Safety and efficacy of various combinations of injectable anaesthetics in BALB/c Mice

Journal article


Buitrago, Sandra, Martin, Thomas, Tetens-Woodring, Joanne, Belicha-Villanueva, Alan and Wilding, Gregory. (2008) Safety and efficacy of various combinations of injectable anaesthetics in BALB/c Mice. Journal of the American Association for Laboratory Animals. 47(1), pp. 11 - 17.
AuthorsBuitrago, Sandra, Martin, Thomas, Tetens-Woodring, Joanne, Belicha-Villanueva, Alan and Wilding, Gregory
Abstract

Four combinations of drugs—ketamine–xylazine, ketamine–xylazine–acepromazine (KXA), ketamine–xylazine–buprenorphine, and ketamine–xylazine–carprofen—were compared for their ability to produce anesthesia in BALB/c mice. Induction time, anesthetic duration, blood pressure, pulse rate, and time to recovery were recorded. The anesthesia induced by each anesthetic combination was assessed by using reflex responses to standardized stimuli. The KXA combination produced stable physiologic parameters and was associated with the longest duration of anesthesia (40 ± 8 min); immobility was produced in all other groups (38 ± 5 min), but a surgical plane of anesthesia could not be confirmed. All anesthetic protocols produced significant hypotension. No deaths occurred. We recommend KXA as a safe and reliable anesthetic for mice requiring a surgical plane of anesthesia.

Year2008
JournalJournal of the American Association for Laboratory Animals
Journal citation47 (1), pp. 11 - 17
PublisherAmerican Association for Laboratory Animal Science
ISSN1559-6109
PubMed ID18210992
Scopus EID2-s2.0-38749152483
Web address (URL)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2652618/
Page range11 - 17
Publisher's version
Place of publicationUnited States of Australia
Permalink -

https://acuresearchbank.acu.edu.au/item/866v9/safety-and-efficacy-of-various-combinations-of-injectable-anaesthetics-in-balb-c-mice

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