Ascorbic acid supplementation improves postprandial glycaemic control and blood pressure in individuals with type 2 diabetes: Findings of a randomized cross-over trial
Journal article
Mason, Shaun A., Rasmussen, Bodil, van Loon, Luc J. C., Salmon, Jo and Wadley, Glenn D.. (2019). Ascorbic acid supplementation improves postprandial glycaemic control and blood pressure in individuals with type 2 diabetes: Findings of a randomized cross-over trial. Diabetes, Obesity and Metabolism: a journal of pharmacology and therapeutics. 21(3), pp. 674 - 682. https://doi.org/10.1111/dom.13571
Authors | Mason, Shaun A., Rasmussen, Bodil, van Loon, Luc J. C., Salmon, Jo and Wadley, Glenn D. |
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Abstract | Aim The primary aim of this study was to investigate whether ascorbic acid (AA) supplementation improves postprandial glucose responses under free‐living conditions in individuals with type 2 diabetes. A secondary aim was to investigate the effect of AA supplementation on blood pressure. Materials and methods A total of 31 individuals with type 2 diabetes (26 males and 5 females; aged 61.8 ± 6.8 years; duration of diabetes, 5.6 ± 4.6 years; HbA1c, 7.6% ± 0.7% [mean ± SD]) were enrolled in a randomized cross‐over study involving 4 months of supplementation with oral AA (2 × 500 mg/d) or placebo. Participants wore continuous glucose monitors for 48 hours and consumed standardized meals pre‐ and post‐supplementation. Measurements included postprandial glucose incremental areas under the curve (iAUC), duration of day in hyper‐ and hypo‐glycaemia status, average 24‐hour and daily postprandial glucose concentrations, HbA1c, insulin, blood pressure (BP) and oxidative stress (F2‐isoprostanes). Results Following AA supplementation, significant decreases were observed in daily postprandial glucose iAUC (−36%), in duration of day with hyperglycaemia (−2.8 h/d) and postprandial hyperglycaemia (−1.7 h/d), in average 24‐hour glucose (−0.8 mmol/L) and daily postprandial glucose (−1.1 mmol/L) concentrations, in systolic (−7 mm Hg) and diastolic (−5 mm Hg) blood pressures and in a specific fraction of free plasma F2‐isoprostanes (−47 pg/mL) as compared to placebo. Conclusions Individuals with type 2 diabetes experienced improved postprandial and 24‐hour glycaemia and decreased BP after 4 months of AA supplementation as compared to placebo. These findings offer evidence for the proposed use of AA as an adjunct therapy to improve glycaemic and BP control in individuals with type 2 diabetes. |
Keywords | antidiabetic drug; clinical trial; continuous glucose monitoring (CGM); glycaemic control; randomised trial; type 2 diabetes |
Year | 2019 |
Journal | Diabetes, Obesity and Metabolism: a journal of pharmacology and therapeutics |
Journal citation | 21 (3), pp. 674 - 682 |
Publisher | Wiley-Blackwell Publishing Ltd. |
ISSN | 1462-8902 |
Digital Object Identifier (DOI) | https://doi.org/10.1111/dom.13571 |
Scopus EID | 2-s2.0-85057715307 |
Open access | Published as green open access |
Page range | 674 - 682 |
Research Group | Mary MacKillop Institute for Health Research |
Author's accepted manuscript | License All rights reserved File Access Level Open |
Publisher's version | License All rights reserved File Access Level Controlled |
Additional information | This is the peer reviewed version of the following article: Mason SA, Rasmussen B, van Loon LJC, Salmon J, Wadley GD. Ascorbic acid supplementation improves postprandial glycaemic control and blood pressure in individuals with type 2 diabetes: Findings of a randomized cross-over trial. Diabetes Obes Metab. 2019;21: 674–682. https://doi.org/10.1111/dom.13571 , which has been published in final form at http://doi.org/10.1111/dom.13571 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
Place of publication | United Kingdom |
https://acuresearchbank.acu.edu.au/item/87wwx/ascorbic-acid-supplementation-improves-postprandial-glycaemic-control-and-blood-pressure-in-individuals-with-type-2-diabetes-findings-of-a-randomized-cross-over-trial
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AM_Mason_2018_Ascorbic_acid_supplementation_improves_postprandial_glycaemic.pdf | |
License: All rights reserved | |
File access level: Open |
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