Monotherapy with levetiracetam versus older AEDs: A randomized comparative trial of effects on bone health

Journal article


Hakami, Tahir, O'Brien, Terence J., Petty, Sandra J., Sakellarides, Mary, Christie, Jemma J., Kantor, Susan, Todaro, Marian, Gorelik, Alexandra, Seibel, Markus J., Yerra, Raju and Wark, John D.. (2016). Monotherapy with levetiracetam versus older AEDs: A randomized comparative trial of effects on bone health. Calcified Tissue International. 98(6), pp. 556 - 565. https://doi.org/10.1007/s00223-016-0109-7
AuthorsHakami, Tahir, O'Brien, Terence J., Petty, Sandra J., Sakellarides, Mary, Christie, Jemma J., Kantor, Susan, Todaro, Marian, Gorelik, Alexandra, Seibel, Markus J., Yerra, Raju and Wark, John D.
Abstract

Long-term anti-epileptic drug (AED) therapy is associated with increased fracture risk. This study tested whether substituting the newer AED levetiracetam has less adverse effects on bone than older AEDs. An open-label randomized comparative trial. Participants had “failed” initial monotherapy for partial epilepsy and were randomized to substitution monotherapy with levetiracetam or an older AED (carbamazepine or valproate sodium). Bone health assessments, performed at 3 and 15 months, included areal bone mineral density (aBMD) and content at lumbar spine (LS), total hip (TH), forearm (FA), and femoral neck (FN), radial and tibial peripheral quantitative computed tomography and serum bone turnover markers. Main outcomes were changes by treatment group in aBMD at LS, TH, and FA, radial and tibial trabecular BMD and cortical thickness. 70/84 patients completed assessments (40 in levetiracetam- and 30 in older AED group). Within-group analyses showed decreases in both groups in LS (−9.0 %; p < 0.001 in levetiracetam vs. −9.8 %; p < 0.001 in older AED group), FA (−1.46 %; p < 0.001 vs. −0.96 %; p < 0.001, respectively) and radial trabecular BMD (−1.46 %; p = 0.048 and −2.31 %; p = 0.013, respectively). C-terminal telopeptides of type I collagen (βCTX; bone resorption marker) decreased in both groups (−16.1 %; p = 0.021 vs. −15.2 %; p = 0.028, respectively) whereas procollagen Ι N-terminal peptide (PΙNP; bone formation marker) decreased in older AED group (−27.3 %; p = 0.008). The treatment groups did not differ in any of these measures. In conclusion, use of both levetiracetam and older AEDs was associated with bone loss over 1 year at clinically relevant fracture sites and a reduction in bone turnover.

Keywordsepilepsy; antiepileptic drugs; bone health
Year2016
JournalCalcified Tissue International
Journal citation98 (6), pp. 556 - 565
PublisherSpringer New York LLC
ISSN0171-967X
Digital Object Identifier (DOI)https://doi.org/10.1007/s00223-016-0109-7
Scopus EID2-s2.0-84957593840
Page range556 - 565
Publisher's version
File Access Level
Controlled
Place of publicationUnited States of America
Permalink -

https://acuresearchbank.acu.edu.au/item/86z7q/monotherapy-with-levetiracetam-versus-older-aeds-a-randomized-comparative-trial-of-effects-on-bone-health

Restricted files

Publisher's version

  • 107
    total views
  • 0
    total downloads
  • 0
    views this month
  • 0
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Clinical prediction tool to identify adults with type 2 diabetes at risk for persistent adverse glycemia in hospital
Kyi, Mervyn, Gorelik, Alexandra, Reid, Jane, Rowan, Lois M., Paul R. Wraight, Peter G. Colman and Spiros Fourlanos. (2021). Clinical prediction tool to identify adults with type 2 diabetes at risk for persistent adverse glycemia in hospital. Canadian Journal of Diabetes. 45(2), pp. 114-121.e3. https://doi.org/10.1016/j.jcjd.2020.06.006
Exploring the facilitators and barriers to using an online infertility risk prediction tool (FoRECAsT) for young women with breast cancer: A qualitative study protocol
Zobaida Edib, Yasmin L. Jayasinghe, Martha Hickey, Lesley Stafford, Richard A. Anderson, H. Irene Su, Kate Stern, Christobel Saunders, Antoinette C. Anazodo, Mary MacHeras-Magias, Shanton Chang, Patrick Pang, Franca Agresta, Chin-Lenn, Wanyuan Cui, Sarah Pratt, Alex Gorelik and Michelle Peate. (2020). Exploring the facilitators and barriers to using an online infertility risk prediction tool (FoRECAsT) for young women with breast cancer: A qualitative study protocol. BMJ Open. 10(2), pp. 1-7. https://doi.org/10.1136/bmjopen-2019-033669
Quantifying use of a health virtual community of practice for general practitioners' continuing professional development : A novel methodology and pilot evaluation
Murad, Abdulaziz, Hyde, Natalie, Chang, Shanton, Lederman, Reeva, Bosua, Rachelle, Pirotta, Marie, Audehm, Ralph, Yates, Christopher J., Briggs, Andrew M., Gorelik, Alexandra, Chiang, Cherie and Wark, John D.. (2019). Quantifying use of a health virtual community of practice for general practitioners' continuing professional development : A novel methodology and pilot evaluation. Journal of Medical Internet Research. 21(11), p. e14545. https://doi.org/10.2196/14545
Using mobile technology to improve bone-related lifestyle risk factors in young women with low bone mineral density : Feasibility randomized controlled trial
Subasinghe, Asvini Kokila, Garland, Suzanne Marie, Gorelik, Alexandra, Tay, Ilona and Wark, John Dennis. (2019). Using mobile technology to improve bone-related lifestyle risk factors in young women with low bone mineral density : Feasibility randomized controlled trial. Journal of Medical Internet Research Formative Research. 3(1), p. e9435. https://doi.org/10.2196/formative.9435
Practice patterns in parathyroid surgery : A survey of asia-pacific parathyroid surgeons
Chen, Rufi, Oh, Han Boon, Parameswaran, Rajeev, Gorelik, Alexandra and Miller, Julie A.. (2019). Practice patterns in parathyroid surgery : A survey of asia-pacific parathyroid surgeons. World Journal of Surgery. 43(8), pp. 1964-1971. https://doi.org/10.1007/s00268-019-04990-4
Early intervention for diabetes in medical and surgical inpatients decreases hyperglycemia and hospital-acquired infections : A cluster randomized trial
Kyi, Mervyn, Colman, Peter G., Wraight, Paul R., Reid, Jane, Gorelik, A., Gorelik, Alexandra, GalligaKumar, Shanaln, Anna, Rowan, Lois M., Marley, Katie A., Nankervis, Alison J., Russell, David M. and Fourlanos, Spiros. (2019). Early intervention for diabetes in medical and surgical inpatients decreases hyperglycemia and hospital-acquired infections : A cluster randomized trial. Diabetes Care. 45(5), pp. 832-840. https://doi.org/10.2337/dc18-2342
Diet and biomarkers of Alzheimer's disease : A systematic review and meta-analysis
Hill, Edward, Goodwill, Alicia M., Gorelik, Alexandra and Szoeke, Cassandra. (2019). Diet and biomarkers of Alzheimer's disease : A systematic review and meta-analysis. Neurobiology of Aging. 76, pp. 45-52. https://doi.org/10.1016/j.neurobiolaging.2018.12.008
Preoperative staging by EBUS in cN0/N1 lung cancer: Systematic review and meta-analysis
Leong, Tracy L., Loveland, Paula M., Gorelik, Alexandra, Irving, Louis and Steinfort, Daniel P.. (2019). Preoperative staging by EBUS in cN0/N1 lung cancer: Systematic review and meta-analysis. Journal of Bronchology & Interventional Pulmonology. 26(3), pp. 155 - 165. https://doi.org/10.1097/LBR.0000000000000545
Robust norms for neuropsychological tests of verbal episodic memory in Australian women
Goodwill, Alicia, Campbell, Stephen, Henderson, Victor W., Gorelik, Alexandra, Dennerstein, Lorraine, McClung, Michael and Szoeke, Cassandra. (2019). Robust norms for neuropsychological tests of verbal episodic memory in Australian women. Neuropsychology. 33(4), pp. 581 - 595. https://doi.org/10.1037/neu0000522
The projected burden of primary total knee and hip replacement for osteoarthritis in Australia to the year 2030
Ackerman, Ilana N., Bohensky, Megan A., Zomer, Ella, Tacey, Mark, Gorelik, Alexandra, Brand, Caroline A. and de Steiger, Richard. (2019). The projected burden of primary total knee and hip replacement for osteoarthritis in Australia to the year 2030. BMC Musculoskeletal Disorders. 20(1), pp. 1 - 10. https://doi.org/10.1186/s12891-019-2411-9
Apolipoprotein E4 mediates the association between midlife dyslipidemia and cerebral amyloid in aging women
Szoeke, Cassandra, Goodwill, Alicia M., Gorelik, Alexandra, Dennerstein, Lorraine, Caeyenberghs, Karen, Simpson, Steve, Hill, Edward and Campbell, Stephen. (2019). Apolipoprotein E4 mediates the association between midlife dyslipidemia and cerebral amyloid in aging women. Journal of Alzheimer's Disease. 68(1), pp. 105 - 114. https://doi.org/10.3233/JAD-180815
Assessment of bronchoscopic dexterity and procedural competency in a low-fidelity simulation model
Steinfort, Daniel P., Yong, Yi Heng, Byrne, Timothy, Gorelik, Alexandra, Colt, Henri and Irving, Louis B.. (2018). Assessment of bronchoscopic dexterity and procedural competency in a low-fidelity simulation model. Journal of Bronchology & Interventional Pulmonology. 25(3), pp. 198-203. https://doi.org/10.1097/LBR.0000000000000481
Predicting response after infliximab salvage in acute severe ulcerative colitis
Matthew C Choy, Dean Seah, Alexandra Gorelik, Yoon-Kyo An, Cheng-Yu Chen, Finlay A Macrae, Miles P Sparrow, William R. Connell, Gregory T Moore, Graham Radford-Smith, Daniel R Van Langenberg and Peter De Cruz. (2018). Predicting response after infliximab salvage in acute severe ulcerative colitis. Journal of Gastroenterology and Hepatology. 33(7), pp. 1347-1352. https://doi.org/10.1111/jgh.14072
Associations between 25-hydroxyvitamin D levels, body composition and metabolic profiles in young women
Marjan Tabesh, Emma T. Callegari, Alexandra Gorelik, Suzanne Garland, Alison Nankervis, Asvini K. Subasinghe and John Wark. (2018). Associations between 25-hydroxyvitamin D levels, body composition and metabolic profiles in young women. European Journal of Clinical Nutrition. 72(8), pp. 1093-1102. https://doi.org/10.1038/s41430-018-0086-1
Determinants of bone mineral density in young Australian women: Results from the Safe-D study
Callegari, Emma T., Garland, Suzanne M., Gorelik, Alex and Wark, John D.. (2017). Determinants of bone mineral density in young Australian women: Results from the Safe-D study. Osteoporosis International. 28(9), pp. 2619 - 2631. https://doi.org/10.1007/s00198-017-4100-6
Serum 25-hydroxyvitamin D and mental health in young Australian women: Results from the Safe-D study
Callegari, Emma T., Reavley, Nicola J., Gorelik, Alexandra, Garland, Suzanne M. and Wark, John D.. (2017). Serum 25-hydroxyvitamin D and mental health in young Australian women: Results from the Safe-D study. Journal of Affective Disorders. 224, pp. 48 - 55. https://doi.org/10.1016/j.jad.2016.10.002
Targeted ultrasound of the liver: Impact on scanning time of a new approach in chronic liver disease
Harris, Nicole, Gorelik, Alexandra and Gibson, Robert N.. (2017). Targeted ultrasound of the liver: Impact on scanning time of a new approach in chronic liver disease. Journal of Medical Imaging and Radiation Oncology. 61(4), pp. 448 - 452. https://doi.org/10.1111/1754-9485.12595
The impact of telephone-delivered cognitive behaviour therapy and befriending on mood disorders in people with chronic obstructive pulmonary disease: A randomized controlled trial
Doyle, Colleen, Bhar, Sunil, Fearn, Marcia, Ames, David, Osborne, Debra, You, Emily, Gorelik, Alex and Dunt, David. (2017). The impact of telephone-delivered cognitive behaviour therapy and befriending on mood disorders in people with chronic obstructive pulmonary disease: A randomized controlled trial. British Journal of Health Psychology. 22(3), pp. 542 - 556. https://doi.org/10.1111/bjhp.12245
Effectiveness of cognitive behavioural therapy in a community-based pulmonary rehabilitation programme: A controlled clinical trial
Luk, Edwin K., Gorelik, Alex, Irving, Louis and Khan, Fary. (2017). Effectiveness of cognitive behavioural therapy in a community-based pulmonary rehabilitation programme: A controlled clinical trial. Journal of Rehabilitation Medicine. 49(3), pp. 264 - 269. https://doi.org/10.2340/16501977-2189
Selective prophylactic calcium supplementation reduces length of stay after total thyroidectomy
Osborne, Jake, Papachristos, Alexander, Skandarajah, Anita, Gorelik, Alexandra, Hng, Daniel and Miller, Julie A.. (2017). Selective prophylactic calcium supplementation reduces length of stay after total thyroidectomy. World Journal of Endocrine Surgery. 9(3), pp. 88 - 93. https://doi.org/10.5005/jp-journals-10002-1218
Bone loss with antiepileptic drug therapy: A twin and sibling study
Ahmad, B. Shiek, Petty, Sandra J., Gorelik, Alex, O'Brien, Terence J., Hill, K. D., Christie, J. J., Sambrook, Philip N. and Wark, John D.. (2017). Bone loss with antiepileptic drug therapy: A twin and sibling study. Osteoporosis International. 28(9), pp. 2591 - 2600. https://doi.org/10.1007/s00198-017-4098-9
Prognostic limitations of donor t cell chimerism after myeloablative allogeneic stem cell transplantation for acute myeloid leukemia and myelodysplastic syndromes
Wong, Eric, Mason, Kate, Collins, Jenny, Hockridge, Barbara, Boyd, Janis, Gorelik, Alexandra, Szer, Jeffrey and Ritchie, David S.. (2017). Prognostic limitations of donor t cell chimerism after myeloablative allogeneic stem cell transplantation for acute myeloid leukemia and myelodysplastic syndromes. Biology of Blood and Marrow Transplantation. 23(5), pp. 840 - 844. https://doi.org/10.1016/j.bbmt.2017.01.086
Impaired bone and muscle development in young people treated with antiepileptic drugs
Simm, Peter J., Seah, Sebastian, Gorelik, Alex, Gilbert, Lauren, Nuguid, Jenning, Werther, George A., Mackay, Mark T., Freeman, Jeremy L., Petty, Sandra J. and Wark, John D.. (2017). Impaired bone and muscle development in young people treated with antiepileptic drugs. Epilepsia. 58(11), pp. 1931 - 1938. https://doi.org/10.1111/epi.13893
Venous thromboembolism management practices and knowledge of guidelines: A survey of Australian haematologists and respiratory physicians
Wallace, Rory, Anderson, Mary-Ann, See, Katharine, Gorelik, Alexandra, Irving, Louis and Manser, Renee. (2017). Venous thromboembolism management practices and knowledge of guidelines: A survey of Australian haematologists and respiratory physicians. Internal Medicine Journal. 47(4), pp. 436 - 446. https://doi.org/10.1111/imj.13382
Health care costs associated with Australian tertiary inflammatory bowel disease care
Jackson, Belinda, Con, Danny, Ma, Ronald, Gorelik, Alexandra, Liew, Danny and De Cruz, Peter. (2017). Health care costs associated with Australian tertiary inflammatory bowel disease care. Scandinavian Journal of Gastroenterology. 52(8), pp. 851 - 856. https://doi.org/10.1080/00365521.2017.1323117
Poorer outcomes and greater healthcare costs for hospitalised older people with dementia and delirium: A retrospective cohort study
Tropea, Joanne, LoGiudice, Dina, Liew, Danny, Gorelik, Alexandra and Brand, Caroline. (2017). Poorer outcomes and greater healthcare costs for hospitalised older people with dementia and delirium: A retrospective cohort study. International Journal of Geriatric Psychiatry. 32(5), pp. 539 - 547. https://doi.org/10.1002/gps.4491
Clinicopathological features and outcomes of progression of CLL on the BCL2 inhibitor venetoclax
Anderson, Mary Ann, Tam, Constantine, Lew, Thomas E., Juneja, Surender, Juneja, Manu, Westerman, David, Wall, Meaghan, Lade, Stephen, Gorelik, Alex, Huang, David C. S., Seymour, John F. and Roberts, Andrew W.. (2017). Clinicopathological features and outcomes of progression of CLL on the BCL2 inhibitor venetoclax. Blood. 129(25), pp. 3362 - 3370. https://doi.org/10.1182/blood-2017-01-763003
Supporting insulin initiation in type 2 diabetes in primary care: Results of the stepping up pragmatic cluster randomised controlled clinical trial
Furler, John, O'Neal, David, Speight, Jane, Manski-Nankervis, Jo-Anne, Gorelik, Alex, Holmes-Truscott, Elizabeth, Ginnivan, Louise, Young, Doris, Best, James D., Patterson, Elizabeth, Liew, Danny, Segal, Leonie, May, Clive N. and Blackberry, Irene. (2017). Supporting insulin initiation in type 2 diabetes in primary care: Results of the stepping up pragmatic cluster randomised controlled clinical trial. BMJ: British Medical Journal. 356, pp. 1 - 10. https://doi.org/10.1136/bmj.j783
The association between inflammation, obesity and elevated blood pressure in 16-25-year-old females
Subasinghe, Asvini K., Wark, John D., Gorelik, Alexandra, Callegari, Emma T. and Garland, S. M.. (2017). The association between inflammation, obesity and elevated blood pressure in 16-25-year-old females. Journal of Human Hypertension. 31(9), pp. 580 - 584. https://doi.org/10.1038/jhh.2017.33
Cohort study of Gorlin syndrome with emphasis on standardised phenotyping and quality of life assessment
Huq, Aamira J., Bogwitz, Michael, Gorelik, Alexandra, Winship, Ingrid M., White, Susan M. and Trainer, Alison H.. (2017). Cohort study of Gorlin syndrome with emphasis on standardised phenotyping and quality of life assessment. Internal Medicine Journal. 47(6), pp. 664 - 673. https://doi.org/10.1111/imj.13429
Junior doctors’ attitudes to opioids for refractory breathlessness in patients with advanced chronic obstructive pulmonary disease
Smallwood, Natasha, Gaffney, Nicole, Gorelik, Alexandra, Irving, Louis, Le, Brian and Philip, Jennifer. (2017). Junior doctors’ attitudes to opioids for refractory breathlessness in patients with advanced chronic obstructive pulmonary disease. Internal Medicine Journal. 47(9), pp. 1050 - 1056. https://doi.org/10.1111/imj.13521
MRI assessment of calf injuries in Australian Football League players: Findings that influence return to play
Waterworth, George, Wein, Sara, Gorelik, Alexandra and Rotstein, Andrew H.. (2017). MRI assessment of calf injuries in Australian Football League players: Findings that influence return to play. Skeletal Radiology. 46(3), pp. 343 - 350. https://doi.org/10.1007/s00256-016-2564-7
Predictors and correlates of serum 25-hydroxyvitamin D concentrations in young women: Results from the Safe-D study
Callegari, Emma T., Garland, Suzanne M., Gorelik, Alexandra, Reavley, Nicola J. and Wark, John D.. (2017). Predictors and correlates of serum 25-hydroxyvitamin D concentrations in young women: Results from the Safe-D study. The British Journal of Nutrition. 118(4), pp. 263 - 272. https://doi.org/10.1017/S0007114517002021
Serologic antibodies in relation to outcome in postoperative Crohn's disease
Hamilton, Amy L., Kamm, Michael A., De Cruz, Peter, Wright, Emily K., Selvaraj, Fabiyola, Princen, Fred, Gorelik, Alexandra, Liew, Danny, Lawrance, Ian C., Andrews, Jane M., Bampton, Peter A., Sparrow, Miles P., Florin, Timothy H., Gibson, Peter R., Debinski, Henry, Gearry, Richard B., Macrae, Finlay A., Leong, Rupert W., Kronborg, Ian, ... Connell, William R.. (2017). Serologic antibodies in relation to outcome in postoperative Crohn's disease. Journal of Gastroenterology and Hepatology. 32(6), pp. 1195 - 1203. https://doi.org/10.1111/jgh.13677
Impact of introduction of an acute surgical unit on management and outcomes of small bowel obstruction
Musiienko, Anton M., Shakerian, Rose, Gorelik, Alexandra, Thomson, Benjamin N. J. and Skandarajah, Anita R.. (2016). Impact of introduction of an acute surgical unit on management and outcomes of small bowel obstruction. ANZ Journal of Surgery. 86(10), pp. 831 - 835. https://doi.org/10.1111/ans.13238
Impact of insulin initiation on glycaemic variability and glucose profiles in a primary healthcare Type 2 diabetes cohort: Analysis of continuous glucose monitoring data from the INITIATION study
Manski-Nankervis, Jo-Anne, Yates, Christopher J., Blackberry, Irene, Furler, John, Ginnivan, Louise, Cohen, N., Jenkins, Alicia J., Vasanthakumar, S., Gorelik, Alexandra, Young, Doris, Best, James D. and O'Neal, David. (2016). Impact of insulin initiation on glycaemic variability and glucose profiles in a primary healthcare Type 2 diabetes cohort: Analysis of continuous glucose monitoring data from the INITIATION study. Diabetic Medicine. 33(6), pp. 803 - 811. https://doi.org/10.1111/dme.12979
Acoustic radiation force impulse accuracy and the impact of hepatic steatosis on liver fibrosis staging
Harris, Nicole, Nadebaum, David P., Christie, Michael, Gorelik, Alexandra, Nicoll, Amanda J., Sood, Siddharth and Gibson, Robert N.. (2016). Acoustic radiation force impulse accuracy and the impact of hepatic steatosis on liver fibrosis staging. Journal of Medical Imaging and Radiation Oncology. 60(5), pp. 587 - 592. https://doi.org/10.1111/1754-9485.12482
Macrophage activation marker soluble CD163 may predict disease progression in hepatocellular carcinoma
Kazankov, Konstantin, Rode, Anthony, Simonsen, Kira, Villadsen, Gerda Elisabeth, Nicoll, Amanda J., Møller, Holger Jon, Lim, Lucy, Angus, Peter, Kronborg, Ian, Arachchi, Niranjan, Gorelik, Alexandra, Liew, Danny, Vilstrup, Hendrik, Frystyk, Jan and Grønbæk, Henning. (2016). Macrophage activation marker soluble CD163 may predict disease progression in hepatocellular carcinoma. Scandinavian Journal of Clinical and Laboratory Investigation. 76(1), pp. 64 - 73. https://doi.org/10.3109/00365513.2015.1099722
Clinicians' attitude towards changes in Australian National Cervical Screening Program
Yap, Desiree, Liang, Xinyu, Garland, Suzanne M., Hartley, Stefanie, Gorelik, Alexandra, Ogilvie, Gina, Tan, Jeffrey, Wrede, C. David H. and Jayasinghe, Yasmin L.. (2016). Clinicians' attitude towards changes in Australian National Cervical Screening Program. Journal of Clinical Virology. 76, pp. S81 - S87. https://doi.org/10.1016/j.jcv.2015.11.018
Circulating CD147 predicts mortality in advanced hepatocellular carcinoma
Lee, Aimei, Rode, Anthony, Nicoll, Amanda J., Maczurek, Annette E., Lim, Lucy, Lim, Seok, Angus, Peter, Kronborg, Ian, Arachchi, Niranjan, Gorelik, Alexandra, Liew, Danny, Warner, Fiona J., Mccaughan, Geoffrey W., Mclennan, Susan V. and Shackel, Nicholas A.. (2016). Circulating CD147 predicts mortality in advanced hepatocellular carcinoma. Journal of Gastroenterology and Hepatology. 31(2), pp. 459 - 466. https://doi.org/10.1111/jgh.13148
Comparison of fecal inflammatory markers in Crohn's disease
Wright, Emily K., Kamm, Michael A., De Cruz, Peter, Hamilton, Amy L., Ritchie, Kathryn J., Keenan, Jacqueline I., Leach, Steven, Burgess, Laura, Aitchison, Alan, Gorelik, Alexandra, Liew, Danny, Day, Andrew S. and Gearry, Richard B.. (2016). Comparison of fecal inflammatory markers in Crohn's disease. Inflammatory Bowel Diseases. 22(5), pp. 1086 - 1094. https://doi.org/10.1097/MIB.0000000000000671
A cost-effectiveness analysis of nivolumab compared with ipilimumab for the treatment of BRAF wild-type advanced melanoma in Australia
Bohensky, Megan A., Pasupathi, Kumar, Gorelik, Alexandra, Kim, Hansoo, Harrison, James P. and Liew, Danny. (2016). A cost-effectiveness analysis of nivolumab compared with ipilimumab for the treatment of BRAF wild-type advanced melanoma in Australia. Value in Health. 19(8), pp. 1009 - 1015. https://doi.org/10.1016/j.jval.2016.05.013
Management of early node‐positive breast cancer in Australia: A multicentre study
Gannan, Emma, Khoo, Jeremy, Nightingale, Sophie, Suhardja, Thomas Surya, Lippey, Jocelyn, Keane, Holly, Tan, Kian Jin, Clouston, David, Gorelik, Alexandra and Mann, Gregory Bruce. (2016). Management of early node‐positive breast cancer in Australia: A multicentre study. The Breast Journal. 22(4), pp. 413 - 419. https://doi.org/10.1111/tbj.12595
Primary HPV DNA based cervical cancer screening at 25 years: Views of young Australian women aged 16-28 years
Jayasinghe, Yasmin L., Rangiah, Cheryl, Gorelik, Alexandra, Ogilvie, Gina, Wark, John D., Hartley, Stefanie and Garland, Suzanne M.. (2016). Primary HPV DNA based cervical cancer screening at 25 years: Views of young Australian women aged 16-28 years. Journal of Clinical Virology. 76, pp. S74 - S80. https://doi.org/10.1016/j.jcv.2015.10.026
Carbetocin versus oxytocin to reduce additional uterotonic use at non-elective caesarean section: A double-blind, randomised trial*
Whigham, Carole-Anne, Gorelik, Alexandra, Loughnan, Terrence E. and Trivedi, Amar. (2016). Carbetocin versus oxytocin to reduce additional uterotonic use at non-elective caesarean section: A double-blind, randomised trial*. The Journal of Maternal-Fetal and Neonatal Medicine. 29(23), pp. 3866 - 3869. https://doi.org/10.3109/14767058.2016.1149564
Hurt feelings in women: The interaction of social and individual difference factors
Burchell, Jodie L., Gorelik, Alexandra and Wilkinson, Ross B.. (2016). Hurt feelings in women: The interaction of social and individual difference factors. Journal of Relationships Research. 7(e1), pp. 1 - 14. https://doi.org/10.1017/jrr.2015.12
Changes in balance function with chronic antiepileptic drug therapy: A twin and sibling study
Ahmad, Baemisla Shiek, Wark, John D., Petty, Sandra J., O'Brien, Terence J., Gorelik, Alexandra, Sambrook, Philip N. and Hill, Keith D.. (2015). Changes in balance function with chronic antiepileptic drug therapy: A twin and sibling study. Epilepsia. 56(11), pp. 1714 - 1722. https://doi.org/10.1111/epi.13136
Outcomes in emergency general surgery following the introduction of a consultant-led unit
Shakerian, Rose, Thomson, Benjamin N. J., Gorelik, Alexandra, Hayes, I. P. and Skandarajah, Anita R.. (2015). Outcomes in emergency general surgery following the introduction of a consultant-led unit. British Journal of Surgery. 102(13), pp. 1726 - 1732. https://doi.org/10.1002/bjs.9954
Effect of intestinal resection on quality of life in Crohn's disease
Wright, Emily K., Kamm, Michael A., De Cruz, Peter, Hamilton, Amy L., Ritchie, Kathryn J., Krejany, Efrosinia O., Gorelik, Alexandra, Liew, Danny, Prideaux, Lani, Lawrance, Ian C., Andrews, Jane M., Bampton, Peter A., Sparrow, Miles P., Florin, Timothy H., Gibson, Peter R., Debinski, Henry, Gearry, Richard B., Macrae, Finlay A., Leong, Rupert W., ... Desmond, Paul V.. (2015). Effect of intestinal resection on quality of life in Crohn's disease. Journal of Crohn's and Colitis. 9(6), pp. 452 - 462. https://doi.org/10.1093/ecco-jcc/jjv058
Measurement of fecal calprotectin improves monitoring and detection of recurrence of Crohn's disease after surgery
Wright, Emily K., Kamm, Michael A., De Cruz, Peter, Hamilton, Amy L., Ritchie, Kathryn J., Krejany, Efrosinia O., Leach, Steven, Gorelik, Alexandra, Liew, Danny, Prideaux, Lani, Lawrance, Ian C., Andrews, Jane M., Bampton, Peter A., Jakobovits, Simon L., Florin, Timothy H., Gibson, Peter R., Debinski, Henry, Macrae, Finlay A., Samuel, Douglas, ... Gearry, Richard B.. (2015). Measurement of fecal calprotectin improves monitoring and detection of recurrence of Crohn's disease after surgery. Gastroenterology. 148(5), pp. 938 - 947. https://doi.org/10.1053/j.gastro.2015.01.026
Efficacy of thiopurines and adalimumab in preventing Crohn's disease recurrence in high-risk patients - A POCER study analysis
De Cruz, Peter, Kamm, Michael A., Hamilton, Amy L., Ritchie, Kathryn J., Krejany, E. O., Gorelik, Alexandra, Liew, Danny, Prideaux, Lani, Lawrance, Ian C., Andrews, Jane M., Bampton, Peter A., Jakobovits, Simon L., Florin, Timothy H., Gibson, Peter R., Debinski, Henry, Gearry, Richard B., Macrae, Finlay A., Leong, Rupert W., Kronborg, Ian, ... Desmond, P. V.. (2015). Efficacy of thiopurines and adalimumab in preventing Crohn's disease recurrence in high-risk patients - A POCER study analysis. Alimentary Pharmacology and Therapeutics. 42(7), pp. 867 - 879. https://doi.org/10.1111/apt.13353
Emergency management of gallbladder disease: Are acute surgical units the new gold standard?
Shakerian, Rose, Skandarajah, Anita, Gorelik, Alexandra and Thomson, Benjamin N. J.. (2015). Emergency management of gallbladder disease: Are acute surgical units the new gold standard? World Journal of Surgery. 39(11), pp. 2636 - 2640. https://doi.org/10.1007/s00268-015-3196-0
Crohn's disease management after intestinal resection: A randomised trial
De Cruz, Peter, Kamm, Michael A., Hamilton, Amy L., Ritchie, Kathryn J., Krejany, Efrosinia O., Gorelik, Alexandra, Liew, Danny, Prideaux, Lani, Lawrance, Ian C., Andrews, Jane M., Bampton, Peter A., Gibson, Peter R., Sparrow, Miles P., Leong, Rupert W., Florin, Timothy H., Gearry, Richard B., Radford-Smith, Graham, Macrae, Finlay A., Debinski, Henry, ... Desmond, Paul V.. (2015). Crohn's disease management after intestinal resection: A randomised trial. The Lancet. 385(9976), pp. 1406 - 1417. https://doi.org/10.1016/S0140-6736(14)61908-5
Posterior retroperitoneoscopic adrenalectomy: Outcomes and lessons learned from initial 50 cases
Cabalag, Miguel S., Mann, G. Bruce, Gorelik, Alexandra and Miller, Julie A.. (2015). Posterior retroperitoneoscopic adrenalectomy: Outcomes and lessons learned from initial 50 cases. ANZ Journal of Surgery. 85(6), pp. 478 - 482. https://doi.org/10.1111/ans.12508
Clinical feasibility of interactive motion-controlled games for stroke rehabilitation
Bower, Kelly, Louie, Julie, Landesrocha, Yoesph, Seedy, Paul, Gorelik, Alexandra and Bernhardt, Julie. (2015). Clinical feasibility of interactive motion-controlled games for stroke rehabilitation. Journal of NeuroEngineering and Rehabilitation (online). 12, pp. 1 - 12. https://doi.org/10.1186/s12984-015-0057-x
Physical therapists as primary practitioners in the emergency department: Six-month prospective practice analysis
de Gruchy, Adam, Granger, Catherine L. and Gorelik, Alexandra. (2015). Physical therapists as primary practitioners in the emergency department: Six-month prospective practice analysis. Physical Therapy. 95(9), pp. 1207 - 1216. https://doi.org/10.2522/ptj.20130552
Obesity is associated with retinopathy and macrovascular disease in type 1 diabetes
Price, Sarah A., Gorelik, Alexandra, Fourlanos, Spiros, Colman, Peter G. and Wentworth, John M.. (2014). Obesity is associated with retinopathy and macrovascular disease in type 1 diabetes. Obesity Research and Clinical Practice. 8(2), pp. e178 - e182. https://doi.org/10.1016/j.orcp.2013.03.007
IDH1 mutation is associated with seizures and protoplasmic subtype in patients with low-grade gliomas
Liubinas, Simon V., D'Abaco, Giovanna M., Moffat, Bradford M., Gonzales, Michael, Feleppa, Frank, Nowell, Cameron J., Gorelik, Alexandra, Drummond, Katharine J., O'Brien, Terence J., Kaye, Andrew H. and Morokoff, Andrew P.. (2014). IDH1 mutation is associated with seizures and protoplasmic subtype in patients with low-grade gliomas. Epilepsia. 55(9), pp. 1438 - 1443. https://doi.org/10.1111/epi.12662
Lifetime risk of total knee replacement and temporal trends in incidence by health care setting, socioeconomic status, and geographic location
Bohensky, Megan A., Ackerman, Ilana, Desteiger, Richard, Gorelik, Alexandra and Brand, Caroline A.. (2014). Lifetime risk of total knee replacement and temporal trends in incidence by health care setting, socioeconomic status, and geographic location. Arthritis Care and Research. 66(3), pp. 424 - 431. https://doi.org/10.1002/acr.22122
Lifetime risk of total hip replacement surgery and temporal trends in utilization: A population-based analysis
Bohensky, Megan A., Ackerman, Ilana, De Steiger, Richard, Gorelik, Alexandra and Brand, Caroline A.. (2014). Lifetime risk of total hip replacement surgery and temporal trends in utilization: A population-based analysis. Arthritis Care and Research. 66(8), pp. 1213 - 1219. https://doi.org/10.1002/acr.22279
Outcomes of ambulatory rehabilitation programmes following botulinum toxin for spas ticity in adults with stroke
Demetrios, Marina, Gorelik, Alexandra, Louie, Julie, Brand, Caroline A., Baguley, Ian J. and Khan, Fary. (2014). Outcomes of ambulatory rehabilitation programmes following botulinum toxin for spas ticity in adults with stroke. Journal of Rehabilitation Medicine. 46(8), pp. 730 - 737. https://doi.org/10.2340/16501977-1842
Drug-induced hepatotoxicity: Incidence of abnormal liver function tests consistent with volatile anaesthetic hepatitis in trauma patients
Lin, Jonathan, Moore, David, Hockey, Brad, Di Lernia, Rachel, Gorelik, Alexandra, Liew, Danny and Nicoll, Amanda J.. (2014). Drug-induced hepatotoxicity: Incidence of abnormal liver function tests consistent with volatile anaesthetic hepatitis in trauma patients. Liver International. 34(4), pp. 576 - 582. https://doi.org/10.1111/liv.12278
Predictors of health care use among patients with or at high risk of atherothrombotic disease: Two-year follow-up data
Ademi, Zanfina, Liew, Danny, Gorelik, Alexandra, Bohensky, Megan A., Zomer, Ella, Hollingsworth, Bruce, Steg, Gabriel, Bhatt, Deepak L. and Reid, Christopher M.. (2014). Predictors of health care use among patients with or at high risk of atherothrombotic disease: Two-year follow-up data. International Journal of Cardiology. 175(1), pp. 72 - 77. https://doi.org/10.1016/j.ijcard.2014.04.230
Long term follow-up after aortic valve replacement (Ross Procedure): Echocardiographic determinants of ventricular recovery
Wilson, William M., Grigg, Leeanne E., Gorelik, Alexandra and Skillington, Peter. (2014). Long term follow-up after aortic valve replacement (Ross Procedure): Echocardiographic determinants of ventricular recovery. Heart, Lung and Circulation. 23(2), pp. 132 - 143. https://doi.org/10.1016/j.hlc.2013.07.008
Geographical variation in incidence of knee arthroscopy for patients with osteoarthritis: A population-based analysis of Victorian hospital separations data
Bohensky, Megan A., Barker, Anna, Morello, Renata Teresa, De Steiger, Richard N., Gorelik, Alexandra and Brand, Caroline A.. (2014). Geographical variation in incidence of knee arthroscopy for patients with osteoarthritis: A population-based analysis of Victorian hospital separations data. Internal Medicine Journal. 44(6), pp. 537 - 545. https://doi.org/10.1111/imj.12438
Thyroid surgery and anticoagulation: Survey of practice of endocrine surgeons in Australia
Verma, Kunal Pradip, Gorelik, Alexandra and Miller, Julie A.. (2013). Thyroid surgery and anticoagulation: Survey of practice of endocrine surgeons in Australia. World Journal of Endocrine Surgery. 5(1), pp. 6 - 11. https://doi.org/10.5005/jp-journals-10002-1115
Primary angiitis of the central nervous system: Experience of a Victorian tertiary-referral hospital
Oon, S., Roberts, Carol, Gorelik, Alexandra, Wicks, I. and Brand, Caroline A.. (2013). Primary angiitis of the central nervous system: Experience of a Victorian tertiary-referral hospital. Internal Medicine Journal. 43(6), pp. 685 - 692. https://doi.org/10.1111/imj.12038
Outcomes and excess costs among patients with cardiovascular disease
Ademi, Zanfina, Liew, Danny, Zomer, Ella, Gorelik, Alexandra, Hollingsworth, Bruce, Steg, Philippe Gabriel, Bhatt, Deepak L. and Reid, Christopher M.. (2013). Outcomes and excess costs among patients with cardiovascular disease. Heart, Lung and Circulation. 22(9), pp. 724 - 730. https://doi.org/10.1016/j.hlc.2013.02.002
Epidemiology of hepatitis B-associated hepatocellular carcinoma in Victoria
Sinclair, M., Roberts, S., Kemp, W., Knight, V., Dev, A., Gow, P., Philpott, H., Kronborg, Ian, Arachchi, Niranjan J., Bell, Sally J., Lim, Lucy, Gorelik, Alexandra and Nicoll, Amanda J.. (2013). Epidemiology of hepatitis B-associated hepatocellular carcinoma in Victoria. Internal Medicine Journal. 43(5), pp. 501 - 506. https://doi.org/10.1111/imj.12068
Who, why and when: Stroke care unit patients seen by a palliative care service within a large metropolitan teaching hospital
Eastman, Peter, McCarthy, Gillian, Brand, Caroline A., Weir, Louise, Gorelik, Alexandra and Le, Brian. (2013). Who, why and when: Stroke care unit patients seen by a palliative care service within a large metropolitan teaching hospital. BMJ Supportive and Palliative Care. 3(1), pp. 77 - 83. https://doi.org/10.1136/bmjspcare-2012-000331