Prenatal and childhood traffic-related air pollution exposure and telomere length in European children: The HELIX Project
Journal article
Clemente, Diana B. P., Vrijheid, Martine, Martens, Dries S., Bustamante, Mariona, Chatzi, Leda, Danileviciute, Asta, de Castro, Montserrat, Grazuleviciene, Regina, Gutzkow, Kristine B., Lepeule, Johanna, Maitre, Lea, McEachan, Rosie R. C., Robinson, Oliver, Schwarze, Per E., Tamayo, Ibon, Vafeiadi, Marina, Wright, John, Slama, Remy, Nieuwenhuijsen, Mark and Nawrot, Timothy S.. (2019). Prenatal and childhood traffic-related air pollution exposure and telomere length in European children: The HELIX Project. Environmental Health Perspectives. 127(8), pp. 1 - 8. https://doi.org/10.1289/EHP4148
Authors | Clemente, Diana B. P., Vrijheid, Martine, Martens, Dries S., Bustamante, Mariona, Chatzi, Leda, Danileviciute, Asta, de Castro, Montserrat, Grazuleviciene, Regina, Gutzkow, Kristine B., Lepeule, Johanna, Maitre, Lea, McEachan, Rosie R. C., Robinson, Oliver, Schwarze, Per E., Tamayo, Ibon, Vafeiadi, Marina, Wright, John, Slama, Remy, Nieuwenhuijsen, Mark and Nawrot, Timothy S. |
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Abstract | Background: Telomere length is a molecular marker of biological aging. Objective: Here we investigated whether early-life exposure to residential air pollution was associated with leukocyte telomere length (LTL) at 8 y of age. Methods: In a multicenter European birth cohort study, HELIX (Human Early Life Exposome) ( n = 1,396 ), we estimated prenatal and 1-y childhood exposure to nitrogen dioxide (NO 2 ), particulate matter with aerodynamic diameter ≤ 2.5μ m (PM 2.5 ), and proximity to major roads. Average relative LTL was measured using quantitative real-time polymerase chain reaction (qPCR). Effect estimates of the association between LTL and prenatal, 1-y childhood air pollution, and proximity to major roads were calculated using multiple linear mixed models with a random cohort effect and adjusted for relevant covariates. Results: LTL was inversely associated with prenatal and 1-y childhoodNO 2 andPM 2.5 exposures levels. Each standard deviation (SD) increase in prenatalNO 2 was associated with a − 1.5 % (95% CI: − 2.8 , − 0.2 ) change in LTL. PrenatalPM 2.5 was nonsignificantly associated with LTL ( − 0.7 % per SD increase; 95% CI: − 2.0 , 0.6). For each SD increment in 1-y childhoodNO 2 andPM 2.5 exposure, LTL shortened by − 1.6 % (95% CI: − 2.9 , − 0.4 ) and − 1.4 % (95% CI: − 2.9 , 0.1), respectively. Each doubling in residential distance to nearest major road during childhood was associated with a 1.6% (95% CI: 0.02, 3.1) lengthening in LTL. Conclusion: Lower exposures to air pollution during pregnancy and childhood were associated with longer telomeres in European children at 8 y of age. These results suggest that reductions in traffic-related air pollution may promote molecular longevity, as exemplified by telomere length, from early life onward. |
Year | 2019 |
Journal | Environmental Health Perspectives |
Journal citation | 127 (8), pp. 1 - 8 |
Publisher | National Institute of Environmental Health Sciences, U.S. Department of Health and Human Services |
ISSN | 0091-6765 |
Digital Object Identifier (DOI) | https://doi.org/10.1289/EHP4148 |
Page range | 1 - 8 |
Research Group | Mary MacKillop Institute for Health Research |
Publisher's version | File Access Level Controlled |
Place of publication | United States of America |
https://acuresearchbank.acu.edu.au/item/881x3/prenatal-and-childhood-traffic-related-air-pollution-exposure-and-telomere-length-in-european-children-the-helix-project
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