Comorbidities and differential diagnosis in heart failure with preserved ejection fraction
Journal article
Campbell, Ross T. and McMurray, John J. V.. (2014). Comorbidities and differential diagnosis in heart failure with preserved ejection fraction. Heart Failure Clinics. 10(3), pp. 481 - 501. https://doi.org/10.1016/j.hfc.2014.04.009
Authors | Campbell, Ross T. and McMurray, John J. V. |
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Abstract | Heart failure ( HF ) is common, affecting 1% to 2% of the general population,1–3with the prevalence rising to more than 10% in those aged more than 80 years.1,4 HF has a high morbidity and reduced life expectancy, with 5- and 10-year survival rates of 50% and 10% reported in epidemiologic studies.5,6 HF can broadly be divided into 2 groups: HF with reduced ejection fraction ( HF-REF ) and HF with preserved ejection fraction ( HF-PEF ). There is a suggestion that HF-PEF accounts for almost half of all patients with HF and that prognosis is equally poor between groups,7,8 although a recent meta-analysis of 41,972 patients showed HF-REF to have a worse prognosis.9 The main difference between these 2 groups is response to treatment. Where HF-REF has several evidence-based therapies proved to improve survival, no treatment has been shown to do so in HF-PEF. The HF-PEF phenotype also differs from HF-REF, with HF-PEF patients being older, more often women, obese, and with more comorbidities. HF-PEF diagnosis is challenging and essentially a diagnosis of exclusion, with comorbidities potentially making the diagnosis more difficult. This article describes the comorbidities commonly associated with HF-PEF, the potential influence of these comorbidities on morbidity and mortality, and the differential diagnosis. |
Keywords | prognosis; comorbidity; HF-PEF; HF-REF |
Year | 2014 |
Journal | Heart Failure Clinics |
Journal citation | 10 (3), pp. 481 - 501 |
Publisher | W.B. Saunders Co. |
ISSN | 1551-7136 |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.hfc.2014.04.009 |
Scopus EID | 2-s2.0-84903394556 |
Page range | 481 - 501 |
Research Group | Mary MacKillop Institute for Health Research |
Publisher's version | File Access Level Controlled |
Place of publication | United States |
https://acuresearchbank.acu.edu.au/item/865w7/comorbidities-and-differential-diagnosis-in-heart-failure-with-preserved-ejection-fraction
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