Jejunal casein feeding is followed by more rapid protein digestion and amino acid absorption when compared with gastric feeding in healthy young men

Journal article


Luttikhold, Joanna, van Norren, Klaske, Buijs, Nikki, Ankersmit, Marjolein, Heijboer, Annemieke C., Gootjes, Jeannette, Rijna, Herman, van Leeuwen, Paul A. M. and van Loon, Luc J.C. (2015) Jejunal casein feeding is followed by more rapid protein digestion and amino acid absorption when compared with gastric feeding in healthy young men. The Journal of Nutrition. 145(9), pp. 2033 - 2038. https://doi.org/10.3945/jn.115.211615
AuthorsLuttikhold, Joanna, van Norren, Klaske, Buijs, Nikki, Ankersmit, Marjolein, Heijboer, Annemieke C., Gootjes, Jeannette, Rijna, Herman, van Leeuwen, Paul A. M. and van Loon, Luc J.C
Abstract

Background: Dietary protein is required to attenuate the loss of muscle mass and to support recovery during a period of hospitalization. Jejunal feeding is preferred over gastric feeding in patients who are intolerant of gastric feeding. However, the impact of gastric vs. jejunal feeding on postprandial dietary protein digestion and absorption kinetics in vivo in humans remains largely unexplored. Objective: We compared the impact of gastric vs. jejunal feeding on subsequent dietary protein digestion and amino acid (AA) absorption in vivo in healthy young men. Methods: In a randomized crossover study design, 11 healthy young men (aged 21 ± 2 y) were administered 25 g specifically produced intrinsically L-[1-13C]phenylalanine–labeled intact casein via a nasogastric and a nasojejunal tube placed ~30 cm distal to the ligament of Treitz. Protein was provided in a 240-mL solution administered over a 65-min period in both feeding regimens. Blood samples were collected during the 7-h postprandial period to assess the increase in plasma AA concentrations and dietary protein–derived plasma L-[1-13C]phenylalanine enrichment. Results: Jejunal feeding compared with gastric feeding resulted in higher peak plasma phenylalanine, leucine, total essential AA (EAA), and total AA concentrations (all P < 0.05). This was attributed to a more rapid release of dietary protein–derived AAs into the circulation, as evidenced by a higher peak plasma L-[1-13C]phenylalanine enrichment concentration (2.9 ± 0.2 vs. 2.2 ± 0.2 mole percent excess; P < 0.05). The total postprandial plasma AA incremental area under the curve and time to peak did not differ after jejunal vs. gastric feeding. Plasma insulin concentrations increased to a greater extent after jejunal feeding when compared with gastric feeding (275 ± 38 vs. 178 ± 38 pmol/L; P < 0.05). Conclusions: Jejunal feeding of intact casein is followed by more rapid protein digestion and AA absorption when compared with gastric feeding in healthy young men. The greater postprandial increase in circulating EAA concentrations may allow a more robust increase in muscle protein synthesis rate after jejunal vs. gastric casein feeding. This trial was registered at trialregister.nl as NTR2801.

Keywordsenteral nutrition; malnutrition; protein; casein; gastric feeding; jejunal feeding
Year2015
JournalThe Journal of Nutrition
Journal citation145 (9), pp. 2033 - 2038
PublisherAmerican Society for Nutrition
ISSN0022-3166
Digital Object Identifier (DOI)https://doi.org/10.3945/jn.115.211615
Scopus EID2-s2.0-84941088235
Open accessOpen access
Page range2033 - 2038
Research GroupMary MacKillop Institute for Health Research
Publisher's version
Place of publicationUnited States of America
Permalink -

https://acuresearchbank.acu.edu.au/item/8815v/jejunal-casein-feeding-is-followed-by-more-rapid-protein-digestion-and-amino-acid-absorption-when-compared-with-gastric-feeding-in-healthy-young-men

  • 1
    total views
  • 12
    total downloads
  • 0
    views this month
  • 1
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as