Study protocol: A pilot clinical trial of topical glyceryl trinitrate for chronic venous leg ulcer healing

Journal article

Miles, Sandra, Lord, Roger, Williams, D. and Fulbrook, Paul. (2019) Study protocol: A pilot clinical trial of topical glyceryl trinitrate for chronic venous leg ulcer healing. Wound Practice & Research. 27(3), pp. 131 - 134. https://doi.org/10.33235/wpr.27.3.131-134

Authors	Miles, Sandra, Lord, Roger, Williams, D. and Fulbrook, Paul
Abstract	Background Chronic venous leg ulcers (VLUs) are costly to the healthcare system and a burden to patients, significantly reducing quality of life. Nitric oxide (NO) is important to wound healing, with a small study demonstrating a NO donor, topical glyceryl trinitrate (GTN), was effective for VLU healing. The aim of this study is to examine the application of topical GTN in relation to VLU healing. Methods A pilot double-blinded randomised controlled clinical trial will be undertaken. Participants in the control group (n=20) will receive a placebo ointment (ointment base) and participants in the treatment group (n=20) will receive a NO donor (base ointment with 2% GTN) weekly for 4 weeks. The inclusion criteria will be adults >18 years of age with a chronic VLU. Rate of healing will be determined by planimetry (ulcer tracing) using the Gillman equation. Significance This clinical trial aims to provide proof of concept of a novel treatment, topical GTN, which may accelerate wound healing through improvements to vasodilation and antimicrobial properties at the wound bed. What is already known - Chronic VLUs are a burden to patients and the healthcare system. - NO is important to wound healing. - GTN is a NO donor. What this study aims to contribute - Pilot a double-blind clinical trial of topical GTN. - Examine the effect of 2% topical GTN on wound healing in VLUs.
Keywords	Glyceryl trinitrate; nitric oxide; venous leg ulcer; wound healing
Year	2019
Journal	Wound Practice & Research
Journal citation	27 (3), pp. 131 - 134
Publisher	Cambridge Publishing
ISSN	1837-6304
Digital Object Identifier (DOI)	https://doi.org/10.33235/wpr.27.3.131-134
Open access	Open access
Page range	131 - 134
Research Group	School of Nursing, Midwifery and Paramedicine
Author's accepted manuscript	AM_Miles_2019_Study_protocol_a_pilot_clinical_trial.pdf
Place of publication	Australia

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Changing the mindset: An inter-disciplinary approach to management of bariatric patient

Nowicki, Tracy, Burns, Cheryl, Fulbrook, Paul Richard and Jones, Jacqueline. (2009) Changing the mindset: An inter-disciplinary approach to management of bariatric patient. Collegian. 16(4), pp. 171 - 175. https://doi.org/10.1016/j.colegn.2009.03.002

Intensive and critical care nursing perspectives

Williams, G. F., Fulbrook, Paul Richard, Alexandrov, A. W., Montanez, W. Canon, Salisu-Kabara, H. M. and Chan, D. W.K.. (2009) Intensive and critical care nursing perspectives. In In A. Gullo, J. Besso and P.D.Lumb & G.F.Williams (Ed.). Intensive and critical care medicine pp. 119 - 132 Springer Verlag.

A clinical improvement project to develop and implement a decision-making framework for the use of seclusion

Hyde, Sandra, Fulbrook, Paul Richard, Fenton, Keryn and Kilshaw, Michael. (2009) A clinical improvement project to develop and implement a decision-making framework for the use of seclusion. International Journal of Mental Health Nursing. 18, pp. 398 - 408. https://doi.org/10.1111/j.1447-0349.2009.00631.x

The effectiveness of a caring protocol: An evaluation study

Fulbrook, Paul. (2009) The effectiveness of a caring protocol: An evaluation study. Journal of Research in Nursing. 14(4), pp. 317 - 318. https://doi.org/10.1177/1744987108093360

The presence of family members during cardiopulmonary resuscitation: Position statement

Lynch, Fiona, Fulbrook, Paul, Latour, Jos, Albarran, John, de Graaf, Wouter, Devictor, Denis and Norekval, Tone. (2008) The presence of family members during cardiopulmonary resuscitation: Position statement. Infant: for neonatal and paediatric healthcare professionals (print version). 4(2), pp. 44 - 45.

Enteral feeding practices in European ICUs: A survey from the European federation of critical care nursing associations (EFCCNA)

Roynette, C., Numico, Anke Bongers, Fulbrook, Paul, Albarran, John and Hofman, Z.. (2008) Enteral feeding practices in European ICUs: A survey from the European federation of critical care nursing associations (EFCCNA). e-SPEN Journal: the European e-journal of clinical nutrition and metabolism. 2(2), pp. 33 - 39. https://doi.org/10.1016/j.eclnm.2007.10.004

Improving Teacher Responsiveness In Making Adjustments for School Children With 'Critical Prone' Medical Conditions

Miles, Sandra and Flowers, Karen. (2008) Improving Teacher Responsiveness In Making Adjustments for School Children With 'Critical Prone' Medical Conditions [Dataset]. Australian Catholic University. https://doi.org/10.26199/acu.85097

Paediatric critical care nurses' attitudes and experiences of parental presence during cardiopulmonary resuscitation: A European survey

Fulbrook, Paul, Latour, Jos and Albarran, John. (2007) Paediatric critical care nurses' attitudes and experiences of parental presence during cardiopulmonary resuscitation: A European survey. International Journal of Nursing Studies. 44(7), pp. 1238 - 1249. https://doi.org/10.1016/j.ijnurstu.2006.05.006

Critical care nursing organizations and activities - a second worldwide review: Original article

Willia, Ged, Chaboyer, Wendy, Alberto, Laura, Thorsteinsdottir, Rosa, Schmollgruber, Shelley, Fulbrook, Paul, Chan, Dominic and Bost, Nerolie. (2007) Critical care nursing organizations and activities - a second worldwide review: Original article. International Nursing Review. 54(2), pp. 151 - 159. https://doi.org/10.1111/j.1466-7657.2007.00543.x

A European survey of enteral nutrition practices and procedures in adult intensive care units

Fulbrook, Paul, Bongers, Anke and Albarran, John. (2007) A European survey of enteral nutrition practices and procedures in adult intensive care units. Journal of Clinical Nursing. 16(11), pp. 2132 - 2141. https://doi.org/10.1111/j.1365-2702.2006.01841.x

The presence of family members during cardiopulmonary resuscitation: European federation of critical care nursing associations, European society of paediatric and neonatal intensive care and European society of cardiology council on cardiovascular

Fulbrook, Paul, Latour, Jos, Albarran, John, de Graaf, Wouter, Lynch, Fiona, Devictor, Denis and Norekval, Tone. (2007) The presence of family members during cardiopulmonary resuscitation: European federation of critical care nursing associations, European society of paediatric and neonatal intensive care and European society of cardiology council on cardiovascular. European Journal of Cardiovascular Nursing. 6(4), pp. 255 - 258. https://doi.org/10.1016/j.ejcnurse.2007.07.003

Understanding the experiences of mothers who are breast feeding an infant with tongue-tie: a hermeneutic phenomenology study.

Miles, Sandra and Fulbrook, Paul. (2007) Understanding the experiences of mothers who are breast feeding an infant with tongue-tie: a hermeneutic phenomenology study [Dataset]. Australian Catholic University. https://doi.org/10.26199/acu.85095

Portable oxygen: Longer for less with oxymizer pendant

Fulbrook, Paul and Serginson, John. (2006) Portable oxygen: Longer for less with oxymizer pendant. Airways Journal (print version). 4(2), pp. 105 - 108.

Education for outreach: Development of an inter-professional MSC in critical care

Fulbrook, Paul and Cockerell, Janet. (2005) Education for outreach: Development of an inter-professional MSC in critical care. Nursing in Critical Care. 10(5), pp. 255 - 262. https://doi.org/10.1111/j.1362-1017.2005.00123.x

Advancing the clinical perspective: A practice development project to develop the nurse practitioner role in an acute hospital trust

Walsgrove, Hilary and Fulbrook, Paul. (2005) Advancing the clinical perspective: A practice development project to develop the nurse practitioner role in an acute hospital trust. Journal of Clinical Nursing. 14(4), pp. 444 - 455. https://doi.org/10.1111/j.1365-2702.2004.01089.x