Trace metal exposure is associated with increased exhaled nitric oxide in asthmatic children

Journal article


Godri Pollitt, Krystal J., Maikawa, Caitlin L., Wheeler, Amanda, Weichenthal, Scott, Dobbin, Nina A., Liu, Ling and Goldberg, Mark S.. (2016) Trace metal exposure is associated with increased exhaled nitric oxide in asthmatic children. Environmental Health: A Global Access Science Source. 15(1), pp. 1 - 11. https://doi.org/10.1186/s12940-016-0173-5
AuthorsGodri Pollitt, Krystal J., Maikawa, Caitlin L., Wheeler, Amanda, Weichenthal, Scott, Dobbin, Nina A., Liu, Ling and Goldberg, Mark S.
Abstract

Background
Children with asthma experience increased susceptibility to airborne pollutants. Exposure to traffic and industrial activity have been positively associated with exacerbation of symptoms as well as emergency room visits and hospitalisations. The effect of trace metals contained in fine particulate matter (aerodynamic diameter 2.5 μm and lower, PM2.5) on acute health effects amongst asthmatic children has not been well investigated. The objective of this panel study in asthmatic children was to determine the association between personal daily exposure to ambient trace metals and airway inflammation, as measured by fractional exhaled nitric oxide (FeNO).
Methods
Daily concentrations of trace metals contained on PM2.5 were determined from personal samples (n = 217) collected from 70 asthmatic school aged children in Montreal, Canada, over ten consecutive days. FeNO was measured daily using standard techniques.
Results
A positive association was found between FeNO and children’s exposure to an indicator of vehicular non-tailpipe emissions (8.9 % increase for an increase in the interquartile range (IQR) in barium, 95 % confidence interval (CI): 2.8, 15.4) as well as exposure to an indicator of industrial emissions (7.6 % increase per IQR increase in vanadium, 95 % CI: 0.1, 15.8). Elevated FeNO was also suggested for other metals on the day after the exposure: 10.3 % increase per IQR increase in aluminium (95 % CI: 4.2, 16.6) and 7.5 % increase per IQR increase in iron (95 % CI: 1.5, 13.9) at a 1-day lag period.
Conclusions
Exposures to ambient PM2.5 containing trace metals that are markers of traffic and industrial-derived emissions were associated in asthmatic children with an enhanced FeNO response.

Year2016
JournalEnvironmental Health: A Global Access Science Source
Journal citation15 (1), pp. 1 - 11
PublisherBioMed Central
ISSN1476-069X
Digital Object Identifier (DOI)https://doi.org/10.1186/s12940-016-0173-5
Scopus EID2-s2.0-84987625140
Open accessOpen access
Page range1 - 11
Research GroupMary MacKillop Institute for Health Research
Publisher's version
License
Place of publicationUnited Kingdom
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