Fake inhibitors: AMPK activation trumps inhibition
Journal article
Langendorf, Christopher G., Scott, John W. and Kemp, Bruce E.. (2017). Fake inhibitors: AMPK activation trumps inhibition. Cell Chemical Biology. 24(7), pp. 775 - 777. https://doi.org/10.1016/j.chembiol.2017.07.005
Authors | Langendorf, Christopher G., Scott, John W. and Kemp, Bruce E. |
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Abstract | Protein kinase inhibitors have become increasingly important therapeutic drugs for the treatment of human diseases; however, resistance and off-target effects can limit their use. In this issue of Cell Chemical Biology, Ross et al. (2017) reveal a novel off-target mechanism where the Src kinase inhibitor SU6656 paradoxically primes AMPK for phosphorylation and activation by the upstream kinase LKB1. |
Year | 2017 |
Journal | Cell Chemical Biology |
Journal citation | 24 (7), pp. 775 - 777 |
Publisher | Cell Press |
ISSN | 2451-9456 |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.chembiol.2017.07.005 |
Scopus EID | 2-s2.0-85024884849 |
Page range | 775 - 777 |
Research Group | Mary MacKillop Institute for Health Research |
Publisher's version | File Access Level Controlled |
Place of publication | United Kingdom |
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