Oxidative stress contributes to muscle atrophy in chronic kidney disease patients

Journal article


Beetham, Kassia S., Howden, Erin, Small, David, Briskey, David, Rossi, Megan, Isbel, Nicole and Coombes, Jeff S.. (2015) Oxidative stress contributes to muscle atrophy in chronic kidney disease patients. Redox Report: Communications in Free Radical Research. 20(3), pp. 126 - 132. https://doi.org/10.1179/1351000214Y.0000000114
AuthorsBeetham, Kassia S., Howden, Erin, Small, David, Briskey, David, Rossi, Megan, Isbel, Nicole and Coombes, Jeff S.
Abstract

Objectives: Patients with chronic kidney disease have impaired muscle metabolism, resulting in muscle atrophy. Oxidative stress has previously been identified as a significant contributor to muscle atrophy in other populations, but the contribution in chronic kidney disease is unknown. The aim of this study was to investigate the association between oxidative stress, grip strength, and lean mass in patients with chronic kidney disease. Methods: This is a cross-sectional study of 152 participants with stage 3 or 4 chronic kidney disease. Outcome measures include grip strength, lean mass, plasma total F2-isoprostanes, inflammation, peak oxygen uptake, and standard clinical measures. Results: Thirty four (22.4%) chronic kidney disease patients had elevated oxidative stress levels (plasma F2- isoprostanes > 250 pg/ml), with 82% of patients below age-predicted grip strength normative values. There was a significant negative association between plasma F2-isoprostanes and grip strength (r = −0.251) and lean mass (r = −0.243). There were no associations with inflammation markers. Multiple linear regression identified plasma F2-isoprostanes as a significant predictor of grip strength independent of other predictors: sex, diabetes status, body mass index, body fat percent, and phosphate (adjusted r 2 = 69.5, P < 0.001). Discussion: Plasma F2-isoprostanes were independently associated with reduced strength in chronic kidney disease patients.

Year2015
JournalRedox Report: Communications in Free Radical Research
Journal citation20 (3), pp. 126 - 132
PublisherManey Publishing
ISSN1351-0002
Digital Object Identifier (DOI)https://doi.org/10.1179/1351000214Y.0000000114
Scopus EID2-s2.0-84926373834
Page range126 - 132
Research GroupSports Performance, Recovery, Injury and New Technologies (SPRINT) Research Centre
Publisher's version
File Access Level
Controlled
Place of publicationUnited Kingdom
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