of child and adolescent asthma emergency department presentations: A systematic review and meta-analysis. Allergy. 73(8), pp. 1632 - 1641. https://doi.org/10.1111/all.13407
Air pollution and otitis media in children: A systematic review of literature
Bowatte, Gayan, Tham, Rachel, Perret, Jennifer L., Bloom, Michael S., Dong, Guanghui, Waidyatillake, Nilakshi, Bui, Dinh, Morgan, Geoffrey G., Jalaludin, Bin, Lodge, Caroline J. and Dharmage, Shyamali C.. (2018) Air pollution and otitis media in children: A systematic review of literature. International Journal of Environmental Research and Public Health. 15(2), pp. 1 - 19. https://doi.org/10.3390/ijerph15020257
Greenspace and atopic sensitization in children and adolescents: A systematic review
Lambert, Katrina A., Bowatte, Gayan, Tham, Rachel, Lodge, Caroline J., Prendergast, Luke A., Heinrich, Joachim, Abramson, Michael J., Dharmage, Shyamali C. and Erbas, Bircan. (2018) Greenspace and atopic sensitization in children and adolescents: A systematic review. International Journal of Environmental Research and Public Health. 15(11), pp. 1 - 12. https://doi.org/10.3390/ijerph15112539
Associations between outdoor fungal spores and childhood and adolescent asthma hospitalizations
Tham, Rachel, Vicendese, Don, Dharmage, S. C., Hyndman, Rob J., Newbigin, E., Lewis, Emma, O'Sullivan, Molly, Lowe, Adrian J., Taylor, Philip, Bardin, Philip, Tang, Mimi L. K., Abramson, Michael J. and Erbas, B.. (2017) Associations between outdoor fungal spores and childhood and adolescent asthma hospitalizations. Journal of Allergy and Clinical Immunology. 139(4), pp. 1140 - 1147. https://doi.org/10.1016/j.jaci.2016.06.046
Effect of season of birth on cord blood IgE and IgE at birth: a systematic review and meta-analysis
Susanto, Nugrobo Harry, Vicendese, Don, Salim, Agus, Lowe, Adrian J., Dharmage, S. C., Tham, Rachel, Lodge, Caroline, Garden, Frances L., Allen, Katie, Svanes, Cecilie, Heinrich, Joachim, Abramson, Michael J. and Erbas, B.. (2017) Effect of season of birth on cord blood IgE and IgE at birth: a systematic review and meta-analysis. Environmental Research. 157, pp. 198 - 205. https://doi.org/10.1016/j.envres.2017.05.026
Residential greenness and allergic respiratory diseases in children and adolescents - a systematic review and meta-analysis
Lambert, K. A., Bowatte, G., Tham, Rachel, Lodge, C., Prendergast, L., Heinrich, J., Abramson, Michael J., Dharmage, S. C. and Erbas, B.. (2017) Residential greenness and allergic respiratory diseases in children and adolescents - a systematic review and meta-analysis. Environmental Research. 159, pp. 212 - 221. https://doi.org/10.1016/j.envres.2017.08.002
The quality of cardiovascular disease prevention in rural primary care
Allenby, Ann, Kinsman, Leigh, Tham, Rachel, Symons, Julie, Jones, Mike and Campbell, Stephen. (2016) The quality of cardiovascular disease prevention in rural primary care. Australian Journal of Rural Health. 24(2), pp. 92 - 98. https://doi.org/10.1111/ajr.12224
Prevention of cardiovascular disease in rural Australian primary care: an exploratory study of the perspectives of clinicians and high-risk men
Kinsman, Leigh, Tham, Rachel, Symons, Julie, Jones, Mike, Campbell, Stephen and Allenby, Ann. (2016) Prevention of cardiovascular disease in rural Australian primary care: an exploratory study of the perspectives of clinicians and high-risk men. Australian Journal of Primary Health. 22(6), pp. 510 - 516. https://doi.org/10.1071/PY15091
Oral health-related knowledge, attitudes and self-efficacy of Australian rural older adults
Marino, Rodrigo Jose, Hopcraft, Matthew, Ghanim, Aghareed, Tham, Rachel, Khew, Chee-Wah and Stevenson, Christine. (2016) Oral health-related knowledge, attitudes and self-efficacy of Australian rural older adults. Gerodontology: an international journal. 33(4), pp. 530 - 538. https://doi.org/10.1111/ger.12202
Breastfeeding and the risk of dental caries: a systematic review and meta-analysis
Tham, Rachel, Bowatte, G., Dharmage, S. C., Tan, D. J., Lau, M. X.Z., Dai, Xiaochen, Allen, K J. and Lodge, C. J.. (2015) Breastfeeding and the risk of dental caries: a systematic review and meta-analysis. Acta Paediatrica. 104(467), pp. 62 - 84. https://doi.org/10.1111/apa.13118
Breastfeeding and asthma and allergies: A systematic review and meta-analysis
Lodge, Caroline J., Tan, D. J., Lau, M. X. Z., Dai, Xiaochen, Tham, Rachel, Lowe, Adrian J., Bowatte, Gayan, Allen, K. J. and Dharmage, Shyamali Chandrika. (2015) Breastfeeding and asthma and allergies: A systematic review and meta-analysis. Acta Paediatrica. 104(467), pp. 38 - 53. https://doi.org/10.1111/apa.13132
Breastfeeding and childhood acute otitis media: A systematic review and meta-analysis
Bowatte, G., Tham, R., Allen, K. J., Tan, D. J., Lau, M. X. Z., Dai, X. and Lodge, C. J.. (2015) Breastfeeding and childhood acute otitis media: A systematic review and meta-analysis. Acta Paediatrica. 104(467), pp. 85 - 95. https://doi.org/10.1111/apa.13151
Reporting dental trauma and its inclusion in an injury surveillance system in Victoria, Australia
Dang, K. M., Day, P. F., Calache, H., Tham, R. and Parashos, P.. (2015) Reporting dental trauma and its inclusion in an injury surveillance system in Victoria, Australia. Australian Dental Journal. 60(1), pp. 88 - 95. https://doi.org/10.1111/adj.12273
Investing in longitudinal studies of primary healthcare: what can we learn about service performance, sustainability and quality?
Ward, Bernadette M., Buykx, P. F., Tham, Rachel, Kinsman, Leigh and Humphreys, John S.. (2014) Investing in longitudinal studies of primary healthcare: what can we learn about service performance, sustainability and quality? Rural and Remote Health. 14(4), pp. 1 - 6.
Staff perceptions of primary healthcare service change: Influences on staff satisfaction
Tham, Rachel, Buykx, Penny, Kinsman, Leigh, Ward, Bernadette, Humphreys, John S., Asaid, Adel, Tuohey, Kathy and Jenner, Rohan. (2014) Staff perceptions of primary healthcare service change: Influences on staff satisfaction. Australian Health Review. 38(5), pp. 580 - 583. https://doi.org/10.1071/AH14015
Outdoor fungi and child asthma health service attendances
Tham, Rachel, Dharmage, Shyamali C., Taylor, Philip E., Katelaris, Constance H., Vicendese, Don, Abramson, Michael J. and Erbas, Bircan. (2014) Outdoor fungi and child asthma health service attendances. Pediatric Allergy and Immunology. 25(5), pp. 439 - 449. https://doi.org/10.1111/pai.12257
Pattern and factors associated with utilization of dental services among older adults in rural Victoria
Mariño, Rodrigo Jose, Khan, A. R., Tham, Rachel, Khew, Chee-Wah and Stevenson, Christine. (2014) Pattern and factors associated with utilization of dental services among older adults in rural Victoria. Australian Dental Journal. 59(4), pp. 504 - 510. https://doi.org/10.1111/adj.12216
The role of seasonal grass pollen on childhood asthma emergency department presentations
Erbas, B., Akram, M., Dharmage, S. C., Tham, R., Dennekamp, M., Newbigin, E., Taylor, P., Tang, M. L. K. and Abramson, M. J.. (2012) The role of seasonal grass pollen on childhood asthma emergency department presentations. Clinical and Experimental Allergy. 42(5), pp. 799 - 805. https://doi.org/10.1111/j.1365-2222.2012.03995.x