Association of cardiovascular system medications with cognitive function and dementia in older adults living in nursing homes in Australia

Journal article

Liu, Enwu, Dyer, Suzanne M., O'Donnell, Lisa Kouladjian, Milte, Rachel, Bradley, Clare E., Harrison, Stephanie L., Gnanamanickam, Emmanuel S., Whitehead, Craig and Crotty, Maria. (2017). Association of cardiovascular system medications with cognitive function and dementia in older adults living in nursing homes in Australia. Journal of Geriatric Cardiology. 14(6), pp. 407 - 415. https://doi.org/10.11909/j.issn.1671-5411.2017.06.009
AuthorsLiu, Enwu, Dyer, Suzanne M., O'Donnell, Lisa Kouladjian, Milte, Rachel, Bradley, Clare E., Harrison, Stephanie L., Gnanamanickam, Emmanuel S., Whitehead, Craig and Crotty, Maria
Abstract

OBJECTIVE:
To examine associations between cardiovascular system medication use with cognition function and diagnosis of dementia in older adults living in nursing homes in Australia.
METHODS:
As part of a cross-sectional study of 17 Australian nursing homes examining quality of life and resource use, we examined the association between cognitive impairment and cardiovascular medication use (identified using the Anatomical Therapeutic Classification System) using general linear regression and logistic regression models. People who were receiving end of life care were excluded.
RESULTS:
Participants included 541 residents with a mean age of 85.5 years (± 8.5), a mean Psychogeriatric Assessment Scale-Cognitive Impairment (PAS-Cog) score of 13.3 (± 7.7), a prevalence of cardiovascular diseases of 44% and of hypertension of 47%. Sixty-four percent of participants had been diagnosed with dementia and 72% had received cardiovascular system medications within the previous 12 months. Regression models demonstrated the use of cardiovascular medications was associated with lower (better) PAS-Cog scores [Coefficient (β) = -3.7; 95% CI: -5.2 to -2.2; P < 0.0001] and a lower probability of a dementia diagnosis (OR = 0.44; 95% CI: 0.26 to 0.75, P = 0.0022). Analysis by subgroups of medications showed cardiac therapy medications (C01), beta blocking agents (C07), and renin-angiotensin system agents (C09) were associated with lower PAS-Cog scores (better cognition) and lower dementia diagnosis probability.
CONCLUSIONS:
This analysis has demonstrated an association between greater cardiovascular system medication use and better cognitive status among older adults living in nursing homes. In this population, there may be differential access to health care and treatment of cardiovascular risk factors. This association warrants further investigation in large cohort studies.

KeywordsCardiovascular agents; Cognitive dysfunction; Dementia; Residential facilities
Year2017
JournalJournal of Geriatric Cardiology
Journal citation14 (6), pp. 407 - 415
PublisherChinese P L A General Hospital * Institute of Geriatric Cardiology
ISSN1671-5411
Digital Object Identifier (DOI)https://doi.org/10.11909/j.issn.1671-5411.2017.06.009
Scopus EID2-s2.0-85026292135
Open accessOpen access
Page range407 - 415
Research GroupMary MacKillop Institute for Health Research
Publisher's version
License
Place of publicationChina
EditorsY. Chen
Permalink -

https://acuresearchbank.acu.edu.au/item/856w3/association-of-cardiovascular-system-medications-with-cognitive-function-and-dementia-in-older-adults-living-in-nursing-homes-in-australia

Log in to edit

Download files

Publisher's version
OA_Liu_2017_Association_of_cardiovascular_system_medications_with.pdf
License: CC BY 4.0

  • 128
    total views
  • 37
    total downloads
  • 0
    views this month
  • 0
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Sexually transmitted infections and associated risk factors among sexual minority women in China
Wang, Xiaofang, Ouyang, Zhaohui, Liu, Enwu and Han, Mengjie. (2023). Sexually transmitted infections and associated risk factors among sexual minority women in China. Scientific Reports. 13(1). https://doi.org/10.1038/s41598-023-48745-7
A new FRAX model for Brazil
Albergaria, Ben Hur, Zerbini, C. A F, Lazaretti-Castro, M. Lazaretti-Castro, Eis, Lazaretti-Castro, Vilaca, Tatiane, Johansson, Helena, Harvey, Nicholas, Liu, Enwu, Vandenput, Liesbeth, Lorentzon, Karl Mattias, Schini, Marian, McCloskey, Eugene and Kanis, John Anthony. (2023). A new FRAX model for Brazil. Archives of Osteoporosis. 18(1), pp. 1-8. https://doi.org/10.1007/s11657-023-01354-3
Adjusting conventional FRAX estimates of fracture probability according to the number of prior falls in the preceding year
Kanis, John A., Johansson, Helena, Harvey, Nicholas C., Lorentzon, Mattias, Liu, Enwu, Vandenput, Liesbeth, Morin, Suzanne, Leslie, William D. and McCloskey, Eugene V.. (2023). Adjusting conventional FRAX estimates of fracture probability according to the number of prior falls in the preceding year. Osteoporosis International. 34(3), pp. 479-487. https://doi.org/10.1007/s00198-022-06633-2
An assessment of intervention thresholds for high fracture risk in Chile
Lopez Gavilanez, Enrique, Luis, Imaicela N., Mario, Navarro G., Johansson, Helena, Harvey, Nicholas C., Lorentzon, Mattias, Liu, Enwu, Vandenput, Liesbeth, McCloskey, Eugene V. and Kanis, John A.. (2023). An assessment of intervention thresholds for high fracture risk in Chile. Archives of Osteoporosis. 18(1), p. Article 11. https://doi.org/10.1007/s11657-022-01198-3
Primary hyperparathyroidism and fracture probability
Kanis, John A., Harvey, Nicholas C., Liu, Enwu, Vandenput, Liesbeth, Lorentzon, Mattias, McCloskey, Eugene V., Bouillon, Roger, Abrahamsen, Bo, Rejnmark, Lars, Johansson, Helena and The Danish Primary Hyperparathyroidism Study Group. (2023). Primary hyperparathyroidism and fracture probability. Osteoporosis International. 34(3), pp. 489-499. https://doi.org/10.1007/s00198-022-06629-y
Update of the fracture risk prediction tool FRAX : a systematic review of potential cohorts and analysis plan
Vandenput, Liesbeth, Johansson, Helena, McCloskey, E, Liu, Enwu, Åkesson, K, Anderson, F, Azagra, R, Bager, C, Beaudart, C, Bischoff-Ferrari, H, Biver, E, Bruyère, O, Cauley, J, Lorentzon, Karl Mattias and Kanis, John Anthony. (2022). Update of the fracture risk prediction tool FRAX : a systematic review of potential cohorts and analysis plan. Osteoporosis International. 33(10), pp. 2103-2136. https://doi.org/10.1007/s00198-022-06435-6
Epidemiology of hip fracture in Qatar and development of a country specific FRAX model
Abdulla, Nabeel, Alsaed, Omar Suhail, Lutf, Abdo, Alam, Fiaz, Abdulmomen, Ibrahim, Al Emadi, Samar, Harvey, Nicholas C., Liu, Enwu, Vandenput, Liesbeth, Lorentzon, Mattias, McCloskey, Eugene, Kanis, John A. and Johansson, Helena. (2022). Epidemiology of hip fracture in Qatar and development of a country specific FRAX model. Archives of Osteoporosis. 17(1), p. Article 49. https://doi.org/10.1007/s11657-022-01083-z
Characteristics and outcomes of a community upper limb rehabilitation group for adult stroke survivors in Australia : A pre-post cohort study
English, Kylie, Daley, Bella, Cahill, Liana, Liu, Enwu, Lannin, Natasha A. and Baker, Anne. (2022). Characteristics and outcomes of a community upper limb rehabilitation group for adult stroke survivors in Australia : A pre-post cohort study. Occupational Therapy in Health Care. 36(4), pp. 440-458. https://doi.org/10.1080/07380577.2021.2012734
Improved fracture risk prediction by adding VFA-identified vertebral fracture data to BMD by DXA and clinical risk factors used in FRAX
Johansson, L, Johansson, H., Axelsson, K. F., Litsne, H., Harvey, N. C., Liu, E., Leslie, W. D., Vandenput, L., McCloskey, E., Kanis, J. A. and Lorentzon, M.. (2022). Improved fracture risk prediction by adding VFA-identified vertebral fracture data to BMD by DXA and clinical risk factors used in FRAX. Osteoporosis International. 33(8), pp. 1725-1738. https://doi.org/10.1007/s00198-022-06387-x
Incidence of hip fracture in Saudi Arabia and the development of a FRAX model
Saleh, Yousef A. L., Sulimani, Riad A., Alomary, Shaker, Alnajjar, Yassmeen I., Vandenput, Liesbeth, Liu, Enwu, Lorentzon, Mattias, Harvey, Nicholas C., McCloskey, Eugene V., Johansson, Helena, Kanis, John A. and the Saudi FRAX Study Group. (2022). Incidence of hip fracture in Saudi Arabia and the development of a FRAX model. Archives of Osteoporosis. 17(1), p. Article 56. https://doi.org/10.1007/s11657-022-01085-x
Analysis of Comorbidities, Clinical Outcomes, and Parathyroidectomy in Adults With Primary Hyperparathyroidism
Axelsson, Kristian F., Wallander, Märit, Johansson, Helena, Harvey, Nicholas C., Vandenput, Liesbeth, McCloskey, Eugene, Liu, Enwu, Kanis, John A., Litsne, Henrik and Lorentzon, Mattias. (2022). Analysis of Comorbidities, Clinical Outcomes, and Parathyroidectomy in Adults With Primary Hyperparathyroidism. JAMA Network Open. 5(6), p. Article e2215396. https://doi.org/10.1001/jamanetworkopen.2022.15396
Potential adverse effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on bisphosphonate efficacy : An exploratory post hoc analysis from a randomized controlled trial of clodronate
Zheng, Zhangan, Johansson, Helena, Harvey, Nicholas C., Lorentzon, Mattias, Vandenput, Liesbeth, Liu, Enwu, Kanis, John A. and McCloskey, Eugene V.. (2022). Potential adverse effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on bisphosphonate efficacy : An exploratory post hoc analysis from a randomized controlled trial of clodronate. Journal of Bone and Mineral Research. 37(6), pp. 1117-1124. https://doi.org/10.1002/jbmr.4548
Osteoporosis treatment in Austria—assessment of FRAX‑based intervention thresholds for high and very high fracture risk
Dimai, Hans P., Johansson, Helena, Harvey, Nicholas C., Lorentzon, Mattias, Liu, Enwu, Vandenput, Liesbeth, Fahrleitner-Pammer, Astrid, Pietschmann, Peter, Muschitz, Christian, McCloskey, Eugene V. and Kanis, John A.. (2022). Osteoporosis treatment in Austria—assessment of FRAX‑based intervention thresholds for high and very high fracture risk. Archives of Osteoporosis. 17, p. Article 141. https://doi.org/10.1007/s11657-022-01175-w
Greater pQCT calf muscle density is associated with lower fracture risk, independent of FRAX, falls and BMD : A meta-analysis in the Osteoporotic Fractures in Men (MrOS) Study
Harvey, Nicholas C., Orwoll, Eric, Cauley, Jane A., Kwok, Timothy, Karlsson, Magnus K., Rosengren, Björn, Ribom, Eva, Cawthon, Peggy M., Ensrud, Kristine, Liu, Enwu, Laskou, Faidra, Ward, Kate A., Dennison, Elaine M., Cooper, Cyrus, Kanis, John A., Vandenput, Liesbeth, Lorentzon, Mattias, Ohlsson, Claes, Mellström, Dan, ... McCloskey, Eugene. (2022). Greater pQCT calf muscle density is associated with lower fracture risk, independent of FRAX, falls and BMD : A meta-analysis in the Osteoporotic Fractures in Men (MrOS) Study. JBMR Plus. 6(12), p. e10696. https://doi.org/10.1002/jbm4.10696
Adjusting conventional FRAX estimates of fracture probability according to the number of prior fractures
Kanis, John Anthony, Johansson, Helena, Harvey, Nicholas, Gudnason, Vilmundur, Sigurdsson, Gunnar, Siggeirsdottir, Kristin, Lorentzon, Karl Mattias, Liu, Enwu, Vandenput, Liesbeth and McCloskey, Eugene. (2022). Adjusting conventional FRAX estimates of fracture probability according to the number of prior fractures. Osteoporosis International. 33, pp. 2507-2515. https://doi.org/10.1007/s00198-022-06550-4
Menopausal hormone therapy reduces the risk of fracture regardless of falls risk or baseline FRAX probability — Results from the Women’s Health Initiative hormone therapy trials
Lorentzon, Mattias, Johansson, Helena, Harvey, Nicholas C., Liu, Enwu, Vandenput, Liesbeth, Crandall, Carolyn J., Cauley, Jane A., LeBoff, Meryl S., McCloskey, Eugene V. and Kanis, John A.. (2022). Menopausal hormone therapy reduces the risk of fracture regardless of falls risk or baseline FRAX probability — Results from the Women’s Health Initiative hormone therapy trials. Osteoporosis International. 33(11), pp. 2297-2305. https://doi.org/10.1007/s00198-022-06483-y
Effects of supervised aerobic exercise on cardiorespiratory fitness and patient-reported health outcomes in colorectal cancer patients undergoing adjuvant chemotherapy — A pilot study
Zopf, Eva M., Schulz, Holger, Poeschko, Jonas, Aschenbroich, Kerstin, Wilhelm, Thomas, Eypasch, Ernst, Kleimann, Elmar, Severin, Kai, Benz, Jutta, Liu, Enwu, Bloch, Wilhelm and Baumann, Freerk T.. (2022). Effects of supervised aerobic exercise on cardiorespiratory fitness and patient-reported health outcomes in colorectal cancer patients undergoing adjuvant chemotherapy — A pilot study. Supportive Care in Cancer. 30(3), pp. 1945-1955. https://doi.org/10.1007/s00520-021-06608-9
FRAX
Kanis, John A., Harvey, Nicholas C., Johansson, Helena, Lorentzon, Mattias, Liu, Enwu, Leslie, William D. and McCloskey, Eugene V.. (2022). FRAX. In In Pape, Hans-Christoph, Kates, Stephen L., Hierholzer, Christian and Bischoff-Ferrari, Heike A. (Ed.). Senior trauma patients : An integrated approach pp. 89-99 Springer. https://doi.org/10.1007/978-3-030-91483-7_10
One leg standing time predicts fracture risk in older women independent of clinical risk factors and BMD
Larsson, B. A. M., Johansson, L., Mellström, D., Johansson, H., Axelsson, K. F., Harvey, N., Vandenput, L., McCloskey, E., Liu, E., Sundh, D, Kanis, J. A. and Lorentzon, M.. (2022). One leg standing time predicts fracture risk in older women independent of clinical risk factors and BMD. Osteoporosis International. 33(1), pp. 185-194. https://doi.org/10.1007/s00198-021-06039-6
Associations between cognitive function, hospitalizations and costs in nursing homes : A cross-sectional study
Gnanamanickam, Emmanuel Sumithran, Dyer, Suzanne Marie, Harrison, Stephanie Lucy, Liu, Enwu, Whitehead, Craig and Crotty, Maria. (2022). Associations between cognitive function, hospitalizations and costs in nursing homes : A cross-sectional study. Journal of Aging and Social Policy. 34(4), pp. 552-567. https://doi.org/10.1080/08959420.2020.1777824
Activity, participation, and goal awareness after acquired brain injury : A prospective observational study of inpatient rehabilitation
Adey-Wakeling, Zoe, Jolliffe, Laura, O'Shannessy, Elizabeth, Hunter, Peter, Morarty, Jacqui, Cameron, Ian D., Liu, Enwu and Lannin, Natasha A.. (2021). Activity, participation, and goal awareness after acquired brain injury : A prospective observational study of inpatient rehabilitation. Annals of Rehabilitation Medicine. 45(6), pp. 413-421. https://doi.org/10.5535/arm.21034
Fracture risk assessment by the FRAX model
McCloskey, E. V., Harvey, N. C., Johansson, H., Lorentzon, M., Liu, E., Vandenput, L., Leslie, W. D. and Kanis, J. A.. (2021). Fracture risk assessment by the FRAX model. Climacteric. 25(1), pp. 22-28. https://doi.org/10.1080/13697137.2021.1945027
The application of FRAX in Saudi Arabia
Al-Daghri, Nasser M., Sabico, Shaun, Al-Saleh, Yousef, Sulimani, Riad, Aljohani, Naji J., Sheshah, Eman, Alodhayani, Abdulaziz, Harvey, Nicholas C., Liu, Enwu, Lorentzon, Mattias, McCloskey, Eugene V., Vandenput, Liesbeth, Johansson, Helena and Kanis, John A.. (2021). The application of FRAX in Saudi Arabia. Archives of Osteoporosis. 16(1), p. Article 166. https://doi.org/10.1007/s11657-021-01024-2
Life expectancy of older people living in aged care facilities after a hip fracture
Liu, Enwu, Killington, Maggie, Cameron, Ian D., Li, Raymond, Kurrle, Susan and Crotty, Maria. (2021). Life expectancy of older people living in aged care facilities after a hip fracture. Scientific Reports. 11(1), p. Article 20266. https://doi.org/10.1038/s41598-021-99685-z
FRAX-based intervention thresholds for Pakistan
Johansson, H., Naureen, G., Iqbal, R., Jafri, L., Khan, A. H., Umer, M., Liu, E., Vandenput, L., Lorentzon, M., McCloskey, E. V., Kanis, J. A. and Harvey, N. C.. (2021). FRAX-based intervention thresholds for Pakistan. Osteoporosis International. 33(1), pp. 105-112. https://doi.org/10.1007/s00198-021-06087-y
Sarcopenia definitions as predictors of fracture risk independent of FRAX®, falls, and BMD in the Osteoporotic Fractures in Men (MrOS) Study : A meta-analysis
Harvey, Nicholas C., Orwoll, Eric, Kwok, Timothy, Karlsson, Magnus K., Rosengren, Björn E., Ribom, Eva, Cauley, Jane A., Cawthon, Peggy M., Ensrud, Kristine, Liu, Enwu, Cruz-Jentoft, Alfonso J., Fielding, Roger A., Cooper, Cyrus, Kanis, John A., Lorentzon, Mattias, Ohlsson, Claes, Mellström, Dan, Johansson, Helena and McCloskey, Eugene. (2021). Sarcopenia definitions as predictors of fracture risk independent of FRAX®, falls, and BMD in the Osteoporotic Fractures in Men (MrOS) Study : A meta-analysis. Journal of Bone and Mineral Research. 36(7), pp. 1235-1244. https://doi.org/10.1002/jbmr.4293
Blood-brain barrier crossing renin-angiotensin drugs and cognition in the elderly : A meta-analysis
Ho, Jean, Moriarty, Frank, Manly, Jennifer J., Larson, Eric B., Evans, Denis A., Rajan, Kumar B., Hudak, Elizabeth M., Hassan, Lamiaa, Liu, Enwu, Sato, Nobuyuki, Hasebe, Naoyuki, Laurin, Danielle, Carmichael, Pierre-Hugues and Nation, Daniel A.. (2021). Blood-brain barrier crossing renin-angiotensin drugs and cognition in the elderly : A meta-analysis. Hypertension. 78(3), pp. 629-643. https://doi.org/10.1161/HYPERTENSIONAHA.121.17049
Ukranian FRAX version in the male osteoporosis management
Povoroznyuk, V, Johansson, Helena, Grygorieva, N, Kanis, John Anthony, Musiienko, A, Lorentzon, Karl Mattias, Harvey, N, McCloskey, E and Liu, Enwu. (2021). Ukranian FRAX version in the male osteoporosis management. Bol', Sustavy, Pozvonochnik (Pain, Joints, Spine). 11(2), pp. 53-61. https://doi.org/10.22141/2224-1507.11.2.2021.236563
Impact of population-based or targeted BMD interventions on fracture incidence
Harvey, N. C., Kanis, J. A., Liu, E., Vandenput, L., Lorentzon, M., Cooper, C, McCloskey, E. and Johansson, H.. (2021). Impact of population-based or targeted BMD interventions on fracture incidence. Osteoporosis International. 32(10), pp. 1973-1979. https://doi.org/10.1007/s00198-021-05917-3
FRAX-based intervention thresholds for osteoporosis treatment in Ukraine
Povoroznyuk, Vladyslav, Grygorieva, Nataliia, Johansson, Helena, Lorentzon, Mattias, Harvey, Nicholas C., McCloskey, Eugene V., Musienko, Anna, Liu, Enwu, Kanis, John A., Zaverukha, Nataliia and Ivanyk, Oksana. (2021). FRAX-based intervention thresholds for osteoporosis treatment in Ukraine. Journal of Osteoporosis. 2021, p. Article 2043479. https://doi.org/10.1155/2021/2043479
An assessment of intervention thresholds for very high fracture risk applied to the NOGG guidelines : A report for the National Osteoporosis Guideline Group (NOGG)
Kanis, J. A., Johansson, H., Harvey, N. C., Lorentzon, M., Liu, E., Vandenput, L. and McCloskey, E. V.. (2021). An assessment of intervention thresholds for very high fracture risk applied to the NOGG guidelines : A report for the National Osteoporosis Guideline Group (NOGG). Osteoporosis International. 32, pp. 1951-1960. https://doi.org/10.1007/s00198-021-05942-2
Associations between quality of life and outdoor access in nursing homes : A cross-sectional study
Dyer, Suzanne M., Liu, Enwu, Gnanamanickam, Emmanuel, Harrison, Stephanie L., Milte, Rachel and Crotty, Maria. (2021). Associations between quality of life and outdoor access in nursing homes : A cross-sectional study. Annals of Long-Term Care. pp. e1-e7. https://doi.org/10.25270/altc.2021.02.00001
The effect on subsequent fracture risk of age, sex, and prior fracture site by recency of prior fracture
Kanis, J. A., Johansson, H., Harvey, N. C., Gudnason, V., Sigurdsson, G., Siggeirsdottir, K., Lorentzon, M., Liu, E., Vandenput, L. and McCloskey, E. V.. (2021). The effect on subsequent fracture risk of age, sex, and prior fracture site by recency of prior fracture. Osteoporosis International. 32(8), pp. 1547-1555. https://doi.org/10.1007/s00198-020-05803-4
Predictive value of DXA appendicular lean mass for incident fractures, falls, and mortality, independent of prior falls, FRAX, and BMD : Findings from the Women's Health Initiative (WHI)
Harvey, Nicholas C., Kanis, John A., Liu, Enwu, Cooper, Cyrus, Lorentzon, Mattias, Bea, Jennifer W., Carbone, Laura, Cespedes Feliciano, Elizabeth M., Laddu, Deepika R., Schnatz, Peter F., Shadyab, Aladdin H., Stefanick, Marcia L., Wactawski-Wende, Jean, Crandall, Carolyn J., Johansson, Helena and McCloskey, Eugene. (2021). Predictive value of DXA appendicular lean mass for incident fractures, falls, and mortality, independent of prior falls, FRAX, and BMD : Findings from the Women's Health Initiative (WHI). Journal of Bone and Mineral Research. 36(4), pp. 654-661. https://doi.org/10.1002/jbmr.4239
FRAX-based fracture probabilities in South Africa
Johansson, Helena, Dela, Sapna S., Cassim, Bilkish, Paruk, Farhanah, Brown, Susan L., Conradie, Magda, Harvey, Nicholas C., Jordaan, Johannes D., Kalla, Asgar A., Liu, Enwu, Lorentzon, Mattias, Lukhele, Mkhululi, McCloskey, Eugene V., Mohamed, Ozayr, Chutterpaul, Pariva, Vandenput, Liesbeth and Kanis, John A.. (2021). FRAX-based fracture probabilities in South Africa. Archives of Osteoporosis. 16(1), p. 51. https://doi.org/10.1007/s11657-021-00905-w
Global impact of COVID-19 on non-communicable disease management : Descriptive analysis of access to FRAX fracture risk online tool for prevention of osteoporotic fractures
McCloskey, E. V., Harvey, N. C., Johansson, H., Lorentzon, M., Vandenput, L., Liu, E. and Kanis, J. A.. (2021). Global impact of COVID-19 on non-communicable disease management : Descriptive analysis of access to FRAX fracture risk online tool for prevention of osteoporotic fractures. Osteoporosis International. 32(1), pp. 39-46. https://doi.org/10.1007/s00198-020-05542-6
A surrogate FRAX model for Pakistan
Naureen, G., Johansson, H., Iqbal, R., Jafri, L., Khan, A. H., Umer, M., Liu, E., Vandenput, L., Lorentzon, M., Harvey, N. C., McCloskey, E. V. and Kanis, J. A.. (2021). A surrogate FRAX model for Pakistan. Archives of Osteoporosis. 16, p. 34. https://doi.org/10.1007/s11657-021-00894-w
The use of 2-, 5-, and 10-year probabilities to characterize fracture risk after a recent sentinel fracture
Kanis, J. A., Johansson, H., Harvey, N. C., Gudnason, V., Sigurdsson, G., Siggeirsdottir, K., Lorentzon, M., Liu, E., Vandenput, L., Leslie, W. D. and McCloskey, E. V.. (2021). The use of 2-, 5-, and 10-year probabilities to characterize fracture risk after a recent sentinel fracture. Osteoporosis International. 32(1), pp. 47-54. https://doi.org/10.1007/s00198-020-05700-w
The timed up and go test predicts fracture risk in older women independently of clinical risk factors and bone mineral density
Larsson, B. A. M., Johansson, L., Johansson, H., Axelsson, K. F., Harvey, N., Vandenput, L., Magnusson, P., McCloskey, E., Liu, E., Kanis, J. A., Sundh, D. and Lorentzon, M.. (2021). The timed up and go test predicts fracture risk in older women independently of clinical risk factors and bone mineral density. Osteoporosis International. 32(1), pp. 75-84. https://doi.org/10.1007/s00198-020-05681-w
Combining fracture outcomes in phase 3 trials of osteoporosis : An analysis of the effects of denosumab in postmenopausal women
Kanis, J. A., Harvey, N. C., Lorentzon, M., Liu, E., Vandenput, L., McCloskey, E. V. and Johansson, H.. (2021). Combining fracture outcomes in phase 3 trials of osteoporosis : An analysis of the effects of denosumab in postmenopausal women. Osteoporosis International. 32(1), pp. 165-171. https://doi.org/10.1007/s00198-020-05699-0
Prognostic markers of overall survival in cancer patients attending a cachexia support service : An evaluation of clinically assessed physical function, malnutrition and inflammatory status
Bland, Kelcey A., Zopf, Eva M., Harrison, Meg, Ely, Matthew, Cormie, Prue, Liu, E., Dowd, Anna and Martin, Peter. (2020). Prognostic markers of overall survival in cancer patients attending a cachexia support service : An evaluation of clinically assessed physical function, malnutrition and inflammatory status. Nutrition and Cancer. 73(8), pp. 1400-1410. https://doi.org/10.1080/01635581.2020.1800765
Algorithm for the management of patients at low, high and very high risk of osteoporotic fractures
John Kanis, Nicholas C. Harvey, Eugene McCloskey, Olivier Bruyere, N. Veronese, Mattias Lorentzon, C. Cooper, Rene Rizzoli, G. Adib, Nasser M. Al-Daghri, C. Campusano, Manju Chandran, Bess Dawson-Hughes, M. K. Javaid, F. Jiwa, Helena Johansson, J K Lee, Enwu Liu, D Messina, ... Jean Yves Reginster. (2020). Algorithm for the management of patients at low, high and very high risk of osteoporotic fractures. Osteoporosis International. 31, pp. 1-12. https://doi.org/10.1007/s00198-019-05176-3
Epidemiology of osteoporotic fracture in Kazakhstan and development of a country specific FRAX model
Issayeva, S., Lesnyak, O., Zakroyeva, A., Issayeva, B., Dilmanova, D., Johansson, H., Liu, E., Lorentzon, M., Harvey, N. C., McCloskey, E. and Kanis, J. A.. (2020). Epidemiology of osteoporotic fracture in Kazakhstan and development of a country specific FRAX model. Archives of Osteoporosis. 15, pp. 1-8. https://doi.org/10.1007/s11657-020-0701-3
A surrogate FRAX model for the Kyrgyz Republic
Lesnyak, O., Zakroyeva, A., Lobanchenko, O., Johansson, H., Liu, E., Lorentzon, M., Harvey, N. C., McCloskey, E. and Kanis, J. A.. (2020). A surrogate FRAX model for the Kyrgyz Republic. Archives of Osteoporosis. 15, pp. 1-5. https://doi.org/10.1007/s11657-020-00743-2
Does telehealth delivery of a dyadic dementia care program provide a noninferior alternative to face-to-face delivery of the same program? A randomized, controlled trial
Laver, Kate, Liu, Enwu, Clemson, Lindy, Davies, Owen, Gray, Leonard, Gitlin, Laura N. and Crotty, Maria. (2020). Does telehealth delivery of a dyadic dementia care program provide a noninferior alternative to face-to-face delivery of the same program? A randomized, controlled trial. American Journal of Geriatric Psychiatry. 28(6), pp. 673 - 682. https://doi.org/10.1016/j.jagp.2020.02.009
A decade of FRAX: How has it changed the management of osteoporosis?
Kanis, John A., Harvey, Nicholas C., Johansson, Helena, Liu, Enwu, Vandenput, Liesbeth, Lorentzon, Mattias, Leslie, William D. and McCloskey, Eugene V.. (2020). A decade of FRAX: How has it changed the management of osteoporosis? Aging Clinical and Experimental Research. 32(2), pp. 187 - 196. https://doi.org/10.1007/s40520-019-01432-y
Use of age-dependent FRAX-based intervention thresholds for Singapore
Kanis, John A., Chandran, Manju, Chionh, Siok Bee, Ganeson, Ganga, Harvey, Nicholas C., Koh, Woon-Puay, Kwok, Timothy, Lau, Tang Ching, Liu, Enwu, Lorentzon, Mattias, McCloskey, Eugene V., Tan, Kelvin Bryan, Vandenput, Liesbeth and Johansson, Helena. (2020). Use of age-dependent FRAX-based intervention thresholds for Singapore. Archives of Osteoporosis. 15, pp. 1 - 10. https://doi.org/10.1007/s11657-020-00782-9
Appendicular lean mass and fracture risk assessment: Implications for FRAX(R) and sarcopenia
Harvey, Nicholas C., Kanis, John A., Liu, Enwu, Johansson, Helena, Lorentzon, Mattias and McCloskey, Eugene. (2019). Appendicular lean mass and fracture risk assessment: Implications for FRAX(R) and sarcopenia. Osteoporosis International. 30(3), pp. 537 - 539. https://doi.org/10.1007/s00198-019-04904-z
Temporal changes in access to FRAX in Thailand between 2010 and 2018
Chotiyarnwong, Pojchong, Harvey, Nicholas C., Johansson, Helena, Liu, Enwu, Lorentzon, Mattias, Kanis, John A. and McCloskey, Eugene V.. (2019). Temporal changes in access to FRAX in Thailand between 2010 and 2018. Archives of Osteoporosis. 14(1), pp. 1 - 7. https://doi.org/10.1007/s11657-019-0613-2
Patterns of medication prescription by dementia diagnosis in Australian nursing home residents: A cross-sectional study
Liu, Enwu, Dyer, Suzanne M., Whitehead, Craig, O'Donnell, Lisa Kouladjian, Gnanamanickam, Emmanuel S., Harrison, Stephanie L., Milte, Rachel and Crotty, Maria. (2019). Patterns of medication prescription by dementia diagnosis in Australian nursing home residents: A cross-sectional study. Journal of Pharmacy Practice and Research. 49(1), pp. 33 - 40. https://doi.org/10.1002/jppr.1457
Alternative staffing structures in a clustered domestic model of residential aged care in Australia
Harrison, Stephanie L., Dyer, Suzanne M., Milte, Rachel, Liu, Enwu, Gnanamanickam, Emmanuel S. and Crotty, Maria. (2019). Alternative staffing structures in a clustered domestic model of residential aged care in Australia. Australasian Journal on Ageing. 38(Suppl 2), pp. 68 - 74. https://doi.org/10.1111/ajag.12674
Should we provide outreach rehabilitation to very old people living in Nursing Care Facilities after a hip fracture? A randomised controlled trial
Crotty, Maria, Killington, Maggie, Liu, Enwu, Cameron, Ian D., Kurrle, Susan, Kaambwa, Billingsley, Davies, Owen, Miller, Michelle D., Chehade, Mellick and Ratcliffe, Julie. (2019). Should we provide outreach rehabilitation to very old people living in Nursing Care Facilities after a hip fracture? A randomised controlled trial. Age and Ageing. 48(3), pp. 373 - 380. https://doi.org/10.1093/ageing/afz005
Clustered domestic residential aged care in Australia: fewer hospitalisations and better quality of life
Dyer, Suzanne M., Liu, Enwu, Gnanamanickam, Emmanuel S., Milte, Rachel, Easton, Tiffany, Harrison, Stephanie L., Bradley, Clare E., Ratcliffe, Julie and Crotty, Maria. (2018). Clustered domestic residential aged care in Australia: fewer hospitalisations and better quality of life. Medical Journal of Australia. 208(10), pp. 433 - 438. https://doi.org/10.5694/mja17.00861
Associations between the drug burden index, potentially inappropriate medications and quality of life in residential aged care
Harrison, Stephanie L., Kouladjian O'Donnell, Lisa, Bradley, Clare E., Milte, Rachel, Dyer, Suzanne M., Gnanamanickam, Emmanuel S., Liu, Enwu, Hilmer, Sarah N. and Crotty, Maria. (2018). Associations between the drug burden index, potentially inappropriate medications and quality of life in residential aged care. Drugs and Aging. 35(1), pp. 83-91. https://doi.org/10.1007/s40266-017-0513-3
Direct health and residential care costs of people living with dementia in Australian residential aged care
Gnanamanickam, Emmanuel S., Dyer, Suzanne M., Milte, Rachel, Harrison, Stephanie L., Liu, Enwu, Easton, Tiffany, Bradley, Clare, Bilton, Rebecca, Shulver, Wendy, Ratcliffe, Julie, Whitehead, Craig and Crotty, Maria. (2018). Direct health and residential care costs of people living with dementia in Australian residential aged care. International Journal of Geriatric Psychiatry. 33(7), pp. 859 - 866. https://doi.org/10.1002/gps.4842
Psychotropic medications in older people in residential care facilities and associations with quality of life: a cross-sectional study
Harrison, Stephanie L., Bradley, Clare E., Milte, Rachel, Liu, Enwu, O'Donnell, Lisa K., Hilmer, Sarah N. and Crotty, Maria. (2018). Psychotropic medications in older people in residential care facilities and associations with quality of life: a cross-sectional study. BMC Geriatrics. 18(60), pp. 1 - 8. https://doi.org/10.1186/s12877-018-0752-0
Costs of potentially inappropriate medication use in residential aged care facilities
Harrison, S. L., O'Donnell, L. K., Milte, R., Dyer, S. M., Gnanamanickam, E. S., Bradley, C., Liu, Enwu, Hilmer, S. N. and Crotty, M.. (2018). Costs of potentially inappropriate medication use in residential aged care facilities. BMC Geriatrics. 18(9), pp. 1 - 10. https://doi.org/10.1186/s12877-018-0704-8
Diagnosis of dementia in residential aged care settings in Australia: An opportunity for improvements in quality of care?
Dyer, Suzanne M., Gnanamanickam, Emmanuel S., Liu, Enwu, Whitehead, Craig and Crotty, Maria. (2018). Diagnosis of dementia in residential aged care settings in Australia: An opportunity for improvements in quality of care? Australasian Journal on Ageing. 37(4), pp. e155 - e158. https://doi.org/10.1111/ajag.12580
Clustered domestic model of residential care is associated with better consumer rated quality of care
Gnanamanickam, Emmanuel S., Dyer, Suzanne M., Milte, Rachel, Liu, Enwu, Ratcliffe, Julie and Crotty, Maria. (2018). Clustered domestic model of residential care is associated with better consumer rated quality of care. International Journal for Quality in Health Care. https://doi.org/10.1093/intqhc/mzy181
An empirical comparison of the EQ-5D-5L, DEMQOL-U and DEMQOL-Proxy-U in a post-hospitalisation population of frail older people living in residential aged care
Ratcliffe, Julie, Flint, Thomas, Easton, Tiffany, Killington, Maggie, Cameron, Ian, Davies, Owen, Whitehead, Craig, Kurrle, Susan, Miller, Michelle D., Liu, Enwu and Crotty, Maria. (2017). An empirical comparison of the EQ-5D-5L, DEMQOL-U and DEMQOL-Proxy-U in a post-hospitalisation population of frail older people living in residential aged care. Applied Health Economics and Health Policy. 15(3), pp. 399 - 412. https://doi.org/10.1007/s40258-016-0293-7
Early supported discharge by caregiver-mediated exercise and e-Health support after stroke - A proof-of-concept trial
Van Den Berg, Maayken, Crotty, Maria, Liu, Enwu, Killington, Maggie, Kwakkel, Gert and van Wegen, Erwin. (2016). Early supported discharge by caregiver-mediated exercise and e-Health support after stroke - A proof-of-concept trial. Stroke. 47(7), pp. 1885 - 1892. https://doi.org/10.1161/STROKEAHA.116.013431
Hemiplegic shoulder pain reduces quality of life after acute stroke - A prospective population-based study
Adey-Wakeling, Zoe, Liu, Enwu, Crotty, Maria, Leyden, James, Kleinig, Timothy, Anderson, Craig and Newbury, Jonathon. (2016). Hemiplegic shoulder pain reduces quality of life after acute stroke - A prospective population-based study. American Journal of Physical Medicine and Rehabilitation. 95(10), pp. 758 - 763. https://doi.org/10.1097/PHM.0000000000000496
New South Wales Child Development Study (NSW-CDS): An Australian multiagency, multigenerational, longitudinal record linkage study
Carr, Vaughan J., Harris, Felicity, Raudino, Alessandra, Luo, Luming, Kariuki, Maina, Liu, Enwu, Tzoumakis, Stacy, Smith, Maxwell, Holbrook, Allyson, Bore, Miles, Brinkman, Sally, Lenroot, Rhoshel, Dix, Katherine, Dean, Kimberlie, Laurens, Kristin R. and Green, Melissa J.. (2016). New South Wales Child Development Study (NSW-CDS): An Australian multiagency, multigenerational, longitudinal record linkage study. BMJ Open. 6(2), pp. 1 - 9. https://doi.org/10.1136/bmjopen-2015-009023
Hospital admission for infection during early childhood influences developmental vulnerabilities at age 5 years
Kariuki, Maina, Raudino, Alessandra, Green, Melissa, Laurens, Kristin, Dean, Kimberlie, Brinkman, Sally, Lenroot, Rhoshel, Liu, Enwu, Harris, Felicity, Luo, Luming and Carr, Vaughn J.. (2016). Hospital admission for infection during early childhood influences developmental vulnerabilities at age 5 years. Journal of Paediatrics and Child Health. 52(9), pp. 882 - 888. https://doi.org/10.1111/jpc.13239
Hospital admission for infection during early childhood influences developmental vulnerabilities at age 5 years
Kariuki, Maina, Raudino, Alessandra, Green, Melissa J., Laurens, Kristin R., Dean, Kimberlie, Brinkman, Sally A., Lenroot, Rhoshel K., Liu, Enwu, Harris, Felicity, Luo, Luming and Carr, Vaughn J.. (2016). Hospital admission for infection during early childhood influences developmental vulnerabilities at age 5 years. Journal of Paediatrics and Child Health. 52(9), pp. 882 - 888. https://doi.org/10.1111/jpc.13239
New South Wales child development study (NSW-CDS): An Australian multiagency, multigenerational, longitudinal record linkage study
Carr, Vaughn J., Harris, Felicity, Raudino, Alessandra, Luo, Luming, Kariuki, Maina, Liu, Enwu, Tzoumakis, Stacy, Smith, Maxwell, Holbrook, Allyson, Bore, Miles, Brinkman, Sally, Lenroot, Rhoshel, Dix, Katherine, Dean, Kimberlie, Laurens, Kristin R. and Green, Melissa J.. (2016). New South Wales child development study (NSW-CDS): An Australian multiagency, multigenerational, longitudinal record linkage study. BMJ Open. 6(2), pp. 1 - 9. https://doi.org/10.1136/bmjopen-2015-009023
Baseline HCV antibody prevalence and risk factors among drug users in China's National Methadone Maintenance Treatment Program
Wang, Changhe, Shi, Cynthia X., Rou, Keming, Zhao, Yan, Cao, Xiaobin, Luo, Wei, Liu, Enwu and Wu, Zunyou. (2016). Baseline HCV antibody prevalence and risk factors among drug users in China's National Methadone Maintenance Treatment Program. PLoS ONE. 11(2), pp. 1 - 14. https://doi.org/10.1371/journal.pone.0147922
Who uses methadone services in China? Monitoring the world's largest methadone programme
Sullivan, Sheena G., Wu, Zunyou, Rou, Keming, Pang, Lin, Luo, Wei, Wang, Changhe, Cao, Xiaobin, Yin, Wenyuan, Liu, Enwu and Mi, Guodong. (2015). Who uses methadone services in China? Monitoring the world's largest methadone programme. Addiction. 110(Suppl. 1), pp. 29 - 39. https://doi.org/10.1111/add.12781
Continued drug use during methadone treatment in China: A retrospective analysis of 19,026 service users
Sullivan, Sheena G., Wu, Zunyou, Cao, Xiaobin, Liu, Enwu and Detels, Roger. (2014). Continued drug use during methadone treatment in China: A retrospective analysis of 19,026 service users. Journal of Substance Abuse Treatment. 47(1), pp. 86 - 92. https://doi.org/10.1016/j.jsat.2013.12.004
Referring heroin users from compulsory detoxification centers to community methadone maintenance treatment : A comparison of three models
Yan, Liping, Liu, Enwu, McGoogan, Jennifer M., Duan, Song, Wu, Li-Tzy, Comulada, Scott and Wu, Zunyou. (2013). Referring heroin users from compulsory detoxification centers to community methadone maintenance treatment : A comparison of three models. BMC Public Health. 13(1), pp. 1-8. https://doi.org/10.1186/1471-2458-13-747
HIV and syphilis prevalence among men who have sex with men : A cross-sectional survey of 61 cities in China
Wu, Zunyou, Xu, Jie, Liu, Enwu, Mao, Yurong, Xiao, Yan, Sun, Xinhua, Liu, Yufen, Jiang, Yan, McGoogan, Jennifer M., Dou, Zhi, Mi, Guodong, Wang, Ning, Sun, Jiangping, Liu, Zhongfu, Wang, Lu, Rou, Keming, Pang, Lin, Xing, Wenge, Xu, Juan, ... National MSM Survey Group. (2013). HIV and syphilis prevalence among men who have sex with men : A cross-sectional survey of 61 cities in China. Clinical Infectious Diseases. 57(2), pp. 298-309. https://doi.org/10.1093/cid/cit210
Factors associated with mortality of HIV-positive clients receiving methadone maintenance treatment in China
Liu, Enwu, Rou, Keming, McGoogan, Jennifer M., Pang, Lin, Cao, Xiaobin, Wang, Changhe, Luo, Wei, Sullivan, Sheena G., Montaner, Julio S. G., Bulterys, Marc, Detels, Roger, Wu, Zunyou and China’s National Working Group on Methadone Maintenance Treatment. (2013). Factors associated with mortality of HIV-positive clients receiving methadone maintenance treatment in China. Journal of Infectious Diseases. 3(1), pp. 442-453. https://doi.org/10.1093/infdis/jit163
Antiretroviral therapy to prevent HIV transmission in serodiscordant couples in China (2003-11) : A national observational cohort study
Jia, Zhongwei, Mao, Yurong, Zhang, Fujie, Ruan, Yuhua, Ma, Ye, Li, Jian, Guo, Wei, Liu, Enwu, Dou, Zhihui, Zhao, Yan, Wang, Lu, Li, Qianqian, Xie, Peiyan, Tang, Houlin, Han, Jing, Jin, Xia, Xu, Juan, Xiong, Ran, Zhao, Decai, ... Shao, Yiming. (2013). Antiretroviral therapy to prevent HIV transmission in serodiscordant couples in China (2003-11) : A national observational cohort study. The Lancet. 382(9899), pp. 1195-1203. https://doi.org/10.1016/S0140-6736(12)61898-4