Physical inactivity and chronic kidney disease in Australian adults : The AusDiab study
Journal article
White, Sarah, Dunstan, David, Polkinghorne, Kevan, Atkins, Robert, Cass, Alan and Chadban, Steven. (2011). Physical inactivity and chronic kidney disease in Australian adults : The AusDiab study. Nutrition Metabolism and Cardiovascular Diseases. 21(2), pp. 104 - 112. https://doi.org/10.1016/j.numecd.2009.08.010
Authors | White, Sarah, Dunstan, David, Polkinghorne, Kevan, Atkins, Robert, Cass, Alan and Chadban, Steven |
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Abstract | Background and Aims: Physical inactivity is associated with cardiovascular risk however its relationship to chronic kidney disease is largely unknown. We examined the association between leisure-time physical activity and risk of chronic kidney disease in a prospective, population-based cohort of Australians aged ≥25 years (AusDiab). Methods and Results: The baseline sample included 10,966 adults (4951 males and 6015 females). From this sample, 6318 participants with complete baseline and 5-year follow-up urinalysis and serum creatinine measurements formed the study population for longitudinal analysis. Self-reported leisure-time physical activity was measured using a validated, interviewer–administered questionnaire. Compared with sufficiently active individuals (≥150 min physical activity per week), those who were inactive (0 min/week) were more likely to have albuminuria at baseline (multivariate-adjusted OR = 1.34, 95% CI 1.10–1.63). Inactivity (versus sufficient physical activity) was associated with increased age- and sex-adjusted odds of an estimated glomerular filtration rate < 3rd percentile (OR = 1.30, 95% CI 1.02–1.65), although this was not significant after multivariate adjustment (OR = 1.17, 95% CI 0.91–1.50). Obese, inactive individuals were significantly more likely to have albuminuria at baseline (multivariate-adjusted OR = 1.74, 95% CI 1.35–2.25), compared with sufficiently active, non-obese individuals. Baseline physical activity status was not significantly associated with longitudinal outcomes. Conclusions: Physical inactivity is cross-sectionally associated with albuminuria prevalence, particularly when combined with obesity. Future studies are needed to determine whether this association is causal and the importance of physical activity in CKD prevention. |
Year | 2011 |
Journal | Nutrition Metabolism and Cardiovascular Diseases |
Journal citation | 21 (2), pp. 104 - 112 |
ISSN | 0939-4753 |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.numecd.2009.08.010 |
Page range | 104 - 112 |
Research Group | Mary MacKillop Institute for Health Research |
Publisher's version | File Access Level Controlled |
https://acuresearchbank.acu.edu.au/item/85y76/physical-inactivity-and-chronic-kidney-disease-in-australian-adults-the-ausdiab-study
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