Cognitive-behavioural therapy with post-session D-cycloserine augmentation for paediatric obsessive-compulsive disorder: Pilot randomised controlled trial
Journal article
Mataix-Cols, David, Turner, Cynthia Michelle, Monzani, Benedetta, Isomura, Kayoko, Murphy, Caroline, Krebs, Georgina and Heyman, Isobel. (2014). Cognitive-behavioural therapy with post-session D-cycloserine augmentation for paediatric obsessive-compulsive disorder: Pilot randomised controlled trial. British Journal of Psychiatry. 204(1), pp. 77 - 78. https://doi.org/10.1192/bjp.bp.113.126284
Authors | Mataix-Cols, David, Turner, Cynthia Michelle, Monzani, Benedetta, Isomura, Kayoko, Murphy, Caroline, Krebs, Georgina and Heyman, Isobel |
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Abstract | A partial N-methyl-d-aspartate agonist, d-cycloserine, enhances fear extinction when given before or shortly after exposure to feared stimuli in animals. In this pilot double-blind placebo-controlled trial (trial number: ISRCTN70977225), 27 youth with obsessive-compulsive disorder were randomised to either 50 mg d-cycloserine or placebo administered immediately after each of ten cognitive-behavioural therapy (CBT) sessions, primarily consisting of exposure and ritual prevention. Both groups improved significantly and maintained their gains at 1-year follow-up, with no significant advantage of d-cycloserine over placebo at any time point. The effects of CBT may not be augmented or accelerated when d-cycloserine is administered after sessions. |
Year | 2014 |
Journal | British Journal of Psychiatry |
Journal citation | 204 (1), pp. 77 - 78 |
Publisher | Royal College of Psychiatrists |
ISSN | 0007-1250 |
Digital Object Identifier (DOI) | https://doi.org/10.1192/bjp.bp.113.126284 |
Scopus EID | 2-s2.0-84891820890 |
Page range | 77 - 78 |
Publisher's version | File Access Level Controlled |
Place of publication | United Kingdom |
https://acuresearchbank.acu.edu.au/item/8832x/cognitive-behavioural-therapy-with-post-session-d-cycloserine-augmentation-for-paediatric-obsessive-compulsive-disorder-pilot-randomised-controlled-trial
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