ERK1/2 in the brain mediates the effects of central resistin on reducing thermogenesis in brown adipose tissue
Kosari, Samin, Camera, Donny Michael, Hawley, John Alan, Stebbing, Martin and Badoer, Emilio. (2013) ERK1/2 in the brain mediates the effects of central resistin on reducing thermogenesis in brown adipose tissue. International Journal of Physiology, Pathophysiology and Pharmacology. 5(3), pp. 184 - 189.
|Authors||Kosari, Samin, Camera, Donny Michael, Hawley, John Alan, Stebbing, Martin and Badoer, Emilio|
We investigated the role of ERK1/2 in the brain on the effects of centrally administered resistin on thermogenesis. Resistin (7 µg) into anaesthetized rats significantly decreased brown adipose tissue temperature by 1.0 ± 0.4 °C (P < 0.005). This response was significantly attenuated by over 60% when ERK1/2 was inhibited by U0126 (7 µg) (P < 0.05). Resistin reduced uncoupling protein-1 mRNA expression (0.11 ± 0.01 vs 1.24 ± 0.85 resistin vs control respectively) and the expression of peroxisome proliferator-activated receptor gamma co-activator 1-α, but the effects were not statistically significant. The results suggest that ERK1/2 in the brain contributes to resistin’s effects on thermogenesis.
|Keywords||Resistin; brown adipose tissue; thermogenesis; ERK1/2|
|Journal||International Journal of Physiology, Pathophysiology and Pharmacology|
|Journal citation||5 (3), pp. 184 - 189|
|Publisher||E-Century Publishing Corporation|
|Web address (URL)||https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773078/|
|Open access||Open access|
|Page range||184 - 189|
|Research Group||Sports Performance, Recovery, Injury and New Technologies (SPRINT) Research Centre|
|Place of publication||United States of America|
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