Peripartum cardiomyopathy: Update 2012

Journal article

Bachelier-Walenta, Katrin, Hilfiker-Kleiner, Denise and Sliwa, Karen. (2013). Peripartum cardiomyopathy: Update 2012. Current Opinion in Critical Care. 19(5), pp. 397 - 403.
AuthorsBachelier-Walenta, Katrin, Hilfiker-Kleiner, Denise and Sliwa, Karen

Purpose of review: Peripartum cardiomyopathy ( PPCM ) is a disorder in which initial left ventricular systolic dysfunction and symptoms of heart failure occur between the late stages of pregnancy and the early postpartum period. Incidences vary geographically; it is common in some countries and rare in others. The acute form of PPCM is a clinical syndrome with reduced cardiac output, tissue hypoperfusion, and increase in the pulmonary capillary wedge pressure. Monitoring of the patient with the acute form of PPCM should be initiated as soon as possible. The syndrome carries a high morbidity and mortality and diagnosis is often delayed. This review focuses on new data and aspects in terms of diagnosis, causes of disease, pharmacological therapy, and management of delivery in patients with PPCM. Recent findings: New investigations reveal that PPCM is likely due to multiple factors. It develops based on oxidative stress leading to cleavage of deleterious 16-kDa prolactin, which can be blocked with bromocriptine. New data show furthermore that it is partly a two-hit vascular disease due to imbalances in angiogenic signaling worsening the severity of the disease. Summary: Different mechanisms have been investigated and give rise to promising therapeutic approach, which will be developed based on the new findings.

Keywordsheart failure; peripartum cardiomyopathy; pregnancy
JournalCurrent Opinion in Critical Care
Journal citation19 (5), pp. 397 - 403
PublisherLippincott Williams & Wilkins
Digital Object Identifier (DOI)
Scopus EID2-s2.0-84885022621
Page range397 - 403
Research GroupMary MacKillop Institute for Health Research
Publisher's version
File Access Level
Place of publicationUnited States of America
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