Safety, tolerability, and efficacy of PBT2 in Huntington's disease: A phase 2, randomised, double-blind, placebo-controlled trial

Journal article


Angus, D., Herd, C., Stone, C., Stout, Julie, Wieler, Marguerite, Reilmann, Ralf, Ritchie, C. W., Dorsey, Earl Ray, Helles, K., Kayson, Elise, Oakes, David, Rosas, Herminia Diana, Vaughan, Carr J., Panegyres, Peter K., Ames, David J., Goh, Anita, Agarwal, Pinky, Churchyard, Andrew, Murathodizic, M., ... Targum, S.. (2015). Safety, tolerability, and efficacy of PBT2 in Huntington's disease: A phase 2, randomised, double-blind, placebo-controlled trial. Lancet Neurology. 14(1), pp. 39 - 47. https://doi.org/10.1016/S1474-4422(14)70262-5
AuthorsAngus, D., Herd, C., Stone, C., Stout, Julie, Wieler, Marguerite, Reilmann, Ralf, Ritchie, C. W., Dorsey, Earl Ray, Helles, K., Kayson, Elise, Oakes, David, Rosas, Herminia Diana, Vaughan, Carr J., Panegyres, Peter K., Ames, David J., Goh, Anita, Agarwal, Pinky, Churchyard, Andrew, Murathodizic, M., Chua, Phyllis, Germaine, D., Lim, D. L., Mack, H., Loy, Clement T. H., Griffith, Jane, Mitchell, Patrick, Corey-Bloom, Jody, Gluhm, Shea, Goldstein, Jody, Levi, L., Margolis, Russell L., Yoritomo, Nadine, Janicki, Sarah Christine, Marder, Karen, Clouse, Ronda, Singer, Carlos, Moore, Henry, Padron, N., Kostyk, Sandra, Daley, A., Sergo, Vicki, Kumar, Rajeev Ananda, Anderson, Karen E., Drazinic, Carolyn M., Hennig, B., Nance, Martha A., Molho, Eric S., Criswell, Susan R., LeDoux, Mark S., Guyot, S., Iannaccone, A., Jennings, B., Leavitt, Blair R., Feigin, Andrew S., Evans, Scott R., Wray, S., Casaceli, Cindy, Orme, Constance, Gao, S., Watts, A., Baker, K., Labuschagne, Izelle, El-Dairi, M., Fekrat, S., Hersch, S., Moscovitch-Lopatin, M., Ranzi, R. and Targum, S.
Abstract

Background: PBT2 is a metal protein-attenuating compound that might reduce metal-induced aggregation of mutant huntingtin and has prolonged survival in a mouse model of Huntington's disease. We aimed to assess the safety, tolerability, and efficacy of PBT2 in patients with Huntington's disease.

Methods: In this 26-week, randomised, double-blind, placebo-controlled trial, adults ( ≥ 25 years old ) with early-stage to mid-stage Huntington's disease were randomly assigned ( 1:1:1 ) by a centralised interactive response system to once daily PBT2 250 mg, PBT2 100 mg, or placebo. Randomisation was stratified by site with a block size of three. Participants, carers, the steering committee, site investigators, study staff, and the study sponsor were masked to treatment assignment. Primary endpoints were safety and tolerability. The safety population consisted of all participants who were randomly assigned and had at least one dose of study drug. The principal secondary endpoint was cognition, measured by the change from baseline to week 26 in the main composite Z score of five cognitive tests ( Category Fluency Test, Trail Making Test Part B, Map Search, Symbol Digit Modalities Test, and Stroop Word Reading Test ) and scores on eight individual cognitive tests ( the five aforementioned plus the Trail Making Test Part A, Montreal Cognitive Assessment, and the Speeded Tapping Test ). The intention-to-treat population comprised participants who were randomly assigned and had at least one efficacy assessment after administration of study drug. This trial is registered with [http://clinicaltrials.gov/] ClinicalTrials.gov, [http://clinicaltrials.gov/show/NCT01590888] NCT01590888.

Findings: Between April 18, 2012, and Dec 14, 2012, 109 participants were randomly assigned to PBT2 250 mg ( n=36 ), PBT2 100 mg ( n=38 ), or placebo ( n=35 ) at 19 research centres in Australia and the USA. 32 ( 89% ) individuals on PBT2 250 mg, 38 ( 100% ) on PBT2 100 mg, and 34 ( 97% ) on placebo completed the study. Six serious adverse events ( acute coronary syndrome, major depression, pneumonia, suicide attempt, viral infection, and worsening of Huntington's disease ) occurred in five participants in the PBT2 250 mg group, three ( fall with subdural haematoma, suicide attempt, and hospital admission for stabilisation of Huntington's disease ) occurred in two participants in the PBT2 100 mg group, and one ( increasing aggression ) occurred in a participant in the placebo group. The site investigators deemed all, except the worsening of Huntington's disease, as unrelated to study drug. 32 ( 89% ) participants on PBT2 250 mg, 30 ( 79% ) on PBT2 100 mg, and 28 ( 80% ) on placebo had at least one adverse event. Compared with placebo, neither PBT2 100 mg ( least-squares mean 0·02, 95% CI −0·10 to 0·14; p=0·772 ) nor PBT2 250 mg ( 0·07, −0·05 to 0·20; p=0·240 ) significantly improved the main composite cognition Zscore between baseline and 26 weeks. Compared with placebo, the Trail Making Test Part B score was improved between baseline and 26 weeks in the PBT2 250 mg group ( 17·65 s, 0·65–34·65; p=0·042 ) but not in the 100 mg group ( 0·79 s improvement, −15·75 to 17·32; p=0·925 ); neither dose significantly improved cognition on the other tests.

Interpretation: PBT2 was generally safe and well tolerated in patients with Huntington's disease. The potential benefit on executive function will need to be confirmed in a larger study.

Funding: Prana Biotechnology Limited.

Year2015
JournalLancet Neurology
Journal citation14 (1), pp. 39 - 47
PublisherLancet Publishing Group
ISSN1474-4422
Digital Object Identifier (DOI)https://doi.org/10.1016/S1474-4422(14)70262-5
Scopus EID2-s2.0-84918785958
Page range39 - 47
Publisher's version
File Access Level
Controlled
Place of publicationUnited Kingdom
Permalink -

https://acuresearchbank.acu.edu.au/item/85vq0/safety-tolerability-and-efficacy-of-pbt2-in-huntington-s-disease-a-phase-2-randomised-double-blind-placebo-controlled-trial

Restricted files

Publisher's version

  • 209
    total views
  • 0
    total downloads
  • 4
    views this month
  • 0
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Concordance in salivary cortisol and subjective anxiety to the trier social stress test in social anxiety disorder
Grace, Caitlin, Heinrichs, Markus, Koval, Peter, Gorelik, Alexandra, von Dawans, Bernadette, Terrett, Gill, Rendell, Peter and Labuschagne, Izelle. (2022). Concordance in salivary cortisol and subjective anxiety to the trier social stress test in social anxiety disorder. Biological Psychology. 175, p. Article 108444. https://doi.org/10.1016/j.biopsycho.2022.108444
Intellectual enrichment and genetic modifiers of cognition and brain volume in Huntington's disease
Papoutsi, Marina, Flower, Michael, Hensman Moss, Davina J., Holmans, Peter, Estevez-Fraga, Carlos, Johnson, Eileanoir B., Scahill, Rachael I., Rees, Geraint, Langbehn, Douglas, Tabrizi, Sarah J., Kraus, Peter, Hoffman, Rainer, Tobin, Alan, Borowsky, Beth, Keenan, S., Whitlock, Kathryn B., Queller, Sarah, Campbell, Colin, Wang, Chiachi, ... Landwehrmeyer, Bernhard. (2022). Intellectual enrichment and genetic modifiers of cognition and brain volume in Huntington's disease. Brain Communications. 4(6), p. Article fcac279. https://doi.org/10.1093/braincomms/fcac279
Effect of high-intensity power training on cognitive function in older adults with type 2 diabetes : Secondary outcomes of the GREAT2DO Study
Zhao, Ren Ru, Mavros, Yorgi, Meiklejohn, Jacinda, Anderberg, Kylie A., Singh, Nalin, Kay, Shelley, Baker, Michael K., Wang, Yi, Climstein, Mike, O'Sullivan, Anthony, De Vos, Nathan, Baune, Bernhard T., Blair, Steven N., Simar, David and Fiatarone Singh, Maria A.. (2022). Effect of high-intensity power training on cognitive function in older adults with type 2 diabetes : Secondary outcomes of the GREAT2DO Study. The Journals of Gerontology: Series A. 77(10), pp. 1975-1985. https://doi.org/10.1093/gerona/glac090
The Efficacy of Exercise Training for Cutaneous Microvascular Reactivity in the Foot in People with Diabetes and Obesity : Secondary Analyses from a Randomized Controlled Trial
Lanting, Sean Michael, Way, Kimberley L., Sabag, A., Sultana, Rachelle, Gerofi, James, Johnson, Nathan, Baker, Michael Kevin, Keating, S, Caterson, Ian, Twigg, Stephen M. and Chuter, Vivienne. (2022). The Efficacy of Exercise Training for Cutaneous Microvascular Reactivity in the Foot in People with Diabetes and Obesity : Secondary Analyses from a Randomized Controlled Trial. Journal of Clinical Medicine. 11(17), pp. 1-12. https://doi.org/10.3390/jcm11175018
Is resting-state functional connectivity altered in regular cannabis users? A systematic review of the literature
Thomson, Hannah, Labuschagne, Izelle, Greenwood, Lisa-Marie, Robinson, Emily, Sehl, Hannah, Suo, Chao and Lorenzetti, Valentina. (2022). Is resting-state functional connectivity altered in regular cannabis users? A systematic review of the literature. Psychopharmacology. 239, pp. 1191-1209. https://doi.org/10.1007/s00213-021-05938-0
Resting-state neuroimaging in social anxiety disorder : A systematic review
Mizzi, Simone, Pedersen, Mangor, Lorenzetti, Valentina, Heinrichs, Markus and Labuschagne, Izelle. (2022). Resting-state neuroimaging in social anxiety disorder : A systematic review. Molecular Psychiatry. 27(1), pp. 164-179. https://doi.org/10.1038/s41380-021-01154-6
Identity and shame in body dysmorphic disorder as compared to obsessive-compulsive disorder
Malcolm, Amy, Pikoos, Toni, Castle, David J., Labuschagne, Izelle and Rossell, Susan L.. (2021). Identity and shame in body dysmorphic disorder as compared to obsessive-compulsive disorder. Journal of Obsessive-Compulsive and Related Disorders. 31, p. Article 100686. https://doi.org/10.1016/j.jocrd.2021.100686
The effect of high-intensity power training on habitual, intervention and total physical activity levels in older adults with type 2 diabetes : Secondary outcomes of the GREAT2DO randomized controlled trial
Mosalman Haghighi, Marjan, Mavros, Yorgi, Kay, Shelley, Simpson, Kylie A., Baker, Michael K., Wang, Yi, Zhao, Ren R., Meiklejohn, Jacinda, Climstein, Mike, O’Sullivan, Anthony J., De Vos, Nathan, Baune, Bernhard T., Blair, Steven N., Simar, David, Singh, Nalin, Schlicht, Jeffrey and Fiatarone Singh, Maria A.. (2021). The effect of high-intensity power training on habitual, intervention and total physical activity levels in older adults with type 2 diabetes : Secondary outcomes of the GREAT2DO randomized controlled trial. Geriatrics. 6(1), p. Article 15. https://doi.org/10.3390/geriatrics6010015
Sex differences in the neuroanatomy of alcohol dependence : Hippocampus and amygdala subregions in a sample of 966 people from the ENIGMA Addiction Working Group
Grace, Sally, Rossetti, Maria Gloria, Allen, Nicholas, Batalla, Albert, Bellani, Marcella, Brambilla, Paolo, Chye, Yann, Cousijn, Janna, Goudriaan, Anna E., Hester, Robert, Hutchison, Kent, Labuschagne, Izelle, Momenan, Reza, Martin-Santos, Rocio, Rendell, Peter, Solowij, Nadia, Sinha, Rajita, Li, Chiang-shan Ray, Schmaal, Lianne, ... Lorenzetti, Valentina. (2021). Sex differences in the neuroanatomy of alcohol dependence : Hippocampus and amygdala subregions in a sample of 966 people from the ENIGMA Addiction Working Group. Translational Psychiatry. 11(1), p. Article 156. https://doi.org/10.1038/s41398-021-01204-1
Empirical evidence for cognitive subgroups in body dysmorphic disorder
Malcolm, Amy, Brennan, Sarah N., Grace, Sally A., Pikoos, Toni D., Toh, Wei Lin, Labuschagne, Izelle, Buchanan, Ben, Kaplan, Ryan A., Castle, David J. and Rossell, Susan L.. (2021). Empirical evidence for cognitive subgroups in body dysmorphic disorder. Australian and New Zealand Journal of Psychiatry. 55(4), pp. 381-390. https://doi.org/10.1177/0004867421998762
Degree of adiposity and obesity severity is associated with cutaneous microvascular dysfunction in type 2 diabetes
Lanting, Sean M., Way, Kimberley L., Sabag, Angelo, Sultana, Rachelle N., Johnson, Nathan A., Baker, Michael K., Gerofi, James A., Caterson, Ian D., Twigg, Stephen M. and Chuter, Vivienne H.. (2021). Degree of adiposity and obesity severity is associated with cutaneous microvascular dysfunction in type 2 diabetes. Microvascular Research. 136(Article 104149). https://doi.org/10.1016/j.mvr.2021.104149
The effect of exercise training on cardiometabolic health in men with prostate cancer receiving androgen deprivation therapy : A systematic review and meta-analysis
Bigaran, Ashley, Zopf, Eva, Gardner, Jason, La Gerche, Andre, Murphy, Declan G., Howden, Erin J., Baker, Michael K. and Cormie, Prue. (2021). The effect of exercise training on cardiometabolic health in men with prostate cancer receiving androgen deprivation therapy : A systematic review and meta-analysis. Prostate Cancer and Prostatic Diseases. 24(1), pp. 35-48. https://doi.org/10.1038/s41391-020-00273-5
Age differences in emotion regulation and facial muscle reactivity to emotional films
Labuschagne, Izelle, Pedder, David J., Henry, Julie D., Terrett, Gill and Rendell, Peter G.. (2020). Age differences in emotion regulation and facial muscle reactivity to emotional films. Gerontology. 66, pp. 74-84. https://doi.org/10.1159/000501584
Task characteristics influence facial emotion recognition age-effects : A meta-analytic review
Hayes, Grace S., McLennan, Skye N., Henry, Julie D., Phillips, Louise H., Terrett, Gill, Rendell, Peter G., Pelly, Rachel M. and Labuschagne, Izelle. (2020). Task characteristics influence facial emotion recognition age-effects : A meta-analytic review. Psychology and Aging. 35(2), pp. 295-315. https://doi.org/10.1037/pag0000441
Hippocampal plasticity underpins long-term cognitive gains from resistance exercise in MCI
Broadhouse, Kathryn M., Singh, Maria Fiatarone, Suo, Chao, Gates, Nicola, Wen, Wei, Brodaty, Henry, Jain, Nidhi, Wilson, Guy C., Meiklejohn, Jacinda, Singh, Nalin, Baune, Bernhard T., Baker, Michael, Foroughi, Nasim, Wang, Yi, Kochan, Nicole, Ashton, Kevin, Brown, Matt, Li, Zhixiu, Mavros, Yorgi, ... Valenzuela, Michael J.. (2020). Hippocampal plasticity underpins long-term cognitive gains from resistance exercise in MCI. NeuroImage: Clinical. 25, p. Article 102182. https://doi.org/10.1016/j.nicl.2020.102182
The effect of low-volume high-intensity interval training on cardiovascular health outcomes in type 2 diabetes : A randomised controlled trial
Way, Kimberley L., Sabag, Angelo, Sultana, Rachelle N., Baker, Michael K., Keating, Shelley E., Lanting, Sean, Gerofi, James, Chuter, Vivienne H., Caterson, Ian D., Twigg, Stephen M. and Johnson, Nathan A.. (2020). The effect of low-volume high-intensity interval training on cardiovascular health outcomes in type 2 diabetes : A randomised controlled trial. International Journal of Cardiology. 320, pp. 148-154. https://doi.org/10.1016/j.ijcard.2020.06.019
The effect of a novel low-volume aerobic exercise intervention on liver fat in type 2 diabetes : A randomized controlled trial
Sabag, Angelo, Way, Kimberley L., Sultana, Rachelle N., Keating, Shelley E., Gerofi, James A., Chuter, Vivienne H., Byrne, Nuala M., Baker, Michael K., George, Jacob, Caterson, Ian D., Twigg, Stephen M. and Johnson, Nathan A.. (2020). The effect of a novel low-volume aerobic exercise intervention on liver fat in type 2 diabetes : A randomized controlled trial. Diabetes Care. 43(10), pp. 2371-2378. https://doi.org/10.2337/dc19-2523
Delusional themes in Body Dysmorphic Disorder (BDD) : Comparisons with psychotic disorders and non-clinical Controls
Rossell, Susan L., Labuschagne, Izelle, Castle, David J. and Toh, Wei Lin. (2020). Delusional themes in Body Dysmorphic Disorder (BDD) : Comparisons with psychotic disorders and non-clinical Controls. Psychiatry Research. 284, p. 112694. https://doi.org/10.1016/j.psychres.2019.112694
An introductory guide to conducting the Trier Social Stress Test
Labuschagne, Izelle, Grace, Caitlin, Rendell, Peter, Terrett, Gillian and Heinrichs, Markus. (2019). An introductory guide to conducting the Trier Social Stress Test. Neuroscience and Biobehavioral Reviews. 107, pp. 686-695. https://doi.org/10.1016/j.neubiorev.2019.09.032
MSH3 modifies somatic instability and disease severity in Huntington's and myotonic dystrophy type 1
Flower, Michael, Lomeikaite, Vilija, Ciosi, Marc, Cumming, Sarah, Morales, Fernando, Lo, Kitty, Hensman Moss, Davina, Jones, Lesley, Holmans, Peter, Kraus, Peter, Hoffman, Rainer, Tobin, Alan, Borowsky, Beth, Keenan, S, Whitlock, Kathryn B., Queller, Sarah, Campbell, Colin, Wang, Chiachi, Langbehn, Doug, ... Tabrizi, Sarah J,. (2019). MSH3 modifies somatic instability and disease severity in Huntington's and myotonic dystrophy type 1. Brain. 142(7), pp. 1876-1886. https://doi.org/10.1093/brain/awz115
Intranasal oxytocin alters amygdala-temporal resting-state functional connectivity in body dysmorphic disorder : A double-blind placebo-controlled randomized trial
Grace, Sally A., Labuschagne, Izelle, Castle, David J. and Rossell, Susan L.. (2019). Intranasal oxytocin alters amygdala-temporal resting-state functional connectivity in body dysmorphic disorder : A double-blind placebo-controlled randomized trial. Psychoneuroendocrinology. 107, pp. 179-186. https://doi.org/10.1016/j.psyneuen.2019.05.022
Apathy associated with impaired recognition of happy facial expressions in Huntington's disease
Osborne-Crowley, Katherine, Andrews, Sophie C., Labuschagne, Izelle, Nair, Akshay, Scahill, Rachael, Craufurd, David, Tabrizi, Sarah J. and Stout, Julie C.. (2019). Apathy associated with impaired recognition of happy facial expressions in Huntington's disease. Journal of the International Neuropsychological Society. 25(5), pp. 453-461. https://doi.org/10.1017/S1355617718001224
The relationship between episodic future thinking and prospective memory in middle childhood : Mechanisms depend on task type
Terrett, Gill, Horner, Katherine, White, Roxanne, Henry, Julie D., Kliegel, Matthias, Labuschagne, Izelle and Rendell, Peter G.. (2019). The relationship between episodic future thinking and prospective memory in middle childhood : Mechanisms depend on task type. Journal of Experimental Child Psychology. 178, pp. 198-213. https://doi.org/10.1016/j.jecp.2018.10.003
The effect of high Intensity interval training versus moderate intensity continuous training on arterial stiffness and 24 h blood pressure responses: A systematic review and meta-analysis
Way, Kimberley L., Sultana, Rachelle N., Sabag, Angelo, Baker, Michael K. and Johnson, Nathan A.. (2019). The effect of high Intensity interval training versus moderate intensity continuous training on arterial stiffness and 24 h blood pressure responses: A systematic review and meta-analysis. Journal of Science and Medicine in Sport. 22(4), pp. 385 - 391. https://doi.org/10.1016/j.jsams.2018.09.228
Brain regions showing white matter loss in Huntington's Disease are enriched for synaptic and metabolic genes
McColgan, Peter, Gregory, Sarah, Seunarine, Kiran K., Razi, Adeel, Papoutsi, Marina, Johnson, Eileanoir B., Dürr, Alexandra, Roos, Raymund, Leavitt, Blair R., Holmans, Peter, Scahill, Rachael I., Clark, Chris A., Rees, Geraint, Tabrizi, Sarah J., Coleman, A., Decolongon, J., Fan, M., Petkau, T., Jauffret, C., ... Crawfurd, D.. (2018). Brain regions showing white matter loss in Huntington's Disease are enriched for synaptic and metabolic genes. Biological Psychiatry. 83(5), pp. 456-465. https://doi.org/10.1016/j.biopsych.2017.10.019
Partnerships in collaborative care : Role of the exercise physiologist
Smith, Sheree M. S., Isenring, Liz, Rice, Vanessa J., Baker, Michael K., Thompson-Butel, Angelica G., Mitchell, Geoffrey, Bissett, Michelle, Zakrzewski, Leearne, Lenson, Shane, Gallego, Gisselle, Wright, Anthony, Hughes, Mark, Gallagher, Hillary and Kenny, Belinda. (2018). Partnerships in collaborative care : Role of the exercise physiologist. In In Chang, Ester and Johnson, Amanda (Ed.). Living with chronic illness and disability : Principles for nursing practice pp. 20-25 Elsevier Australia.
Testing a longitudinal compensation model in premanifest Huntington's disease
Gregory, Sarah, Long, Jeffrey D., Klöppel, Stefan, Razi, Adeel, Scheller, Elisa, Minkova, Lora, Johnson, Eileanoir B., Durr, Alexandra, Roos, Raymund A. C., Leavitt, Blair R., Mills, James A., Stout, Julie C., Scahill, Rachael I., Tabrizi, Sarah J., Rees, Geraint, the Track-On investigators and Labuschagne, Izelle*. (2018). Testing a longitudinal compensation model in premanifest Huntington's disease. Brain. 141(7), pp. 2156-2166. https://doi.org/10.1093/brain/awy122
Working memory-related effective connectivity in Huntington's disease patients
Lahr, Jacob, Minkova, Lora, Tabrizi, Sarah J., Stout, Julie C., Klöppel, Stefan, Scheller, Elisa, the TrackOn-HD Investigators and Labuschagne, I.. (2018). Working memory-related effective connectivity in Huntington's disease patients. Frontiers in Neurology. 9, p. Article 370. https://doi.org/10.3389/fneur.2018.00370
The relationship between body dysmorphic disorder and obsessive-compulsive disorder: A systematic review of direct comparative studies
Malcolm, Amy, Labuschagne, Izelle, Castle, David J, Terrett, Gill, Rendell, Peter and Rossell, Susan. (2018). The relationship between body dysmorphic disorder and obsessive-compulsive disorder: A systematic review of direct comparative studies. Australian and New Zealand Journal of Psychiatry. 52(11), pp. 1030-1049. https://doi.org/10.1177/0004867418799925
Visual scanning of the eye region of human faces predicts emotion recognition performance in Huntington's disease
Catarina C. Kordsachia, Izelle Labuschagne and Julie C Stout. (2018). Visual scanning of the eye region of human faces predicts emotion recognition performance in Huntington's disease. Neuropsychology. 32(3), pp. 356-365. https://doi.org/10.1037/neu0000424
Oxytocin selectively modulates brain processing of disgust in Huntington's disease gene carriers
Izelle Labuschagne, Govinda Poudel, Catarina C. Kordsachia, Qizhu Wu, Hannah Thomson, Nellie Georgiou-Karistianis and Julie C Stout. (2018). Oxytocin selectively modulates brain processing of disgust in Huntington's disease gene carriers. Progress in Neuropsychopharmacology and Biological Psychiatry. 81, pp. 11-16. https://doi.org/10.1016/j.pnpbp.2017.09.023
Oxytocin and brain activity in humans: A systematic review and coordinate-based meta-analysis of functional MRI studies
Sally A. Grace, Susan Rossell, Markus Heinrichs, Catarina C. Kordsachia and Izelle Labuschagne. (2018). Oxytocin and brain activity in humans: A systematic review and coordinate-based meta-analysis of functional MRI studies. Psychoneuroendocrinology. 96, pp. 6-24. https://doi.org/10.1016/j.psyneuen.2018.05.031
Intranasal oxytocin does not reduce age-related difficulties in social cognition
Sarah A. Grainger, Julie Henry, Henriette R. Steinvik, Eric J Vanman, Peter Rendell and Izelle Labuschagne. (2018). Intranasal oxytocin does not reduce age-related difficulties in social cognition. Hormones and Behaviour. 99, pp. 25-34. https://doi.org/10.1016/j.yhbeh.2018.01.009
Diminished facial EMG responses to disgusting scenes and happy and fearful faces in Huntington's disease
Catarina C. Kordsachia, Izelle Labuschagne, Sophie C. Andrews and Julie C. Stout. (2018). Diminished facial EMG responses to disgusting scenes and happy and fearful faces in Huntington's disease. Cortex. 106, pp. 185-199. https://doi.org/10.1016/j.cortex.2018.05.019
Decision-making, somatic markers and emotion processing in opiate users
Kathryn Biernacki, Gill Terrett, Skye McLennan, Izelle Labuschagne, Phoebe Morton and Peter Rendell. (2018). Decision-making, somatic markers and emotion processing in opiate users. Psychopharmacology. 235(1), pp. 223-232. https://doi.org/10.1007/s00213-017-4760-0
Brief Report: The Impact of Sensory Hypersensitivity and Intolerance of Uncertainty on Anxiety in Williams Syndrome
Mirko Uljarević, Izelle Labuschagne, Rebecca Bobin, Anna Atkinson and Darren R. Hocking. (2018). Brief Report: The Impact of Sensory Hypersensitivity and Intolerance of Uncertainty on Anxiety in Williams Syndrome. Journal of Autism and Developmental Disorders. 48(11), pp. 3958-3964. https://doi.org/10.1007/s10803-018-3631-9
Reliability and validity of a Mediterranean diet and culinary index (MediCul) tool in an older population with mild cognitive impairment
Radd-Vagenas, Sue, Fiatarone Singh, Maria A., Inskip, Michael, Mavros, Yorgi, Gates, Nicola J., Wilson, Guy C., Jain, Nidhi, Meiklejohn, Jacinda, Brodaty, Henry, Wen, Wei, Singh, Nalin, Baune, Bernhard T., Suo, Chao, Baker, Michael K., Foroughi, Nasim, Sachdev, Peminder S., Valenzuela, Michael and Flood, Victoria M.. (2018). Reliability and validity of a Mediterranean diet and culinary index (MediCul) tool in an older population with mild cognitive impairment. The British Journal of Nutrition. 120(10), pp. 1189 - 1200. https://doi.org/10.1017/S0007114518002428
Intranasal oxytocin reduces heart rate variability during a mental arithmetic task: A randomised, double-blind, placebo-controlled cross-over study
Tracy, Lincoln M., Gibson, Stephen J., Labuschagne, Izelle, Georgiou-Karistianis, Nellie and Giummarra, Melita J.. (2018). Intranasal oxytocin reduces heart rate variability during a mental arithmetic task: A randomised, double-blind, placebo-controlled cross-over study. Progress in Neuropsychopharmacology and Biological Psychiatry. 81, pp. 408 - 415. https://doi.org/10.1016/j.pnpbp.2017.08.016
Exercise preserves physical function in prostate cancer patients with bone metastases
Galvao, Daniel A., Taaffe, Dennis R., Spry, Nigel A., Cormie, Prue, Joseph, David, Chambers, Suzanne K., Chee, Raphael, Peddle-McIntyre, Carolyn J., Hart, Nicolas H., Baumann, Freerk T., Denham, James, Baker, Michael K. and Newton, Robert U.. (2018). Exercise preserves physical function in prostate cancer patients with bone metastases. Medicine and Science in Sports and Exercise. 50(3), pp. 393 - 399. https://doi.org/10.1249/MSS.0000000000001454
Whole body vibration exposure on markers of bone turnover, body composition, and physical functioning in breast cancer patients receiving aromatase inhibitor therapy: A randomized controlled trial
Baker, Michael K., Peddle-McIntyre, Carolyn J., Galvão, Daniel A., Hunt, Catherine, Spry, Nigel A. and Newton, Robert U.. (2018). Whole body vibration exposure on markers of bone turnover, body composition, and physical functioning in breast cancer patients receiving aromatase inhibitor therapy: A randomized controlled trial. Integrative Cancer Therapies. 17(3), pp. 968 - 978. https://doi.org/10.1177/1534735418781489
Feasibility and preliminary efficacy of a 10-week resistance and aerobic exercise intervention during neoadjuvant chemoradiation treatment in rectal cancer patients
Singh, Favil, Galvão, Daniel A., Newton, Robert U., Spry, Nigel A., Baker, Michael K. and Taaffe, Dennis R.. (2018). Feasibility and preliminary efficacy of a 10-week resistance and aerobic exercise intervention during neoadjuvant chemoradiation treatment in rectal cancer patients. Integrative Cancer Therapies. 17(3), pp. 952 - 959. https://doi.org/10.1177/1534735418781736
Families affected by Huntington's Disease report difficulties in communication, emotional involvement, and problem solving
Jona, Celine M. H., Labuschagne, Izelle, Mercieca, Emily-Clare, Fisher, Fiona, Gluyas, Cathy, Stout, Julie C. and Andrews, Sophie C.. (2017). Families affected by Huntington's Disease report difficulties in communication, emotional involvement, and problem solving. Journal of Huntington's Disease. 6(3), pp. 169-177. https://doi.org/10.3233/JHD-170250
Sex-specific effects of intranasal oxytocin on thermal pain perception: A randomised, double-blind, placebo-controlled cross-over study
Tracy, Lincoln M., Labuschagne, Izelle, Georgiou-Karistianis, Nellie, Gibson, Stephen J. and Giummarra, Melita J.. (2017). Sex-specific effects of intranasal oxytocin on thermal pain perception: A randomised, double-blind, placebo-controlled cross-over study. Psychoneuroendocrinology. 83, pp. 101 - 110. https://doi.org/10.1016/j.psyneuen.2017.05.028
Exercise and ectopic fat in type 2 diabetes: A systematic review and meta-analysis
Sabag, A., Way, Kimberley L., Keating, S. E., Sultana, Rachelle N., O'Connor, Helen T., Baker, Michael K., Chuter, Vivienne H., George, J. and Johnson, Nathan A.. (2017). Exercise and ectopic fat in type 2 diabetes: A systematic review and meta-analysis. Diabetes and Metabolism. 43(3), pp. 195 - 210. https://doi.org/10.1016/j.diabet.2016.12.006
Beyond emotion recognition deficits: A theory guided analysis of emotion processing in Huntington's disease
Kordsachia, Catarina C., Labuschagne, Izelle and Stout, Julie C.. (2017). Beyond emotion recognition deficits: A theory guided analysis of emotion processing in Huntington's disease. Neuroscience and Biobehavioral Reviews. 73, pp. 276 - 292. https://doi.org/10.1016/j.neubiorev.2016.11.020
Non-invasive lower limb small arterial measures co-segregate strongly with foot complications in people with diabetes
Lanting, Sean Michael, Twigg, Stephen M., Johnson, Nathan Anthony, Baker, Michael Kevin, Caterson, Ian Douglas and Chuter, Vivienne Helaine. (2017). Non-invasive lower limb small arterial measures co-segregate strongly with foot complications in people with diabetes. Journal of Diabetes and Its Complications. 31(3), pp. 589 - 593. https://doi.org/10.1016/j.jdiacomp.2016.11.010
Impairments in spatiotemporal gait adaptation during obstacle navigation in Huntington’s disease
Anwar, Naznine, Labuschagne, Izelle, Simpson, Katrina, Smith, Luke and Georgiou-Karistianis, Nellie. (2017). Impairments in spatiotemporal gait adaptation during obstacle navigation in Huntington’s disease. Neurorehabilitation and Neural Repair. 31(10-11), pp. 934 - 943. https://doi.org/10.1177/1545968317736818
Impaired heel to toe progression during gait is related to reduced ankle range of motion in people with Multiple Sclerosis
Psarakis, Michael, Greene, David, Moresi, Mark, Baker, Michael, Stubbs, Peter, Brodie, Matthew, Lord, Stephen and Hoang, Phu. (2017). Impaired heel to toe progression during gait is related to reduced ankle range of motion in people with Multiple Sclerosis. Clinical Biomechanics. 49, pp. 96-100. https://doi.org/10.1016/j.clinbiomech.2017.08.012
Abnormal visual scanning of emotionally evocative natural scenes in Huntington's disease
Kordsachia, Catarina C., Labuschagne, Izelle and Stout, Julie C.. (2017). Abnormal visual scanning of emotionally evocative natural scenes in Huntington's disease. Frontiers in Psychology. 8(March), pp. 1 - 10. https://doi.org/10.3389/fpsyg.2017.00405
White matter predicts functional connectivity in premanifest Huntington's disease
McColgan, Peter, Gregory, Sarah, Razi, Adeel, Seunarine, Kiran K., Gargouri, Fatma, Durr, Alexandra, Roos, Raymund A. C., Leavitt, Blair R., Scahill, Rachael I., Clark, Chris A., Tabrizi, Sarah J., Rees, Geraint, Coleman, Allison J., Decolongon, J., Fan, M., Petkau, T., Jauffret, Céline, Justo, Damian, Lehericy, S., ... Johnson, H.. (2017). White matter predicts functional connectivity in premanifest Huntington's disease. Annals of Clinical and Translational Neurology. 4(2), pp. 106 - 118. https://doi.org/10.1002/acn3.384
The neurobiology of body dysmorphic disorder: A systematic review and theoretical model
Grace, Sally A., Labuschagne, Izelle, Kaplan, Ryan A. and Rossell, Susan L.. (2017). The neurobiology of body dysmorphic disorder: A systematic review and theoretical model. Neuroscience and Biobehavioral Reviews. 83, pp. 83 - 96. https://doi.org/10.1016/j.neubiorev.2017.10.003
Effects of cold water immersion and contrast water therapy for recovery from team sport: A systematic review and meta-analysis
Higgins, Trevor R., Greene, David A. and Baker, Michael K.. (2017). Effects of cold water immersion and contrast water therapy for recovery from team sport: A systematic review and meta-analysis. Journal of Strength and Conditioning Research. 31(5), pp. 1443 - 1460. https://doi.org/10.1519/JSC.0000000000001559
The feasibility of a pragmatic distance-based intervention to increase physical activity in lung cancer survivors
Peddle-Mcintye, C. J., Baker, Michael, Lee, Y. C.G., Galvao, Daniel A., Cormie, Prue, Graham, V. and Newton, Robert U.. (2017). The feasibility of a pragmatic distance-based intervention to increase physical activity in lung cancer survivors. European Journal of Cancer Care. 27(1), pp. 1 - 10. https://doi.org/10.1111/ecc.12722
The effect of calcium and vitamin D supplementation on bone health of male Jockeys
Silk, Leslie N., Greene, David A., Baker, Michael K. and Jander, Caron B.. (2017). The effect of calcium and vitamin D supplementation on bone health of male Jockeys. Journal of Science and Medicine in Sport. 20(3), pp. 225 - 229. https://doi.org/10.1016/j.jsams.2016.08.004
Emotion processing in persons who respond vicariously towards others in pain: Disinhibited left-lateralized neural activity for threatening expressions
Giummarra, Melita J., Poudel, Govinda, Niu, P. Amanda, Nicholls, Michael E. R., Fielding, Joanne, Verdejo-Garcia, Antonio and Labuschagne, Izelle. (2017). Emotion processing in persons who respond vicariously towards others in pain: Disinhibited left-lateralized neural activity for threatening expressions. Laterality: Assymetries of body, brain and cognition. 23(2), pp. 184 - 208. https://doi.org/10.1080/1357650X.2017.1349781
Mediation of cognitive function improvements by strength gains after resistance training in older adults with mild cognitive impairment: Outcomes of the study of mental and resistance training
Mavros, Yorgi, Gates, Nicola, Wilson, Guy C., Jain, Nidhi, Meiklejohn, Jacinda, Brodaty, Henry, Wen, Wei, Singh, Nalin, Baune, Bernhard T., Suo, Chao, Baker, Michael K., Foroughi, Nasim, Wang, Yi, Sachdev, Peminder S., Valenzuela, Michael and Fiatarone Singh, Maria A.. (2017). Mediation of cognitive function improvements by strength gains after resistance training in older adults with mild cognitive impairment: Outcomes of the study of mental and resistance training. Journal of the American Geriatrics Society. 65(5), pp. 550 - 559. https://doi.org/10.1111/jgs.14542
The effect of exercise training on cutaneous microvascular reactivity: A systematic review and meta-analysis
Lanting, Sean M., Johnson, Nathan A., Baker, Michael K., Caterson, Ian D. and Chuter, Vivienne H.. (2017). The effect of exercise training on cutaneous microvascular reactivity: A systematic review and meta-analysis. Journal of Science and Medicine in Sport. 20(2), pp. 170 - 177. https://doi.org/10.1016/j.jsams.2016.04.002
Feasibility of presurgical exercise in men with prostate cancer undergoing prostatectomy
Singh, Favil, Newton, Robert U., Baker, Michael K., Spry, Nigel A., Taaffe, Dennis R., Thavaseelan, Jeffery and Galvão, Daniel A.. (2017). Feasibility of presurgical exercise in men with prostate cancer undergoing prostatectomy. Integrative Cancer Therapies. 16(3), pp. 290 - 299. https://doi.org/10.1177/1534735416666373
Identification of genetic variants associated with Huntington's disease progression: A genome-wide association study
Hensman Moss, Davina J., Pardiñas, Antonio F., Langbehn, Douglas, Lo, Kitty, Leavitt, Blair R., Roos, Raymund, Durr, Alexandra, Mead, Simon, TRACK-HD investigators,, REGISTRY investigators,, Labuschagne, Izelle, TRACK-HD investigators and REGISTRY investigators. (2017). Identification of genetic variants associated with Huntington's disease progression: A genome-wide association study. The Lancet Neurology. 16(9), pp. 701 - 711. https://doi.org/10.1016/S1474-4422(17)30161-8
Cardiac rehabilitation for patients with coronary artery disease: a practical guide to enhance patient outcomes through continuity of care
Giuliano, Catherine, Parmenter, Belinda, Baker, Michael, Mitchell, Braden, Williams, Andrew, Lyndon, Katie, Mair, Tarryn, Maiorana, Andrew, Smart, Neil A. and Levinger, Itamar. (2017). Cardiac rehabilitation for patients with coronary artery disease: a practical guide to enhance patient outcomes through continuity of care. Clinical Medicine Insights: Cardiology. 11, pp. 1 - 7. https://doi.org/10.1177/1179546817710028
Effect of resistance training on liver fat and visceral adiposity in adults with obesity: A randomized controlled trial
Keating, Shelley E., Hackett, Daniel A., Parker, Helen M., Way, Kimberley L., O'Connor, Helen T., Sainsbury, Amanda, Baker, Michael K., Chuter, Vivienne H., Caterson, Ian D., George, Jacob and Johnson, Nathan A.. (2016). Effect of resistance training on liver fat and visceral adiposity in adults with obesity: A randomized controlled trial. Hepatology Research. https://doi.org/10.1111/hepr.12781
The effect of exercise on vascular function and stiffness in type 2 diabetes: A systematic review and meta-analysis
Way, Kimberley Larisa, Keating, Shelley Elizabeth, Baker, Michael Kevin, Chuter, Vivienne Helaine and Johnson, Nathan Anthony. (2016). The effect of exercise on vascular function and stiffness in type 2 diabetes: A systematic review and meta-analysis. Current Diabetes Reviews. 12(4), pp. 369 - 383. https://doi.org/10.2174/1573399811666150817124601
The effect of regular exercise on insulin sensitivity in type 2 diabetes mellitus: A systematic review and meta-analysis
Way, Kimberley L., Hackett, Daniel A., Baker, Michael Kevin and Johnson, Nathan A.. (2016). The effect of regular exercise on insulin sensitivity in type 2 diabetes mellitus: A systematic review and meta-analysis. Diabetes and Metabolism Journal. 40(4), pp. 253 - 269. https://doi.org/10.4093/dmj.2016.40.4.253
Therapeutically relevant structural and functional mechanisms triggered by physical and cognitive exercise
Suo, Chao, Singh, Maria Fiatarone, Gates, Nicola J., Wen, Wei, Sachdev, Perminder, Brodaty, Henry, Saigal, Nidhi, Wilson, Guy C., Meiklejohn, Jacinda, Singh, Nalin, Baune, Bernhard T., Baker, Michael Kevin, Foroughi, Nasim, Wang, Yi, Mavros, Yorgi, Lampit, Amit, Leung, Isabella and Valenzuela, Michael J.. (2016). Therapeutically relevant structural and functional mechanisms triggered by physical and cognitive exercise. Molecular Psychiatry. 21(11), pp. 1633 - 1642. https://doi.org/10.1038/mp.2016.19
The wisdom to know the difference : Strategy-situation fit in emotion regulation in daily life is associated with well-being
Haines, Simon J., Gleeson, John, Kuppens, Peter, Hollenstein, Tom, Ciarrochi, Joseph, Labuschagne, Izelle, Grace, Caitlin and Koval, Peter. (2016). The wisdom to know the difference : Strategy-situation fit in emotion regulation in daily life is associated with well-being. Psychological Science. 27(12), pp. 1651-1659. https://doi.org/10.1177/0956797616669086
Objectively quantified physical activity and sedentary behavior in predicting visceral adiposity and liver fat
Keating, Shelley E., Parker, Helen M., Pavey, Toby G., Baker, Michael Kevin, Caterson, Ian D., George, Jacob and Johnson, Nathan A.. (2016). Objectively quantified physical activity and sedentary behavior in predicting visceral adiposity and liver fat. Journal of Obesity. 2016, pp. 1 - 10. https://doi.org/10.1155/2016/2719014
Improving research standards to restore trust in intranasal oxytocin
Carson, Dean S., Yuan, Hsiangkuo and Labuschagne, Izelle. (2016). Improving research standards to restore trust in intranasal oxytocin. Biological Psychiatry. 79(8), pp. e53 - e54. https://doi.org/10.1016/j.biopsych.2015.08.031
Effects of oxytocin and genetic variants on brain and behaviour : Implications for treatment in schizophrenia
Bartholomeusz, Cali, Ganella, Eleni, Labuschagne, Izelle, Bousman, Chad and Pantelis, Christos. (2015). Effects of oxytocin and genetic variants on brain and behaviour : Implications for treatment in schizophrenia. Schizophrenia Research. 168(3), pp. 614 - 627. https://doi.org/10.1016/j.schres.2015.06.007
Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder
Gorka, Stephanie M., Fitzgerald, Daniel A., Labuschagne, Izelle, Hosanagar, Avinash, Wood, Amanda G., Nathan, Pradeep J. and Phan, K. Luan. (2015). Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder. Neuropsychopharmacology. 40(2), pp. 278 - 286. https://doi.org/10.1038/npp.2014.168
Tibial bone responses to 6-month calcium and vitamin D supplementation in young male jockeys : A randomised controlled trial
Silk, Leslie, Greene, David, Baker, Michael and Jander, Caron. (2015). Tibial bone responses to 6-month calcium and vitamin D supplementation in young male jockeys : A randomised controlled trial. Bone. 81(12), pp. 554 - 561. https://doi.org/10.1016/j.bone.2015.09.004
Detection of motor changes in huntington's disease using dynamic causal modeling
Minkova, Lora, Scheller, Elisa, Peter, Jessica, Abdulkadir, Ahmed, Kaller, Christoph P., Roos, Raymund A. C., Dürr, Alexandra, Leavitt, Blair R., Tabrizi, Sarah J., Kloppel, Stefan, Coleman, Allison J., Decolongon, J., Fan, M., Koren, T., Jauffret, Céline, Justo, Damian, Lehericy, Stephane, Nigaud, Kevin, Valabrègue, Romain, ... Mills, J.. (2015). Detection of motor changes in huntington's disease using dynamic causal modeling. Frontiers in Human Neuroscience. 9, pp. 1 - 13. https://doi.org/10.3389/fnhum.2015.00634
Exercise and cancer survivorship
Cormie, Prue, Peddle-McIntyre, Carolyn, Hayes, Sandra C., Naumann, Fiona, Turner, Jane, Murnane, Andrew and Baker, Michael K.. (2015). Exercise and cancer survivorship. Cancer Forum. 39(2), pp. 105 - 112.
Compensation in preclinical Huntington's disease: Evidence from the track-on hd study
Kloppel, Stefan, Gregory, Sarah, Scheller, Elisa, Minkova, Lora, Razi, Adeel, Durr, Alexandra, Roos, Raymund A. C., Leavitt, Blair R., Papoutsi, Marina, Landwehrmeyer, G. Bernhard, Reilmann, Ralf, Borowsky, Beth, Johnson, Hans, Mills, James A., Owen, Gail N., Stout, Julie C., Scahill, Rachael I., Long, Jeffrey D., Rees, Geraint, ... Orth, M.. (2015). Compensation in preclinical Huntington's disease: Evidence from the track-on hd study. EBioMedicine. 2(10), pp. 1420 - 1429. https://doi.org/10.1016/j.ebiom.2015.08.002
Neuropsychiatry and white matter microstructure in Huntington's Disease
Gregory, Sarah L., Scahill, Rachael I., Seunarine, Kiran K., Stopford, Cheryl, Zhang, Hui, Zhang, Jiaying, Orth, Michael, Dürr, Alexandra, Roos, Raymund A. C., Langbehn, Douglas R., Long, Jeffrey D., Johnson, Hans, Rees, Geraint, Tabrizi, Sarah J., Craufurd, David I. O., Campbell, C., Campbell, Melissa, Labuschagne, Izelle, Milchman, C., ... Campbell, Colin. (2015). Neuropsychiatry and white matter microstructure in Huntington's Disease. Journal of Huntington's Disease. 4(3), pp. 239 - 249. https://doi.org/10.3233/JHD-150160
Differential effects of social stress on laboratory-based decision-making are related to both impulsive personality traits and gender
Wise, Richard J., Phung, Alissa L., Labuschagne, Izelle and Stout, Julie C.. (2015). Differential effects of social stress on laboratory-based decision-making are related to both impulsive personality traits and gender. Cognition and Emotion. 29, pp. 1475 - 1485. https://doi.org/10.1080/02699931.2014.989815
Reply to the Letter to the Editor by O'Caoimh et al
Singh, Maria Fiatarone, Gates, Nicola J., Saigal, Nidhi, Wilson, Guy C., Meiklejohn, Jacinda, Brodaty, Henry, Wen, Wei, Singh, Nalin, Baune, Bernhard T., Suo, Chao, Baker, Michael, Foroughi, Nasim, Foroughi, Nasim, Wang, Yi, Sachdev, Peminder and Valenzuela, Michael. (2015). Reply to the Letter to the Editor by O'Caoimh et al. Journal of the American Medical Directors Association (JAMDA): long-term care: management, applied research and clinical issues. 16(11), pp. 999 - 1001. https://doi.org/10.1016/j.jamda.2015.08.021
The effect of calcium or calcium and vitamin d supplementation on bone mineral density in healthy males : A systematic review and meta-analysis
Silk, Leslie, Greene, David and Baker, Michael. (2015). The effect of calcium or calcium and vitamin d supplementation on bone mineral density in healthy males : A systematic review and meta-analysis. International Journal of Sport Nutrition and Exercise Metabolism. 25(5), pp. 510 - 524. https://doi.org/10.1123/ijsnem.2014-0202
The impact of occipital lobe cortical thickness on cognitive task performance : An investigation in Huntington's Disease
Johnson, Eileanoir, Rees, Elin, Labuschagne, Izelle, Durr, Alexandra, Leavitt, Blair, Roos, Raymund, Reilmann, Ralf, Johnson, Hans, Hobbs, Nicola, Langbehn, Douglas, Stout, Julie, Tabrizi, Sarah and Scahill, Rachael. (2015). The impact of occipital lobe cortical thickness on cognitive task performance : An investigation in Huntington's Disease. Neuropsychologia. 79, pp. 138 - 146. https://doi.org/10.1016/j.neuropsychologia.2015.10.033
Modulation of resting-state amygdala-frontal functional connectivity by oxytocin in generalized social anxiety disorder
Dodhia, Sonam, Hosanagar, Avinash, Fitzgerald, Daniel A., Labuschagne, Izelle, Wood, Amanda G., Nathan, Pradeep J. and Phan, Kinhluan Luan. (2014). Modulation of resting-state amygdala-frontal functional connectivity by oxytocin in generalized social anxiety disorder. Neuropsychopharmacology. 39(9), pp. 2061 - 2069. https://doi.org/10.1038/npp.2014.53
Using theories of delusion formation to explain abnormal beliefs in Body Dysmorphic Disorder (BDD)
Rossell, Susan L., Labuschagne, Izelle, Dunai, Judith, Kyrios, Michael and Castle, David. (2014). Using theories of delusion formation to explain abnormal beliefs in Body Dysmorphic Disorder (BDD). Psychiatry Research. 215(3), pp. 599 - 605. https://doi.org/10.1016/j.psychres.2013.12.030
Reductions in C-reactive protein in older adults with type 2 diabetes are related to improvements in body composition following a randomized controlled trial of resistance training
Mavros, Yorgi, Kay, Shelley, Simpson, Kylie, Baker, Michael, Wang, Yi, Zhao, Renru, Meiklejohn, Jacinda, Climstein, Michael, O'Sullivan, Anthony and De Vos, Nathan. (2014). Reductions in C-reactive protein in older adults with type 2 diabetes are related to improvements in body composition following a randomized controlled trial of resistance training. Journal of Cachexia, Sarcopenia and Muscle. 5(2), pp. 111 - 120. https://doi.org/10.1007/s13539-014-0134-1
The potential of composite cognitive scores for tracking progression in Huntington's disease.
Jones, Rebecca D., Stout, Julie C., Labuschagne, Izelle, Say, Miranda Julia, Justo, Damian, Coleman, Allison J., Dumas, Eve M., Hart, Ellen P., Owen, Gail N., Durr, Alexandra, Leavitt, Blair R., Roos, Raymund A. C., O'Regan, Alison M., Langbehn, Doug R., Tabrizi, Sarah J. and Frost, Chris D.. (2014). The potential of composite cognitive scores for tracking progression in Huntington's disease. Journal of Huntington's Disease. 3(2), pp. 197 - 207. https://doi.org/10.3233/JHD-140101
The cognitive burden in Huntington's disease: Pathology, phenotype and mechanisms of compensation
Papoutsi, Marina, Labuschagne, Izelle, Tabrizi, Sarah J. and Stout, Julie C.. (2014). The cognitive burden in Huntington's disease: Pathology, phenotype and mechanisms of compensation. Movement Disorders Society. 29(5), pp. 673 - 683. https://doi.org/10.1002/mds.25864
A comparison of executive function in Body Dysmorphic Disorder (BDD) and Obsessive-Compulsive Disorder (OCD)
Labuschagne, Izelle, Rossell, Susan, Dunai, Judith, Castle, David and Kyrios, Michael. (2013). A comparison of executive function in Body Dysmorphic Disorder (BDD) and Obsessive-Compulsive Disorder (OCD). Journal of Obsessive-Compulsive and Related Disorders. 2(3), pp. 257 - 262. https://doi.org/10.1016/j.jocrd.2013.05.003
Oxytocin enhances resting-state connectivity between amygdala and medial frontal cortex
Sripada, Chandra, Phan, Kinhluan, Labuschagne, Izelle, Welsh, Robert, Nathan, Pradeep and Wood, Amanda. (2013). Oxytocin enhances resting-state connectivity between amygdala and medial frontal cortex. International Journal of Neuropsychopharmacology (print). 16(2), pp. 255 - 260. https://doi.org/10.1017/S1461145712000533
Emotional face recognition deficits and medication effects in pre-manifest through stage-II Huntington's disease
Labuschagne, Izelle, Jones, Rebecca, Callaghan, Jenny, Whitehead, Daisy, Dumas, Eve, Say, Miranda, Hart, Ellen, Justo, Damian, Coleman, Allison, Dar Santos, Rachelle, Frost, Chris, Craufurd, David, Trabrizi, Sarah and Stout, Julie. (2013). Emotional face recognition deficits and medication effects in pre-manifest through stage-II Huntington's disease. Psychiatry Research. 207(1-2), pp. 118 - 126. https://doi.org/10.1016/j.psychres.2012.09.022
A systematic review of pre-surgical exercise intervention studies with cancer patients
Singh, Favil, Newton, U, Galvao, Daniel, Spry, Nigel and Baker, Michael. (2013). A systematic review of pre-surgical exercise intervention studies with cancer patients. Surgical Oncology. https://doi.org/10.1016/j.suronc.2013.01.004
Long-term effects of intermittent androgren suppression therapy on lean and fat mass : a 33 month prospective study
Spry, Nigel, Taaffe, D R., England, P J., Judge, J S., Stephens, D A., Peddle-McIntyre, C, Baker, Michael, Newton, R and Galvao, Daniel. (2013). Long-term effects of intermittent androgren suppression therapy on lean and fat mass : a 33 month prospective study. Prostate Cancer and Prostatic Diseases. https://doi.org/10.1038/pcan.2012.33
Emotional face recognition deficits and medication effects in pre-manifest through stage-II Huntington's disease
Labuschagne, Izelle, Jones, Rebecca, Callaghan, Jenny, Whitehead, Daisy, Dumas, Eve, Say, Miranda, Hart, Ellen, Justo, Damian, Coleman, Allison, Dar Santos, Rachelle, Frost, Chris, Craufurd, David, Tabrizi, Sarah and Stout, Julie. (2013). Emotional face recognition deficits and medication effects in pre-manifest through stage-II Huntington's disease. Psychiatry Research. 207(1-2), pp. 118 - 126. https://doi.org/10.1016/j.psychres.2012.09.022
Changes in insulin resistance and HbA1c are related to exercise-mediated changes in body composition in older adults with Type 2 Diabetes : Interim outcomes from the GREAT2DO trial
Mavros, Yorgi, Kay, Shelley, Anderberg, Kylie, Baker, Michael K., Wang, Yi, Zhao, Renru, Meiklejohn, Jacinda, Climstein, Mike, O'Sullivan, Anthony and De Vos, Nathan. (2013). Changes in insulin resistance and HbA1c are related to exercise-mediated changes in body composition in older adults with Type 2 Diabetes : Interim outcomes from the GREAT2DO trial. Diabetes Care. 36(8), pp. 2372 - 2379. https://doi.org/10.2337/dc12-2196
Oxytocin enhances resting-state connectivity between amygdala and medial frontal cortex
Sripada, Chandra, Phan, Kinhluan, Labuschagne, Izelle, Welsh, Robert, Nathan, Pradeep and Wood, Amanda. (2013). Oxytocin enhances resting-state connectivity between amygdala and medial frontal cortex. International Journal of Neuropsychopharmacology. 16(2), pp. 255 - 260. https://doi.org/10.1017/S1461145712000533
Visual working memory impairment in premanifest gene-carriers and early Huntington's Disease
Dumas, Eve M., Say, Miranda Julia, Jones, Rebecca D., Labuschagne, Izelle, O'Regan, Alison M., Hart, Ellen P., van den Bogaard, Simon J. A., Queller, Sarah, Justo, Damian, Coleman, Allison J., dar Santos, Rachelle C., Durr, Alexandra, Leavitt, Blair R., Tabrizi, Sarah J., Roos, Raymund A. C. and Stout, Julie C.. (2012). Visual working memory impairment in premanifest gene-carriers and early Huntington's Disease. Journal of Huntington's Disease. 1(1), pp. 97 - 106. https://doi.org/10.3233/JHD-2012-120010
Evaluation of longitudinal 12 and 24 month cognitive outcomes in premanifest and early Huntington's disease
Stout, Julie, Jones, Rebecca, Labuschagne, Izelle, O'Regan, Alison, Say, Miranda, Dumas, Eve, Queller, Sarah, Justo, Damian, Dar Santos, Rachelle, Coleman, Allison, Hart, Ellen, Durr, Alexandra, Leavitt, Blair, Roos, Raymund, Langbehn, Doug, Tabrizi, Sarah J. and Frost, Chris. (2012). Evaluation of longitudinal 12 and 24 month cognitive outcomes in premanifest and early Huntington's disease. Journal of Neurology, Neurosurgery and Psychiatry. 83(7), pp. 687 - 694. https://doi.org/10.1136/jnnp-2011-301940
Exercise prescriptions for patients with type 2 diabetes and pre-diabetes : A position statement from Exercise and Sports Science Australia
Hordern, Matthew, Dunstan, David, Prins, Johannes, Baker, Michael, Fiatarone Singh, Maria and Coombes, Jeff. (2012). Exercise prescriptions for patients with type 2 diabetes and pre-diabetes : A position statement from Exercise and Sports Science Australia. Journal of Science and Medicine in Sport. 15(1), pp. 25 - 31. https://doi.org/10.1016/j.jsams.2011.04.005
Medial frontal hyperactivity to sad faces in generalized social anxiety disorder and modulation by oxytocin
Labuschagne, Izelle, Phan, K. Luan, Wood, Amanda, Angstadt, Mike, Chua, Phyllis, Heinrichs, Markus, Stout, Julie C., Nathan, Pradeep J. and Pradeep,. (2012). Medial frontal hyperactivity to sad faces in generalized social anxiety disorder and modulation by oxytocin. International Journal of Neuropsychopharmacology (print). 15(7), pp. 883 - 896. https://doi.org/10.1017/S1461145711001489
Evaluation of longitudinal 12 and 24 month cognitive outcomes in premanifest and early Huntington's disease
Stout, Julie, Jones, Rebecca, Labuschagne, Izelle, O'Regan, Alison, Say, Miranda, Dumas, Eve, Queller, Sarah, Justo, Damian, Dar Santos, Rachelle, Coleman, Allison, Hart, Ellen, Durr, Alexandra, Leavitt, Blair, Roos, Raymund, Langbehn, Douglas, Tabrizi, Sarah J. and Frost, Chris. (2012). Evaluation of longitudinal 12 and 24 month cognitive outcomes in premanifest and early Huntington's disease. Journal of Neurology, Neurosurgery and Psychiatry. 83(7), pp. 687 - 694. https://doi.org/10.1136/jnnp-2011-301940
Study of Mental Activity and Regular Training (SMART) in at risk individuals: A randomised double blind, sham controlled, longitudinal trial
Gates, Nicola, Valenzuela, Michael, Sachdev, Peminder, Singh, Nalin, Baune, Bernhard, Brodaty, Henry, Suo, Chao, Jain, Nidhi, Wilson, Guy, Wang, Yi, Baker, Michael, Williamson, Dominique, Foroughi, Nasim and Fiatarone Singh, Maria Antoinette. (2011). Study of Mental Activity and Regular Training (SMART) in at risk individuals: A randomised double blind, sham controlled, longitudinal trial. BMC Geriatrics. 11(19), pp. 19 - 33. https://doi.org/10.1186/1471-2318-11-19
Behavioral strategies in diabetes prevention programs :A systematic review of randomized controlled trials
Baker, Michael, Simpson, Kylie, Lloyd, Bradley, Bauman, Adrian and Fiatarone Singh, Maria. (2011). Behavioral strategies in diabetes prevention programs :A systematic review of randomized controlled trials. Diabetes Research and Clinical Practice. 91(1), pp. 1 - 12. https://doi.org/10.1016/j.diabres.2010.06.030
Lower limb muscle strengthening does not change frontal plane moments in women with knee osteoarthritis :A randomized controlled trial
Foroughi, Nasim, Smith, Richard, Lange, Angela, Baker, Michael, Fiatarone Singh, Maria and Vanwanseele, Benedicte. (2011). Lower limb muscle strengthening does not change frontal plane moments in women with knee osteoarthritis :A randomized controlled trial. Clinical Biomechanics. 26(2), pp. 167 - 174. https://doi.org/10.1016/j.clinbiomech.2010.08.011
Implementation of evidence-based treatment protocols to manage fever, hyperglycaemia, and swallowing dysfunction in acute stroke (QASC) : A cluster randomised controlled trial
Middleton, Sandy, McElduff, Patrick, Ward, Jeanette, Grimshaw, Jeremy M., Dale, Simeon, D'Este, Catherine, Drury, Peta, Griffiths, Rhonda, Cheung, N. Wah, Quinn, Clare, Evans, Malcolm, Cadilhac, Dominique and Levi, Christopher. (2011). Implementation of evidence-based treatment protocols to manage fever, hyperglycaemia, and swallowing dysfunction in acute stroke (QASC) : A cluster randomised controlled trial. The Lancet. 378(9804), pp. 1699-706. https://doi.org/10.1016/S0140-6736(11)61485-2
A randomized controlled trial of whole body vibration exposure on markers of bone turnover in postmenopausal women
Turner, Sarah, Torode, Margaret Ellen, Climstein, Michael, Naughton, Geraldine, Greene, David, Baker, Michael and Fiatarone Singh, Maria. (2011). A randomized controlled trial of whole body vibration exposure on markers of bone turnover in postmenopausal women. Journal of Osteoporosis. 2011(1), pp. 1 - 10. https://doi.org/10.4061/2011/710387
Core self-evaluation as a predictor of strength training adoption in older adults
Baker, Michael, Kennedy, David, Bohle, Philip, Campbell, Deena, Wiltshire, James and Fiatarone Singh, Maria Antoinette. (2011). Core self-evaluation as a predictor of strength training adoption in older adults. Maturitas. 68(1), pp. 88 - 93. https://doi.org/10.1016/j.maturitas.2010.10.001
Efficacy and safety of a modular multi-modal exercise program in prostate cancer patients with bone metastases: a randomized controlled trial
Galvao, Daniel, Taaffe, D R, Cormie, P, Spry, Nigel, Chambers, Suzanne, Peddle-McIntyre, C, Baker, Michael, Denham, James, Joseph, David and Groom, Geoff. (2011). Efficacy and safety of a modular multi-modal exercise program in prostate cancer patients with bone metastases: a randomized controlled trial. BMC Cancer. 11(13), pp. 517 - 523. https://doi.org/10.1186/1471-2407-11-517
A systematic review and meta-analysis on the effect of aerobic vs. resistance exercise training on visceral fat
Ismail, I, Keating, S, Baker, Michael and Johnson, Nathan. (2011). A systematic review and meta-analysis on the effect of aerobic vs. resistance exercise training on visceral fat. Obesity Reviews. 13(1), pp. 68 - 91. https://doi.org/10.1111/j.1467-789X.2011.00931.x
Death, dependency and health status 90 days following hospital admission for acute stroke in NSW
Middleton, S., Levi, C., Ward, J., Grimshaw, J., Griffiths, R., D'Este, C., Dale, S., Quinn, C., Evans, M., Cadilhac, D. and McElduff, P.. (2011). Death, dependency and health status 90 days following hospital admission for acute stroke in NSW. Internal Medicine Journal. 41(10), pp. 736-743. https://doi.org/10.1111/j.1445-5994.2010.02330.x
What the cognitive deficits in body dysmorphic disorder tell us about the underlying neurobiology: An investigation of three cases
Labuschagne, Izelle, Castle, David and Rossell, Susan L.. (2011). What the cognitive deficits in body dysmorphic disorder tell us about the underlying neurobiology: An investigation of three cases. International Journal of Cognitive Therapy. 4(1), pp. 21 - 33. https://doi.org/10.1521/ijct.2011.4.1.21
Oxytocin attenuates amygdala reactivity to fear in generalized social anxiety disorder
Labuschagne, Izelle, Phan, K. Luan, Wood, Amanda G., Angstadt, Mike, Chua, Phyllis, Heinrichs, Markus, Stout, Julie C. and Nathan, Pradeep. (2010). Oxytocin attenuates amygdala reactivity to fear in generalized social anxiety disorder. Neuropsychopharmacology. 35(12), pp. 2403 - 2413. https://doi.org/10.1038/npp.2010.123
The relationship between knee adduction moment and cartilage and meniscus morphology in women with osteoarthritis
Vanwanseele, Benedicte, Eckstein, Felix, Smith, Richard, Lange, Angela, Foroughi, Nasim, Baker, Michael, Shnier, Ron and Fiatarone Singh, Maria Antoinette. (2010). The relationship between knee adduction moment and cartilage and meniscus morphology in women with osteoarthritis. Osteoarthritis and Cartilage. 18(7), pp. 894 - 901. https://doi.org/10.1016/j.joca.2010.04.006
Augmenting serotonin neurotransmission with citalopram modulates emotional expression decoding but not structural encoding of moderate intensity sad facial emotional stimuli: An event-related potential (ERP) investigation
Labuschagne, Izelle, Croft, Rodney, Phan, K. Luan and Nathan, Pradeep. (2010). Augmenting serotonin neurotransmission with citalopram modulates emotional expression decoding but not structural encoding of moderate intensity sad facial emotional stimuli: An event-related potential (ERP) investigation. Journal of Psychopharmacology. 24(8), pp. 1153 - 1164. https://doi.org/10.1177/0269881108097878
Executive function in body dysmorphic disorder
Dunai, Judith, Labuschagne, Izelle, Castle, David J., Kyrios, Michael and Rossell, Susan. (2010). Executive function in body dysmorphic disorder. Psychological Medicine. 40(9), pp. 1541 - 1548. https://doi.org/10.1017/S003329170999198X
Dynamic alignment and its association with knee adduction moment in medial knee osteoarthritis
Foroughi, Nasim, Smith, Richard, Lange, Angela, Baker, Michael, Fiatarone Singh, Maria and Vanwanseele, Benedicte. (2010). Dynamic alignment and its association with knee adduction moment in medial knee osteoarthritis. The Knee. 17(3), pp. 210 - 216. https://doi.org/10.1016/j.knee.2009.09.006
An examination of delusional thinking and cognitive styles in body dysmorphic disorder
Labuschagne, Izelle, Castle, David J., Dunai, Judith, Kyrios, Michael and Rossell, Susan. (2010). An examination of delusional thinking and cognitive styles in body dysmorphic disorder. Australian and New Zealand Journal of Psychiatry. 44(8), pp. 706 - 712. https://doi.org/10.3109/00048671003671007
Resistive exercise for arthritic cartilage health (REACH): A randomized double-blind, sham-exercise controlled trial
Lange, Angela K., Vanwanseele, Benedicte, Foroughi, Nasim, Baker, Michael Kevin, Shnier, Ronald C., Smith, Richard M. and Singh, Maria Fiatarone. (2009). Resistive exercise for arthritic cartilage health (REACH): A randomized double-blind, sham-exercise controlled trial. BMC Geriatrics. 9(1), pp. 1 - 10. https://doi.org/10.1186/1471-2318-9-1
Evidence for modulation of facial emotional processing bias during emotional expression decoding by serotonergic and noradrenergic antidepressants: An event-related potential (ERP) study
Kerestes, Rebecca, Labuschagne, Izelle, Croft, Rodney, O'Neill, Barry, Bhagwagar, Zubin M., Phan, K Luan and Nathan, Pradeep. (2009). Evidence for modulation of facial emotional processing bias during emotional expression decoding by serotonergic and noradrenergic antidepressants: An event-related potential (ERP) study. Psychopharmacology. 202(4), pp. 621 - 634. https://doi.org/10.1007/s00213-008-1340-3
Obesity effects on depression: Systematic review of epidemiological studies
Atlantis, Evan and Baker, Michael Kevin. (2008). Obesity effects on depression: Systematic review of epidemiological studies. International Journal of Obesity. 32(6), pp. 881 - 891. https://doi.org/10.1038/ijo.2008.54
Multi-modal exercise programs for older adults
Baker, Michael, Atlantis, Evan and Fiatarone Singh, Maria. (2007). Multi-modal exercise programs for older adults. Age and Ageing. 36, pp. 375 - 381. https://doi.org/10.1093/ageing/afm054
Efficacy and feasibility of a novel tri-modal robust exercise prescription in a retirement community : A randomized, controlled trial
Baker, Michael, Kennedy, David, Bohle, Philip, Campbell, Deena, Knapman, Leona, Grady, Jodie, Wiltshire, James, McNamara, Maria, Evans, William and Fiatarone Singh, Maria. (2007). Efficacy and feasibility of a novel tri-modal robust exercise prescription in a retirement community : A randomized, controlled trial. Journal of the American Geriatrics Society. 55, pp. 1 - 10. https://doi.org/10.1111/j.1532-5415.2006.01031.x
Degenerative meniscus tears and mobility impairment in women with knee osteoarthritis
Lange, Angela, Fiatarone Singh, Maria, Smith, Richard, Foroughi, Nasim, Baker, Michael, Shnier, Ron and Vanwanseele, Benedicte. (2007). Degenerative meniscus tears and mobility impairment in women with knee osteoarthritis. Osteoarthritis and Cartilage. 15(6), pp. 701 - 708. https://doi.org/10.1016/j.joca.2006.11.004