Self-reported confusion is related to global and regional ß-amyloid: data from the Women's healthy ageing project
Journal article
McCluskey, Georgia E., Yates, Patsy, Villemagne, Victor L., Rowe, Christopher C. and Szoeke, Cassandra. (2018). Self-reported confusion is related to global and regional ß-amyloid: data from the Women's healthy ageing project. Brain Imaging and Behavior: an international journal. 12(1), pp. 78 - 86. https://doi.org/10.1007/s11682-016-9668-5
| Authors | McCluskey, Georgia E., Yates, Patsy, Villemagne, Victor L., Rowe, Christopher C. and Szoeke, Cassandra |
|---|---|
| Abstract | Disease-modifying treatments for Alzheimer’s disease (AD) may require implementation during early stages of β-amyloid accumulation, well before patients have objective cognitive decline. In this study we aimed to assess the clinical value of subjective cognitive impairment (SCI) by examining the cross-sectional relationship between β-amyloid load and SCI. Cerebral β-amyloid and SCI was assessed in a cohort of 112 cognitively normal subjects. Subjective cognition was evaluated using specific questions on memory and cognition and the MAC-Q. Participants had cerebral β-amyloid load measured with 18F–Florbetaben Positron Emission Tomography (PET). No associations were found between measures of subjective memory impairment and cerebral β-amyloid. However, by self-reported confusion was predictive of a higher global β-amyloid burden (p = 0.002), after controlling for confounders. Regional analysis revealed significant associations of confusion with β-amyloid in the prefrontal region (p = 0.004), posterior cingulate and precuneus cortices (p = 0.004) and the lateral temporal lobes (p = 0.001) after controlling for confounders. An in vivo biomarker for AD pathology was associated with SCI by self-reported confusion on cross-sectional analysis. Whilst there has been a large body of research on SMC, our results indicate more research is needed to explore symptoms of confusion. |
| Keywords | Alzheimer’s disease; Subjective cognitive impairment; subjective memory; β-amyloid; PET imaging; confusion |
| Year | 2018 |
| Journal | Brain Imaging and Behavior: an international journal |
| Journal citation | 12 (1), pp. 78 - 86 |
| Publisher | Springer New York LLC |
| ISSN | 1931-7557 |
| Digital Object Identifier (DOI) | https://doi.org/10.1007/s11682-016-9668-5 |
| Scopus EID | 2-s2.0-85009914897 |
| Page range | 78 - 86 |
| Research Group | Institute for Health and Ageing |
| Publisher's version | File Access Level Controlled |
| Place of publication | United States |
| Editors | A. J. Saykin |
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