Influence of fetal glutathione S-transferase copy number variants on adverse reproductive outcomes
Journal article
Bustamante, Mariona, Danileviciute, Asta, Espinosa, Ana, González, Juan R., Subirana, I., Cordier, Sylvaine, Chevrier, Cécile, Chatzi, Leda, Grazuleviciene, Regina, Sunyer, Jordi, Ibarluzea, Jesus, Ballester, Ferran, Villanueva, Cristina M., Nieuwenhuijsen, Mark, Estivill, Xavier and Kogevinas, Manolis. (2012). Influence of fetal glutathione S-transferase copy number variants on adverse reproductive outcomes. BJOG: An International Journal of Obstetrics and Gynaecology. 119(9), pp. 1141 - 1146. https://doi.org/10.1111/j.1471-0528.2012.03400.x
Authors | Bustamante, Mariona, Danileviciute, Asta, Espinosa, Ana, González, Juan R., Subirana, I., Cordier, Sylvaine, Chevrier, Cécile, Chatzi, Leda, Grazuleviciene, Regina, Sunyer, Jordi, Ibarluzea, Jesus, Ballester, Ferran, Villanueva, Cristina M., Nieuwenhuijsen, Mark, Estivill, Xavier and Kogevinas, Manolis |
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Abstract | A nested case–control association study was designed to investigate the influence of maternal and fetal copy number variants (CNVs) on reproductive outcomes. Genotypes of ten CNVs encompassing GST and CYP genes were assessed. Significant associations were only found for child CNV genotypes. In particular, the child GSTM1 insertion allele was associated with prematurity protection (odds ratio, 95% CI: 0.67, 0.51–0.89; P < 0.01), whereas the child GSTT2B insertion allele was associated with an increased risk of being small for gestational age (odds ratio, 95% CI: 1.33, 1.07–1.67; P = 0.01). The study highlights the role of the fetal genome in prenatal development and also the need to analyse CNVs in a systematic manner. |
Keywords | copy number variant; glutathione s-transferase; preterm; small for gestational age |
Year | 2012 |
Journal | BJOG: An International Journal of Obstetrics and Gynaecology |
Journal citation | 119 (9), pp. 1141 - 1146 |
Publisher | Wiley-Blackwell |
ISSN | 1470-0328 |
Digital Object Identifier (DOI) | https://doi.org/10.1111/j.1471-0528.2012.03400.x |
Scopus EID | 2-s2.0-84863728091 |
Page range | 1141 - 1146 |
Research Group | Mary MacKillop Institute for Health Research |
Publisher's version | File Access Level Controlled |
Place of publication | United Kingdom |
https://acuresearchbank.acu.edu.au/item/879xx/influence-of-fetal-glutathione-s-transferase-copy-number-variants-on-adverse-reproductive-outcomes
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