Wip1 phosphatase positively modulates dendritic spine morphology and memory processes through the p38MAPK signaling pathway

Journal article


Fernandez, Francesca, Soon, Irene, Li, Zeng, Kuan, Tan Chee, Min, Deng Hong, Wong, Esther Sook-Miin, Demidov, Oleg N., Paterson, Malcom C., Dawe, Gavin, Bulavin, Dmitry V. and Xiao, Zhi-Cheng. (2012) Wip1 phosphatase positively modulates dendritic spine morphology and memory processes through the p38MAPK signaling pathway. Cell Adhesion and Migration. 6(4), pp. 333 - 343. https://doi.org/10.4161/cam.20892
AuthorsFernandez, Francesca, Soon, Irene, Li, Zeng, Kuan, Tan Chee, Min, Deng Hong, Wong, Esther Sook-Miin, Demidov, Oleg N., Paterson, Malcom C., Dawe, Gavin, Bulavin, Dmitry V. and Xiao, Zhi-Cheng
Abstract

Dendritic spine morphology is modulated by protein kinase p38, a mitogen-activated protein (MAPK), in the hippocampus. Protein p38MAPK is a substrate of wip1, a protein phosphatase. The role of wip1 in the central nervous system (CNS) has never been explored. Here, we report a novel function of wip1 in dendritic spine morphology and memory processes. Wip1 deficiency decreases dendritic spine size and density in pyramidal neurons of the hippocampal CA1 region. Simultaneously, impairments in object recognition tasks and contextual memory occur in wip1 deficient mice, but are reversed in wip1/p38 double mutant mice. Thus, our findings demonstrate that wip1 modulates dendritic morphology and memory processes through the p38MAPK signaling pathway. In addition to the well-characterized role of the wip1/p38MAPK in cell death and differentiation, we revealed the novel contribution of wip1 to cognition and dendritic spine morphology, which may suggest new approaches to treating neurodegenerative disorders.

KeywordsWip1 phosphatase; p38MAPK; memory; dendritic spine morphology; hippocampus; signaling pathway
Year2012
JournalCell Adhesion and Migration
Journal citation6 (4), pp. 333 - 343
PublisherTaylor & Francis Inc.
ISSN1933-6918
Digital Object Identifier (DOI)https://doi.org/10.4161/cam.20892
Scopus EID2-s2.0-84867267566
Page range333 - 343
Research GroupSchool of Behavioural and Health Sciences
Place of publicationUnited States of America
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