Associations of calf inter- and intra-muscular adipose tissue with cardiometabolic health and physical function in community-dwelling older adults

Journal article


Scott, D., Trbojevic, T., Skinner, E., Clark, R. A., Levinger, P., Haines, T. P., Sanders, K. M. and Ebeling, P. R.. (2015). Associations of calf inter- and intra-muscular adipose tissue with cardiometabolic health and physical function in community-dwelling older adults. The Journal of Musculoskeletal and Neuronal Interactions. 15(4), pp. 350 - 357.
AuthorsScott, D., Trbojevic, T., Skinner, E., Clark, R. A., Levinger, P., Haines, T. P., Sanders, K. M. and Ebeling, P. R.
Abstract

Objectives: To determine associations of inter- and intra-muscular adipose tissue (IMAT) with cardiometabolic health and physical function in older adults. Methods: 48 community-dwelling older adults aged ≥65 years (mean 71.6±4.8 years; 52% women) underwent whole-body dual-energy X-ray absorptiometry, to assess appendicular lean mass (ALM), and peripheral quantitative computed tomography (pQCT; 66% tibia), to assess calf IMAT cross-sectional area ([CSA]; cm2 ) and muscle density (mg/cm3 ; higher values indicate lower fat infiltration). Fasting glucose, lipids, triglycerides and C-reactive protein (CRP) were analysed. Physical function was assessed by postural sway (computerised posturography; N=41), and gait analysis (GAITRite Electronic Walkway; N=40). Results: Higher IMAT CSA and muscle density were associated with significantly higher (B=0.85 95%CI [0.34, 1.36]) and lower (-2.14 [-4.20, -0.08]) CRP and higher (0.93 [0.56, 1.30]) and lower postural sway (-3.12 [-4.74, -1.50]), respectively, after adjustment for age, sex and ALM/BMI. Higher IMAT CSA was associated with slower gait speed and cadence, and greater step time and step width (all P<0.03), while higher muscle density was associated with smaller step width (P<0.01) only. Conclusions: Older adults with higher calf IMAT have poorer balance, mobility and inflammatory status. Interventions aimed at improving physical function in older adults should incorporate strategies to reduce IMAT.

Keywordsintermuscular adipose tissue; sarcopenia; balance; mobility; ageing
Year2015
JournalThe Journal of Musculoskeletal and Neuronal Interactions
Journal citation15 (4), pp. 350 - 357
PublisherInternational Society of Musculoskeletal and Neuronal Interactions
ISSN1108-7161
Scopus EID2-s2.0-84949186696
Web address (URL)http://www.ismni.org/jmni/pdf/62/V15I4_07SCOTT.pdf
Page range350 - 357
Research GroupSports Performance, Recovery, Injury and New Technologies (SPRINT) Research Centre
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File Access Level
Controlled
Place of publicationGreece
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