Inflammatory cytokine responses to progressive resistance training and supplementation with fortified milk in men aged 50+ years: An 18-month randomized controlled trial
Journal article
Peake, Jonathan, Kukuljan, Sonja, Nowson, Caryl, Sanders, Kerrie and Daly, Robin. (2011). Inflammatory cytokine responses to progressive resistance training and supplementation with fortified milk in men aged 50+ years: An 18-month randomized controlled trial. European Journal of Applied Physiology. 111(12), pp. 3079 - 3088. https://doi.org/10.1007/s00421-011-1942-z
Authors | Peake, Jonathan, Kukuljan, Sonja, Nowson, Caryl, Sanders, Kerrie and Daly, Robin |
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Abstract | We examined the effects of progressive resistance training (PRT) and supplementation with calcium-vitamin D3 fortified milk on markers of systemic inflammation, and the relationship between inflammation and changes in muscle mass, size and strength. Healthy men aged 50–79 years (n = 180) participated in this 18-month randomized controlled trial that comprised a factorial 2 × 2 design. Participants were randomized to (1) PRT + fortified milk supplement, (2) PRT, (3) fortified milk supplement, or (4) a control group. Participants assigned to PRT trained 3 days per week, while those in the supplement groups consumed 400 ml day−1 of milk containing 1,000 mg calcium plus 800 IU vitamin D3. We collected venous blood samples at baseline, 12 and 18 months to measure the serum concentrations of IL-6, TNF-α and hs-CRP. There were no exercise × supplement interactions, but serum IL-6 was 29% lower (95% CI, −62, 0) in the PRT group compared with the control group after 12 months. Conversely, IL-6 was 31% higher (95% CI, −2, 65) in the supplement group compared with the non-supplemented groups after 12 and 18 months. These between-group differences did not persist after adjusting for changes in fat mass. In the PRT group, mid-tibia muscle cross-sectional area increased less in men with higher pre-training inflammation compared with those men with lower inflammation (net difference ~2.5%, p < 0.05). In conclusion, serum IL-6 concentration decreased following PRT, whereas it increased after supplementation with fortified milk concomitant with changes in fat mass. Furthermore, low-grade inflammation at baseline restricted muscle hypertrophy following PRT. |
Year | 2011 |
Journal | European Journal of Applied Physiology |
Journal citation | 111 (12), pp. 3079 - 3088 |
ISSN | 1439-6319 |
Digital Object Identifier (DOI) | https://doi.org/10.1007/s00421-011-1942-z |
Page range | 3079 - 3088 |
Research Group | Institute for Health and Ageing |
Publisher's version | File Access Level Controlled |
https://acuresearchbank.acu.edu.au/item/88q20/inflammatory-cytokine-responses-to-progressive-resistance-training-and-supplementation-with-fortified-milk-in-men-aged-50-years-an-18-month-randomized-controlled-trial
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