Resolving relaxometry and diffusion properties within the same voxel in the presence of crossing fibres by combining inversion recovery and diffusion-weighted acquisitions
Journal article
Santis, Silvia De, Barazany, Daniel, Jones, Derek K. and Assaf, Yaniv. (2016). Resolving relaxometry and diffusion properties within the same voxel in the presence of crossing fibres by combining inversion recovery and diffusion-weighted acquisitions. Magnetic Resonance in Medicine. 75(1), pp. 372 - 380. https://doi.org/10.1002/mrm.25644
Authors | Santis, Silvia De, Barazany, Daniel, Jones, Derek K. and Assaf, Yaniv |
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Abstract | Purpose: A comprehensive image-based characterization ofwhite matter should include the ability to quantify myelin and axo-nal attributes i rrespective of the complexity of fibre organizationwithin the voxel. While progress has been made with diffusionMRI-based approaches to measure axonal morphology, to dateavailable myelin metrics simply assign a single scalar value to thevoxel, reflecting some form of average of its constituent fibres.Here, a new experimental framework that combines diffusi on MRIand r elaxometry is intr oduced. It provides, for the first time, theability to assign to each un ique fibre system within a voxel, aunique value of the longitudinal relaxation time, T1, which is largelyinfluenced by the myelin content.Methods: We demonstrate the method through simulations, ina crossing fibres phantom, in fixed brains and in vivo.Results: The method is capable of recovering unique valuesof T1for each fibre population.Conclusion: The ability to extract fibr e-specific relaxometry prop-erties will provide enhanced specificity and, therefore, sensitivityto differ ences in white matter architecture, which will be invaluablein many neur oimaging studies. Further the enhanced specificitysho ul d ultimately lead to earlier diagnosis and access to treatmentin a range of white matter diseases where axon s are affected.Magn Reson Med 75:372–380, 2016.VC2015 The Authors. Mag-netic Resonance in Medicine Published by Wiley Periodicals,Inc. on behalf of International Society of Medicine in Reso-nance. This is an open access article under the terms of theCreative Commons Attribution License, which permits use,distribution, and reproduction in any medium, provided theoriginal work is properly cited. |
Keywords | diffusion tensor; MRI; myelin; CHARMED; whitematter microstructure; g-ratio |
Year | 2016 |
Journal | Magnetic Resonance in Medicine |
Journal citation | 75 (1), pp. 372 - 380 |
Publisher | John Wiley & Sons, Inc. |
ISSN | 0740-3194 |
Digital Object Identifier (DOI) | https://doi.org/10.1002/mrm.25644 |
Scopus EID | 2-s2.0-84923834068 |
Page range | 372 - 380 |
Publisher's version | File Access Level Controlled |
Place of publication | United States |
https://acuresearchbank.acu.edu.au/item/855x0/resolving-relaxometry-and-diffusion-properties-within-the-same-voxel-in-the-presence-of-crossing-fibres-by-combining-inversion-recovery-and-diffusion-weighted-acquisitions
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