Mild cognitive impairment impacts health outcomes of patients with atrial fibrillation undergoing a disease management intervention

Journal article


Ball, Jocasta, Loechen, Maja-Lisa, Carrington, Melinda, Wiley, Joshua and Stewart, S.. (2018) Mild cognitive impairment impacts health outcomes of patients with atrial fibrillation undergoing a disease management intervention. Open Heart (online). 5(1), pp. 1 - 11. https://doi.org/10.1136/openhrt-2017-000755
AuthorsBall, Jocasta, Loechen, Maja-Lisa, Carrington, Melinda, Wiley, Joshua and Stewart, S.
Abstract

Objective: Mild cognitive impairment (MCI) is prevalent in atrial fibrillation (AF) and has the potential to contribute to poor outcomes. We investigated the influence of MCI on survival and rehospitalisation in patients with chronic forms of AF undergoing a home-based, AF-specific disease management intervention (home-based intervention (HBI)) or standard management(SM). Methods The Montreal Cognitive Assessment tool was administered at baseline (a score of < 26/30 indicated MCI) in patients with AF randomised to HBI versus SM. Post hoc analyses of mortality and rehospitalisations during a minimum 24-month follow-up were conducted in the overall cohort and in each study group separately. Results Of 260 patients (mean age 72±11, 47% female), 65% demonstrated MCI on screening (34% in SM; 31% in HBI). Overall, the number of days spent alive and outof- hospital during follow-up (P=0.012) and all-cause rehospitalisation were influenced by MCI during follow-up (OR 3.16 (95% CI 1.46 to 6.84)) but MCI did not influence any outcomes in the SM group. However, survival was negatively influenced by MCI in the HBI group (P=0.036); those with MCI in this group were 5.6 times more likely to die during follow-up (OR 5.57 (95% CI 1.10 to 28.1)). Those with MCI in the HBI group also spent less days alive and out-of-hospital than those with no MCI (P=0.022). MCI was also identified as a significant independent correlate of shortest duration of event-free survival (OR 3.48 (95% CI 1.06 to 11.4)), allcause rehospitalisation (OR 3.30 (95% CI 1.25 to 8.69)) and cardiovascular disease (CVD)-related rehospitalisation (OR 2.35 (95% CI 1.12 to 4.91)) in this group. Conclusions The effectiveness of home-based, disease management for patients with chronic forms of AF is negatively affected by comorbid MCI. The benefit of adjunctive support for patients with MCI on CVD-related health outcomes requires further investigation.

Keywordsadult; aged; atrial fibrillation; cardiovascular disease; chronic disease; clinical effectiveness; clinical outcome; cohort analysis; comorbidity; controlled study; correlation analysis; disease management; event free survival; female; follow up; home care; hospital readmission; human; major clinical study; male; mild cognitive impairment; Montreal cognitive assessment; mortality; post hoc analysis; priority journal; randomized controlled trial; screening; smoking; survival; very elderly
Year2018
JournalOpen Heart (online)
Journal citation5 (1), pp. 1 - 11
PublisherB M J Group
ISSN2053-3624
Digital Object Identifier (DOI)https://doi.org/10.1136/openhrt-2017-000755
Scopus EID2-s2.0-85041532869
Open accessOpen access
Page range1 - 11
Research GroupMary MacKillop Institute for Health Research
Publisher's version
Place of publicationUnited Kingdom
EditorsP. Meier
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Stewart, Simon, Chan, Yih-Kai, Wong, Chiew, Jennings, Garry, Scuffham, Paul, Esterman, Adrian and Carrington, Melinda. (2015) Impact of a nurse-led home and clinic-based secondary prevention programme to prevent cardiac dysfunction in high risk individuals : The Nurse-led Intervention for Less Chronic Heart Failure (NIL-CHF) randomized controlled study. European Journal of Heart Failure. 17, pp. 620 - 630. https://doi.org/10.1002/ejhf.272
A cluster-randomized controlled trial to reduce sedentary behavior and promote physical activity and health of 8-9 year olds: The Transform-Us! Study
Salmon, Vasiliki, Frost, Steven, Newton, Phillip, Macdonald, Peter, Stewart, Simon, Carrington, Melinda, Chan, Yih and Davidson, Patricia. (2015) A cluster-randomized controlled trial to reduce sedentary behavior and promote physical activity and health of 8-9 year olds: The Transform-Us! Study. BMC Public Health. 24(11), pp. 1068 - 1073. https://doi.org/10.1186/1471-2458-11-759
Cost-effectiveness of a home based intervention for secondary prevention of readmission with chronic heart disease
Byrnes, Joshua, Carrington, Melinda, Chan, Yih-Kai, Pollicino, Christine, Dubrowin, Natalie and Stewart, Simon. (2015) Cost-effectiveness of a home based intervention for secondary prevention of readmission with chronic heart disease. PLoS ONE. 10(12), pp. 1 - 13. https://doi.org/10.1371/journal.pone.0144545
Systematic review of model-based analyses reporting the cost-effectiveness and cost-utility of cardiovascular disease management programs
Maru, Shoko, Byrnes, Joshua, Whitty, Jennifer, Carrington, Melinda, Stewart, Simon and Scuffham, Paul. (2015) Systematic review of model-based analyses reporting the cost-effectiveness and cost-utility of cardiovascular disease management programs. European Journal of Cardiovascular Nursing. 14(1), pp. 26 - 33. https://doi.org/10.1177/1474515114536093
Cost-effectiveness of home versus clinic-based management of chronic heart failure: Extended follow-up of pragmatic, multicentre randomized trial cohort - The WHICH? Study
Maru, Shoko, Byrnes, Joshua, Carrington, Melinda J., Chan, Yih-Kai, Thompson, David R., Stewart, Simon and Scuffham, Paul A.. (2015) Cost-effectiveness of home versus clinic-based management of chronic heart failure: Extended follow-up of pragmatic, multicentre randomized trial cohort - The WHICH? Study. International Journal of Cardiology. 201, pp. 368 - 375. https://doi.org/10.1016/j.ijcard.2015.08.066
Standard versus atrial fibrillation-specific management strategy (SAFETY) to reduce recurrent admission and prolong survival : Pragmatic, multicentre, randomised controlled trial
Stewart, Simon, Ball, Jocasta, Horowitz, John D., Marwick, Thomas H., Mahadevan, Gnanadevan, Wong, Chiew, Abhayaratna, Walter P., Chan, Yih K., Esterman, Adrian, Thompson, David R., Scuffham, Paul and Carrington, Melinda J.. (2015) Standard versus atrial fibrillation-specific management strategy (SAFETY) to reduce recurrent admission and prolong survival : Pragmatic, multicentre, randomised controlled trial. The Lancet. 385(9970), pp. 775 - 784. https://doi.org/10.1016/S0140-6736(14)61992-9
Cardiometabolic risk and disease in Indigenous Australians: The heart of the heart study
Brown, Alex, Carrington, Melinda Jane, McGrady, Michele, Lee, Geraldine, Zeitz, Christopher, Krum, Henry, Rowley, Kevin and Stewart, Simon. (2014) Cardiometabolic risk and disease in Indigenous Australians: The heart of the heart study. International Journal of Cardiology. 171(3), pp. 377 - 383. https://doi.org/10.1016/j.ijcard.2013.12.026
How stress gets under the skin o como el estres psicologico se introduce bajo la piel
Ortiz, Manuel S., Wiley, Joshua F. and Chiang, Jessica J.. (2014) How stress gets under the skin o como el estres psicologico se introduce bajo la piel. Revista Medica de Chile. 142(6), pp. 767 - 774. https://doi.org/10.4067/S0034-98872014000600011
Predictors of mean arterial pressure morning rate of rise and power function in subjects undergoing ambulatory blood pressure recording
Head, Geoffrey, Andrianopoulos, Nick, McGrath, Barry, Martin, Catherine, Carrington, Melinda, Lukoshkova, Elena, Davern, Pamela, Jennings, Garry and Reid, Christopher. (2014) Predictors of mean arterial pressure morning rate of rise and power function in subjects undergoing ambulatory blood pressure recording. PLoS ONE. 9(3), pp. 1 - 10. https://doi.org/10.1371/journal.pone.0093186
Visual network asymmetry and default mode network function in ADHD : An fMRI study
Hale, T., Kane, Andrea, Kaminsky, Olivia, Tung, Kelly, Wiley, Joshua, McGough, James, Loo, Sandra and Kaplan, Jonas. (2014) Visual network asymmetry and default mode network function in ADHD : An fMRI study. Frontiers in Psychiatry (online). 5(81), pp. 1 - 20. https://doi.org/10.3389/fpsyt.2014.00081
Visual network asymmetry and default mode network function in ADHD : An fMRI study
Hale, T. Sigi, Kane, Andrea M., Kaminsky, Olivia, Tung, Kelly L., Wiley, Joshua F., McGough, James J., Loo, Sandra K. and Kaplan, Jonas T.. (2014) Visual network asymmetry and default mode network function in ADHD : An fMRI study. Frontiers in Psychiatry. 5(81), pp. 1 - 20. https://doi.org/10.3389/fpsyt.2014.00081
Changes in self-efficacy and outcome expectancy as predictors of anxiety outcomes from the CALM study
Brown, Lily A., Wiley, Joshua F., Wolitzky-Taylor, Kate, Roy-Byrne, Peter, Sherbourne, Cathy, Stein, Murray B., Sullivan, Greer, Rose, Raphael D., Bystritsky, Alexander and Craske, Michelle G.. (2014) Changes in self-efficacy and outcome expectancy as predictors of anxiety outcomes from the CALM study. Depression and Anxiety. 31(8), pp. 678 - 689. https://doi.org/10.1002/da.22256
Cardiovascular disease prevention via a nurse-facilitated intervention clinic in a regional setting : The Protecting Healthy Hearts Program
Carrington, Melinda and Stewart, Simon. (2014) Cardiovascular disease prevention via a nurse-facilitated intervention clinic in a regional setting : The Protecting Healthy Hearts Program. European Journal of Cardiovascular Nursing. 14(4), pp. 1 - 10. https://doi.org/10.1177/1474515114537022
The Child Anxiety Impact Scale : Examining parent-and child-reported impairment in child anxiety disorders
Langley, Audra, Falk, Avital, Peris, Tara, Wiley, Joshua, Kendall, Philip, Ginsburg, Golda, Birmaher, Boris, March, John, Albano, Ann Marie and Piacentini, John. (2014) The Child Anxiety Impact Scale : Examining parent-and child-reported impairment in child anxiety disorders. Journal of Clinical Child and Adolescent Psychology. 43(4), pp. 579 - 591. https://doi.org/10.1080/15374416.2013.817311
Prolonged impact of home versus clinic-based management of chronic heart failure: Extended follow-up of a pragmatic, multicentre randomized trial cohort
Stewart, Simon, Carrington, Melinda, Horowitz, John, Marwick, Thomas, Newton, Phillip, Davidson, Patricia, Macdonald, Peter, Thompson, David R., Chan, Yih Kai and Krum, Henry. (2014) Prolonged impact of home versus clinic-based management of chronic heart failure: Extended follow-up of a pragmatic, multicentre randomized trial cohort. International Journal of Cardiology. 174(3), pp. 600 - 610. https://doi.org/10.1016/j.ijcard.2014.04.164
Cardiometabolic risk and disease in Indigenous Australians : The heart of the heart study
Brown, Alex, Carrington, Melinda, McGrady, Michele, Lee, Geraldine, Zeitz, Christopher, Krum, Henry, Rowley, Kevin and Stewart, Simon. (2014) Cardiometabolic risk and disease in Indigenous Australians : The heart of the heart study. International Journal of Cardiology. 171, pp. 377 - 383. https://doi.org/10.1016/j.ijcard.2013.12.026
Post-discharge electrocardiogram Holter monitoring in recently hospitalized individuals with chronic atrial fibrillation to enhance therapeutic monitoring and identify potentially predictive phenotypes
Ball, Jocasta Clare, Carrington, Melinda Jane, Thompson, David, Horowitz, John and Stewart, Simon. (2014) Post-discharge electrocardiogram Holter monitoring in recently hospitalized individuals with chronic atrial fibrillation to enhance therapeutic monitoring and identify potentially predictive phenotypes. European Journal of Cardiovascular Nursing. https://doi.org/10.1177/1474515114547650
The Child Anxiety Impact Scale: Examining Parent- and Child-Reported Impairment in Child Anxiety Disorders
Langley, Audra K., Falk, Avital, Peris, Tara, Wiley, Joshua F., Kendall, Philip C., Ginsburg, Golda, Birmaher, Boris, March, John, Albano, Ann Marie and Piacentini, John. (2014) The Child Anxiety Impact Scale: Examining Parent- and Child-Reported Impairment in Child Anxiety Disorders. Journal of Clinical Child and Adolescent Psychology. 43(4), pp. 579 - 591. https://doi.org/10.1080/15374416.2013.817311
Lower levels of high-density lipoprotein cholesterol in urban Africans presenting with communicable versus non-communicable forms of heart disease : The 'Heart of Soweto' hospital registry study
Lyons, Jasmine, Sliwa, Karen, Carrington, Melinda, Raal, Frederick, Pretorius, Sandra, Thienemann, Friedrich and Stewart, Simon. (2014) Lower levels of high-density lipoprotein cholesterol in urban Africans presenting with communicable versus non-communicable forms of heart disease : The 'Heart of Soweto' hospital registry study. BMJ Open. 4(7), pp. 1 - 8. https://doi.org/10.1136/bmjopen-2014-005069
Perceived social support mediates anxiety and depressive symptom changes following primary care intervention
Dour, Halina J., Wiley, Joshua F., Roy-Byrne, Peter, Stein, Murray B., Sullivan, Greer, Sherbourne, Cathy D., Bystritsky, Alexander, Rose, Raphael D. and Craske, Michelle G.. (2014) Perceived social support mediates anxiety and depressive symptom changes following primary care intervention. Depression and Anxiety. 31(5), pp. 436 - 442. https://doi.org/10.1002/da.22216
Long-term tolerance and efficacy of adjunctive exenatide therapy on glycaemic control and bodyweight in type 2 diabetes: A retrospective study from a specialist diabetes outpatient clinic
Carrington, Melinda Jane, Chan, Yih, Stewart, Simon, Sjourke, B., Brazilek, R. and Cohen, N.. (2014) Long-term tolerance and efficacy of adjunctive exenatide therapy on glycaemic control and bodyweight in type 2 diabetes: A retrospective study from a specialist diabetes outpatient clinic. Internal Medicine Journal. 44(4), pp. 345 - 353. https://doi.org/10.1111/imj.12377
Redefining the ECG in urban South Africans : Electrocardiographic findings in heart disease-free Africans
Sliwa, Karen, Lee, Geraldine, Carrington, Melinda, Obel, Pro and Stewart, Simon. (2013) Redefining the ECG in urban South Africans : Electrocardiographic findings in heart disease-free Africans. International Journal of Cardiology. https://doi.org/10.1016/j.ijcard.2012.06.005
The frequency and cost of treatment perceived to be futile in critical care
Huynh, Thanh, Kleerup, Eric, Wiley, Joshua F., Savitsky, Terrance, Guse, Diana, Garber, Bryan and Wenger, Neil. (2013) The frequency and cost of treatment perceived to be futile in critical care. JAMA Internal Medicine. 173(20), pp. 1887 - 1894. https://doi.org/10.1001/jamainternmed.2013.10261
Time from symptoms to definitive diagnosis of idiopathic pulmnary arterial hypertension : The delay study
Strange, Geoff, Kermeen, Fiona, Gabbay, Eli, Williams, Trevor, Carrington, Melinda, Stewart, Simon and Keogh, Anne. (2013) Time from symptoms to definitive diagnosis of idiopathic pulmnary arterial hypertension : The delay study. Pulmonary Circulation. https://doi.org/10.4103/2045-8932.109919
Women Versus Men with Chronic Atrial Fibrillation: insights from the Standard Versus Atrial Fibrillation spEcific managemenT studY (SAFETY)
Ball, Jocasta, Carrington, Melinda, Wood, Kathryn and Stewart, Simon. (2013) Women Versus Men with Chronic Atrial Fibrillation: insights from the Standard Versus Atrial Fibrillation spEcific managemenT studY (SAFETY). PLoS ONE. 8(5), pp. 1 - 9. https://doi.org/10.1371/journal.pone.0065795
Determinants of achieving early blood pressure control with monotherapy in a primary care setting
Stewart, Simon, Carrington, Melinda, Swemmer, Carla, Kurstjens, Nicol, Brown, Alex, Burrell, Louise, Nelson, Mark, Stocks, Nigel and Jennings, Garry. (2013) Determinants of achieving early blood pressure control with monotherapy in a primary care setting. Journal of Clinical Hypertension. https://doi.org/10.1111/jch.12164
Profile and burden of an evolving epidemic in the 21st century
Ball, Jocasta, Carrington, Melinda, McMurray, J and Stewart, Simon. (2013) Profile and burden of an evolving epidemic in the 21st century. International Journal of Cardiology. https://doi.org/10.1016/j.ijcard.2012.12.093
A multicenter, randomized trial of a nurse-led, home-based intervention for optimal secondary cardiac prevention suggests some benefits for men but not for women : the Young at Heart Study
Carrington, Melinda, Chan, Yih Kai, Calderone, Alicia, Scuffham, Paul, Esterman, Adrian and Goldstein, Stan. (2013) A multicenter, randomized trial of a nurse-led, home-based intervention for optimal secondary cardiac prevention suggests some benefits for men but not for women : the Young at Heart Study. Circulation: Cardiovascular Quality and Outcomes. https://doi.org/10.1161/CIRCOUTCOMES.111.000006
Navigating the fine line between benefit and risk in chronic atrial fibrillation : Rationale and Design of the standard versus Atrial fibrillation specific management study (SAFETY)
Carrington, Melinda, Ball, Jocasta, Horowitz, John, Marwick, Thomas, Mahadevan, Gnanadevan, Wong, Chiew, Abhayaratna, Walter, Haluska, Brian, Thompson, David and Scuffham, Paul. (2013) Navigating the fine line between benefit and risk in chronic atrial fibrillation : Rationale and Design of the standard versus Atrial fibrillation specific management study (SAFETY). International Journal of Cardiology. https://doi.org/10.1016/j.ijcard.2011.10.065
Patient preferences and willingness-to-pay for a home or clinic based program of chronic heart failure management: findings from the Which? Trial
Stewart, Simon, Whitty, Jennifer, Carrington, Melinda, Calderone, Alicia, Marwick, Thomas, Horowitz, John, Krum, Henry, Davidson, Patricia, Macdonald, Peter and Reid, Christopher. (2013) Patient preferences and willingness-to-pay for a home or clinic based program of chronic heart failure management: findings from the Which? Trial. PLoS ONE. 8(3), pp. 1 - 8. https://doi.org/10.1371/journal.pone.0058347
Determinants of achieving early blood pressure control with monotherapy in a primary care setting
Stewart, Simon, Carrington, Melinda, Swemmer, Carla, Kurstjens, Nicol, Brown, Alex, Burrell, Louise, Nelson, Mark, Stocks, Nigel and Jennings, Garry. (2013) Determinants of achieving early blood pressure control with monotherapy in a primary care setting. Journal of Clinical Hypertension. https://doi.org/10.1111/jch.12164
Atrial fibrillation : Profile and burden of an evolving epidemic in the 21st century
Ball, Jocasta, Carrington, Melinda, McMurray, J and Stewart, Simon. (2013) Atrial fibrillation : Profile and burden of an evolving epidemic in the 21st century. International Journal of Cardiology. https://doi.org/10.1016/j.ijcard.2012.12.093
Reply: Diagnosing vascular mild cognitive impairment with atrial fibrillation remains a challenge
Ball, Jocasta. (2013) Reply: Diagnosing vascular mild cognitive impairment with atrial fibrillation remains a challenge. Heart. 99(11), pp. 819 - 820. https://doi.org/10.1136/heartjnl-2013-303965
Navigating the fine line between benefit and risk in chronic atrial fibrillation : Rationale and design of the Standard versus Atrial Fibrillation spEcific managemenT studY (SAFETY)
Carrington, Melinda, Ball, Jocasta, Horowitz, John, Marwick, Thomas, Mahadevan, Gnanadevan, Wong, Chiew, Abhayaratna, Walter, Haluska, Brian, Thompson, David and Scuffham, Paul. (2013) Navigating the fine line between benefit and risk in chronic atrial fibrillation : Rationale and design of the Standard versus Atrial Fibrillation spEcific managemenT studY (SAFETY). International Journal of Cardiology. https://doi.org/10.1016/j.ijcard.2011.10.065
Navigating the fine line between benefit and risk in chronic atrial fibrillation : Rationale and design of the Standard versus Atrial Fibrillation spEcific managemenT studY (SAFETY)
Carrington, Melinda, Ball, Jocasta, Horowitz, John, Marwick, Thomas, Mahadevan, Gnanadevan, Wong, Chiew, Abhayaratna, Walter, Haluska, Brian, Thompson, David and Scuffham, Paul. (2013) Navigating the fine line between benefit and risk in chronic atrial fibrillation : Rationale and design of the Standard versus Atrial Fibrillation spEcific managemenT studY (SAFETY). International Journal of Cardiology. https://doi.org/10.1016/j.ijcard.2011.10.065
Mild cognitive impairment in high-risk patients with chronic atrial fibrillation : A forgotten component of clinical management?
Ball, Jocasta, Carrington, Melinda and Stewart, Simon. (2013) Mild cognitive impairment in high-risk patients with chronic atrial fibrillation : A forgotten component of clinical management? Heart. https://doi.org/10.1136/heartjnl-2012-303182
The Green, Amber, Red Delineation of Risk and Need (GARDiAN) management system : A pragmatic approach to optimizing heart health from primary prevention to chronic disease management
Carrington, Melinda J., Kok, Simon and Jansen, Kiki. (2013) The Green, Amber, Red Delineation of Risk and Need (GARDiAN) management system : A pragmatic approach to optimizing heart health from primary prevention to chronic disease management. European Journal of Cardiovascular Nursing. https://doi.org/10.1177/1474515112451702
Quality of life and cancer-related needs in patients with choroidal melanoma
Wiley, Joshua F., Laird, Kelsey, Beran, Tammy, McCannel, Tara and Stanton, Annette. (2013) Quality of life and cancer-related needs in patients with choroidal melanoma. British Journal of Ophthalmology. 97(11), pp. 1471 - 1474. https://doi.org/10.1136/bjophthalmol-2013-303635
Atrial fibrillation : Profile and burden of an evolving epidemic in the 21st century
Ball, Jocasta, Carrington, Melinda, McMurray, J and Stewart, Simon. (2013) Atrial fibrillation : Profile and burden of an evolving epidemic in the 21st century. International Journal of Cardiology. https://doi.org/10.1016/j.ijcard.2012.12.093
Mild cognitive impairment in high-risk patients with chronic atrial fibrillation : A forgotten component of clinical management?
Ball, Jocasta, Carrington, Melinda and Stewart, Simon. (2013) Mild cognitive impairment in high-risk patients with chronic atrial fibrillation : A forgotten component of clinical management? Heart. https://doi.org/10.1136/heartjnl-2012-303182
Pressure points in primary care : Blood pressure and management of hypertension in 532 050 patients from 2005 to 2010
Carrington, Melinda, Jennings, Garry and Stewart, Simon. (2013) Pressure points in primary care : Blood pressure and management of hypertension in 532 050 patients from 2005 to 2010. Journal of Hypertension. https://doi.org/10.1097/HJH.0b013e3283606bc7
Quality of life and cancer-related needs in patients with choroidal melanoma
Wiley, Joshua, Laird, Kelsey, Beran, Tammy, McCannel, Tara and Stanton, Annette. (2013) Quality of life and cancer-related needs in patients with choroidal melanoma. British Journal of Ophthalmology. 97(11), pp. 1471 - 1474. https://doi.org/10.1136/bjophthalmol-2013-303635
Redefining the ECG in urban South Africans : Electrocardiographic findings in heart disease-free Africans
Sliwa, Karen, Lee, Geraldine, Carrington, Melinda, Obel, Pro, Okreglicki, Andrzeq and Stewart, Simon. (2013) Redefining the ECG in urban South Africans : Electrocardiographic findings in heart disease-free Africans. International Journal of Cardiology. https://doi.org/10.1016/j.ijcard.2012.06.005
Women versus men with chronic atrial fibrillation: insights from the Standard Versus Atrial Fibrillation spEcific managemenT studY (SAFETY)
Ball, Jocasta, Carrington, Melinda, Wood, Kathryn and Stewart, Simon. (2013) Women versus men with chronic atrial fibrillation: insights from the Standard Versus Atrial Fibrillation spEcific managemenT studY (SAFETY). PLoS ONE. 8(5), pp. 1 - 9. https://doi.org/10.1371/journal.pone.0065795
Patient preferences and willingness-to-pay for a home or clinic based program of chronic heart failure management: findings from the Which? Trial
Stewart, Simon, Whitty, Jennifer, Carrington, Melinda, Calderone, Alicia, Marwick, Thomas, Horowitz, John, Krum, Henry, Davidson, Patricia, Macdonald, Peter and Reid, Christopher. (2013) Patient preferences and willingness-to-pay for a home or clinic based program of chronic heart failure management: findings from the Which? Trial. PLoS ONE. 8(3), pp. 1 - 8. https://doi.org/10.1371/journal.pone.0058347
The frequency and cost of treatment perceived to be futile in critical care
Huynh, Thanh, Kleerup, Eric, Wiley, Joshua, Savitsky, Terrance, Guse, Diana, Garber, Bryan and Wenger, Neil. (2013) The frequency and cost of treatment perceived to be futile in critical care. JAMA Internal Medicine (print). 173(20), pp. 1887 - 1894. https://doi.org/10.1001/jamainternmed.2013.10261
Different lipid profiles according to ethnicity in the Heart of Soweto study cohort of de novo presentations of heart disease
Sliwa, Karen, Lyons, Jasmine, Carrington, Melinda, Lecour, Sandrin, Marais, A and Raal, Frederick. (2012) Different lipid profiles according to ethnicity in the Heart of Soweto study cohort of de novo presentations of heart disease. Cardiovascular Journal of Africa. 23(7), pp. 389 - 395. https://doi.org/10.5830/CVJA-2012-036
Impact of home versus clinic-based management of chronic heart failure : The WHiCH? (Which heart failure intervention is most cost-effective & consumer friendly in reducing hospital care) multicenter, randomized trial
Stewart, Simon, Carrington, Melinda, Marwick, Thomas, Davidson, Patricia, Macdonald, Peter, Horowitz, John, Krum, Henry, Newton, Phillip, Reid, Christopher and Chan, Yih Kai. (2012) Impact of home versus clinic-based management of chronic heart failure : The WHiCH? (Which heart failure intervention is most cost-effective & consumer friendly in reducing hospital care) multicenter, randomized trial. Journal of the American College of Cardiology. 60(14), pp. 1239 - 1248. https://doi.org/10.1016/j.jacc.2012.06.025
Patient preferences for the delivery of disease management in chronic heart failure : A qualitative study
Whitty, Jennifer, Carrington, Melinda, Stewart, Simon, Holliday, Julie, Marwick, Thomas and Scuffham, Paul. (2012) Patient preferences for the delivery of disease management in chronic heart failure : A qualitative study. The Journal of Cardiovascular Nursing. 27(3), pp. 201 - 207. https://doi.org/10.1097/JCN.0b013e31821abf22
Contribution of the human immunodeficiency virus/acquired immunodeficiency syndrome epidemic to de novo presentations of heart disease in the Heart of Soweto Study cohort
Sliwa, Karen, Carrington, Melinda, Becker, Anthony, Thienemann, Friedrich and Ntsekhe, Mpiko. (2012) Contribution of the human immunodeficiency virus/acquired immunodeficiency syndrome epidemic to de novo presentations of heart disease in the Heart of Soweto Study cohort. European Heart Journal. 33(7), pp. 866 - 874. https://doi.org/10.1093/eurheartj/ehr398
The 12-lead ECG in peripartum cardiomyopathy
Tibazarwa, Kemi, Lee, Geraldine, Mayosi, Bongani, Carrington, Melinda, Stewart, Simon and Sliwa, Karen. (2012) The 12-lead ECG in peripartum cardiomyopathy. Cardiovascular Journal of Africa. 23(6), pp. 322 - 329. https://doi.org/10.5830/CVJA-2012-006
Effect of intensive structured care on individual blood pressure targets in primary care : Multicentre randomised controlled trial
Stewart, Simon, Carrington, Melinda, Swemmer, Carla, Anderson, Craig, Kurstjens, Nicol, Amerena, John, Brown, Alex, Burrell, Louise, de Looze, Ferdinandus and Harris, Mark. (2012) Effect of intensive structured care on individual blood pressure targets in primary care : Multicentre randomised controlled trial. British Medical Journal. 345(7884), pp. 1 - 16. https://doi.org/10.1136/bmj.e7156
Elevated risk factors but low burden of heart disease in urban African primary care patients : A fundamental role for primary prevention
Stewart, Simon, Carrington, Melinda, Pretorius, Sandra, Ogah, Okechukwu, Blauwet, Lori, Antras-Ferry, Jocelyn and Sliwa, Karen. (2012) Elevated risk factors but low burden of heart disease in urban African primary care patients : A fundamental role for primary prevention. International Journal of Cardiology. 158(2), pp. 205 - 210. https://doi.org/10.1016/j.ijcard.2011.01.022
Assessing cardiovascular risk in regional areas: The Healthy Hearts - Beyond City Limits program
Carrington, Melinda, Jennings, Garry, Clark, Robyn and Stewart, Simon. (2012) Assessing cardiovascular risk in regional areas: The Healthy Hearts - Beyond City Limits program. BMC Health Services Research. 12(1), pp. 1 - 10. https://doi.org/10.1186/1472-6963-12-296
Impact of Home Versus Clinic-Based Management of Chronic Heart Failure : The WHICH? (Which Heart Failure Intervention Is Most Cost-Effective & Consumer Friendly in Reducing Hospital Care) Multicenter, Randomized Trial
Stewart, Simon, Carrington, Melinda, Marwick, Thomas, Davidson, Patricia, Macdonald, Peter, Horowitz, John, Krum, Henry, Newton, Phillip, Reid, Christopher, Chan, Yih and Scuffham, Paul. (2012) Impact of Home Versus Clinic-Based Management of Chronic Heart Failure : The WHICH? (Which Heart Failure Intervention Is Most Cost-Effective & Consumer Friendly in Reducing Hospital Care) Multicenter, Randomized Trial. Journal of the American College of Cardiology. 60(14), pp. 1239 - 1248. https://doi.org/10.1016/j.jacc.2012.06.025
Individual differences in brain structure underpin empathizing-systemizing cognitive styles in male adults
Lai, Meng-Chuan, Lombardo, M. V., Chakrabarti, Bhismadev, Ecker, Christine, Sadek, Susan A., Wheelwright, Sally J., Murphy, Declan G. M., Suckling, John, Bullmore, Edward T., Baron-Cohen, Simon, Bailey, Anthony J., Bolton, Patrick F., Carrington, Sarah, Daly, E. M., Deoni, Sean C. L., Happé, Francesca, Henty, Julian, Jezzard, Peter, Johnston, P., ... Williams, Steven C.. (2012) Individual differences in brain structure underpin empathizing-systemizing cognitive styles in male adults. NeuroImage. 61(4), pp. 1347 - 1354. https://doi.org/10.1016/j.neuroimage.2012.03.018
Exploring the potential to remain "Young @ Heart" : initial findings of a multi-centre, randomised study of nurse-led, home-based intervention in a hybrid health care system
Chan, Yih-Kai, Stewart, Simon, Calderone, Alicia, Scuffham, Paul, Goldstein, Stan and Carrington, Melinda J.. (2012) Exploring the potential to remain "Young @ Heart" : initial findings of a multi-centre, randomised study of nurse-led, home-based intervention in a hybrid health care system. International Journal of Cardiology. 154(1), pp. 52 - 58. https://doi.org/10.1016/j.ijcard.2010.08.071
Heart failure, ventricular dysfunction and risk factor prevalence in Australian Aboriginal peoples : The Heart of the Heart Study
McGrady, Michele, Krum, Henry, Carrington, Melinda, Stewart, Simon, Zeitz, Christopher, Lee, Geraldine, Marwick, Thomas, Haluska, Brian and Brown, Alex. (2012) Heart failure, ventricular dysfunction and risk factor prevalence in Australian Aboriginal peoples : The Heart of the Heart Study. Heart. 98(21), pp. 1562 - 1567. https://doi.org/10.1136/heartjnl-2012-302229
Effect of intensive structured care on individual blood pressure targets in primary care : Multicentre randomised controlled trial
Stewart, Simon, Carrington, Melinda, Swemmer, Carla, Anderson, Craig, Kurstjens, Nicol, Amerena, John, Brown, Alex, Burrell, Louise, de Looze, Ferdinandus and Harris, Mark. (2012) Effect of intensive structured care on individual blood pressure targets in primary care : Multicentre randomised controlled trial. British Medical Journal. 345(7884), pp. 1 - 16. https://doi.org/10.1136/bmj.e7156
The WHiCH? Trial: Rationale and design of a pragmatic randomized, multicentre comparison of home- vs. clinic-based management of chronic heart failure patients
Stewart, Simon, Carrington, Melinda J., Marwick, Thomas, Davidson, Patricia M., Macdonald, Peter, Horowitz, John, Krum, Henry, Newton, Phillip J., Reid, Christopher and Scuffham, Paul A.. (2011) The WHiCH? Trial: Rationale and design of a pragmatic randomized, multicentre comparison of home- vs. clinic-based management of chronic heart failure patients. European Journal of Heart Failure. 13(8), pp. 909 - 916. https://doi.org/10.1093/eurjhf/hfr048
The clinical consequences and challenges of hypertension in urban-dwelling black Africans :insights from the Heart of Soweto Study
Stewart, Simon, Libhaber, Elena, Carrington, Melinda, Damasceno, Albertino, Abbasi, Haroon, Hansen, Craig, Wilkinson, David and Sliwa, Karen. (2011) The clinical consequences and challenges of hypertension in urban-dwelling black Africans :insights from the Heart of Soweto Study. International Journal of Cardiology. 146(1), pp. 22 - 27. https://doi.org/10.1016/j.ijcard.2009.05.061
Evidence-based chronic heart-failure management programmes: Reality or myth?
Driscoll, A., Worrall-Carter, Linda, Hare, D., Davidson, P., Riegel, B., Tonkin, A. and Stewart, S.. (2011) Evidence-based chronic heart-failure management programmes: Reality or myth? BMJ Quality and Safety (print version). 20(1), pp. 31 - 37. https://doi.org/10.1136/qshc.2008.028035
A not-so-rare form of heart failure in urban black Africans :Pathways to right heart failure in the Heart of Soweto Study cohort
Stewart, Simon, Mocumbi, Ana, Carrington, Melinda, Pretorius, Sandra, Burton, Rosie and Sliwa, Karen. (2011) A not-so-rare form of heart failure in urban black Africans :Pathways to right heart failure in the Heart of Soweto Study cohort. European Journal of Heart Failure. 13(10), pp. 1070 - 1077. https://doi.org/10.1093/eurjhf/hfr108
Optimising management of hypertension in primary care :The Valsartan intensified Primary Care Reduction of Blood Pressure (Viper-Bp) Study
Stewart, Simon, Carrington, Melinda, Swemmer, Carla, Kurstjens, Nicol and Jennings, Garry. (2011) Optimising management of hypertension in primary care :The Valsartan intensified Primary Care Reduction of Blood Pressure (Viper-Bp) Study. International Journal of Cardiology. 153(3), pp. 317 - 322. https://doi.org/10.1016/j.ijcard.2010.12.055
Standing at the crossroads between new and historically prevalent heart disease :Effects of migration and socio-economic factors in the Heart of Soweto cohort study
Stewart, Simon, Carrington, Melinda, Pretorius, Sandra, Methusi, Puthuma and Sliwa, Karen. (2011) Standing at the crossroads between new and historically prevalent heart disease :Effects of migration and socio-economic factors in the Heart of Soweto cohort study. European Heart Journal. 32(4), pp. 492 - 499. https://doi.org/10.1093/eurheartj/ehq439
Predisposing factors and incidence of newly diagnosed atrial fibrillation in an urban African community : insights from the Heart of Soweto Study
Sliwa, Karen, Carrington, Melinda, Klug, Eric, Opie, Lionel, Lee, Geraldine and Stewart, Simon. (2010) Predisposing factors and incidence of newly diagnosed atrial fibrillation in an urban African community : insights from the Heart of Soweto Study. Heart. 96(23), pp. 1878 - 1882. https://doi.org/10.1136/hrt.2010.206938
Bridging the gap in heart failure prevention: Rationale and design of the Nurse-led intervention for Less Chronic Heart Failure (NiL-CHF) Study
Carrington, Melinda J. and Stewart, Simon. (2010) Bridging the gap in heart failure prevention: Rationale and design of the Nurse-led intervention for Less Chronic Heart Failure (NiL-CHF) Study. European Journal of Heart Failure. 12(1), pp. 82 - 88. https://doi.org/10.1093/eurjhf/hfp161
Structured telephone support or telemonitoring programs for patients with chronic heart failure
Inglis, Sally, Clark, Robyn, McAlister, F, Ball, Jocasta, Lewinter, Christian, Cullington, Damien, Stewart, Simon and Cleland, John. (2010) Structured telephone support or telemonitoring programs for patients with chronic heart failure. Cochrane Database of Systematic Reviews. 8, pp. 1 - 144. https://doi.org/10.1002/14651858.CD007228
Pattern of blood pressure in Australian adults : Results from a National Blood Pressure Screening Day of 13,825 adults
Carrington, Melinda, Jennings, Garry L. and Stewart, Simon. (2010) Pattern of blood pressure in Australian adults : Results from a National Blood Pressure Screening Day of 13,825 adults. International Journal of Cardiology. 145(3), pp. 461 - 467. https://doi.org/10.1016/j.ijcard.2009.06.003
Theoretical exploration of the neural bases of behavioural disinhibition, apathy and executive dysfunction in preclinical Alzheimer's disease in people with Down's syndrome: Potential involvement of multiple frontal-subcortical neuronal circuits
Ball, S., Holland, Anne, Watson, P. and Huppert, Felicia. (2010) Theoretical exploration of the neural bases of behavioural disinhibition, apathy and executive dysfunction in preclinical Alzheimer's disease in people with Down's syndrome: Potential involvement of multiple frontal-subcortical neuronal circuits. Journal of Intellectual Disability Research. 54(4), pp. 320 - 336. https://doi.org/10.1111/j.1365-2788.2010.01261.x
Structured telephone support or telemonitoring programs for patients with chronic heart failure
Inglis, Sally, Clark, Robyn, McAlister, F, Ball, Jocasta, Lewinter, Christian, Cullington, Damien, Stewart, Simon and Cleland, John. (2010) Structured telephone support or telemonitoring programs for patients with chronic heart failure. Cochrane Database of Systematic Reviews. 8, pp. 1 - 144. https://doi.org/10.1002/14651858.CD007228.pub2
Incidence and characteristics of newly diagnosed rheumatic heart disease in Urban African adults : insights from the Heart of Soweto Study
Sliwa, Karen, Carrington, Melinda, Mayosi, Bongani, Zigiriadis, Elias and Mvungi, Robert. (2010) Incidence and characteristics of newly diagnosed rheumatic heart disease in Urban African adults : insights from the Heart of Soweto Study. European Heart Journal. 31(6), pp. 719 - 727. https://doi.org/10.1093/eurheartj/ehp530
Predisposing factors and incidence of newly diagnosed atrial fibrillation in an urban African community : insights from the Heart of Soweto Study
Sliwa, Karen, Carrington, Melinda, Klug, Eric, Opie, Lionel, Lee, Geraldine and Stewart, Simon. (2010) Predisposing factors and incidence of newly diagnosed atrial fibrillation in an urban African community : insights from the Heart of Soweto Study. Heart. 96(23), pp. 1878 - 1882. https://doi.org/10.1136/hrt.2010.206938
Cholesterol complacency in Australia: Time to revisit the basics of cardiovascular disease prevention
Carrington, Melinda Jane, Retegan, Claudia, Johnston, Colin I., Jennings, Garry L. and Stewart, Simon. (2009) Cholesterol complacency in Australia: Time to revisit the basics of cardiovascular disease prevention. Journal of Clinical Nursing. 18(5), pp. 678 - 686. https://doi.org/10.1111/j.1365-2702.2008.02507.x
Nature's clocks and human mood: The circadian system modulates reward motivation
Murray, Greg, Nicholas, Christian, Kleiman, Jan, Dwyer, Robyn, Carrington, Melinda, Allen, Nicholas and Trinder, John. (2009) Nature's clocks and human mood: The circadian system modulates reward motivation. Emotion (online version). 9(5), pp. 705 - 716. https://doi.org/10.1037/a0017080
A time bomb of cardiovascular risk factors in South Africa: Results from the Heart of Soweto Study "Heart Awareness Days"
Tibazarwa, Kemi, Ntyintyane, Lucas, Sliwa, Karen, Gernholtz, Trevor, Carrington, Melinda Jane, Wilkinson, David and Stewart, Simon. (2009) A time bomb of cardiovascular risk factors in South Africa: Results from the Heart of Soweto Study "Heart Awareness Days". International Journal of Cardiology. 132(2), pp. 233 - 239. https://doi.org/10.1016/j.ijcard.2007.11.067
Blood pressure and heart rate during continuous experimental sleep fragmentation in health adults
Carrington, Melinda Jane and Trinder, John. (2008) Blood pressure and heart rate during continuous experimental sleep fragmentation in health adults. Sleep. 31(12), pp. 1701 - 1712. https://doi.org/10.1093/sleep/31.12.1701
The effects on cardiovascular autonomic control of repetitive arousal from sleep
Chaicharn, Jaree, Carrington, Melinda Jane, Trinder, John and Khoo, Michael. (2008) The effects on cardiovascular autonomic control of repetitive arousal from sleep. Sleep. 31(1), pp. 93 - 103. https://doi.org/10.1093/sleep/31.1.93
Is fenofibrate a cost-saving treatment for middle-aged individuals with type ii diabetes? An economic analysis of the FIELD Study
Carrington, Melinda Jane and Stewart, Simon. (2008) Is fenofibrate a cost-saving treatment for middle-aged individuals with type ii diabetes? An economic analysis of the FIELD Study. International Journal of Cardiology. 127(1), pp. 51 - 56. https://doi.org/10.1016/j.ijcard.2007.04.040
Prognostic impact of pulmonary arterial hypertension: A population-based analysis
Carrington, Melinda Jane, Murphy, Niamh F., Strange, Geoff, Peacock, Andrew, McMurray, John J.V. and Stewart, Simon. (2008) Prognostic impact of pulmonary arterial hypertension: A population-based analysis. International Journal of Cardiology. 124(2), pp. 183 - 187. https://doi.org/10.1016/j.ijcard.2006.12.045
The effects on cardiovascular autonomic control of repetitive arousal from sleep
Chaicharn, Jaree, Carrington, Melinda, Trinder, John and Khoo, Michael. (2008) The effects on cardiovascular autonomic control of repetitive arousal from sleep. Sleep (online version). 31(1), pp. 93 - 103. https://doi.org/10.1093/sleep/31.1.93
Are ECG abnormalities common in black AFricans with heart failure? Results from the Heart of Soweto study
Lee, Geraldine, Carrington, Melinda Jane, Sliwa, Karen and Stewart, Simon. (2008) Are ECG abnormalities common in black AFricans with heart failure? Results from the Heart of Soweto study. South African Heart Journal. 5(1), pp. 4 - 11. https://doi.org/10.24170/5-1-2056
Blood pressure and heart rate during continuous experimental sleep fragmentation in health adults
Carrington, Melinda and Trinder, John. (2008) Blood pressure and heart rate during continuous experimental sleep fragmentation in health adults. Sleep (online version). 31(12), pp. 1701 - 1712. https://doi.org/10.1093/sleep/31.12.1701
Changes in cardiovascular function during the sleep onset period in young adults
Carrington, Melinda Jane, Barbieri, R., Colrain, I. M., Crowley, K. E., Kim, Y. and Trinder, J.. (2005) Changes in cardiovascular function during the sleep onset period in young adults. Journal of Applied Physiology. 98(2), pp. 468 - 476. https://doi.org/10.1152/japplphysiol.00702.2004
Subjective and predicted sleepiness while driving in young adults
Smith, Simon, Carrington, Melinda Jane and Trinder, John. (2005) Subjective and predicted sleepiness while driving in young adults. Accident Analysis and Prevention. 37(6), pp. 1066 - 1073. https://doi.org/10.1016/j.aap.2005.06.008
The influence of sleep onset on the diurnal variation in cardiac activity and cardiac control
Carrington, Melinda Jane, Walsh, Michelle, Stambas, Thalia, Kleiman, Jan and Trinder, John. (2003) The influence of sleep onset on the diurnal variation in cardiac activity and cardiac control. Journal of Sleep Research. 12(3), pp. 213 - 221. https://doi.org/10.1046/j.1365-2869.2003.00364.x
The effects of normal aging on sleep spindle and K-complex production
Crowley, Kate, Trinder, John, Kim, Young, Carrington, Melinda Jane and Colrain, Ian M.. (2002) The effects of normal aging on sleep spindle and K-complex production. Clinical Neurophysiology. 113(10), pp. 1615 - 1622. https://doi.org/10.1016/S1388-2457(02)00237-7
Autonomic activity during human sleep as a function of time and sleep stage
Trinder, John, Kleiman, Jan, Carrington, Melinda, Smith, Simon, Breen, Sibilah, Tan, Nellie and Kim, Young. (2001) Autonomic activity during human sleep as a function of time and sleep stage. Journal of Sleep Research. 10(4), pp. 253 - 264. https://doi.org/10.1046/j.1365-2869.2001.00263.x
Autonomic activity during human sleep as a function of time and sleep stage
Trinder, John, Kleiman, Jan, Carrington, Melinda Jane, Smith, Simon, Breen, Sibilah, Tan, Nellie and Kim, Young. (2001) Autonomic activity during human sleep as a function of time and sleep stage. Journal of Sleep Research. 10(4), pp. 253 - 264. https://doi.org/10.1046/j.1365-2869.2001.00263.x