Time-varying effective connectivity of the cortical neuroelectric activity associated with behavioural microsleeps

Journal article


Toppi, Jlenia, Astolfi, Laura, Poudel, Govinda, H., Babiloni, Fabio, Jones, Richard and Innes, Carrie R. H.. (2016) Time-varying effective connectivity of the cortical neuroelectric activity associated with behavioural microsleeps. NeuroImage. 124, pp. 421 - 432. https://doi.org/10.1016/j.neuroimage.2015.08.059
AuthorsToppi, Jlenia, Astolfi, Laura, Poudel, Govinda, H., Babiloni, Fabio, Jones, Richard and Innes, Carrie R. H.
Abstract

An episode of complete failure to respond during an attentive task accompanied by behavioural signs of sleep is called a behavioural microsleep. We proposed a combination of high-resolution EEG and an advanced method for time-varying effective connectivity estimation for reconstructing the temporal evolution of the causal relations between cortical regions when microsleeps occur during a continuous visuomotor task. We found connectivity patterns involving left–right frontal, left–right parietal, and left-frontal/right-parietal connections commencing in the interval [− 500; − 250] ms prior to the onset of microsleeps and disappearing at the end of the microsleeps. Our results from global graph indices derived from effective connectivity analysis have revealed EEG-based biomarkers of all stages of microsleeps (preceding, onset, pre-recovery, recovery). In particular, this raises the possibility of being able to predict microsleeps in real-world tasks and initiate a ‘wake-up’ intervention to avert the microsleeps and, hence, prevent injurious and even multi-fatality accidents.

KeywordsBehavioural microsleeps; Effective connectivity; Graph theory; Time-varying connectivity; EEG
Year2016
JournalNeuroImage
Journal citation124, pp. 421 - 432
PublisherElsevier
ISSN1053-8119
Digital Object Identifier (DOI)https://doi.org/10.1016/j.neuroimage.2015.08.059
Scopus EID2-s2.0-84941985416
Page range421 - 432
Research GroupMary MacKillop Institute for Health Research
Publisher's version
File Access Level
Controlled
Place of publicationUnited States of America
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