Multitissue assessment of in vivo postprandial intracellular lipid partitioning in rats using localized 1H-[13C] magnetic resonance spectroscopy
Journal article
Jonkers, Richard A. M., Geraedts, Tom R., Van Loon, Luc J.C., Nicolay, Klaas and Prompers, Jeanine J.. (2012). Multitissue assessment of in vivo postprandial intracellular lipid partitioning in rats using localized 1H-[13C] magnetic resonance spectroscopy. Magnetic Resonance in Medicine. 68(4), pp. 997 - 1006. https://doi.org/10.1002/mrm.23321
Authors | Jonkers, Richard A. M., Geraedts, Tom R., Van Loon, Luc J.C., Nicolay, Klaas and Prompers, Jeanine J. |
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Abstract | Excess accumulation of lipids in nonadipose tissues such asskeletal muscle and liver has been implicated in the develop-ment of obesity-related disorders, but the cause of this ec-topic lipid overload remains unknown. The aim of this studywas to determine in vivo postprandial lipid partitioning in ratskeletal muscle and liver, using localized1H-[13C] magneticresonance spectroscopy in combination with the oral admin-istration of13C-labeled lipids. Six rats were measured atbaseline and 5 and 24 h after administration of 400 mg[U-13C]-labeled algal lipids. Five hours after administration,fractional13C enrichments of the lipid pools in muscle andliver were increased 3.9-fold and 4.6-fold (P < 0.05), respec-tively, indicating that part of the ingested lipids had beentaken up by muscle and liver tissue. At 24 h, fractional13Cenrichments of muscle and liver lipids were decreased 1.6-fold and 2.2-fold (P < 0.05), respectively, compared with the 5h values. This can be interpreted as a depletion of13C-labeledlipids from the intracellular lipid pools as a consequence oflipid turnover. In conclusion, the novel application of1H-[13C]magnetic resonance spectroscopy in combination with theoral administration of13C-labeled lipids is applicable for thelongitudinal assessment of in vivo lipid partitioning betweenmultiple tissues. Magn Reson Med 68:997–1006, 2012.VC2011Wiley Periodicals, Inc.Key words: magnetic resonance spectroscopy; muscle lipids;liver lipids; carbon-13 |
Keywords | magnetic resonance spectroscopy; muscle lipids; liver lipids; carbon-13 |
Year | 2012 |
Journal | Magnetic Resonance in Medicine |
Journal citation | 68 (4), pp. 997 - 1006 |
Publisher | John Wiley & Sons, Inc. |
ISSN | 0740-3194 |
Digital Object Identifier (DOI) | https://doi.org/10.1002/mrm.23321 |
Scopus EID | 2-s2.0-84866734722 |
Page range | 997 - 1006 |
Research Group | Mary MacKillop Institute for Health Research |
Publisher's version | File Access Level Controlled |
Place of publication | United States |
https://acuresearchbank.acu.edu.au/item/86338/multitissue-assessment-of-in-vivo-postprandial-intracellular-lipid-partitioning-in-rats-using-localized-1h-13c-magnetic-resonance-spectroscopy
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