High dietary fat intake increases fat oxidation and reduces skeletal muscle mitochondrial respiration in trained humans
Journal article
Leckey, Jill J., Hoffman, Nolan J., Parr, Evelyn B., Devlin, Brooke L., Trewin, Adam J., Stepto, Nigel K., Morton, James P., Burke, Louise M. and Hawley, John A.. (2018) High dietary fat intake increases fat oxidation and reduces skeletal muscle mitochondrial respiration in trained humans. FASEB Journal. 32(6), pp. 2979 - 2991. https://doi.org/10.1096/fj.201700993R
Authors | Leckey, Jill J., Hoffman, Nolan J., Parr, Evelyn B., Devlin, Brooke L., Trewin, Adam J., Stepto, Nigel K., Morton, James P., Burke, Louise M. and Hawley, John A. |
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Abstract | High-fat, low-carbohydrate (CHO) diets increase whole-body rates of fat oxidation and down-regulate CHO metabolism. We measured substrate utilization and skeletal muscle mitochondrial respiration to determine whether these adaptations are driven by high fat or low CHO availability. In a randomized crossover design, 8male cyclists consumed5dof a high-CHO diet [>70%energy intake (EI)], followed by 5dof either an isoenergetic high-fat (HFAT; >65% EI) or high-protein diet (HPRO; >65% EI) with CHO intake clamped at |
Keywords | Adaptation; carbohydrate; exercise; metabolism; substrate utilization; mitochondrial respiration; muscle mitochondrion |
Year | 2018 |
Journal | FASEB Journal |
Journal citation | 32 (6), pp. 2979 - 2991 |
ISSN | 0892-6638 |
Digital Object Identifier (DOI) | https://doi.org/10.1096/fj.201700993R |
Scopus EID | 2-s2.0-85049177776 |
Open access | Published as non-open access |
Page range | 2979 - 2991 |
Research Group | Mary MacKillop Institute for Health Research |
Author's accepted manuscript | File Access Level Controlled |
Publisher's version |
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