Resting heart rate predicts incident myocardial infarction, atrial fibrillation, ischaemic stroke and death in the general population: The Tromsø Study
Journal article
Sharashova, Ekaterina, Wilsgaard, Tom, Mathiesen, Ellisiv Bøgeberg, Løchen, Maja-Lisa, Njølstad, Inger and Brenn, Tormod. (2016). Resting heart rate predicts incident myocardial infarction, atrial fibrillation, ischaemic stroke and death in the general population: The Tromsø Study. Journal of Epidemiology and Community Health. 70(9), pp. 902 - 909. https://doi.org/10.1136/jech-2015-206663
Authors | Sharashova, Ekaterina, Wilsgaard, Tom, Mathiesen, Ellisiv Bøgeberg, Løchen, Maja-Lisa, Njølstad, Inger and Brenn, Tormod |
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Abstract | Background: Elevated resting heart rate (RHR) increases risk of death overall, but a comprehensive picture of the associations between RHR, cardiovascular morbidity and mortality events has not yet been presented. We aimed to investigate the effect of RHR on the risk of 5 cardiovascular events: incident myocardial infarction (MI), incident atrial fibrillation (AF), incident ischaemic stroke, total death and cardiovascular death in a general population from Norway. Methods: We followed 24 489 men and women from the Tromsø Study 1994–1995, a population-based cohort study, for 18 years, and analysed the association between RHR and the investigated cardiovascular events. Sex-specific Cox regression with time-dependent covariates was applied with the best-fitting fractional polynomials of RHR. Results: Among men, an independent positive relationship was observed for MI and AF (adjusted HR for AF per 20 bpm increase=1.14; 95% CI 1.02 to 1.27). In women, the corresponding HR for MI was 1.23 (1.09 to 1.40). A J-shaped association was observed for ischaemic stroke in women when compared with a RHR of 70 bpm (HR for 50 bpm=1.31; 0.90 to 1.90; HR for 100 bpm=1.32; 1.04 to 1.69). Total and cardiovascular death showed a strong positive association with RHR in men. In women, the pattern for total death was similar. Conclusions: RHR is an independent risk factor for several cardiovascular events. A novel finding is the positive association between RHR and AF in men and the sex difference in association with ischaemic stroke. |
Year | 2016 |
Journal | Journal of Epidemiology and Community Health |
Journal citation | 70 (9), pp. 902 - 909 |
Publisher | BMJ Publishing Group |
ISSN | 0143-005X |
Digital Object Identifier (DOI) | https://doi.org/10.1136/jech-2015-206663 |
Scopus EID | 2-s2.0-84960890025 |
Page range | 902 - 909 |
Research Group | Mary MacKillop Institute for Health Research |
Publisher's version | File Access Level Controlled |
Place of publication | United Kingdom |
https://acuresearchbank.acu.edu.au/item/8643y/resting-heart-rate-predicts-incident-myocardial-infarction-atrial-fibrillation-ischaemic-stroke-and-death-in-the-general-population-the-troms-study
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