Omics and exercise : Global approaches for mapping exercise biological networks

Journal article

Hoffman, Nolan John. (2017). Omics and exercise : Global approaches for mapping exercise biological networks. Cold Spring Harbor Perspectives in Medicine. 7(10), pp. 1-17. https://doi.org/10.1101/cshperspect.a029884
AuthorsHoffman, Nolan John
Abstract

The application of global “omics” technologies to exercise has introduced new opportunities to map the complexity and interconnectedness of biological networks underlying the tissue-specific responses and systemic health benefits of exercise. This review will introduce major research tracks and recent advancements in this emerging field, as well as critical gaps in understanding the orchestration of molecular exercise dynamics that will benefit from unbiased omics investigations. Furthermore, significant research hurdles that need to be overcome to effectively fill these gaps related to data collection, computation, interpretation, and integration across omics applications will be discussed. Collectively, a cross-disciplinary physiological and omics-based systems approachwill lead to discovery of a wealth of novel exercise-regulated targets for future mechanistic validation. This frontier in exercise biology will aid the development of personalized therapeutic strategies to improve athletic performance and human health through precision exercise medicine.

Keywordsathletic performance; dynamic exercise; epigenetics; personalised medicine; biomedical research; genome
Year2017
JournalCold Spring Harbor Perspectives in Medicine
Journal citation7 (10), pp. 1-17
PublisherCold Spring Harbor Laboratory Press
ISSN2157-1422
Digital Object Identifier (DOI)https://doi.org/10.1101/cshperspect.a029884
Scopus EID2-s2.0-85030679292
Open accessPublished as green open access
Page range1-17
Research GroupMary MacKillop Institute for Health Research
Author's accepted manuscript
File Access Level
Open
Publisher's version
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All rights reserved
File Access Level
Controlled
Place of publicationWoodbury, United States of America
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