Red cell distribution width is associated with incident myocardial infarction in a general population: The Tromsø Study

Journal article


Skjelbakken, Tove, Lappegard, Jostein, Ellingsen, Trygve S., Barret-Connor, Elizabeth, Brox, Jan, Løchen, Maja-Lisa, Njølstad, Inger, Wilsgaard, Tom, Mathiesen, Ellisiv B., Braekkan, Sigrid K. and Hansen, John-Bjarne. (2014). Red cell distribution width is associated with incident myocardial infarction in a general population: The Tromsø Study. Journal of the American Heart Association. 3(4), pp. 1 - 10. https://doi.org/10.1161/JAHA.114.001109
AuthorsSkjelbakken, Tove, Lappegard, Jostein, Ellingsen, Trygve S., Barret-Connor, Elizabeth, Brox, Jan, Løchen, Maja-Lisa, Njølstad, Inger, Wilsgaard, Tom, Mathiesen, Ellisiv B., Braekkan, Sigrid K. and Hansen, John-Bjarne
Abstract

Background: Red cell distribution width (RDW), a measure of the variability in size of circulating erythrocytes, is associated with mortality and adverse outcome in selected populations with cardiovascular disease. It is scarcely known whether RDW is associated with incident myocardial infarction (MI). We aimed to investigate whether RDW was associated with risk of first-ever MI in a large cohort study with participants recruited from a general population. Methods and Results: Baseline characteristics, including RDW, were collected for 25 612 participants in the Tromsø Study in 1994–1995. Incident MI during follow-up was registered from inclusion through December 31, 2010. Cox regression models were used to calculate hazard ratios with 95% confidence intervals for MI, adjusted for age, sex, body mass index, smoking, hemoglobin, white blood cells, platelets, and other traditional cardiovascular risk factors. A total of 1779 participants experienced a first-ever MI during a median follow-up time of 15.8 years. There was a linear association between RDW and risk of MI, for which a 1% increment in RDW was associated with a 13% increased risk (hazard ratio 1.13; 95% CI, 1.07 to 1.19). Participants with RDW above the 95th percentile had 71% higher risk of MI compared with those with RDW in the lowest quintile (hazard ratio 1.71; 95% CI, 1.34 to 2.20). All effect estimates were essentially similar after exclusion of participants with anemia (n=1297) from the analyses. Conclusion: RDW is associated with incident MI in a general population independent of anemia and cardiovascular risk factors.

Keywordsblood cells; cardiovascular disease; epidemiology; risk factors
Year2014
JournalJournal of the American Heart Association
Journal citation3 (4), pp. 1 - 10
PublisherWiley-Blackwell Publishing, Inc.
ISSN2047-9980
Digital Object Identifier (DOI)https://doi.org/10.1161/JAHA.114.001109
Scopus EID2-s2.0-84939460771
Open accessOpen access
Page range1 - 10
Research GroupMary MacKillop Institute for Health Research
Publisher's version
Additional information

© 2014 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Place of publicationUnited States of America
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