Cardiorespiratory fitness and cardiovascular burden in chronic kidney disease

Journal article


Howden, Erin, Weston, Kassia S., Leano, Rodel, Sharman, James E., Marwick, Thomas, Isbel, Nicole and Coombes, Jeff S.. (2015). Cardiorespiratory fitness and cardiovascular burden in chronic kidney disease. Journal of Science and Medicine in Sport. 18(4), pp. 492 - 497. https://doi.org/10.1016/j.jsams.2014.07.005
AuthorsHowden, Erin, Weston, Kassia S., Leano, Rodel, Sharman, James E., Marwick, Thomas, Isbel, Nicole and Coombes, Jeff S.
Abstract

Objectives: Reduced functional capacity is associated with poor prognosis. In patients with chronic kidney disease the factors that contribute to low cardiorespiratory fitness are unclear. The objective of this study was to evaluate the cardiorespiratory and cardiovascular response to exercise in chronic kidney disease patients, and secondly investigate the relationships between cardiorespiratory fitness and cardiovascular burden. Design: Cross-sectional analysis. Methods: Baseline demographic, anthropometric and biochemical data were examined in 136 patients withmoderate chronic kidneydisease (age 59.7 ± 9.6 yrs, eGFR40 ± 9 ml/min/1.73 m2, 55%male, 39% with a history of cardiovascular disease, 38% diabetic and 17% current smokers). Cardiorespiratory fitness was measured as peak VO2, left ventricular morphology and function using echocardiography, central arterial stiffness by aortic pulse wave velocity and left ventricular afterload using augmentation index. Physical activity levels were assessed using the Active Australia questionnaire. Results: Peak VO2 (22.9 ± 6.5 ml/kg/min) and peak heart rate (148 ± 22 bpm) were 17% and 12% lower than the age-predicted values, respectively. The low fit group were significantly older, and were more likely to have type II diabetes, cardiovascular disease, a higher BMI and be less active than the high fit group (P < 0.05). The independent predictors of peak VO2 were age, type II diabetes, hemoglobin level, physical activity, aortic pulse wave velocity, augmentation index, and global longitudinal strain. Conclusions: In patients with chronic kidney disease, the peak VO2 and heart rate response is markedly impaired. Reduced cardiorespiratory fitness is independently associated with increased aortic stiffness, increased left ventricle afterload, poor left ventricle function and higher burden of cardiovascular risk.

Year2015
JournalJournal of Science and Medicine in Sport
Journal citation18 (4), pp. 492 - 497
PublisherElsevier Ltd
ISSN1440-2440
Digital Object Identifier (DOI)https://doi.org/10.1016/j.jsams.2014.07.005
Scopus EID2-s2.0-84946487882
Page range492 - 497
Research GroupSports Performance, Recovery, Injury and New Technologies (SPRINT) Research Centre
Publisher's version
File Access Level
Controlled
Place of publicationAustralia
EditorsG. Kolt
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