Human metabolomics reveal daily variations under nutritional challenges specific to serum and skeletal muscle

Journal article

Sato, Shogo, Evelyn, Parr,, Devlin, Brooke, Hawley, John and Sassone-Corsi, Paolo 2018. Human metabolomics reveal daily variations under nutritional challenges specific to serum and skeletal muscle. Molecular Metabolism. 16, pp. 1 - 11. https://doi.org/10.1016/j.molmet.2018.06.008
AuthorsSato, Shogo, Evelyn, Parr,, Devlin, Brooke, Hawley, John and Sassone-Corsi, Paolo
Abstract

Objective: Advances in the field of metabolomics and the concomitant development of bioinformatics tools constitute a promising avenue towards the development of precision medicine and personalized profiling for numerous disease states. Studies in animal models have strengthened this concept, but the application in human subjects is scarce. Methods: Utilizing high-throughput metabolomics, we have analyzed the metabolome levels of human serum and skeletal muscle in the morning and evening in response to divergent nutritional challenges in order to identify unique signatures present in serum and muscle. Results: We reveal dynamic daily variation of human metabolome unique to serum and muscle. The overall effect of nutritional challenges on the serum and muscle metabolome results in a profound rewiring of morning-evening metabolic profiles in human participants in response to the timing and type of dietary challenge. Conclusion: We highlight time-of-day and meal-composition dependence of reprogramming of human metabolome by nutritional challenges.

Year2018
JournalMolecular Metabolism
Journal citation16, pp. 1 - 11
PublisherElsevier
ISSN2212-8778
Digital Object Identifier (DOI)https://doi.org/10.1016/j.molmet.2018.06.008
Scopus EID2-s2.0-85049105650
Open accessOpen access
Page range1 - 11
Research GroupMary MacKillop Institute for Health Research
Publisher's version
License
Place of publicationGermany
EditorsM. Tschöp
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Increasing leucine concentration stimulates mechanistic target of rapamycin signaling an cell growth in C2C12 skeletal muscle cells
Areta, José, Hawley, John A., Ye, Ji-Ming, Chan, M. H. Stanley and Coffey, Vernon 2014. Increasing leucine concentration stimulates mechanistic target of rapamycin signaling an cell growth in C2C12 skeletal muscle cells. Nutrition Research. 34 (11), pp. 1000 - 1007. https://doi.org/10.1016/j.nutres.2014.09.011
Reduced resting skeletal muscle protein synthesis is reduced by resistance exercise and protein ingestion following short-term energy deficit
Areta, José, Burke, Louise, Camera, Donny, West, Daniel, Crawshay, Siobhan, Moore, Daniel, Stellingwerff, Trent, Phillips, Stuart, Hawley, John A. and Coffey, Vernon 2014. Reduced resting skeletal muscle protein synthesis is reduced by resistance exercise and protein ingestion following short-term energy deficit. American Journal of Physiology - Endocrinology and Metabolism. 306 (8), pp. E989 - E997. https://doi.org/10.1152/ajpendo.00590.2013
Ramping up the signal: Promoting endurance training adaptation in skeletal muscle by nutritional manipulation
Hawley, John Alan and Morton, James 2014. Ramping up the signal: Promoting endurance training adaptation in skeletal muscle by nutritional manipulation. Clinical and Experimental Pharmacology & Physiology. 41 (8), pp. 608 - 613. https://doi.org/10.1111/1440-1681.12246
Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis
Rao, Rajesh, Long, Jonathan, White, James, Svensson, Katrin, Lou, Jesse, Lokurkar, Isha, Jedrychowski, Mark, Ruas, Jorge, Wrann, Christiane, Lo, James, Camera, Donny, Lachey, Jenn, Gygi, Steven, Seehra, Jasbir, Hawley, John and Spiegelman, Bruce 2014. Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis. Cell. 157 (6), pp. 1279 - 1291. https://doi.org/10.1016/j.cell.2014.03.065
Integrative biology of exercise
Hawley, John A., Hargreaves, Mark, Joyner, Michael J. and Zierath, Juleen R. 2014. Integrative biology of exercise. Cell. 159 (6), pp. 738 - 749. https://doi.org/10.1016/j.cell.2014.10.029
Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis
Rao, Rajesh, Long, Jonathan Z., White, James P., Svensson, Katrin J., Lou, Jesse, Lokurkar, Isha, Jedrychowski, Mark P., Ruas, Jorge L., Wrann, Christine D., Camera, Donny, Lachey, Jenn, Gygi, Steven, Seehra, Jasbir, Hawley, John and Spiegelman, Bruce M. 2014. Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis. Cell. 157 (6), pp. 1279 - 1291. https://doi.org/10.1016/j.cell.2014.03.065
Acute changes to biomarkers as a consequence of prolonged strenuous running
Bird, Stephen R., Linden, Matthew and Hawley, John Alan 2014. Acute changes to biomarkers as a consequence of prolonged strenuous running. Annals of Clinical Biochemistry. 51 (2), pp. 137 - 150. https://doi.org/10.1177/0004563213492147
Two weeks of reduced-volume sprint interval or traditional exercise training does not improve metabolic functioning in sedentary obese men
Skleryk, J, Karagounis, Leonidas, Hawley, John, Sharman, Matthew, Laursen, Paul and Watson, Greg 2013. Two weeks of reduced-volume sprint interval or traditional exercise training does not improve metabolic functioning in sedentary obese men. Diabetes, Obesity and Metabolism: a journal of pharmacology and therapeutics. https://doi.org/10.1111/dom.12150
Nutritional strategies to modulate the adaptive response to endurance training
Hawley, John Alan 2013. Nutritional strategies to modulate the adaptive response to endurance training. Nestle Nutrition Institute Workshop Series. 75, pp. 1 - 14. https://doi.org/10.1159/000345813
Exercise training enhances white adipose tissue metabolism in rats selectively bred for low- or high-endurance running capacity
Stephenson, Erin, Lessard, Sarah, Rivas, Donato, Watt, Matthew, Yaspelkis III, Ben, Koch, Lauren, Britton, Steven and Hawley, John 2013. Exercise training enhances white adipose tissue metabolism in rats selectively bred for low- or high-endurance running capacity. American Journal of Physiology - Endocrinology and Metabolism. https://doi.org/10.1152/ajpendo.00544.2012
Caffeine ingestion and cycling power output in a low or normal muscle glycogen state
Lane, Suzanne, Areta, José, Bird, S, Coffey, Vernon, Burke, Louise, Desbrow, B, Karagounis, L and Hawley, John A. 2013. Caffeine ingestion and cycling power output in a low or normal muscle glycogen state. Medicine and Science in Sports and Exercise. https://doi.org/10.1249/MSS.0b013e31828af183
Effect of a carbohydrate mouth rinse on simulated cycling time-trial performance commenced in a fed or fasted state
Lane, Stephen, Bird, S, Burke, Louise and Hawley, John 2013. Effect of a carbohydrate mouth rinse on simulated cycling time-trial performance commenced in a fed or fasted state. Applied Physiology, Nutrition and Metabolism. https://doi.org/10.1139/apnm-2012-0300
ERK1/2 in the brain mediates the effects of central resistin on reducing thermogenesis in brown adipose tissue
Kosari, Samin, Camera, Donny Michael, Hawley, John Alan, Stebbing, Martin and Badoer, Emilio 2013. ERK1/2 in the brain mediates the effects of central resistin on reducing thermogenesis in brown adipose tissue. International Journal of Physiology, Pathophysiology and Pharmacology. 5 (3), pp. 184 - 189.
Preexercise aminoacidemia and muscle protein synthesis after resistance exercise
Burke, Louise, Hawley, John, Ross, M, Moore, Daniel, Phillips, S, Slater, G, Stellingwerff, T, Tipton, K, Garnham, A and Coffey, Vernon 2012. Preexercise aminoacidemia and muscle protein synthesis after resistance exercise. Medicine and Science in Sports and Exercise. 44 (10), pp. 1968 - 1977. https://doi.org/10.1249/MSS.0b013e31825d28fa
Skeletal muscle respiratory capacity is enhanced in rats consuming an obesogenic Western diet
Stephenson, E, Camera, Donny, Jenkins, T, Kosari, S, Lee, Joohyung, Hawley, John and Stepto, N 2012. Skeletal muscle respiratory capacity is enhanced in rats consuming an obesogenic Western diet. American Journal of Physiology - Endocrinology and Metabolism. 302 (12), pp. E1541 - E1549. https://doi.org/10.1152/ajpendo.00590.2011
What's new since Hippocrates? : Preventing type 2 diabetes by physical exercise and diet
Hawley, John and Gibala, M 2012. What's new since Hippocrates? : Preventing type 2 diabetes by physical exercise and diet. Diabetologia. 55 (3), pp. 535 - 539. https://doi.org/10.1007/s00125-012-2460-1
Daytime pattern of post-exercise protein intake affects whole-body protein turnover in resistance-trained males
Moore, Daniel, Areta, José, Coffey, Vernon, Stellingwerff, Trent, Phillips, Stuart, Burke, Louise, Cleroux, Marilyn, Godin, Jean-Philippe and Hawley, John Alan 2012. Daytime pattern of post-exercise protein intake affects whole-body protein turnover in resistance-trained males. Nutrition and Metabolism. 9 (91), pp. 1 - 5. https://doi.org/10.1186/1743-7075-9-91
Divergent skeletal muscle respiratory capacities in rats artificially selected for high and low running ability : A role for Nor1?
Stephenson, E, Stepto, N, Koch, L, Britton, S and Hawley, John 2012. Divergent skeletal muscle respiratory capacities in rats artificially selected for high and low running ability : A role for Nor1? Journal of Applied Physiology. 113 (9), pp. 1403 - 1412. https://doi.org/10.1152/japplphysiol.00788.2012
Reply from M. J. Gibala, J. P. Little, M. J. MadDonald and J. A. Hawley
Gibala, M. J., Little, John, Macdonald, M. J. and Hawley, John 2012. Reply from M. J. Gibala, J. P. Little, M. J. MadDonald and J. A. Hawley. The Journal of Physiology. 590 (14), pp. 3391 - 3391. https://doi.org/10.1113/jphysiol.2012.235127
Preexercise nutrient timing in endurance activity
Broad, E., Karagounis, L. and Hawley, John Alan 2012. Preexercise nutrient timing in endurance activity. in: C. M. Kerksick (ed.) Nutrient Timing: Metabolic Optimization for Health, Performance, and Recovery United States of America: Taylor & Francis. pp. 118 - 118
Sex-based comparisons of myofibrillar protein synthesis after resistance exercise in the fed state
West, D, Burd, N, Churchward-Venne, T, Camera, Donny, Mitchell, Cameron, Baker, S, Hawley, John, Coffey, Vernon and Phillips, S 2012. Sex-based comparisons of myofibrillar protein synthesis after resistance exercise in the fed state. Journal of Applied Physiology. 112 (11), pp. 1805 - 1813. https://doi.org/10.1152/japplphysiol.00170.2012
Low muscle glycogen concentration does not suppress the anabolic response to resistance exercise
Camera, Donny, West, D, Burd, N, Phillips, S, Garnham, A, Hawley, John and Coffey, Vernon 2012. Low muscle glycogen concentration does not suppress the anabolic response to resistance exercise. Journal of Applied Physiology. 113 (2), pp. 206 - 214. https://doi.org/10.1152/japplphysiol.00395.2012
Physiological adaptations to low-volume, high-intensity interval training in health and disease
Gibala, M, Little, John, Macdonald, M and Hawley, John 2012. Physiological adaptations to low-volume, high-intensity interval training in health and disease. The Journal of Physiology. 590 (5), pp. 1077 - 1084. https://doi.org/10.1113/jphysiol.2011.224725
Nutrient provision increases signalling and protein synthesis in human skeletal muscle after repeated sprints
Coffey, Vernon, Moore, Daniel, Burd, N, Rerecich, T, Stellingwerff, T, Garnham, A, Phillips, S and Hawley, John 2011. Nutrient provision increases signalling and protein synthesis in human skeletal muscle after repeated sprints. European Journal of Applied Physiology. 111 (7), pp. 1473 - 1483. https://doi.org/10.1007/s00421-010-1768-0
Rapid aminoacidemia enhances myofibrillar protein synthesis and anabolic intramuscular signaling responses after resistance exercise
West, D, Burd, N, Coffey, Vernon, Baker, S, Burke, Louise, Hawley, John, Moore, Daniel, Stellingwerff, T and Phillips, S 2011. Rapid aminoacidemia enhances myofibrillar protein synthesis and anabolic intramuscular signaling responses after resistance exercise. American Journal of Clinical Nutrition: A journal reporting the practical application of our world-wide knowledge of nutrition. 94 (3), pp. 795 - 803. https://doi.org/10.3945/ajcn.111.013722
Nutritional modulation of training-induced skeletal muscle adaptations
Hawley, John, Burke, Louise, Phillips, S and Spriet, L 2011. Nutritional modulation of training-induced skeletal muscle adaptations. Journal of Applied Physiology. 110 (3), pp. 834 - 845. https://doi.org/10.1152/japplphysiol.00949.2010
Single-leg cycle training is superior to double-leg cycling in improving the oxidative potential and metabolic profile of trained skeletal muscle
Abbiss, Chris, Karagounis, L, Laursen, P, Peiffer, J, Martin, D, Hawley, John, Fatehee, N and Martin, J 2011. Single-leg cycle training is superior to double-leg cycling in improving the oxidative potential and metabolic profile of trained skeletal muscle. Journal of Applied Physiology. 110 (5), pp. 1248 - 1255. https://doi.org/10.1152/japplphysiol.01247.2010
Carbohydrates for training and competition
Burke, Louise, Hawley, John, Wong, S and Jeukendrup, A 2011. Carbohydrates for training and competition. Journal of Sports Sciences. 29 (Suppl 1), pp. S17 - S27. https://doi.org/10.1080/02640414.2011.585473
Exercise training reverses impaired skeletal muscle metabolism induced by artificial selection for low aerobic capacity
Lessard, S, Rivas, D, Stephenson, E, Yaspelkis, Koch, L, Britton, S, Hawley, John and III, B Yaspelkis 2011. Exercise training reverses impaired skeletal muscle metabolism induced by artificial selection for low aerobic capacity. American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 300 (1), pp. R175 - R182. https://doi.org/10.1152/ajpregu.00338.2010
Low intrinsic running capacity is associated with reduced skeletal muscle substrate oxidation and lower mitochondrial content in white skeletal muscle
Rivas, D, Lessard, S, Saito, M, Friedhuber, A, Koch, L, Britton, S, Yaspelkis III, B and Hawley, John 2011. Low intrinsic running capacity is associated with reduced skeletal muscle substrate oxidation and lower mitochondrial content in white skeletal muscle. American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 300 (4), pp. 835 - 843. https://doi.org/10.1152/ajpregu.00659.2010
The effect of exercise on the skeletal muscle phospholipidome of rats fed a high-fat diet
Mitchell, Todd, Turner, Nigel, Else, Paul, Hulbert, Anthony and Hawley, John 2010. The effect of exercise on the skeletal muscle phospholipidome of rats fed a high-fat diet. International Journal of Molecular Sciences. 11 (10), pp. 3954 - 3964. https://doi.org/10.3390/ijms11103954
Acute signalling responses to intense endurance training commenced with low or normal muscle glycogen : Experimental Physiology-Research Paper
Yeo, W, McGee, S, Carey, A, Paton, C, Garnham, A, Hargreaves, M and Hawley, John 2010. Acute signalling responses to intense endurance training commenced with low or normal muscle glycogen : Experimental Physiology-Research Paper. Experimental Physiology. 95 (2), pp. 351 - 358. https://doi.org/10.1113/expphysiol.2009.049353
Reply
Hawley, John and Martin, David 2010. Reply. International Journal of Sports Physiology and Performance. 5 (4), pp. 434 - 436.
Early time course of akt phosphorylation after endurance and resistance exercise
Camera, Donny, Edge, J, Short, M, Hawley, John and Coffey, Vernon 2010. Early time course of akt phosphorylation after endurance and resistance exercise. Medicine and Science in Sports and Exercise. 42 (10), pp. 1843 - 1852. https://doi.org/10.1249/MSS.0b013e3181d964e4
Short-term endurance training does not alter the oxidative capacity of human subcutaneous adipose tissue
Camera, Donny, Anderson, Malcolm, Hawley, John and Carey, A 2010. Short-term endurance training does not alter the oxidative capacity of human subcutaneous adipose tissue. European Journal of Applied Physiology. 109 (2), pp. 307 - 316. https://doi.org/10.1007/s00421-010-1356-3
Contraction-induced changes in TNFalpha and Akt-mediated signalling are associated with increased myofibrillar protein in rat skeletal muscle
Karagounis, L, Yaspelkis III, B, Reeder, D, Lancaster, G, Hawley, John and Coffey, Vernon 2010. Contraction-induced changes in TNFalpha and Akt-mediated signalling are associated with increased myofibrillar protein in rat skeletal muscle. European Journal of Applied Physiology. 109 (5), pp. 839 - 848. https://doi.org/10.1007/s00421-010-1427-5
Gamma tocopherol supplementation prevents exercise induced coagulation and platelet aggregation
Vucinic, L, Singh, I, Spargo, F, Hawley, John and Linden, M 2010. Gamma tocopherol supplementation prevents exercise induced coagulation and platelet aggregation. Thrombosis Research: vascular obstruction, hemorrhage and hemostasis. 125 (2), pp. 196 - 199. https://doi.org/10.1016/j.thromres.2009.11.015
Carbohydrate availability and training adaptation: Effects on cell metabolism
Hawley, John and Burke, Louise 2010. Carbohydrate availability and training adaptation: Effects on cell metabolism. Exercise and Sport Sciences Reviews. 38 (4), pp. 152 - 160. https://doi.org/10.1097/JES.0b013e3181f44dd9
Daily training with high carbohydrate availability increases exogenous carbohydrate oxidation during endurance cycling
Cox, Geoffrey, Clark, Sally, Cox, A, Halson, Shona, Hargreaves, M, Hawley, John, Jeacocke, N, Snow, Rod, Yeo, W and Burke, Louise 2010. Daily training with high carbohydrate availability increases exogenous carbohydrate oxidation during endurance cycling. Journal of Applied Physiology. 109 (1), pp. 126 - 134. https://doi.org/10.1152/japplphysiol.00950.2009
Aerobic training reverses high-fat diet-induced pro-inflammatory signalling in rat skeletal muscle
Yaspelkis III, B, Kvasha, I, Lessard, S, Rivas, D and Hawley, John 2010. Aerobic training reverses high-fat diet-induced pro-inflammatory signalling in rat skeletal muscle. European Journal of Applied Physiology. 110 (4), pp. 779 - 788. https://doi.org/10.1007/s00421-010-1559-7
Cytokine responses to carbohydrate ingestion during recovery from exercise-induced muscle injury
Ross, M, Halson, Shona, Suzuki, K, Garnham, A, Hawley, John, Cameron-Smith, David and Peake, J 2010. Cytokine responses to carbohydrate ingestion during recovery from exercise-induced muscle injury. Journal of Interferon and Cytokine Research. 30 (5), pp. 329 - 337. https://doi.org/10.1089/jir.2009.0079
Skeletal muscle : increasing the size of the locomotor cell
Karagounis, L and Hawley, John 2010. Skeletal muscle : increasing the size of the locomotor cell. The International Journal of Biochemistry and Cell Biology. 42 (9), pp. 1376 - 1379. https://doi.org/10.1016/j.biocel.2010.05.013
Global gene expression in skeletal muscle from well-trained strength and endurance athletes
Stepto, Nigel K., Coffey, Vernon Glenn, Carey, Andrew L., Ponnampalam, Anna P., Canny, Benedict J., Powell, David and Hawley, John Alan 2009. Global gene expression in skeletal muscle from well-trained strength and endurance athletes. Medicine and Science in Sports and Exercise. 41 (3), pp. 546 - 565. https://doi.org/10.1249/MSS.0b013e31818c6be9
Effect of consecutive repeated sprint and resistance exercise bouts on acute adaptive responses in human skeletal muscle
Coffey, Vernon Glenn, Jemiolo, Bozena, Edge, Johann, Garnham, Andrew P., Trappe, Scott W. and Hawley, John Alan 2009. Effect of consecutive repeated sprint and resistance exercise bouts on acute adaptive responses in human skeletal muscle. American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 297 (5), pp. 1441 - 1451. https://doi.org/10.1152/ajpregu.00351.2009
Exercise intensity and insulin sensitivity: How low can you go?
Hawley, John Alan and Gibala, M. J. 2009. Exercise intensity and insulin sensitivity: How low can you go? Diabetologia. 52 (9), pp. 1709 - 1713. https://doi.org/10.1007/s00125-009-1425-5
Lipid-induced mTOR activation in rat skeletal muscle reversed by exercise and 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside
Rivas, Donato A., Yaspelkis, Ben B., Hawley, John Alan and Lessard, Sarah J. 2009. Lipid-induced mTOR activation in rat skeletal muscle reversed by exercise and 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside. Journal of Endocrinology. 202 (3), pp. 441 - 451. https://doi.org/10.1677/JOE-09-0202
Molecular responses to strength and endurance training: Are they incompatible?
Hawley, John Alan 2009. Molecular responses to strength and endurance training: Are they incompatible? Applied Physiology, Nutrition and Metabolism. 34 (3), pp. 355 - 361. https://doi.org/10.1139/H09-023
The 5' adenosine monophosphate-activated protein kinase: Regulating the ebb and flow of cellular energetics
Karagounis, Leonidas G. and Hawley, John Alan 2009. The 5' adenosine monophosphate-activated protein kinase: Regulating the ebb and flow of cellular energetics. The International Journal of Biochemistry and Cell Biology. 41 (12), pp. 2360 - 2363. https://doi.org/10.1016/j.biocel.2009.07.004
Exercise: It's the real thing!
Hawley, John Alan and Holloszy, J O. 2009. Exercise: It's the real thing! Nutrition Reviews. 67 (3), pp. 172 - 178. https://doi.org/10.1111/j.1753-4887.2009.00185.x
Impaired skeletal muscle beta-adrenergic activation and lipolysis are associated with whole-body insulin resistance in rats bred for low intrinsic exercise capacity
Lessard, Sarah J., Rivas, Donato A., Chen, Zhu-Ping, van Denderen, Bryce J., Watt, Matthew J., Koch, Lauren G., Britton, Steven L., Kemp, Bruce Ernest and Hawley, John Alan 2009. Impaired skeletal muscle beta-adrenergic activation and lipolysis are associated with whole-body insulin resistance in rats bred for low intrinsic exercise capacity. Endocrinology. 150 (11), pp. 4883 - 4891. https://doi.org/10.1210/en.2009-0158
Spectroscopic correlation analysis of NMR-based metabonomics in exercise science
Kirwan, Gemma M., Coffey, Vernon Glenn, Niere, Julie O., Hawley, John Alan and Adams, Michael J. 2009. Spectroscopic correlation analysis of NMR-based metabonomics in exercise science. Analytica Chimica Acta. 652 (1-2), pp. 173 - 179. https://doi.org/10.1016/j.aca.2009.07.011
Consecutive bouts of diverse contractile activity alter acute responses in human skeletal muscle
Coffey, Vernon Glenn, Pilegaard, Henriette, Garnham, Andrew P., O'Brien, Brendan J. and Hawley, John Alan 2009. Consecutive bouts of diverse contractile activity alter acute responses in human skeletal muscle. Journal of Applied Physiology. 106 (4), pp. 1187 - 1197. https://doi.org/10.1152/japplphysiol.91221.2008
Specificity of training adaptation: Time for a rethink?
Hawley, John Alan 2008. Specificity of training adaptation: Time for a rethink? The Journal of Physiology. 586 (1), pp. 1 - 2. https://doi.org/10.1113/jphysiol.2007.147397
Evidence for presribing exercise as a therapy for treating patients with type 2 diabetes
Lessard, Sarah J. and Hawley, John Alan 2008. Evidence for presribing exercise as a therapy for treating patients with type 2 diabetes. in: J.A. Hawley and J. R. Zierath (ed.) Physical activity and type 2 diabetes: Therapeutic effects and mechanisms of action United States of America: Human Kinetics Publishers Inc.. pp. 203 - 214
The effects of polyphenols in olive leaves on platelet function
Singh, Indu, Mok, Michelle, Christensen, Anne-Marie, Turner, Alan H. and Hawley, John Alan 2008. The effects of polyphenols in olive leaves on platelet function. Nutrition Metabolism and Cardiovascular Diseases. 18 (2), pp. 127 - 132. https://doi.org/10.1016/j.numecd.2006.09.001
Skeletal muscle adaptation and performance responses to once a day versus twice every second day endurance training regimens
Yeo, Wee Kian, Paton, Carl D., Garnham, Andrew P., Burke, Louise M., Carey, Andrew L. and Hawley, John Alan 2008. Skeletal muscle adaptation and performance responses to once a day versus twice every second day endurance training regimens. Journal of Applied Physiology. 105 (5), pp. 1462 - 1470. https://doi.org/10.1152/japplphysiol.90882.2008
Commentary on viewpoint: Exercise and cardiovascular risk reduction: Time to update the rationale for exercise?
Reid, Julianne J. and Hawley, John Alan 2008. Commentary on viewpoint: Exercise and cardiovascular risk reduction: Time to update the rationale for exercise? Journal of Applied Physiology. 105 (2), pp. 772 - 772. https://doi.org/10.1152/japplphysiol.90362.2008
Metabolic adaptations to training
Hawley, John Alan and Nader, Gustavo A. 2008. Metabolic adaptations to training. in: M.P. Schwellnus (ed.) Olympic textbook of medicine in sport United Kingdom: Wiley-Blackwell. pp. 78 - 87
Exercise training-induced improvements in insulin action
Hawley, John Alan and Lessard, S. J. 2008. Exercise training-induced improvements in insulin action. Acta Physiologica. 192 (1), pp. 127 - 135. https://doi.org/10.1111/j.1748-1716.2007.01783.x
Exercise-induced phospho-proteins in skeletal muscle
Deshmukh, A. S., Hawley, John Alan and Zierath, J. R. 2008. Exercise-induced phospho-proteins in skeletal muscle. International Journal of Obesity. 32 (SUPPL.4), pp. S18 - S23. https://doi.org/10.1038/ijo.2008.118
Activation of atypical protein kinase Czeta toward TC10 is regulated by high-fat diet and aerobic exercise in skeletal muscle
Saito, Misato, Lessard, S. J., Rivas, Donato A., Reeder, Donald W., Hawley, John Alan and Yaspelkis, Ben B. 2008. Activation of atypical protein kinase Czeta toward TC10 is regulated by high-fat diet and aerobic exercise in skeletal muscle. Metabolism: Clinical and experimental. 57 (9), pp. 1173 - 1180. https://doi.org/10.1016/j.metabol.2008.03.023
Commentary on viewpoint: Perspective on the future use of genomics in exercise prescription
Hawley, John Alan 2008. Commentary on viewpoint: Perspective on the future use of genomics in exercise prescription. Journal of Applied Physiology. 104 (4), pp. 1249 - 1249. https://doi.org/10.1152/japplphysiol.00047.2008
Oxidative stress-induced insulin resistance in skeletal muscle cells is ameliorated by gamma-tocopherol treatment
Singh, Indu, Carey, Andrew L., Watson, Nadine, Febbraio, Mark A. and Hawley, John Alan 2008. Oxidative stress-induced insulin resistance in skeletal muscle cells is ameliorated by gamma-tocopherol treatment. European Journal of Nutrition. 47 (7), pp. 387 - 392. https://doi.org/10.1007/s00394-008-0739-2
High rates of muscle glycogen resynthesis after exhaustive exercise when carbohydrate is coingested with caffeine
Pedersen, David J., Lessard, Sarah J., Coffey, Vernon Glenn, Churchley, Emmanuel G., Wootton, Andrew M., Ng, They, Watt, Matthew J. and Hawley, John Alan 2008. High rates of muscle glycogen resynthesis after exhaustive exercise when carbohydrate is coingested with caffeine. Journal of Applied Physiology. 105 (1), pp. 7 - 13. https://doi.org/10.1152/japplphysiol.01121.2007
Overweight and obesity in Australia
Hawley, John Alan and Dunstan, David Wayne 2008. Overweight and obesity in Australia. Medical Journal of Australia. 188 (11), pp. 678 - 679.
Fat adaptation followed by carbohydrate restoration increases AMPK activity in skeletal muscle from trained humans
Yeo, Wee Kian, Lessard, Sarah J., Chen, Zhi-Ping, Garnham, Andrew P., Burke, Louise, Rivas, Donato A., Kemp, Bruce Ernest and Hawley, John Alan 2008. Fat adaptation followed by carbohydrate restoration increases AMPK activity in skeletal muscle from trained humans. Journal of Applied Physiology. 105 (5), pp. 1519 - 1526. https://doi.org/10.1152/japplphysiol.90540.2008
The battle against obesity - Attacking physical inactivity as a primary means of defense
Hawley, John and Dunstan, David 2008. The battle against obesity - Attacking physical inactivity as a primary means of defense. Nature Reviews Endocrinology. 4 (10), pp. 548 - 549. https://doi.org/10.1038/ncpendmet0918