Genome-wide association studies on serum sex steroid levels
Journal article
Vandenput, Liesbeth and Ohlsson, Claes. (2014). Genome-wide association studies on serum sex steroid levels. Molecular and Cellular Endocrinology. 382(1), pp. 758 - 766. https://doi.org/10.1016/j.mce.2013.03.009
Authors | Vandenput, Liesbeth and Ohlsson, Claes |
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Abstract | Even though the levels of circulating sex steroid hormones are to a large extent heritable, their genetic determinants are largely unknown. With the advent of genome-wide association studies (GWAS), much progress has been made and several genetic loci have been identified to be associated with serum levels of dehydroepiandrosterone sulfate, testosterone and sex hormone-binding globulin. The variants identified so far only explain a small amount of the overall heritability, but may help to elucidate the role of sex steroid hormones in common disorders such as hypogonadism, type 2 diabetes and hormone-sensitive cancers. This review provides an overview of the current state of knowledge of the genetic determinants of sex steroid hormones, with a focus on recent GWAS and brief directions for elucidating the remaining heritability. |
Keywords | genome-wide association studies; testosterone; estradiol; sex hormone-binding globulin; dehydroepiandrosterone; hypogonadism |
Year | 2014 |
Journal | Molecular and Cellular Endocrinology |
Journal citation | 382 (1), pp. 758 - 766 |
Publisher | Elsevier Ireland Ltd. |
ISSN | 0303-7207 |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.mce.2013.03.009 |
Scopus EID | 2-s2.0-84888380305 |
Page range | 758 - 766 |
Research Group | Mary MacKillop Institute for Health Research |
Publisher's version | File Access Level Controlled |
Place of publication | Ireland |
https://acuresearchbank.acu.edu.au/item/881w9/genome-wide-association-studies-on-serum-sex-steroid-levels
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