Low-power 2-MHz pulsed-wave transcranial ultrasound reduces ischemic brain damage in rats

Journal article


Alexandrov, Andrei V., Barlinn, Kristian, Strong, Roger, Alexandrov, Anne W. and Aronowski, Jaroslaw 2011. Low-power 2-MHz pulsed-wave transcranial ultrasound reduces ischemic brain damage in rats. Translational Stroke Research. 2 (3), pp. 376 - 381. https://doi.org/10.1007/s12975-011-0080-6
AuthorsAlexandrov, Andrei V., Barlinn, Kristian, Strong, Roger, Alexandrov, Anne W. and Aronowski, Jaroslaw
Abstract

It is largely unknown whether prolonged insonation with ultrasound impacts the ischemic brain tissue by itself. Our goal was to evaluate safety and the effect of high-frequency ultrasound on infarct volume in rats. Thirty-two Long–Evans rats with permanent middle cerebral and carotid artery occlusions received either 2-MHz ultrasound at two levels of insonation power (128 or 10 mW) or no ultrasound (controls). We measured cerebral hemorrhage, indirect and direct infarct volume as well as edema volume at 24 h. No cerebral hemorrhages were detected in all animals. Exposure to low-power (10 mW) ultrasound resulted in a significantly decreased indirect infarct volume (p = 0.0039), direct infarct volume (p = 0.0031), and brain edema volume (p = 0.01) compared with controls. High-power (128 mW) ultrasound had no significant effects. An additional experiment with India ink showed a greater intravascular penetration of dye into ischemic tissues exposed to low-power ultrasound. Insonation with high-frequency, low-power ultrasound reduces ischemic brain damage in rat. Its effect on edema reduction and possible promotion of microcirculation could be used to facilitate drug and nutrient delivery to ischemic areas.

Keywordscerebral ischemia; transcranial ultrasound; brain edema reduction; microcirculation
Year2011
JournalTranslational Stroke Research
Journal citation2 (3), pp. 376 - 381
PublisherSpringer New York LLC
ISSN1868-4483
Digital Object Identifier (DOI)https://doi.org/10.1007/s12975-011-0080-6
Scopus EID2-s2.0-80052198682
Page range376 - 381
Place of publicationUnited States of America
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