Rewriting the transcriptome: adenosine-to-inosine RNA editing by ADARs
Journal article
Walkley, Carl and Li, Jin Billy. (2017). Rewriting the transcriptome: adenosine-to-inosine RNA editing by ADARs. Genome Biology. 18(1), pp. 1 - 13. https://doi.org/10.1186/s13059-017-1347-3
Authors | Walkley, Carl and Li, Jin Billy |
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Abstract | One of the most prevalent forms of post-transcritpional RNA modification is the conversion of adenosine nucleosides to inosine (A-to-I), mediated by the ADAR family of enzymes. The functional requirement and regulatory landscape for the majority of A-to-I editing events are, at present, uncertain. Recent studies have identified key in vivo functions of ADAR enzymes, informing our understanding of the biological importance of A-to-I editing. Large-scale studies have revealed how editing is regulated both in cis and in trans. This review will explore these recent studies and how they broaden our understanding of the functions and regulation of ADAR-mediated RNA editing. |
Year | 2017 |
Journal | Genome Biology |
Journal citation | 18 (1), pp. 1 - 13 |
Publisher | BioMed Central |
ISSN | 1474-7596 |
Digital Object Identifier (DOI) | https://doi.org/10.1186/s13059-017-1347-3 |
Scopus EID | 2-s2.0-85032579510 |
Open access | Open access |
Page range | 1 - 13 |
Research Group | Mary MacKillop Institute for Health Research |
Publisher's version | License |
Place of publication | United Kingdom |
Editors | B. Cheifet |
https://acuresearchbank.acu.edu.au/item/85y27/rewriting-the-transcriptome-adenosine-to-inosine-rna-editing-by-adars
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Publisher's version
OA_Walkley_2017_Rewriting_the_transcriptome_adenosine_to_inosine.pdf | |
License: CC BY 4.0 |
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