A copper(II)-selective chelator ameliorates diabetes-evoked renal fibrosis and albuminuria, and suppresses pathogenic TGF-β activation in the kidneys of rats used as a model of diabetes

Journal article

Gong, D., Lu, J., Chen, X., Reddy, S., Crossman, D. J., Glyn-Jones, S., Choong, Y.-S., Kennedy, J., Barry, B., Zhang, S., Chan, Y.-K., Ruggiero, K., Phillips, A. R. J. and Cooper, G. J. S.. (2008). A copper(II)-selective chelator ameliorates diabetes-evoked renal fibrosis and albuminuria, and suppresses pathogenic TGF-β activation in the kidneys of rats used as a model of diabetes. Diabetologia. 51(9), pp. 1741-1751. https://doi.org/10.1007/s00125-008-1088-7
AuthorsGong, D., Lu, J., Chen, X., Reddy, S., Crossman, D. J., Glyn-Jones, S., Choong, Y.-S., Kennedy, J., Barry, B., Zhang, S., Chan, Y.-K., Ruggiero, K., Phillips, A. R. J. and Cooper, G. J. S.
Abstract

Aims/hypothesis
The selective CuII chelator triethylenetetramine (TETA) extracts systemic CuII into the urine of diabetic humans and rats as a model of diabetes, and in the process also normalises hallmarks of diabetic heart disease. However, the role of Cu and its response to TETA in animals with diabetic nephropathy were previously unknown. Here, we report the effects of TETA treatment on Cu and other essential elements, as well as on indices of renal injury and known pathogenic molecular processes, in kidneys from a rat model of diabetes.

Methods
Rats at 8 weeks after streptozotocin-induction of diabetes were treated with oral TETA (34 mg/day in drinking water) for a further 8 weeks and then compared with untreated diabetic control animals.

Results
Renal tissue Cu was substantively elevated by diabetes and normalised by TETA, which also suppressed whole-kidney and glomerular hypertrophy without lowering blood glucose. The urinary albumin: creatinine ratio was significantly elevated in the rat model of diabetes but lowered by TETA. Total collagen was also elevated in diabetic kidneys and significantly improved by TETA. Furthermore, renal cortex levels of TGF-β1, MAD homologue (SMAD) 4, phosphorylated SMAD2, fibronectin-1, collagen-III, collagen-IV, plasminogen activator inhibitor-1 and semicarbazide-sensitive amine oxidase all tended to be elevated in diabetes and normalised by TETA.

Conclusions/interpretation
Dysregulation of renal Cu homeostasis may be a key event eliciting development of diabetic nephropathy. Selective CuII chelation can protect against pathogenic mechanisms that lead to or cause diabetic nephropathy and might be clinically useful in the treatment of early-stage diabetic kidney disease.

Keywordsalbuminuria; diabetic nephropathy; divalent copper; extracellular matrix; glomerular hypertrophy; semicarbazide-sensitive amine oxidase; SSAO; TGF-β; triethylenetetramine
Year2008
JournalDiabetologia
Journal citation51 (9), pp. 1741-1751
PublisherSpringer
ISSN0012-186X
Digital Object Identifier (DOI)https://doi.org/10.1007/s00125-008-1088-7
PubMed ID18636238
Scopus EID2-s2.0-49249098236
Page range1741-1751
Publisher's version
License
All rights reserved
File Access Level
Controlled
Output statusPublished
Publication dates
Online18 Jul 2008
Publication process dates
Accepted21 May 2008
Permalink -

https://acuresearchbank.acu.edu.au/item/8706w/a-copper-ii-selective-chelator-ameliorates-diabetes-evoked-renal-fibrosis-and-albuminuria-and-suppresses-pathogenic-tgf-activation-in-the-kidneys-of-rats-used-as-a-model-of-diabetes

Log in to edit

Restricted files

Publisher's version

  • 146
    total views
  • 0
    total downloads
  • 49
    views this month
  • 0
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Clinical to Population Prevalence of Hypertrophic Cardiomyopathy Phenotype: Insights From the National Echo Database Australia
Playford, David, Strange, Geoffrey, Atherton, John, Harris, Sarah Ann, Chan, Yih Kai and Stewart, Simon. (2024). Clinical to Population Prevalence of Hypertrophic Cardiomyopathy Phenotype: Insights From the National Echo Database Australia. Heart Lung and Circulation. 33(2), pp. 212-221. https://doi.org/10.1016/j.hlc.2023.10.021
Projected burden and distribution of elevated blood pressure levels and its consequence among adolescents in sub-Saharan Africa
Chen, Alexander, Mocumbi, Ana Olga, Ojji, Dike, Waite, Laura, Chan, Yih Kai, Beilby, Justin, Celermajer, David, Nkeh-Chungag, Benedicta Ngwenchi, Damasceno, Albertino, Codde, Jim and Stewart, Simon. (2024). Projected burden and distribution of elevated blood pressure levels and its consequence among adolescents in sub-Saharan Africa. Journal of Global Health. 14, pp. 1-12. https://doi.org/10.7189/jogh.14.04136
Hypertension among people living with human immunodeficiency virus in sub-Saharan Africa : a systematic review and meta-analysis
Chen, Alexander, Chan, Yih Kai, Mocumbi, Ana, Ojji, Dike, Waite, Laura, Beilby, Justin, Codde, Jim, Dobe, Igor, Nkeh-Chungag, Benedicta Ngwenchi, Damasceno, Albertino and Stewart, Simon. (2024). Hypertension among people living with human immunodeficiency virus in sub-Saharan Africa : a systematic review and meta-analysis. Scientific Reports. 14, pp. 1-11. https://doi.org/10.1038/s41598-024-67703-5
Associations of the neighbourhood built and natural environment with cardiometabolic health indicators : A cross-sectional analysis of environmental moderators and behavioural mediators
Cerin, Ester, Chan, Yih Kai, Symmons, Mark, Soloveva, Maria, Martino, Erika, Shaw, J., Knibbs, Luke, Jalaludin, Bin and Barnett, Anthony. (2024). Associations of the neighbourhood built and natural environment with cardiometabolic health indicators : A cross-sectional analysis of environmental moderators and behavioural mediators. Environmental Research. 240, pp. 1-17. https://doi.org/10.1016/j.envres.2023.117524
Pattern and Prognostic Impact of Regional Wall Motion Abnormalities in 255 697 Men and 236 641 Women Investigated with Echocardiography
Playford, David, Stewart, Simon, Harris, Sarah Ann, Chan, Y. and Strange, Geoff. (2023). Pattern and Prognostic Impact of Regional Wall Motion Abnormalities in 255 697 Men and 236 641 Women Investigated with Echocardiography. Journal of the American Heart Association. 12(22), pp. 1-13. https://doi.org/10.1161/JAHA.123.031243
Incident pulmonary hypertension in 13488 cases investigated with repeat echocardiography : A clinical cohort study
Stewart, Simon, Chan, Yih Kai, Playford, David, Harris, Sarah and Strange, Geoffrey A.. (2023). Incident pulmonary hypertension in 13488 cases investigated with repeat echocardiography : A clinical cohort study. ERJ Open Research. 9(4), pp. Article 00082-2023. https://doi.org/10.1183/23120541.00082-2023
Vulnerability to environmental and climatic health provocations among women and men hospitalised with chronic heart disease : Insights from the RESILIENCE TRIAL cohort
Stewart, Simon, Patel, Sheila K., Lancefield, Terase F., Rodrigues, Thalys S., Doumtsis, Nicolas, Jess, Ashleigh, Vaughan-Fowler, Emily-Rose, Chan, Yih Kai, Ramchand, Jay, Yates, Paul A., Kwong, Jason C., McDonald, Christine F. and Burrell, Louise M.. (2023). Vulnerability to environmental and climatic health provocations among women and men hospitalised with chronic heart disease : Insights from the RESILIENCE TRIAL cohort. European Journal of Cardiovascular Nursing. pp. 1-9. https://doi.org/10.1093/eurjcn/zvad076
Elevated blood pressure among adolescents in sub-Saharan Africa : A systematic review and meta-analysis
Chen, Alexander, Waite, Laura, Mocumbi, Ana O., Chan, Yih Kai, Beilby, Justin, Ojji, Dike B. and Stewart, Simon. (2023). Elevated blood pressure among adolescents in sub-Saharan Africa : A systematic review and meta-analysis. The Lancet Global Health. 11(8), pp. e1238-e1246. https://doi.org/10.1016/S2214-109X(23)00218-8
An inevitable or modifiable trajectory towards heart failure in high-risk individuals : Insights from the nurse-led intervention for less chronic heart failure (NIL-CHF) study
Chan, Yih Kai, Stickland, Nerolie and Stewart, Simon. (2022). An inevitable or modifiable trajectory towards heart failure in high-risk individuals : Insights from the nurse-led intervention for less chronic heart failure (NIL-CHF) study. European Journal of Cardiovascular Nursing. 22(1), pp. 33-42. https://doi.org/10.1093/eurjcn/zvac036
Characteristics of symptoms and symptom change across different heart failure subtypes : A sex-stratified analysis
Seckin, Muzeyyen, Johnston, Bridget, Petrie, Mark C., Stewart, Simon and Chan, Yih Kai. (2022). Characteristics of symptoms and symptom change across different heart failure subtypes : A sex-stratified analysis. European Journal of Cardiovascular Nursing. 22(7), p. 690–700. https://doi.org/10.1093/eurjcn/zvac099
Mild pulmonary hypertension and premature mortality among 154 956 men and women undergoing routine echocardiography
Stewart, Simon, Chan, Yih Kai, Playford, David and Strange, Geoffrey A.. (2022). Mild pulmonary hypertension and premature mortality among 154 956 men and women undergoing routine echocardiography. European Respiratory Journal. 59(1), pp. 1-13. https://doi.org/10.1183/13993003.00832-2021
Incremental value of global longitudinal strain in the long-term prediction of heart failure among patients with coronary artery disease
Haji, Kawa, Marwick, Thomas H., Stewart, Simon, Carrington, Melinda, Chan, Yih Kai, Chan, William, Huynh, Quan, Neil, Christopher and Wong, Chiew. (2022). Incremental value of global longitudinal strain in the long-term prediction of heart failure among patients with coronary artery disease. Journal of the American Society of Echocardiography. 35(2), pp. 187-195. https://doi.org/10.1016/j.echo.2021.09.003
Counting the cost of premature mortality with progressively worse aortic stenosis in Australia : a clinical cohort study
Stewart, Simon, Afoakwah, Clifford, Chan, Yih Kai, Strom, Jordan, Playford, David and Strange, Geoffrey. (2022). Counting the cost of premature mortality with progressively worse aortic stenosis in Australia : a clinical cohort study. The Lancet Healthy Longevity. 3(9), pp. 599-606. https://doi.org/10.1016/S2666-7568(22)00168-4
Incident aortic stenosis in 49 449 men and 42 229 women investigated with routine echocardiography
Stewart, Simon, Chan, Yih-Kai, Playford, David, Strange, Geoffrey A. and NEDA Investigators. (2022). Incident aortic stenosis in 49 449 men and 42 229 women investigated with routine echocardiography. Heart. 108(11), pp. 875-881. https://doi.org/10.1136/heartjnl-2021-319697
Change in ejection fraction and long-term mortality in adults referred for echocardiography
Strange, Geoff, Playford, David, Scalia, Gregory M., Celermajer, David S., Prior, David, Codde, Jim, Chan, Yih-Kai, Bulsara, Max K., Stewart, S. and on behalf of the Neda Investigators. (2021). Change in ejection fraction and long-term mortality in adults referred for echocardiography. European Journal of Heart Failure. 23(4), pp. 555-563. https://doi.org/10.1002/ejhf.2161
International Mind, Activities and Urban Places (iMAP) study: methods of a cohort study on environmental and lifestyle influences on brain and cognitive health
Ester Cerin, Anthony Barnett, Basile Chaix, Mark Nieuwenhuijsen, Karen Caeyenberghs, Bin Jalaludin, Takemi Sugiyama, James Sallis, Nicola T. Lautenschlager, Michael Y Ni, Govinda Poudel, David Donaire Gonzalez, Rachel Tham, Amanda Wheeler, Luke Knibbs, Linwei Tian, Kai Chan, David Dunstan, Alison Carver and Kaarin Anstey. (2020). International Mind, Activities and Urban Places (iMAP) study: methods of a cohort study on environmental and lifestyle influences on brain and cognitive health. BMJ Open. 10(3), pp. 1-15. https://doi.org/10.1136/bmjopen-2019-036607
Left ventricular dysfunction and exercise capacity trajectory: Implications for subclinical heart failure staging criteria
Sacre, Julian W., Wong, Chiew, Chan, Yih-Kai, Carrington, Melinda J., Stewart, Simon and Kingwell, Bronwyn A.. (2019). Left ventricular dysfunction and exercise capacity trajectory: Implications for subclinical heart failure staging criteria. JACC: Cardiovascular Imaging. 12(5), pp. 798 - 806. https://doi.org/10.1016/j.jcmg.2017.10.023
Differential patterns of disease and injury in Mozambique: New perspectives from a pragmatic, multicenter, surveillance study of 7809 emergency presentations
Mocumbi, Ana O., Cebola, Bonifácio, Muloliwa, Artur, Sebastião, Federico, Sitefane, Samuel J., Manafe, Naisa, Dobe, Igor, Lumbandali, Norberto, Keates, Kimberley, Stickland, Nerolie, Chan, Yih-Kai and Stewart, Simon. (2019). Differential patterns of disease and injury in Mozambique: New perspectives from a pragmatic, multicenter, surveillance study of 7809 emergency presentations. PLoS ONE. 14(7), pp. 1 - 18. https://doi.org/10.1371/journal.pone.0219273
Within trial cost-utility analysis of disease management program for patients hospitalized with atrial fibrillation: Results from the SAFETY trial
Byrnes, Joshua, Ball, Jocasta, Gao, Lan, Chan, Kai, Kularatna, Sanjeewa, Stewart, Simon and Scuffham, Paul. (2019). Within trial cost-utility analysis of disease management program for patients hospitalized with atrial fibrillation: Results from the SAFETY trial. Journal of Medical Economics. 22(9), pp. 945 - 952. https://doi.org/10.1080/13696998.2019.1631831
Prevalence and profile of "seasonal frequent flyers" with chronic heart disease: Analysis of 1598 patients and 4588 patient-years follow-up
Loader, Jordan, Chan, Yih-Kai, Hawley, John A., Moholdt, Trine, McDonald, Christine F., Jhund, Pardeep, Petrie, Mark C., McMurray, John J., Scuffham, Paul A., Ramchand, Jay, Burrell, Louise M. and Stewart, Simon. (2019). Prevalence and profile of "seasonal frequent flyers" with chronic heart disease: Analysis of 1598 patients and 4588 patient-years follow-up. International Journal of Cardiology. 279, pp. 126 - 132. https://doi.org/10.1016/j.ijcard.2018.12.060
Malignant and benign phenotypes of multimorbidity in heart failure: Implications for clinical practice
Chen, Lei, Chan, Yih-Kai, Busija, Lucy, Norekval, Tone M., Riegel, Barbara and Stewart, Simon. (2019). Malignant and benign phenotypes of multimorbidity in heart failure: Implications for clinical practice. Journal of Cardiovascular Nursing. 34(3), pp. 258 - 266. https://doi.org/10.1097/JCN.0000000000000557
Mild cognitive impairment is associated with subclinical diastolic dysfunction in patients with chronic heart disease
Sacre, Julian W., Ball, Jocasta, Wong, Chiew, Chan, Kai, Stewart, Simon, Kingwell, Bronwyn A. and Carrington, Melinda. (2018). Mild cognitive impairment is associated with subclinical diastolic dysfunction in patients with chronic heart disease. European Heart Journal: Cardiovascular Imaging. 19(3), pp. 285 - 292. https://doi.org/10.1093/ehjci/jex169
Economic evaluation of a nurse-led home and clinic-based secondary prevention programme to prevent progressive cardiac dysfunction in high-risk individuals: the nurse-led intervention for less chronic heart failure (nil-chf) randomized controlled study
Maru, Shoku, Byrnes, Joshua, Carrington, Melinda, Chan, Kai, Stewart, Simon and Scuffham, Paul. (2018). Economic evaluation of a nurse-led home and clinic-based secondary prevention programme to prevent progressive cardiac dysfunction in high-risk individuals: the nurse-led intervention for less chronic heart failure (nil-chf) randomized controlled study. European Journal of Cardiovascular Nursing. 17(5), pp. 439 - 445. https://doi.org/10.1177/1474515117743979
Multimorbidity and the risk of all-cause 30-day readmission in the setting of multidisciplinary management of chronic heart failure: A retrospective analysis of 830 hospitalized patients in Australia
Wiley, Joshua F., Chan, Yih-Kai, Ahamed, Yasmin, Ball, Jocasta, Carrington, Melinda J., Reigel, Barbara and Stewart, Simon. (2018). Multimorbidity and the risk of all-cause 30-day readmission in the setting of multidisciplinary management of chronic heart failure: A retrospective analysis of 830 hospitalized patients in Australia. Journal of Cardiovascular Nursing. 33(5), pp. 437 - 445. https://doi.org/10.1097/JCN.0000000000000391
Small particle size lipid emulsions, satiety and energy intake in lean men
Chan, Kai, Budgett, S. C., MacGibbon, A. K., Quek, S. Y., Kindleysides, Sophie and Poppitt, S. D.. (2017). Small particle size lipid emulsions, satiety and energy intake in lean men. Physiology & Behavior. 169, pp. 98 - 105. https://doi.org/10.1016/j.physbeh.2016.11.025
Comparison of the EQ-5D-3L and the SF-6D (SF-12) contemporaneous utility scores in patients with cardiovascular disease
Kularatna, Sanjeewa, Byrnes, Joshua, Chan, Yih Kai, Ski, Chantal F., Carrington, Melinda, Thompson, David, Stewart, Simon and Scuffham, Paul A.. (2017). Comparison of the EQ-5D-3L and the SF-6D (SF-12) contemporaneous utility scores in patients with cardiovascular disease. Quality of Life Research. 26(12), pp. 3399 - 3408. https://doi.org/10.1007/s11136-017-1666-6
Comparison of contemporaneous responses for EQ-5D-3L and Minnesota living with heart failure; A case for disease specific multiattribute utility instrument in cardiovascular conditions
Kularatna, Sanjeewa, Byrnes, Joshua, Chan, Yih Kai, Carrington, Melinda Jane, Stewart, Simon and Scuffham, Paul A.. (2017). Comparison of contemporaneous responses for EQ-5D-3L and Minnesota living with heart failure; A case for disease specific multiattribute utility instrument in cardiovascular conditions. International Journal of Cardiology. 227, pp. 172 - 176. https://doi.org/10.1016/j.ijcard.2016.11.030
Standard vs. Intensified management of heart failure to reduce healthcare costs: results of a multicentre, randomized controlled trial
Scuffham, Paul, Ball, Jocasta, Horowitz, John, Wong, C., Newton, P J., MacDonald, P., McVeigh, J., Rischbieth, Amanda, Emanuele, N., Carrington, Melinda, Reid, C. M., Chan, Kai and Stewart, Simon. (2017). Standard vs. Intensified management of heart failure to reduce healthcare costs: results of a multicentre, randomized controlled trial. European Heart Journal. 38(30), pp. 2340 - 2348. https://doi.org/10.1093/eurheartj/ehx259
Cardiovascular and other outcomes postintervention with insulin glargine and omega-3 fatty acids (ORIGINALE)
ORIGIN Trial Investigators* and Chan, Yih. (2016). Cardiovascular and other outcomes postintervention with insulin glargine and omega-3 fatty acids (ORIGINALE). Diabetes Care. 39(5), pp. 709-716. https://doi.org/10.2337/dc15-1676
Gender-specific secondary prevention? Differential psychosocial risk factors for major cardiovascular events
Kure, Christina, Chan, Kai, Ski, Chantal, Thompson, David, Carrington, Melinda and Stewart, Simon. (2016). Gender-specific secondary prevention? Differential psychosocial risk factors for major cardiovascular events. Open Heart (online). 3(1), pp. 1 - 8. https://doi.org/10.1136/openhrt-2015-000356
Current and projected burden of heart failure in the Australian adult population: A substantive but still ill-defined major health issue
Chan, Yih-Kai, Tuttle, Camilla, Ball, Jocasta C., Teng, Tiew-Hwa Katherine, Ahamed, Yasmin, Carrington, Melinda Jane and Stewart, Simon. (2016). Current and projected burden of heart failure in the Australian adult population: A substantive but still ill-defined major health issue. BMC Health Services Research. 16(501), pp. 1 - 10. https://doi.org/10.1186/s12913-016-1748-0
Impact of nurse-led, multidisciplinary home-based intervention on event-free survival across the spectrum of chronic heart disease: Composite analysis of health outcomes in 1226 patients from 3 randomized trials
Stewart, Simon, Wiley, Joshua F., Ball, Jocasta Clare, Chan, Yih-Kai, Ahamed, Yasmin, Thompson, David Robert and Carrington, Melinda Jane. (2016). Impact of nurse-led, multidisciplinary home-based intervention on event-free survival across the spectrum of chronic heart disease: Composite analysis of health outcomes in 1226 patients from 3 randomized trials. Circulation. 133(19), pp. 1867 - 1877. https://doi.org/10.1161/CIRCULATIONAHA.116.020730
Integrity of the human faecal microbiota following long-term sample storage
Kia, Elahe, Mackenzie, Brett W., Middleton, Danielle, Lau, Anna, Waite, David W., Lewis, Gillian, Chan, Yih Kai, Silvestre, Marta, Cooper, Garth J. S., Poppitt, Sally D. and Taylor, Michael W.. (2016). Integrity of the human faecal microbiota following long-term sample storage. PLoS ONE. 11(10), pp. 1 - 8. https://doi.org/10.1371/journal.pone.0163666
Impact of a nurse-led home and clinic-based secondary prevention programme to prevent cardiac dysfunction in high risk individuals : The Nurse-led Intervention for Less Chronic Heart Failure (NIL-CHF) randomized controlled study
Stewart, Simon, Chan, Yih-Kai, Wong, Chiew, Jennings, Garry, Scuffham, Paul, Esterman, Adrian and Carrington, Melinda. (2015). Impact of a nurse-led home and clinic-based secondary prevention programme to prevent cardiac dysfunction in high risk individuals : The Nurse-led Intervention for Less Chronic Heart Failure (NIL-CHF) randomized controlled study. European Journal of Heart Failure. 17(6), pp. 620 - 630. https://doi.org/10.1002/ejhf.272
Rediscovering Heart Failure: The contemporary burden and profile of heart failure in Australia
Chan, Yih-Kai, Gerber, Tracey, Tuttle, Camilla, Ball, Jocasta, Teng, Tiew-Hwa Katherine, Ahamed, Yasmin and Carrington, Melinda. (2015). Rediscovering Heart Failure: The contemporary burden and profile of heart failure in Australia Melbourne, Australia: Mary MacKillop Institute for Health Research.
Standard versus atrial fibrillation-specific management strategy (SAFETY) to reduce recurrent admission and prolong survival : Pragmatic, multicentre, randomised controlled trial
Stewart, Simon, Ball, Jocasta, Horowitz, John, Marwick, Thomas, Mahadevan, Gnanadevan, Wong, Chiew, Abhayaratna, Walter, Chan, Yih, Esterman, Adrian, Thompson, David, Scuffham, Paul and Carrington, Melinda. (2015). Standard versus atrial fibrillation-specific management strategy (SAFETY) to reduce recurrent admission and prolong survival : Pragmatic, multicentre, randomised controlled trial. The Lancet (online version). 385, pp. 775 - 784. https://doi.org/10.1016/S0140-6736(14)61992-9
Composite outcome measures in a pragmatic clinical trial of chronic heart failure management: A comparative assessment
Chang, Sungwon, Davidson, Patricia, Newton, Phillip, Macdonald, Peter, Carrington, Melinda, Marwick, Thomas H., Horowitz, John, Krum, Henry, Reid, Christopher, Chan, Kai, Scuffham, Paul, Sibbritt, David and Stewart, Simon. (2015). Composite outcome measures in a pragmatic clinical trial of chronic heart failure management: A comparative assessment. International Journal of Cardiology. 185, pp. 62 - 68. https://doi.org/10.1016/j.ijcard.2015.03.071
Impact of a nurse-led home and clinic-based secondary prevention programme to prevent cardiac dysfunction in high risk individuals : The Nurse-led Intervention for Less Chronic Heart Failure (NIL-CHF) randomized controlled study
Stewart, Simon, Chan, Yih-Kai, Wong, Chiew, Jennings, Garry, Scuffham, Paul, Esterman, Adrian and Carrington, Melinda. (2015). Impact of a nurse-led home and clinic-based secondary prevention programme to prevent cardiac dysfunction in high risk individuals : The Nurse-led Intervention for Less Chronic Heart Failure (NIL-CHF) randomized controlled study. European Journal of Heart Failure. 17, pp. 620 - 630. https://doi.org/10.1002/ejhf.272
A cluster-randomized controlled trial to reduce sedentary behavior and promote physical activity and health of 8-9 year olds: The Transform-Us! Study
Salmon, Vasiliki, Frost, Steven, Newton, Phillip, Macdonald, Peter, Stewart, Simon, Carrington, Melinda, Chan, Yih and Davidson, Patricia. (2015). A cluster-randomized controlled trial to reduce sedentary behavior and promote physical activity and health of 8-9 year olds: The Transform-Us! Study. BMC Public Health. 24(11), pp. 1068 - 1073. https://doi.org/10.1186/1471-2458-11-759
The development, validation and use of the Rural and Remote Teaching, Working, Living and Learning Environment Survey (RRTWLLES)
Dorman, Jeffrey, Kennedy, Joy and Young, Janelle. (2015). The development, validation and use of the Rural and Remote Teaching, Working, Living and Learning Environment Survey (RRTWLLES). Learning Environments Research. 18(1), pp. 15 - 32. https://doi.org/10.1007/s10984-014-9171-0
Cost-effectiveness of a home based intervention for secondary prevention of readmission with chronic heart disease
Byrnes, Joshua, Carrington, Melinda, Chan, Yih-Kai, Pollicino, Christine, Dubrowin, Natalie and Stewart, Simon. (2015). Cost-effectiveness of a home based intervention for secondary prevention of readmission with chronic heart disease. PLoS ONE. 10(12), pp. 1 - 13. https://doi.org/10.1371/journal.pone.0144545
Investigating acute satiation and meal termination effects of a commercial lipid emulsion : A breakfast meal study
Poppitt, Sally, Han, Shuang, Strik, Caroline, Kindleysides, Sophie and Chan, Yih-Kai. (2015). Investigating acute satiation and meal termination effects of a commercial lipid emulsion : A breakfast meal study. Physiology & Behavior. 152, pp. 20 - 25. https://doi.org/10.1016/j.physbeh.2015.09.008
Cost-effectiveness of home versus clinic-based management of chronic heart failure: Extended follow-up of pragmatic, multicentre randomized trial cohort - The WHICH? Study
Maru, Shoko, Byrnes, Joshua, Carrington, Melinda J., Chan, Yih-Kai, Thompson, David R., Stewart, Simon and Scuffham, Paul A.. (2015). Cost-effectiveness of home versus clinic-based management of chronic heart failure: Extended follow-up of pragmatic, multicentre randomized trial cohort - The WHICH? Study. International Journal of Cardiology. 201, pp. 368 - 375. https://doi.org/10.1016/j.ijcard.2015.08.066
Standard versus atrial fibrillation-specific management strategy (SAFETY) to reduce recurrent admission and prolong survival : Pragmatic, multicentre, randomised controlled trial
Stewart, Simon, Ball, Jocasta, Horowitz, John D., Marwick, Thomas H., Mahadevan, Gnanadevan, Wong, Chiew, Abhayaratna, Walter P., Chan, Yih K., Esterman, Adrian, Thompson, David R., Scuffham, Paul and Carrington, Melinda J.. (2015). Standard versus atrial fibrillation-specific management strategy (SAFETY) to reduce recurrent admission and prolong survival : Pragmatic, multicentre, randomised controlled trial. The Lancet. 385(9970), pp. 775 - 784. https://doi.org/10.1016/S0140-6736(14)61992-9
Prolonged impact of home versus clinic-based management of chronic heart failure: Extended follow-up of a pragmatic, multicentre randomized trial cohort
Stewart, Simon, Carrington, Melinda, Horowitz, John, Marwick, Thomas, Newton, Phillip, Davidson, Patricia, Macdonald, Peter, Thompson, David R., Chan, Yih Kai and Krum, Henry. (2014). Prolonged impact of home versus clinic-based management of chronic heart failure: Extended follow-up of a pragmatic, multicentre randomized trial cohort. International Journal of Cardiology. 174(3), pp. 600 - 610. https://doi.org/10.1016/j.ijcard.2014.04.164
Long-term tolerance and efficacy of adjunctive exenatide therapy on glycaemic control and bodyweight in type 2 diabetes: A retrospective study from a specialist diabetes outpatient clinic
Carrington, Melinda Jane, Chan, Yih, Stewart, Simon, Sjourke, B., Brazilek, R. and Cohen, N.. (2014). Long-term tolerance and efficacy of adjunctive exenatide therapy on glycaemic control and bodyweight in type 2 diabetes: A retrospective study from a specialist diabetes outpatient clinic. Internal Medicine Journal. 44(4), pp. 345 - 353. https://doi.org/10.1111/imj.12377
A multicenter, randomized trial of a nurse-led, home-based intervention for optimal secondary cardiac prevention suggests some benefits for men but not for women : the Young at Heart Study
Carrington, Melinda, Chan, Yih Kai, Calderone, Alicia, Scuffham, Paul, Esterman, Adrian and Goldstein, Stan. (2013). A multicenter, randomized trial of a nurse-led, home-based intervention for optimal secondary cardiac prevention suggests some benefits for men but not for women : the Young at Heart Study. Circulation: Cardiovascular Quality and Outcomes. https://doi.org/10.1161/CIRCOUTCOMES.111.000006
Impact of home versus clinic-based management of chronic heart failure : The WHiCH? (Which heart failure intervention is most cost-effective & consumer friendly in reducing hospital care) multicenter, randomized trial
Stewart, Simon, Carrington, Melinda, Marwick, Thomas, Davidson, Patricia, Macdonald, Peter, Horowitz, John, Krum, Henry, Newton, Phillip, Reid, Christopher and Chan, Yih Kai. (2012). Impact of home versus clinic-based management of chronic heart failure : The WHiCH? (Which heart failure intervention is most cost-effective & consumer friendly in reducing hospital care) multicenter, randomized trial. Journal of the American College of Cardiology. 60(14), pp. 1239 - 1248. https://doi.org/10.1016/j.jacc.2012.06.025
The emulsified lipid Fabuless (Olibra) does not decrease food intake but suppresses appetite when consumed with yoghurt but not alone or with solid foods : A food effect study
Chan, Yih, Strik, C, Budget, S, McGill, A T., Proctor, J and Poppitt, Sally. (2012). The emulsified lipid Fabuless (Olibra) does not decrease food intake but suppresses appetite when consumed with yoghurt but not alone or with solid foods : A food effect study. Physiology & Behavior. 105(3), pp. 742 - 748. https://doi.org/10.1016/j.physbeh.2011.08.042
Impact of Home Versus Clinic-Based Management of Chronic Heart Failure : The WHICH? (Which Heart Failure Intervention Is Most Cost-Effective & Consumer Friendly in Reducing Hospital Care) Multicenter, Randomized Trial
Stewart, Simon, Carrington, Melinda, Marwick, Thomas, Davidson, Patricia, Macdonald, Peter, Horowitz, John, Krum, Henry, Newton, Phillip, Reid, Christopher, Chan, Yih and Scuffham, Paul. (2012). Impact of Home Versus Clinic-Based Management of Chronic Heart Failure : The WHICH? (Which Heart Failure Intervention Is Most Cost-Effective & Consumer Friendly in Reducing Hospital Care) Multicenter, Randomized Trial. Journal of the American College of Cardiology. 60(14), pp. 1239 - 1248. https://doi.org/10.1016/j.jacc.2012.06.025
Exploring the potential to remain "Young @ Heart" : initial findings of a multi-centre, randomised study of nurse-led, home-based intervention in a hybrid health care system
Chan, Yih-Kai, Stewart, Simon, Calderone, Alicia, Scuffham, Paul, Goldstein, Stan and Carrington, Melinda J.. (2012). Exploring the potential to remain "Young @ Heart" : initial findings of a multi-centre, randomised study of nurse-led, home-based intervention in a hybrid health care system. International Journal of Cardiology. 154(1), pp. 52 - 58. https://doi.org/10.1016/j.ijcard.2010.08.071
Influence of tail versus cardiac sampling on blood glucose and lipid profiles in mice
Chan, Yih, Davis, Paul, Poppitt, Sally, Sun, Xueying, Greenhill, Nicholas, Krishnamurthi, Rita, Przerpiorski, Aneta, McGill, Anne-Thea and Krissansen, Geoffrey. (2012). Influence of tail versus cardiac sampling on blood glucose and lipid profiles in mice. Laboratory Animals. 46(2), pp. 142 - 147. https://doi.org/10.1258/la.2011.011136
Facing the challenge of retaining new teachers in rural and remote settings: A report of two case studies using a community-based mentoring model in Queensland, Australia
Young, Janelle and Kennedy, Joy. (2011). Facing the challenge of retaining new teachers in rural and remote settings: A report of two case studies using a community-based mentoring model in Queensland, Australia. In J. Wright (Ed.). AARE 2011 Conference Proceedings. Australia: Australian Association for Research in Education. pp. 1 - 11
The school choice decision of Catholic families
Kennedy, Joy, Mulholland, J. and Dorman, J.. (2011). The school choice decision of Catholic families. Journal of Catholic School Studies (print version). 83(1), pp. 6 - 19.
Copper(ii)-selective chelation improves function and antioxidant defences in cardiovascular tissues of rats as a model of diabetes: Comparisons between triethylenetetramine and three less copper-selective transition-metal-targeted treatments
Lu, J., Gong, D., Choong, Y. S., Xu, H., Chan, Kai, Chen, X., Fitzpatrick, S., Glyn-Jones, S., Zhang, S., Nakamura, T., Ruggiero, K., Obolonkin, V., Poppitt, S. D., Phillips, A. R. J. and Cooper, G. J. S.. (2010). Copper(ii)-selective chelation improves function and antioxidant defences in cardiovascular tissues of rats as a model of diabetes: Comparisons between triethylenetetramine and three less copper-selective transition-metal-targeted treatments. Diabetologia. 53(6), pp. 1217 - 1226. https://doi.org/10.1007/s00125-010-1698-8
No evidence of an effect of alterations in dietary fatty acids on fasting adiponectin over 3 weeks
Lithander, Fiona E., Keogh, Geraldine F., Wang, Yu, Cooper, G. J. S., Mulvey, Tom B., Chan, Kai, McArdle, Brian H. and Poppitt, S D.. (2008). No evidence of an effect of alterations in dietary fatty acids on fasting adiponectin over 3 weeks. Obesity. 16(3), pp. 592 - 599. https://doi.org/10.1038/oby.2007.97
Postprandial response of adiponectin, interleukin-6, tumor necrosis factor-alpha, and C-reactive protein to a high-fat dietary load
Poppitt, S. D., Keogh, Geraldine F., Lithander, Fiona E., Chan, Kai, Wang, Yu, Mulvey, Tom B., McArdle, Brian H. and Cooper, G J. S.. (2008). Postprandial response of adiponectin, interleukin-6, tumor necrosis factor-alpha, and C-reactive protein to a high-fat dietary load. Nutrition. 24(4), pp. 322 - 329. https://doi.org/10.1016/j.nut.2007.12.012
Triethylenetetramine and metabolites: levels in relation to copper and zinc excretion in urine of healthy volunteers and type 2 diabetic patients
Lu, Jun, Chan, Kai, Gamble, Gregory D., Poppitt, S D., Othman, Asma A. and Cooper, G. J. S.. (2007). Triethylenetetramine and metabolites: levels in relation to copper and zinc excretion in urine of healthy volunteers and type 2 diabetic patients. Drug Metabolism and Disposition. 35(2), pp. 221 - 227. https://doi.org/10.1124/dmd.106.012922
Practicum in Teacher Education :Implications for School Leaders
Kennedy, Joy and Dorman, Jeffrey Paul. (2007). Practicum in Teacher Education :Implications for School Leaders. Directions for Catholic Educational Leadership in the 21st Century: The vision, challenges and reality: Proceedings of the 2007 International Conference on Catholic Educational leadership. Sydney, Australia: Australian Catholic University. pp. 1 - 33
Determination of triethylenetetramine (TETA) and its metabolites in human plasma and urine by liquid chromatography-mass spectrometry (LC-MS)
Lu, Jun, Chan, Kai, Poppitt, S. D. and Cooper, G J. S.. (2007). Determination of triethylenetetramine (TETA) and its metabolites in human plasma and urine by liquid chromatography-mass spectrometry (LC-MS). Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 859(1), pp. 62 - 68. https://doi.org/10.1016/j.jchromb.2007.09.001
Professional Partnerships in Teacher Education :Implications for practice from an Australian learning environment study
Kennedy, Joy. (2007). Professional Partnerships in Teacher Education :Implications for practice from an Australian learning environment study. In Dr R Mark - Director of Research Queens University Belfast (Ed.). 37th Annual SCUTREA Conference. Leeds,United Kingdom: Standing Conference on University Teaching and Res.... pp. 1 - 10
A study of learning environment in the extended practicum of a pre-service teacher education course at a Catholic University
Kennedy, Joy. (2006). A study of learning environment in the extended practicum of a pre-service teacher education course at a Catholic University [Thesis]. https://doi.org/10.4226/66/5a94bb025e4dd
Effect of high-fat meals and fatty acid saturation on postprandial levels of the hormones ghrelin and leptin in healthy men
Poppitt, S. D., Leahy, F. E., Keogh, G. F., Wang, Y, Mulvey, T B., Stojkovic, M, Chan, Kai, Choong, Y S., McArdle, B H. and Cooper, G. J. S.. (2006). Effect of high-fat meals and fatty acid saturation on postprandial levels of the hormones ghrelin and leptin in healthy men. European Journal of Clinical Nutrition. 60(1), pp. 77 - 84. https://doi.org/10.1038/sj.ejcn.1602270
Molecular changes evoked by triethylenetetramine treatment in the extracellular matrix of the heart and aorta in diabetic rats
Gong, Deming, Lu, Jun, Chen, Xiuyin, Choong, Soon Y., Zhang, Shaoping, Chan, Kai, Glyn-Jones, Sarah, Gamble, Gregory D., Phillips, Anthony R. J. and Cooper, Garth J. S.. (2006). Molecular changes evoked by triethylenetetramine treatment in the extracellular matrix of the heart and aorta in diabetic rats. Molecular Pharmacology. 70(6), pp. 2045 - 2051. https://doi.org/10.1124/mol.106.028605
Demonstratuon of hyperglycemia-driven pathogenic abnormality of copper homeostasis in diabetes and its reversibility by selective chelation
Cooper, G. J. S., Chan, Kai, Dissanayake, Ajith M., Leahy, Fiona E., Keogh, Geraldine F., Frampton, Chris M., Gamble, Gregory D., Brunton, Dianne H., Baker, John R. and Poppitt, S D.. (2005). Demonstratuon of hyperglycemia-driven pathogenic abnormality of copper homeostasis in diabetes and its reversibility by selective chelation. Diabetes. 54(5), pp. 1468 - 1476.
Regeneration of the heart in diabetes by selective copper chelation
Cooper, G. J. S., Phillips, Anthony R. J., Choong, Soon Y., Leonard, Bridget L., Crossman, David J., Brunton, Dianne H., Saafi, Etuate L., Dissanayake, Ajith M., Cowan, Brett R., Young, Alistair A., Occleshaw, Christopher J., Chan, Kai, Leahy, Fiona E., Keogh, Geraldine F., Gamble, Gregory D., Allen, Grant R., Pope, Adele J., Boyd, Peter D. W., Poppitt, S D., ... Baker, John R.. (2004). Regeneration of the heart in diabetes by selective copper chelation. Diabetes. 53(9), pp. 2501 - 2508.
Development and validation of the extended practicum learning environment inventory
Dorman, Jeffrey Paul and Kennedy, Joy. (2002). Development and validation of the extended practicum learning environment inventory. In J. Reid and T. Brown (Ed.). Challenging Futures: Changing Agendas in Teacher Education. Armidale, Australia: University of New England.