Biochemical profiling of proteins and metabolites in wound exudate from chronic wound environments

Journal article


Broszczak, Daniel, Stupar, Dario, Compay, Arnulf Lloyd L., Sharma, Masti Venugopal Srihari, Parker, Tony J., Shooter, Gary K., Upton, Z. and Fernandez, Melissa L.. (2012) Biochemical profiling of proteins and metabolites in wound exudate from chronic wound environments. Wound Practice & Research. 20(2), pp. 62 - 72.
AuthorsBroszczak, Daniel, Stupar, Dario, Compay, Arnulf Lloyd L., Sharma, Masti Venugopal Srihari, Parker, Tony J., Shooter, Gary K., Upton, Z. and Fernandez, Melissa L.
Abstract

The lack of fundamental knowledge on the biological processes associated with wound healing represents a significant challenge. Understanding the biochemical changes that occur within a chronic wound could provide insights into the wound environment and enable more effective wound management. We report on the stability of wound fluid samples under various conditions and describe a high-throughput approach to investigate the altered biochemical state within wound samples collected from various types of chronic, ulcerated wounds. Furthermore, we discuss the viability of this approach in the early stages of wound sample protein and metabolite profiling and subsequent biomarker discovery. This approach will facilitate the detection of factors that may correlate with wound severity and/or could be used to monitor the response to a particular treatment.

Year2012
JournalWound Practice & Research
Journal citation20 (2), pp. 62 - 72
PublisherCambridge Publishing
ISSN2202-9729
Page range62 - 72
Research GroupSchool of Behavioural and Health Sciences
Place of publicationAustralia
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https://acuresearchbank.acu.edu.au/item/85640/biochemical-profiling-of-proteins-and-metabolites-in-wound-exudate-from-chronic-wound-environments

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