Testosterone but not estradiol level is positively related to muscle strength and physical performance independent of muscle mass: a cross-sectional study in 1489 older men
Journal article
Auyeung, Tung Wai, Shun Wah Lee, Jenny, Kwok, Timothy, Leung, Jason, Ohlsson, Claes, Vandenput, Liesbeth, Leung, Ping Ching and Woo, Jean. (2011). Testosterone but not estradiol level is positively related to muscle strength and physical performance independent of muscle mass: a cross-sectional study in 1489 older men. European Journal of Endocrinology. 164(5), pp. 811 - 817. https://doi.org/10.1530/EJE-10-0952
Authors | Auyeung, Tung Wai, Shun Wah Lee, Jenny, Kwok, Timothy, Leung, Jason, Ohlsson, Claes, Vandenput, Liesbeth, Leung, Ping Ching and Woo, Jean |
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Abstract | Objective: To examine the relationship between different measures of testosterone and estradiol (E2), muscle mass, muscle strength, and physical performance; and to test whether the association of sex hormone level with muscle strength and physical performance was independent of muscle mass. Design and methods: A cross-sectional survey on 1489 community-dwelling men older than 64 years of age. Serum levels of testosterone and E2 were measured by mass spectrometry, and sex hormone-binding globulin (SHBG) levels were measured by immunoradioassay. Muscle mass was examined by dual-energy X-ray absorptiometry and physical performance was assessed by hand-grip strength, gait speed, step length and chair-stand test. Results: Appendicular skeletal mass (ASM) was positively associated with total testosterone (TT; P<0.001), free testosterone (FT; P<0.001), and total E2 (P<0.001) but not with free E2 (P=0.102). After adjustment for age, serum SHBG and relative ASM, both TT and FT were significantly associated with grip strength, narrow-walk speed and the composite neuromuscular score. Higher total E2, but not free E2 was associated with lower grip strength (P<0.05) after adjustment for age, FT, SHBG and relative ASM. Conclusions: Testosterone level was related to both muscle mass, strength and physical performance. Total E2 level, though related to muscle mass positively, affected muscle strength adversely in older men. |
Year | 2011 |
Journal | European Journal of Endocrinology |
Journal citation | 164 (5), pp. 811 - 817 |
Publisher | BioScientifica Ltd. |
ISSN | 0804-4643 |
Digital Object Identifier (DOI) | https://doi.org/10.1530/EJE-10-0952 |
Scopus EID | 2-s2.0-79955536922 |
Page range | 811 - 817 |
Research Group | Mary MacKillop Institute for Health Research |
Publisher's version | File Access Level Controlled |
Place of publication | United Kingdom |
https://acuresearchbank.acu.edu.au/item/86526/testosterone-but-not-estradiol-level-is-positively-related-to-muscle-strength-and-physical-performance-independent-of-muscle-mass-a-cross-sectional-study-in-1489-older-men
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