Determinants of exercise intolerance in breast cancer patients prior to anthracycline chemotherapy

Journal article


Beaudry, Rhys I., Howden, Erin J., Foulkes, Stephen J., Bigaran, Ashley, Claus, Piet, Haykowsky, Mark J. and La Gerche, Andre. (2019). Determinants of exercise intolerance in breast cancer patients prior to anthracycline chemotherapy. Physiological Reports. 7(1), pp. 1 - 8. https://doi.org/10.14814/phy2.13971
AuthorsBeaudry, Rhys I., Howden, Erin J., Foulkes, Stephen J., Bigaran, Ashley, Claus, Piet, Haykowsky, Mark J. and La Gerche, Andre
Abstract

Women with early‐stage breast cancer have reduced peak exercise oxygen uptake (peak V O2). The purpose of this study was to evaluate peak V O2 and right (RV ) and left (LV ) ventricular function prior to adjuvant chemotherapy. Twenty‐nine early‐stage breast cancer patients (mean age: 48 years) and 10 age‐matched healthy women were studied. Participants performed an upright cycle exercise test with expired gas analysis to measure peak V O2. RV and LV volumes and function were measured at rest, submaximal and peak supine cycle exercise using cardiac magnetic resonance imaging. Peak V O2 was significantly lower in breast cancer patients versus controls (1.7 ± 0.4 vs. 2.3 ± 0.5 L/min, P = 0.0013; 25 ± 6 vs. 35 ± 6 mL/kg/min, P = 0.00009). No significant difference was found between groups for peak upright exercise heart rate (174 ± 13 vs. 169 ± 16 bpm, P = 0.39). Rest, submaximal and peak exercise RV and LV end‐diastolic and end‐systolic volume index, stroke index, and cardiac index were significantly lower in breast cancer patients versus controls (P < 0.05 for all). No significant difference was found between groups for rest and exercise RV and LV ejection fraction. Despite preserved RV and LV ejection fraction, the decreased peak V O2 in early‐stage breast cancer patients prior to adjuvant chemotherapy is due in part to decreased peak cardiac index secondary to reductions in RV and LV end‐diastolic volumes.

Keywordsbreast cancer; cardiac function; exercise MRI; neoadjuvant; VO2.
Year2019
JournalPhysiological Reports
Journal citation7 (1), pp. 1 - 8
PublisherJohn Wiley & Sons
ISSN2051-817X
Digital Object Identifier (DOI)https://doi.org/10.14814/phy2.13971
Scopus EID2-s2.0-85059829680
Open accessOpen access
Page range1 - 8
Research GroupMary MacKillop Institute for Health Research
Publisher's version
License
Place of publicationUnited Kingdom
Permalink -

https://acuresearchbank.acu.edu.au/item/88703/determinants-of-exercise-intolerance-in-breast-cancer-patients-prior-to-anthracycline-chemotherapy

Download files

  • 76
    total views
  • 117
    total downloads
  • 2
    views this month
  • 1
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Traditional markers of cardiac toxicity fail to detect marked reductions in cardiorespiratory fitness among cancer patients undergoing anti-cancer treatment
Howden, Erin J., Foulkes, Steve, Dillon, Hayley T., Bigaran, Ashley, Wright, Leah, Janssens, Kristel, Comie, Prue, Costello, Benedict and La Gerche, André. (2021). Traditional markers of cardiac toxicity fail to detect marked reductions in cardiorespiratory fitness among cancer patients undergoing anti-cancer treatment. European Heart Journal: Cardiovascular Imaging. 22(4), pp. 451-458. https://doi.org/10.1093/ehjci/jeaa421
The effect of exercise training on cardiometabolic health in men with prostate cancer receiving androgen deprivation therapy : A systematic review and meta-analysis
Bigaran, Ashley, Zopf, Eva, Gardner, Jason, La Gerche, Andre, Murphy, Declan G., Howden, Erin J., Baker, Michael K. and Cormie, Prue. (2021). The effect of exercise training on cardiometabolic health in men with prostate cancer receiving androgen deprivation therapy : A systematic review and meta-analysis. Prostate Cancer and Prostatic Diseases. 24(1), pp. 35-48. https://doi.org/10.1038/s41391-020-00273-5
A 12-month lifestyle intervention does not improve cardiac autonomic function in patients with chronic kidney disease
Huppertz, Nina, Beetham, Kassia S., Howden, Erin J., Leicht, Anthony S., Isbel, Nicole M. and Coombes, Jeff S.. (2020). A 12-month lifestyle intervention does not improve cardiac autonomic function in patients with chronic kidney disease. Autonomic Neuroscience: Basic and Clinical. 224, pp. 1 - 6. https://doi.org/10.1016/j.autneu.2020.102642
Exercise attenuates cardiotoxicity of anthracycline chemotherapy measured by global longitudinal strain [Letter]
Costello, Benedict T., Roberts, Timothy J., Howden, Erin J., Bigaran, Ashley, Foulkes, Stephen J., Beaudry, Rhys I., Janssens, Kristel, Haykowsky, Mark J., Antill, Yolland, Nightingale, Sophie, Loi, Sherene and La Gerche, Andre. (2019). Exercise attenuates cardiotoxicity of anthracycline chemotherapy measured by global longitudinal strain [Letter] Elsevier Inc.. https://doi.org/10.1016/j.jaccao.2019.09.002
Exercise as a diagnostic and therapeutic tool for the prevention of cardiovascular dysfunction in breast cancer patients
Howden, Erin J., Bigaran, Ashley, Beaudry, Rhys, Fraser, Steve, Selig, Steve, Foulkes, Steve, Antill, Yoland, Nightingale, Sophie, Loi, Sherene, Haykowsky, Mark J. and La Gerche, Andre´. (2019). Exercise as a diagnostic and therapeutic tool for the prevention of cardiovascular dysfunction in breast cancer patients. European Journal of Preventative Cardiology. 26(3), pp. 305 - 315. https://doi.org/10.1177/2047487318811181
Persistent impairment in cardiopulmonary fitness after breast cancer chemotherapy
Foulkes, Stephen J., Howden, Erin J., Bigaran, Ashley, Janssens, Kristel, Antill, Yoland, Loi, Sherene, Claus, Piet, Haykowsky, Mark J., Daly, Robin M., Fraser, Steve F. and La Gerche, Andre. (2019). Persistent impairment in cardiopulmonary fitness after breast cancer chemotherapy. Medicine and Science in Sports and Exercise. 51(8), pp. 1573 - 1581. https://doi.org/10.1249/MSS.0000000000001970
High-intensity interval training in chronic kidney disease: A randomized pilot study
Beetham, Kassia S., Howden, Erin J., Fassett, Robert G., Petersen, Aaron, Trewin, Adam J., Isbel, Nicole M. and Coombes, Jeff S.. (2019). High-intensity interval training in chronic kidney disease: A randomized pilot study. Scandinavian Journal of Medicine & Science in Sports. 29(8), pp. 1197 - 1204. https://doi.org/10.1111/sms.13436
Agreement between cystatin-C and creatinine based eGFR estimates after a 12-month exercise intervention in patients with chronic kidney disease
Beetham, Kassia S., Howden, Erin J., Isbel, Nicole M. and Coombes, Jeff S.. (2018). Agreement between cystatin-C and creatinine based eGFR estimates after a 12-month exercise intervention in patients with chronic kidney disease. BMC Nephrology. 19(1), pp. 1 - 11. https://doi.org/10.1186/s12882-018-1146-4
Standing up to the cardiometabolic consequences of hematological cancers
Howden, Erin J., La Gerche, Andre, Arthur, Jane F., McMullen, Julie R., Jennings, Garry L., Dunstan, David, Owen, Neville, Avery, Sharon and Kingwell, Bronwyn A.. (2018). Standing up to the cardiometabolic consequences of hematological cancers. Blood Reviews. 32(5), pp. 349 - 360. https://doi.org/10.1016/j.blre.2018.02.005
Feasibility of higher intensity exercise in patients with chronic kidney disease
Weston, Kassia S., Howden, Erin, Krishnasamy, Rathika, Isbel, Nicole and Coombes, Jeff S.. (2018). Feasibility of higher intensity exercise in patients with chronic kidney disease. The Journal of Sports Medicine and Physical Fitness. 58(1-2), pp. 1 - 1. https://doi.org/10.23736/S0022-4707.16.06575-0
Effects of exercise and lifestyle intervention on oxidative stress in chronic kidney disease
Small, David, Beetham, Kassia, Howden, Erin, Briskey, David, Johnson, David, Isbel, Nicole, Gobe, Glenda and Coombes, Jeff S.. (2017). Effects of exercise and lifestyle intervention on oxidative stress in chronic kidney disease. Redox Report. 22(3), pp. 127 - 136. https://doi.org/10.1080/13510002.2016.1276314
Oxidative stress is associated with decreased heart rate variability in patients with chronic kidney disease
Fadaee, Shannon, Weston, Kassia S., Howden, Erin, Stanton, Tony, Isbel, Nicole and Coombes, Jeff S.. (2017). Oxidative stress is associated with decreased heart rate variability in patients with chronic kidney disease. Redox Report: Communications in Free Radical Research. 22(5), pp. 197 - 204. https://doi.org/10.1080/13510002.2016.1173326
Association between left ventricular global longitudinal strain, health-related quality of life and functional capacity in chronic kidney disease patients with preserved ejection fraction
Krishnasamy, Rathika, Hawley, Carmel, Stanton, Tony, Howden, Erin, Weston, Kassia S., Strand, Haakan, Leano, Rodel, Haluska, Brian, Coombes, Jeff S. and Isbel, Nicole. (2016). Association between left ventricular global longitudinal strain, health-related quality of life and functional capacity in chronic kidney disease patients with preserved ejection fraction. Nephrology. 21(2), pp. 108 - 115. https://doi.org/10.1111/nep.12557
Oxidative stress contributes to muscle atrophy in chronic kidney disease patients
Beetham, Kassia S., Howden, Erin, Small, David, Briskey, David, Rossi, Megan, Isbel, Nicole and Coombes, Jeff S.. (2015). Oxidative stress contributes to muscle atrophy in chronic kidney disease patients. Redox Report: Communications in Free Radical Research. 20(3), pp. 126 - 132. https://doi.org/10.1179/1351000214Y.0000000114
Cardiorespiratory fitness and cardiovascular burden in chronic kidney disease
Howden, Erin, Weston, Kassia S., Leano, Rodel, Sharman, James E., Marwick, Thomas, Isbel, Nicole and Coombes, Jeff S.. (2015). Cardiorespiratory fitness and cardiovascular burden in chronic kidney disease. Journal of Science and Medicine in Sport. 18(4), pp. 492 - 497. https://doi.org/10.1016/j.jsams.2014.07.005