Neuropsychological functioning in mid-life treatment-seeking adults with obesity: a cross-sectional study
Journal article
Prickett, Christina, Stolwyk, Renerus, O'Brien, Paul and Brennan, Leah. (2018). Neuropsychological functioning in mid-life treatment-seeking adults with obesity: a cross-sectional study. Obesity Surgery. 28(2), pp. 532 - 540. https://doi.org/10.1007/s11695-017-2894-0
Authors | Prickett, Christina, Stolwyk, Renerus, O'Brien, Paul and Brennan, Leah |
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Abstract | Objective: To compare cognitive functioning between treatment-seeking individuals with obesity and healthy-weight adults. Design and Methods: Sixty-nine bariatric surgery candidates (BMI>30kg/m2) and 65 healthy-weight control participants (BMI 18.5-25kg/m2) completed a neuropsychological battery and a self-report psychosocial questionnaire battery. Results: Hierarchical regression analyses indicated that obesity was predictive of poorer performance in the domains of psychomotor speed (p=.043), verbal learning (p<.001), verbal memory (p=.002), complex attention (p=.002), semantic verbal fluency (p=.009), working memory (p=.002), and concept formation and set-shifting (p=.003), independent of education. Obesity remained a significant predictor of performance in each of these domains, except verbal memory, following control for obesity-related comorbidities. Obesity was not predictive of visual construction, visual memory, phonemic verbal fluency or inhibition performance. Individuals with obesity also had significantly poorer decision making compared to healthy-weight controls. Conclusions: Findings support the contribution of obesity to selective aspects of mid-life cognition after controlling for obesity-related comorbidities, while addressing limitations of previous research including employment of an adequate sample, a healthy-weight control group, and stringent exclusion criteria. Further investigation into the functional impact of such deficits, the mechanisms underlying these poorer cognitive outcomes, and the impact of weight-loss on cognition is required. |
Keywords | Obesity; body mass index; cognition; bariatric surgery; executive function; CVD risk factors |
Year | 2018 |
Journal | Obesity Surgery |
Journal citation | 28 (2), pp. 532 - 540 |
ISSN | 0960-8923 |
Digital Object Identifier (DOI) | https://doi.org/10.1007/s11695-017-2894-0 |
Scopus EID | 2-s2.0-85028551194 |
Open access | Published as green open access |
Page range | 532 - 540 |
Research Group | Centre for Health and Social Research |
Author's accepted manuscript | License All rights reserved File Access Level Open |
Publisher's version | License All rights reserved File Access Level Controlled |
Grant ID | SPG077 |
Additional information | “This is a post-peer-review, pre-copyedit version of an article published in Obesity Surgery. The final authenticated version is available online at: http://dx.doi.org/10.1007/s11695-017-2894-0” |
https://acuresearchbank.acu.edu.au/item/86685/neuropsychological-functioning-in-mid-life-treatment-seeking-adults-with-obesity-a-cross-sectional-study
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AM_Prickett_2017_Neuropsychological_functioning_in_mid_life_treatment_seeking_adults.pdf | |
License: All rights reserved | |
File access level: Open |
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