The effect of beta-blockers on foetal birth weight in pregnancies in women with structural heart disease: a prospective cohort study
Journal article
Baard, Johann, Azibani, Feriel, Osman, Ayesha, Dowling, Wentzel, Rayner, Brian and Sliwa, Karen. (2019). The effect of beta-blockers on foetal birth weight in pregnancies in women with structural heart disease: a prospective cohort study. Cardiovascular Journal of Southern Africa. 31(3), pp. 136 - 141. https://doi.org/10.5830/CVJA-2019-061
Authors | Baard, Johann, Azibani, Feriel, Osman, Ayesha, Dowling, Wentzel, Rayner, Brian and Sliwa, Karen |
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Abstract | Objective: To examine whether treatment with beta-blockers (BBs) in pregnant women with structural heart disease (SHD) resulted in a decrease in foetal birth weight (FBW) in a South African cohort. Methods: This was a prospective cohort study conducted in a tertiary-level hospital in Cape Town from 2010 to 2016. Of the 178 pregnant women with SHD, 24.2% received BBs for a minimum of two weeks. Adverse foetal outcomes and mean FBW were compared between the BB groups and subgroups (congenital, valvular, cardiomyopathy and other). Adverse foetal outcome was defined as: low birth weight (LBW) < 2 500 g, Apgar score < 7, premature birth (< 37 weeks) and small for gestational age (SGA). Results: BB exposure during pregnancy was found to be associated with a non-significant increased FBW (2 912 vs 2 807 g, p = 0.347). A significant decrease (p = 0.009) was noted in FBW for valvular SHD pregnancies using BBs, while a significant increase (p = 0.049) was observed for the same outcome in the cardiomyopathy subgroup using BBs. A significant increase was observed for SGA (p = 0.010) and LBW (p = 0.003) pregnancies within the valvular subgroup when exposed to BBs. Conclusion: BB use in pregnant women with SHD in a South African cohort showed no association with a decrease in FBW or an increase in adverse foetal outcomes when compared to non-BB usage. |
Keywords | beta-blockers; pregnancy; women; heart disease; foetal outcome |
Year | 2019 |
Journal | Cardiovascular Journal of Southern Africa |
Journal citation | 31 (3), pp. 136 - 141 |
Publisher | Clinics - Cardive Publishing Co. |
ISSN | 1015-9657 |
Digital Object Identifier (DOI) | https://doi.org/10.5830/CVJA-2019-061 |
Page range | 136 - 141 |
Research Group | Mary MacKillop Institute for Health Research |
Publisher's version | File Access Level Controlled |
Place of publication | South Africa |
https://acuresearchbank.acu.edu.au/item/85x38/the-effect-of-beta-blockers-on-foetal-birth-weight-in-pregnancies-in-women-with-structural-heart-disease-a-prospective-cohort-study
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