Cognitive-behavioural therapy with post-session D-cycloserine augmentation for paediatric obsessive-compulsive disorder: Pilot randomised controlled trial

Journal article

Mataix-Cols, David, Turner, Cynthia Michelle, Monzani, Benedetta, Isomura, Kayoko, Murphy, Caroline, Krebs, Georgina and Heyman, Isobel. (2014). Cognitive-behavioural therapy with post-session D-cycloserine augmentation for paediatric obsessive-compulsive disorder: Pilot randomised controlled trial. British Journal of Psychiatry. 204(1), pp. 77 - 78. https://doi.org/10.1192/bjp.bp.113.126284
AuthorsMataix-Cols, David, Turner, Cynthia Michelle, Monzani, Benedetta, Isomura, Kayoko, Murphy, Caroline, Krebs, Georgina and Heyman, Isobel
Abstract

A partial N-methyl-d-aspartate agonist, d-cycloserine, enhances fear extinction when given before or shortly after exposure to feared stimuli in animals. In this pilot double-blind placebo-controlled trial (trial number: ISRCTN70977225), 27 youth with obsessive-compulsive disorder were randomised to either 50 mg d-cycloserine or placebo administered immediately after each of ten cognitive-behavioural therapy (CBT) sessions, primarily consisting of exposure and ritual prevention. Both groups improved significantly and maintained their gains at 1-year follow-up, with no significant advantage of d-cycloserine over placebo at any time point. The effects of CBT may not be augmented or accelerated when d-cycloserine is administered after sessions.

Year2014
JournalBritish Journal of Psychiatry
Journal citation204 (1), pp. 77 - 78
PublisherRoyal College of Psychiatrists
ISSN0007-1250
Digital Object Identifier (DOI)https://doi.org/10.1192/bjp.bp.113.126284
Scopus EID2-s2.0-84891820890
Page range77 - 78
Publisher's version
File Access Level
Controlled
Place of publicationUnited Kingdom
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