Structural covariance in the hallucinating brain: A voxel-based morphometry study

Journal article


Modinos, Gemma, Vercammen, Ans, Mechelli, Andrea, Knegtering, Henderikus, McGuire, Paul K.W. and Aleman, Andre. (2009). Structural covariance in the hallucinating brain: A voxel-based morphometry study. Journal of Psychiatry and Neuroscience. 34(6), pp. 465 - 469.
AuthorsModinos, Gemma, Vercammen, Ans, Mechelli, Andrea, Knegtering, Henderikus, McGuire, Paul K.W. and Aleman, Andre
Abstract

Neuroimaging studies have indicated that a number of cortical regions express altered patterns of structural covariance in schizophrenia. The relation between these alterations and specific psychotic symptoms is yet to be investigated. We used voxel-based morphometry to examine regional grey matter volumes and structural covariance associated with severity of auditory verbal hallucinations. We applied optimized voxel-based morphometry to volumetric magnetic resonance imaging data from 26 patients with medication-resistant auditory verbal hallucinations (AVHs); statistical inferences were made at p < 0.05 after correction for multiple comparisons. Grey matter volume in the left inferior frontal gyrus was positively correlated with severity of AVHs. Hallucination severity influenced the pattern of structural covariance between this region and the left superior/middle temporal gyri, the right inferior frontal gyrus and hippocampus, and the insula bilaterally. The results are based on self-reported severity of auditory hallucinations. Complementing with a clinician-based instrument could have made the findings more compelling. Future studies would benefit from including a measure to control for other symptoms that may covary with AVHs and for the effects of antipsychotic medication. The results revealed that overall severity of AVHs modulated cortical intercorrelations between frontotemporal regions involved in language production and verbal monitoring, supporting the critical role of this network in the pathophysiology of hallucinations.

Year2009
JournalJournal of Psychiatry and Neuroscience
Journal citation34 (6), pp. 465 - 469
PublisherCanadian Medical Association/Association Medical Canadienne
ISSN1488-2434
Web address (URL)https://search.proquest.com/docview/217294077?accountid=8194
Page range465 - 469
Place of publicationCanada
Permalink -

https://acuresearchbank.acu.edu.au/item/861zx/structural-covariance-in-the-hallucinating-brain-a-voxel-based-morphometry-study

  • 85
    total views
  • 0
    total downloads
  • 0
    views this month
  • 0
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Adjunctive selective estrogen receptor modulator increases neural activity in the hippocampus and inferior frontal gyrus during emotional face recognition in schizophrenia
Ji, Ellen, Weickert, Cynthia S., Lenroot, Rhoshel, Kindler, J., Skilleter, Ashley J., Vercammen, Ans, White, Christopher, Gur, R. E. and Weickert, Thomas W.. (2016). Adjunctive selective estrogen receptor modulator increases neural activity in the hippocampus and inferior frontal gyrus during emotional face recognition in schizophrenia. Translational Psychiatry. 6, pp. 1 - 9. https://doi.org/10.1038/tp.2016.59
Anodal tDCS targeting the right orbitofrontal cortex enhances facial expression recognition
Willis, Megan L., Murphy, Jillian M., Ridley, Nicole J. and Vercammen, Ans. (2015). Anodal tDCS targeting the right orbitofrontal cortex enhances facial expression recognition. Social Cognitive and Affective Neuroscience. 10(12), pp. 1677 - 1683. https://doi.org/10.1093/scan/nsv057
Short and long term effects of left and bilateral repetitive transcranial magnetic stimulation in schizophrenia patients with auditory verbal hallucinations: A randomized controlled trial
Bais, Leonie, Vercammen, Ans, Stewart, Roy, van Es, Frank, Visser, Bert, Aleman, Andre and Knegtering, Henderikus. (2014). Short and long term effects of left and bilateral repetitive transcranial magnetic stimulation in schizophrenia patients with auditory verbal hallucinations: A randomized controlled trial. PLoS ONE. 9(10), pp. 1 - 10. https://doi.org/10.1371/journal.pone.0108828
Common polymorphisms in dopamine-related genes combine to produce a 'schizophrenia-like' prefrontal hypoactivity
Vercammen, Ans, Weickert, Cynthia, Skilleter, Ashley, Lenroot, Rhoshel, Schofield, Peter and Weickert, Thomas. (2014). Common polymorphisms in dopamine-related genes combine to produce a 'schizophrenia-like' prefrontal hypoactivity. Translational Psychiatry. 4(2), pp. 1 - 7. https://doi.org/10.1038/tp.2013.125
Testosterone is inversely related to brain activity during emotional inhibition in schizophrenia
Vercammen, Ans, Skilleter, Ashley, Lenroot, Rhoshel, Catts, Stanley, Weickert, Cynthia and Weickert, Thomas. (2013). Testosterone is inversely related to brain activity during emotional inhibition in schizophrenia. PLoS ONE. 8(10), pp. 1 - 10. https://doi.org/10.1371/journal.pone.0077496
Serum testosterone levels are related to cognitive function in men with schizophrenia
Moore, Loretta, Kyaw, Merribel, Vercammen, Ans, Lenroot, Rhoshel, Kulkarni, Jayashri, Curtis, Jackie, O'Donnell, Maryanne, Carr, Vaughn, Weickert, Cynthia and Weickert, Thomas. (2013). Serum testosterone levels are related to cognitive function in men with schizophrenia. Psychoneuroendocrinology. https://doi.org/10.1016/j.psyneuen.2013.02.007
When Broca goes uninformed : reduced information flow to Broca's area in Schizophrenia patients with auditory hallucinations
Curcic-Blake, Branislava, Liemburg, Edith, Vercammen, Ans, Swart, Marte, Knegtering, Henderikus, Bruggeman, Richard and Aleman, Andre. (2013). When Broca goes uninformed : reduced information flow to Broca's area in Schizophrenia patients with auditory hallucinations. Schizophrenia Bulletin. https://doi.org/10.1093/schbul/sbs107
Serum testosterone levels are related to cognitive function in men with schizophrenia
Moore, Loretta, Kyaw, Merribel, Vercammen, Ans, Lenroot, Rhoshel, Kulkarni, Jayashri, Curtis, Jackie, O'Donnell, Maryanne, Carr, Vaughn, Weickert, Cynthia and Weickert, Thomas. (2013). Serum testosterone levels are related to cognitive function in men with schizophrenia. Psychoneuroendocrinology. https://doi.org/10.1016/j.psyneuen.2013.02.007
Testosterone is inversely related to brain activity during emotional inhibition in schizophrenia
Vercammen, Ans, Skilleter, Ashley, Lenroot, Rhoshel, Catts, Stanley, Weickert, Cynthia and Weickert, Thomas. (2013). Testosterone is inversely related to brain activity during emotional inhibition in schizophrenia. PLoS ONE. 8(10), pp. 1 - 10. https://doi.org/10.1371/journal.pone.0077496
When Broca goes uninformed : reduced information flow to Broca's area in Schizophrenia patients with auditory hallucinations
Curcic-Blake, Branislava, Liemburg, Edith, Vercammen, Ans, Swart, Marte, Knegtering, Henderikus, Bruggeman, Richard and Aleman, Andre. (2013). When Broca goes uninformed : reduced information flow to Broca's area in Schizophrenia patients with auditory hallucinations. Schizophrenia Bulletin. https://doi.org/10.1093/schbul/sbs107
Rethinking schizophrenia in the context of normal neurodevelopment
Catts, Vibeke, Fung, Samantha, Long, Leonora, Joshi, Dipesh, Vercammen, Ans, Katherine, Allen, Fillman, Stu, Rothmond, Debora, Sinclair, Duncan and Tiwari, Yash. (2013). Rethinking schizophrenia in the context of normal neurodevelopment. Frontiers in Cellular Neuroscience. https://doi.org/10.3389/fncel.2013.00060
Abnormal connectivity between attentional, language and auditory networks in schizophrenia
Liemburg, Edith, Vercammen, Ans, Horst, Gert-Jan, Curcic-Blake, Branislava, Knegtering, Henderikus and Aleman, Andre. (2012). Abnormal connectivity between attentional, language and auditory networks in schizophrenia. Schizophrenia Research. 135(2016-03-01), pp. 15 - 22. https://doi.org/10.1016/j.schres.2011.12.003
Disambiguating ventral striatum fMRI-related BOLD signal during reward prediction in schizophrenia
Morris, Richard, Vercammen, Ans, Lenroot, Rhoshel, Moore, Loretta, Langton, Julia, Short, Brooke, Kulkarni, Jayashri, Curtis, Jackie, O'Donnell, Maryanne and Weickert, Cynthia. (2012). Disambiguating ventral striatum fMRI-related BOLD signal during reward prediction in schizophrenia. Molecular Psychiatry. 17(3), pp. 280 - 289. https://doi.org/10.1038/mp.2011.75
Disambiguating ventral striatum fMRI-related BOLD signal during reward prediction in schizophrenia
Morris, Richard, Vercammen, Ans, Lenroot, Rhoshel, Moore, Loretta, Langton, Julia, Short, Brooke, Kulkarni, Jayashri, Curtis, Jackie, O'Donnell, Maryanne and Weickert, Cynthia. (2012). Disambiguating ventral striatum fMRI-related BOLD signal during reward prediction in schizophrenia. Molecular Psychiatry. 17(3), pp. 280 - 289. https://doi.org/10.1038/mp.2011.75
Functional neuroimaging of hallucinations
Aleman, Andre and Vercammen, Ans. (2012). Functional neuroimaging of hallucinations. In In I. Sommer and J. D. Blom (Ed.). Hallucinations: Research and Practice pp. 267 - 281 Springer.
The "bottom-up" and "top-down" components of the hallucinatory phenomenon
Aleman, Andre and Vercammen, Ans. (2012). The "bottom-up" and "top-down" components of the hallucinatory phenomenon. In In R. Jardri, A. Cachia and P. Thomas (Ed.). The Neuroscience of Hallucinations pp. 107 - 121 Springer.
Reduced neural activity of the prefrontal cognitive control circuitry during response inhibition to negative words in people with schizophrenia
Vercammen, Ans, Morris, Richard, Green, Melissa, Lenroot, Rhoshel, Kulkarni, Jayashri, Carr, Vaughn, Weickert, Cynthia and Weickert, Thomas. (2012). Reduced neural activity of the prefrontal cognitive control circuitry during response inhibition to negative words in people with schizophrenia. Journal of Psychiatry and Neuroscience. 37(6), pp. 379 - 388. https://doi.org/10.1503/jpn.110088
Reduced neural activity of the prefrontal cognitive control circuitry during response inhibition to negative words in people with schizophrenia
Vercammen, Ans, Morris, Richard, Green, Melissa, Lenroot, Rhoshel, Kulkarni, Jayashri, Carr, Vaughn, Weickert, Cynthia and Weickert, Thomas. (2012). Reduced neural activity of the prefrontal cognitive control circuitry during response inhibition to negative words in people with schizophrenia. Journal of Psychiatry and Neuroscience. 37(6), pp. 379 - 388. https://doi.org/10.1503/jpn.110088
Abnormal connectivity between attentional, language and auditory networks in schizophrenia
Liemburg, Edith, Vercammen, Ans, Horst, Gert-Jan, Curcic-Blake, Branislava, Knegtering, Henderikus and Aleman, Andre. (2012). Abnormal connectivity between attentional, language and auditory networks in schizophrenia. Schizophrenia Research. 135(1-3), pp. 15 - 22. https://doi.org/10.1016/j.schres.2011.12.003
Subjective loudness and reality of auditory verbal hallucinations and activation of the inner speech processing network
Vercammen, Ans, Knegtering, Henderikus, Bruggeman, Richard and Aleman, Andre. (2011). Subjective loudness and reality of auditory verbal hallucinations and activation of the inner speech processing network. Schizophrenia Bulletin. 37(5), pp. 1009 - 1016. https://doi.org/10.1093/schbul/sbq007
Transcranial direct current stimulation influences probabilistic association learning in schizophrenia
Vercammen, Ans, Rushby, Jacqueline, Loo, Colleen, Short, Brooke, Weickert, Cynthia and Weickert, Thomas. (2011). Transcranial direct current stimulation influences probabilistic association learning in schizophrenia. Schizophrenia Research. 131(1-3), pp. 198 - 205. https://doi.org/10.1016/j.schres.2011.06.021
Frontal and parietal contributions to probabilistic association learning
Rushby, Jacqueline, Vercammen, Ans, Loo, Colleen, Short, Brooke, Weickert, Cynthia and Weickert, Thomas. (2011). Frontal and parietal contributions to probabilistic association learning. Cerebral Cortex. 21(8), pp. 1879 - 1888. https://doi.org/10.1093/cercor/bhq255
Semantic expectations can induce false perceptions in hallucination-prone individuals
Vercammen, Ans and Aleman, Andre. (2010). Semantic expectations can induce false perceptions in hallucination-prone individuals. Schizophrenia Bulletin. 36(1), pp. 151 - 156. https://doi.org/10.1093/schbul/sbn063
Functional connectivity of the temporo-parietal region in schizophrenia : effects of rTMS treatment of auditory hallucinations
Vercammen, Ans, Knegtering, Henderikus, Liemburg, Edith, den Boer, Hans and Aleman, Andre. (2010). Functional connectivity of the temporo-parietal region in schizophrenia : effects of rTMS treatment of auditory hallucinations. Journal of Psychiatric Research. 44(11), pp. 725 - 731. https://doi.org/10.1016/j.jpsychires.2009.12.011
Functional connectivity of the temporo-parietal region in schizophrenia : effects of rTMS treatment of auditory hallucinations
Vercammen, Ans, Knegtering, Henderikus, Liemburg, Edith, den Boer, Hans and Aleman, Andre. (2010). Functional connectivity of the temporo-parietal region in schizophrenia : effects of rTMS treatment of auditory hallucinations. Journal of Psychiatric Research. 44(11), pp. 725 - 731. https://doi.org/10.1016/j.jpsychires.2009.12.011
Auditory hallucinations in schizophrenia are associated with reduced functional connectivity of the temporo-parietal area
Vercammen, Ans, Knegtering, Henderikus, den Boer, Hans, Liemburg, Edith and Aleman, Andre. (2010). Auditory hallucinations in schizophrenia are associated with reduced functional connectivity of the temporo-parietal area. Biological Psychiatry. 67(10), pp. 912 - 918. https://doi.org/10.1016/j.biopsych.2009.11.017
Auditory hallucinations in schizophrenia are associated with reduced functional connectivity of the temporo-parietal area
Vercammen, Ans, Knegtering, Henderikus, den Boer, Hans, Liemburg, Edith and Aleman, Andre. (2010). Auditory hallucinations in schizophrenia are associated with reduced functional connectivity of the temporo-parietal area. Biological Psychiatry. 67(10), pp. 912 - 918. https://doi.org/10.1016/j.biopsych.2009.11.017
Semantic expectations can induce false perceptions in hallucination-prone individuals
Vercammen, Ans and Aleman, Andre. (2010). Semantic expectations can induce false perceptions in hallucination-prone individuals. Schizophrenia Bulletin. 36(1), pp. 151 - 156.
Effects of bilateral repetitive transcranial magnetic stimulation on treatment resistant auditory-verbal hallucinations in schizophrenia: a randomized controlled trial
Vercammen, Ans, Knegtering, Henderikus, Bruggeman, Richard, Westenbroek, Hanneke M., Jenner, Jack A., Slooff, Cees J., Wunderink, Lex and Aleman, Andre. (2009). Effects of bilateral repetitive transcranial magnetic stimulation on treatment resistant auditory-verbal hallucinations in schizophrenia: a randomized controlled trial. Schizophrenia Research. 114(1-3), pp. 172 - 179. https://doi.org/10.1016/j.schres.2009.07.013
Conceptual and physical object qualities contribute differently to motor affordances
Vingerhoets, Guy, Vandamme, Kim and Vercammen, Ans. (2009). Conceptual and physical object qualities contribute differently to motor affordances. Brain and Cognition. 69(3), pp. 481 - 489. https://doi.org/10.1016/j.bandc.2008.10.003
Hearing a voice in the noise: Auditory hallucinations and speech perception
Vercammen, Ans, de Haan, Edward H.F. and Aleman, Andre. (2008). Hearing a voice in the noise: Auditory hallucinations and speech perception. Psychological Medicine. 38(8), pp. 1177 - 1184. https://doi.org/10.1017/S0033291707002437