A major reduction in hospital-onset staphylococcus aureus Bacteremia in Australia - 12 years of progress: An observational study
Journal article
Mitchell, Brett, Collignon, Peter, McCann, Rebecca, Wilkinson, Irene and Wells, Anne. (2014). A major reduction in hospital-onset staphylococcus aureus Bacteremia in Australia - 12 years of progress: An observational study. Clinical Infectious Diseases. 59(7), pp. 969 - 975. https://doi.org/10.1093/cid/ciu508
Authors | Mitchell, Brett, Collignon, Peter, McCann, Rebecca, Wilkinson, Irene and Wells, Anne |
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Abstract | There have been efforts worldwide to reduce the incidence of hospital-onset Staphylococcus aureus bacteremia (SAB). This longitudinal study demonstrates a nationwide reduction in both methicillin-resistant and methicillin-susceptible SAB in Australia. Background. Staphylococcus aureus bacteremia (SAB) is a serious cause of morbidity and mortality. This longitudinal study describes significant reductions in hospital-onset SAB (HO-SAB) in Australian hospitals over the past 12 years. Methods. An observational cohort study design was used. Prospective surveillance of HO-SAB in 132 hospitals in Australia was undertaken. Aggregated data from all patients who acquired HO-SAB was collected (defined as 1 or more blood cultures positive for S. aureus taken from a patient who had been admitted to hospital for >48 hours). The primary outcome was the incidence of HO-SAB, including both methicillin-resistant (MRSA) and methicillin-susceptible (MSSA) S. aureus strains. Results. A total of 2733 HO-SAB cases were identified over the study period, giving an aggregate incidence of 0.90 per 10 000 patient-days (PDs) (95% confidence interval [CI], .86–.93). There was a 63% decrease in the annual incidence, from 1.72 per 10 000 PDs in 2002 (95% CI, 1.50–1.97) to 0.64 per 10 000 PDs (95% CI, .53–.76) in 2013. The mean reduction per year was 9.4% (95% CI, −8.1% to −10.7%). Significant reductions in both HO-MRSA (from 0.77 to 0.18 per 10 000 PDs) and HO-MSSA (from 1.71 to 0.64 per 10 000 PDs) bacteremia were observed. Conclusions. There was a major and significant reduction in incidence of HO-SAB caused by both MRSA and MSSA in Australian hospitals since 2002. This reduction coincided with a range of infection prevention and control activities implemented during this time. It suggests that national and local efforts to reduce the burden of healthcare-associated infections have been very successful. |
Keywords | bacteremia; bloodstream infection; healthcare-associated infections; infection control; Staphylococcus aureus |
Year | 2014 |
Journal | Clinical Infectious Diseases |
Journal citation | 59 (7), pp. 969 - 975 |
Publisher | Oxford University Press |
ISSN | 1058-4838 |
Digital Object Identifier (DOI) | https://doi.org/10.1093/cid/ciu508 |
Scopus EID | 2-s2.0-84918530208 |
Page range | 969 - 975 |
Research Group | School of Nursing, Midwifery and Paramedicine |
Place of publication | United States of America |
https://acuresearchbank.acu.edu.au/item/879wx/a-major-reduction-in-hospital-onset-staphylococcus-aureus-bacteremia-in-australia-12-years-of-progress-an-observational-study
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