Carotid atherosclerosis predicts future myocardial infarction but not venous thromboembolism: The Tromsø Study

Journal article


Hald, Erin M., Lijfering, Willem M., Mathiesen, Ellisiv B., Johnsen, Stein Harald, Løchen, Maja-Lisa, Njølstad, I., Wilsgaard, Tom, Rosendaal, Frits R., Braekkan, Sigrid K. and Hansen, John-Bjarne. (2014). Carotid atherosclerosis predicts future myocardial infarction but not venous thromboembolism: The Tromsø Study. Arteriosclerosis Thrombosis and Vascular Biology. 34(1), pp. 226 - 230. https://doi.org/10.1161/Atvbaha.113.302162
AuthorsHald, Erin M., Lijfering, Willem M., Mathiesen, Ellisiv B., Johnsen, Stein Harald, Løchen, Maja-Lisa, Njølstad, I., Wilsgaard, Tom, Rosendaal, Frits R., Braekkan, Sigrid K. and Hansen, John-Bjarne
Abstract

Objective: Recent studies have suggested that arterial and venous thrombosis share common risk factors. Although carotid atherosclerosis is associated with arterial cardiovascular events, its role in venous thromboembolic disease is unclear. We wanted to investigate and compare the effect of carotid atherosclerosis on the risk of myocardial infarction (MI) and venous thromboembolism (VTE) in a general population, taking into account competing risks. Approach and Results: Mean intima-media thickness and total plaque area in the right carotid artery were measured with ultrasound in 6257 people aged 25 to 84 years who participated in a population-based health study, the Tromsø Study, from 1994 to 1995. Incident MI and VTE events were registered from date of enrollment to end of follow-up on December 31, 2010. Cox proportional hazards regression models using age as time scale were used to estimate cause-specific hazard ratios with 95% confidence intervals for MI and VTE by increasing levels of intima-media thickness and total plaque area. There were 894 incident MI cases and 256 VTE events during a median of 15.4 years of follow-up. The risk of MI increased significantly across quartiles of mean intima-media thickness (P for trend < 0.001) and with increasing total plaque area (P for trend < 0.001), but neither intima-media thickness (P for trend=0.94) nor total plaque area (P for trend=0.45) was associated with VTE risk in multivariable-adjusted analysis. Conclusions: In this study, carotid atherosclerosis was strongly associated with future MI but not with VTE. Our findings suggest that carotid atherosclerosis does not represent a link between arterial and venous thrombosis.

Keywordsatherosclerosis; carotid stenosis; epidemiology; myocardial infarction; venous thromboembolism
Year2014
JournalArteriosclerosis Thrombosis and Vascular Biology
Journal citation34 (1), pp. 226 - 230
PublisherLippincott Williams & Wilkins
ISSN1079-5642
Digital Object Identifier (DOI)https://doi.org/10.1161/Atvbaha.113.302162
Scopus EID2-s2.0-84891831482
Page range226 - 230
Research GroupMary MacKillop Institute for Health Research
Publisher's version
File Access Level
Controlled
Place of publicationUnited States of America
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