Clinical effects of probiotics in cystic fibrosis patients: A systematic review

Journal article


Van Biervliet, Stephanie, Declercq, Dimitri and Somerset, Shawn. (2017). Clinical effects of probiotics in cystic fibrosis patients: A systematic review. Clinical Nutrition ESPEN. 18, pp. 37 - 43. https://doi.org/10.1016/j.clnesp.2017.01.007
AuthorsVan Biervliet, Stephanie, Declercq, Dimitri and Somerset, Shawn
Abstract

Cystic fibrosis (CF) is characterised by a build-up of thick, intransient mucus linings of the digestive and respiratory mucosa, which disrupts digestive system functioning and microbiota composition. In view of the potential for probiotics to enhance microbiota composition in other contexts, this study investigated the current evidence for probiotics as an adjunct to usual therapy for CF. Electronic clinical databases were interrogated for human randomised, controlled, intervention trials (1985–2015) testing the effects of probiotics on clinical endpoints in CF were reviewed. From 191 articles identified in initial searches, six studies met the critical inclusion criteria, and were reviewed in detail. These studies varied in size (n = 22 to 61) but were generally small and showed substantial diversity in protocol, specific probiotic species used and range of clinical outcomes measured. Probiotic administration showed beneficial effects on fecal calprotectin levels, pulmonary exacerbation risk, and quality of life indicators. In one study, such changes were associated with variations in gut microbiota composition. Despite encouraging preliminary results, the limited number of small and highly varied studies to date do not justify the addition of probiotics as an adjunct to current CF treatment protocols. Importantly, very minimal adverse effects of probiotics have been reported.

KeywordsProbiotics; Inflammation; Cystic fibrosis; Systematic review
Year2017
JournalClinical Nutrition ESPEN
Journal citation18, pp. 37 - 43
PublisherElsevier
ISSN2405-4577
Digital Object Identifier (DOI)https://doi.org/10.1016/j.clnesp.2017.01.007
Scopus EID2-s2.0-85013482347
Page range37 - 43
Research GroupSchool of Allied Health
Publisher's version
File Access Level
Controlled
Place of publicationUnited Kingdom
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