Gaucher disease and bone manifestations
Journal article
Marcucci, Gemma, Zimran, Ari, Bembi, Bruno, Kanis, John, Reginster, Jean-Yves, Rizzoli, Rene, Cooper, Cyrus and Brandi, Maria Luisa. (2014). Gaucher disease and bone manifestations. Calcified Tissue International. 95(6), pp. 477 - 494. https://doi.org/10.1007/s00223-014-9923-y
Authors | Marcucci, Gemma, Zimran, Ari, Bembi, Bruno, Kanis, John, Reginster, Jean-Yves, Rizzoli, Rene, Cooper, Cyrus and Brandi, Maria Luisa |
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Abstract | Gaucher disease is a relatively rare metabolic disease caused by the inherited deficiency of the lysosomal enzyme glucocerebrosidase. Gaucher disease affects multiple organs, among which is the skeleton. Bone involvement occurs frequently in Gaucher disease, and is one of its most debilitating features, reducing the quality of life of patients. Bone status is an important consideration for treatment to ameliorate symptoms and reduce the risk of irreversible complications. We have conducted a systematic review of all the various aspects of Gaucher disease, focusing on different skeletal manifestations, pathophysiology of bone alterations, clinical symptoms, and current diagnostic and therapeutic approaches. |
Keywords | Gaucher disease Bone Biomarkers Enzyme replacement therapy Substrate reduction therapy Osteonecrosis |
Year | 2014 |
Journal | Calcified Tissue International |
Journal citation | 95 (6), pp. 477 - 494 |
Publisher | Springer New York LLC |
ISSN | 0171-967X |
Digital Object Identifier (DOI) | https://doi.org/10.1007/s00223-014-9923-y |
Scopus EID | 2-s2.0-84919418204 |
Page range | 477 - 494 |
Research Group | Institute for Health and Ageing |
Publisher's version | File Access Level Controlled |
Place of publication | United States |
https://acuresearchbank.acu.edu.au/item/858v8/gaucher-disease-and-bone-manifestations
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