Low YKL-40 in chronic heart failure may predict beneficial effects of statins: Analysis from the controlled rosuvastatin multinational trial in heart failure (CORONA)
Journal article
Arain, Fizza, Gullestad, Lars, Nymo, Ståle, Kjekshus, John, Cleland, John G., Michelsen, Annika, McMurray, John J., Wikstrand, John, Aukrust, Pål and Ueland, Thor. (2017). Low YKL-40 in chronic heart failure may predict beneficial effects of statins: Analysis from the controlled rosuvastatin multinational trial in heart failure (CORONA). Biomarkers. 22(3 to 4), pp. 261 - 267. https://doi.org/10.1080/1354750X.2016.1204003
Authors | Arain, Fizza, Gullestad, Lars, Nymo, Ståle, Kjekshus, John, Cleland, John G., Michelsen, Annika, McMurray, John J., Wikstrand, John, Aukrust, Pål and Ueland, Thor |
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Abstract | ABSTRACT Context and objective: To evaluate if YKL-40 can provide prognostic information in patients with ischemic heart failure (HF) and identify patients who may benefit from statin therapy. Materials and methods: The association between serum YKL-40 and predefined outcome was evaluated in 1344 HF patients assigned to rosuvastatin or placebo. Results: YKL-40 was not associated with outcome in adjusted analysis. In YKL-40 tertile 1, an effect on the primary outcome (HR 0.50, p¼0.006) and CV death (HR 0.54, p¼0.040) was seen by rosuvastatin in adjusted analysis. Conclusions: A beneficial modification of outcome was observed with statin therapy in patients with low YKL-40 levels. |
Keywords | Heart failure; mortality; risk prediction; YKL-40 |
Year | 2017 |
Journal | Biomarkers |
Journal citation | 22 (3 to 4), pp. 261 - 267 |
Publisher | Taylor and Francis Ltd |
ISSN | 1354-750X |
Digital Object Identifier (DOI) | https://doi.org/10.1080/1354750X.2016.1204003 |
Scopus EID | 2-s2.0-84978152295 |
Page range | 261 - 267 |
Research Group | Mary MacKillop Institute for Health Research |
Publisher's version | File Access Level Controlled |
Place of publication | United Kingdom |
https://acuresearchbank.acu.edu.au/item/872xv/low-ykl-40-in-chronic-heart-failure-may-predict-beneficial-effects-of-statins-analysis-from-the-controlled-rosuvastatin-multinational-trial-in-heart-failure-corona
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